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GeneBe API Showcase
This page demonstrates how to use the GeneBe API to query variant information. The API provides programmatic access to genomic annotations and variant data.
API presented here should be used for checking single variants. If you want to check many variants at once, please use other API endpoints that you will find in the documentation.
Documentation & Advanced Usage
• Complete API documentation:docs.genebe.net/docs/api/overview/
• Interactive endpoint tester:api.genebe.net/cloud/gb-api-doc/swagger-ui/
• Python client for pandas:pypi.org/project/genebe/
• Java CLI for VCF files:github.com/pstawinski/genebe-cli
• All tools documented at:docs.genebe.net
API Request Examples for Variant: 3-113278222-G-A (hg38)
Bash / cURL Example
bash
curl "https://api.genebe.net/cloud/api-public/v1/variant?chr=3&pos=113278222&ref=G&alt=A&genome=hg38&allGenes=true"API Response
json
{
"variants": [
{
"chr": "3",
"pos": 113278222,
"ref": "G",
"alt": "A",
"effect": "missense_variant",
"transcript": "ENST00000682979.1",
"consequences": [
{
"aa_ref": "G",
"aa_alt": "E",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 10,
"exon_rank_end": null,
"exon_count": 20,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "BOC",
"gene_hgnc_id": 17173,
"hgvs_c": "c.1670G>A",
"hgvs_p": "p.Gly557Glu",
"transcript": "NM_001378074.1",
"protein_id": "NP_001365003.1",
"transcript_support_level": null,
"aa_start": 557,
"aa_end": null,
"aa_length": 1115,
"cds_start": 1670,
"cds_end": null,
"cds_length": 3348,
"cdna_start": 2299,
"cdna_end": null,
"cdna_length": 4574,
"mane_select": "ENST00000682979.1",
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "G",
"aa_alt": "E",
"canonical": true,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 10,
"exon_rank_end": null,
"exon_count": 20,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "BOC",
"gene_hgnc_id": 17173,
"hgvs_c": "c.1670G>A",
"hgvs_p": "p.Gly557Glu",
"transcript": "ENST00000682979.1",
"protein_id": "ENSP00000507783.1",
"transcript_support_level": null,
"aa_start": 557,
"aa_end": null,
"aa_length": 1115,
"cds_start": 1670,
"cds_end": null,
"cds_length": 3348,
"cdna_start": 2299,
"cdna_end": null,
"cdna_length": 4574,
"mane_select": "NM_001378074.1",
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "G",
"aa_alt": "E",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 10,
"exon_rank_end": null,
"exon_count": 20,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "BOC",
"gene_hgnc_id": 17173,
"hgvs_c": "c.1670G>A",
"hgvs_p": "p.Gly557Glu",
"transcript": "ENST00000273395.8",
"protein_id": "ENSP00000273395.4",
"transcript_support_level": 1,
"aa_start": 557,
"aa_end": null,
"aa_length": 1115,
"cds_start": 1670,
"cds_end": null,
"cds_length": 3348,
"cdna_start": 2009,
"cdna_end": null,
"cdna_length": 4276,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "G",
"aa_alt": "E",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 10,
"exon_rank_end": null,
"exon_count": 20,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "BOC",
"gene_hgnc_id": 17173,
"hgvs_c": "c.1667G>A",
"hgvs_p": "p.Gly556Glu",
"transcript": "ENST00000495514.5",
"protein_id": "ENSP00000418663.1",
"transcript_support_level": 1,
"aa_start": 556,
"aa_end": null,
"aa_length": 1114,
"cds_start": 1667,
"cds_end": null,
"cds_length": 3345,
"cdna_start": 2371,
"cdna_end": null,
"cdna_length": 4646,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "G",
"aa_alt": "E",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 10,
"exon_rank_end": null,
"exon_count": 20,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "BOC",
"gene_hgnc_id": 17173,
"hgvs_c": "c.1670G>A",
"hgvs_p": "p.Gly557Glu",
"transcript": "NM_001301861.2",
"protein_id": "NP_001288790.1",
"transcript_support_level": null,
"aa_start": 557,
"aa_end": null,
"aa_length": 1115,
"cds_start": 1670,
"cds_end": null,
"cds_length": 3348,
"cdna_start": 2421,
"cdna_end": null,
"cdna_length": 4696,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "G",
"aa_alt": "E",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 10,
"exon_rank_end": null,
"exon_count": 20,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "BOC",
"gene_hgnc_id": 17173,
"hgvs_c": "c.1670G>A",
"hgvs_p": "p.Gly557Glu",
"transcript": "NM_001378073.1",
"protein_id": "NP_001365002.1",
"transcript_support_level": null,
"aa_start": 557,
"aa_end": null,
"aa_length": 1115,
"cds_start": 1670,
"cds_end": null,
"cds_length": 3348,
"cdna_start": 2303,
"cdna_end": null,
"cdna_length": 4578,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "G",
"aa_alt": "E",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 10,
"exon_rank_end": null,
"exon_count": 20,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "BOC",
"gene_hgnc_id": 17173,
"hgvs_c": "c.1670G>A",
"hgvs_p": "p.Gly557Glu",
"transcript": "NM_001387919.1",
"protein_id": "NP_001374848.1",
"transcript_support_level": null,
"aa_start": 557,
"aa_end": null,
"aa_length": 1115,
"cds_start": 1670,
"cds_end": null,
"cds_length": 3348,
"cdna_start": 2417,
"cdna_end": null,
"cdna_length": 4692,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "G",
"aa_alt": "E",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 10,
"exon_rank_end": null,
"exon_count": 20,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "BOC",
"gene_hgnc_id": 17173,
"hgvs_c": "c.1667G>A",
"hgvs_p": "p.Gly556Glu",
"transcript": "NM_001378075.1",
"protein_id": "NP_001365004.1",
"transcript_support_level": null,
"aa_start": 556,
"aa_end": null,
"aa_length": 1114,
"cds_start": 1667,
"cds_end": null,
"cds_length": 3345,
"cdna_start": 2442,
"cdna_end": null,
"cdna_length": 4717,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "G",
"aa_alt": "E",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 10,
"exon_rank_end": null,
"exon_count": 20,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "BOC",
"gene_hgnc_id": 17173,
"hgvs_c": "c.1667G>A",
"hgvs_p": "p.Gly556Glu",
"transcript": "NM_001387920.1",
"protein_id": "NP_001374849.1",
"transcript_support_level": null,
"aa_start": 556,
"aa_end": null,
"aa_length": 1114,
"cds_start": 1667,
"cds_end": null,
"cds_length": 3345,
"cdna_start": 2246,
"cdna_end": null,
"cdna_length": 4521,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "G",
"aa_alt": "E",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 10,
"exon_rank_end": null,
"exon_count": 20,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "BOC",
"gene_hgnc_id": 17173,
"hgvs_c": "c.1667G>A",
"hgvs_p": "p.Gly556Glu",
"transcript": "NM_001387921.1",
"protein_id": "NP_001374850.1",
"transcript_support_level": null,
"aa_start": 556,
"aa_end": null,
"aa_length": 1114,
"cds_start": 1667,
"cds_end": null,
"cds_length": 3345,
"cdna_start": 2242,
"cdna_end": null,
"cdna_length": 4517,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "G",
"aa_alt": "E",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 10,
"exon_rank_end": null,
"exon_count": 20,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "BOC",
"gene_hgnc_id": 17173,
"hgvs_c": "c.1667G>A",
"hgvs_p": "p.Gly556Glu",
"transcript": "NM_033254.4",
"protein_id": "NP_150279.1",
"transcript_support_level": null,
"aa_start": 556,
"aa_end": null,
"aa_length": 1114,
"cds_start": 1667,
"cds_end": null,
"cds_length": 3345,
"cdna_start": 2296,
"cdna_end": null,
"cdna_length": 4571,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "G",
"aa_alt": "E",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 10,
"exon_rank_end": null,
"exon_count": 20,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "BOC",
"gene_hgnc_id": 17173,
"hgvs_c": "c.1667G>A",
"hgvs_p": "p.Gly556Glu",
"transcript": "ENST00000355385.7",
"protein_id": "ENSP00000347546.3",
"transcript_support_level": 5,
"aa_start": 556,
"aa_end": null,
"aa_length": 1114,
"cds_start": 1667,
"cds_end": null,
"cds_length": 3345,
"cdna_start": 2006,
"cdna_end": null,
"cdna_length": 4278,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "G",
"aa_alt": "E",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 9,
"exon_rank_end": null,
"exon_count": 19,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "BOC",
"gene_hgnc_id": 17173,
"hgvs_c": "c.1397G>A",
"hgvs_p": "p.Gly466Glu",
"transcript": "NM_001387924.1",
"protein_id": "NP_001374853.1",
"transcript_support_level": null,
"aa_start": 466,
"aa_end": null,
"aa_length": 1024,
"cds_start": 1397,
"cds_end": null,
"cds_length": 3075,
"cdna_start": 2026,
"cdna_end": null,
"cdna_length": 4301,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "G",
"aa_alt": "E",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 10,
"exon_rank_end": null,
"exon_count": 19,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "BOC",
"gene_hgnc_id": 17173,
"hgvs_c": "c.1667G>A",
"hgvs_p": "p.Gly556Glu",
"transcript": "NM_001387925.1",
"protein_id": "NP_001374854.1",
"transcript_support_level": null,
"aa_start": 556,
"aa_end": null,
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"cds_start": 1667,
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"cdna_start": 2300,
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"mane_select": null,
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"biotype": null,
"feature": null
},
{
"aa_ref": "G",
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"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 10,
"exon_rank_end": null,
"exon_count": 15,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "BOC",
"gene_hgnc_id": 17173,
"hgvs_c": "c.1670G>A",
"hgvs_p": "p.Gly557Glu",
"transcript": "NM_001387926.1",
"protein_id": "NP_001374855.1",
"transcript_support_level": null,
"aa_start": 557,
"aa_end": null,
"aa_length": 871,
"cds_start": 1670,
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"cds_length": 2616,
"cdna_start": 2299,
"cdna_end": null,
"cdna_length": 3264,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "G",
"aa_alt": "E",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 10,
"exon_rank_end": null,
"exon_count": 15,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "BOC",
"gene_hgnc_id": 17173,
"hgvs_c": "c.1667G>A",
"hgvs_p": "p.Gly556Glu",
"transcript": "NM_001387927.1",
"protein_id": "NP_001374856.1",
"transcript_support_level": null,
"aa_start": 556,
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"cdna_start": 2300,
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"mane_select": null,
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"biotype": null,
"feature": null
},
{
"aa_ref": "G",
"aa_alt": "E",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 10,
"exon_rank_end": null,
"exon_count": 15,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "BOC",
"gene_hgnc_id": 17173,
"hgvs_c": "c.1667G>A",
"hgvs_p": "p.Gly556Glu",
"transcript": "NM_001387928.1",
"protein_id": "NP_001374857.1",
"transcript_support_level": null,
"aa_start": 556,
"aa_end": null,
"aa_length": 870,
"cds_start": 1667,
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"cdna_start": 2242,
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"cdna_length": 3207,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "G",
"aa_alt": "E",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 9,
"exon_rank_end": null,
"exon_count": 19,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "BOC",
"gene_hgnc_id": 17173,
"hgvs_c": "c.1679G>A",
"hgvs_p": "p.Gly560Glu",
"transcript": "XM_047449173.1",
"protein_id": "XP_047305129.1",
"transcript_support_level": null,
"aa_start": 560,
"aa_end": null,
"aa_length": 1152,
"cds_start": 1679,
"cds_end": null,
"cds_length": 3459,
"cdna_start": 1854,
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"cdna_length": 4231,
"mane_select": null,
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"biotype": null,
"feature": null
},
{
"aa_ref": "G",
"aa_alt": "E",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 9,
"exon_rank_end": null,
"exon_count": 19,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "BOC",
"gene_hgnc_id": 17173,
"hgvs_c": "c.1679G>A",
"hgvs_p": "p.Gly560Glu",
"transcript": "XM_047449175.1",
"protein_id": "XP_047305131.1",
"transcript_support_level": null,
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"aa_end": null,
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"feature": null
},
{
"aa_ref": "G",
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"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 9,
"exon_rank_end": null,
"exon_count": 19,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "BOC",
"gene_hgnc_id": 17173,
"hgvs_c": "c.1679G>A",
"hgvs_p": "p.Gly560Glu",
"transcript": "XM_047449176.1",
"protein_id": "XP_047305132.1",
"transcript_support_level": null,
"aa_start": 560,
"aa_end": null,
"aa_length": 1152,
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"cdna_start": 1894,
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"biotype": null,
"feature": null
},
{
"aa_ref": "G",
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"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 9,
"exon_rank_end": null,
"exon_count": 19,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "BOC",
"gene_hgnc_id": 17173,
"hgvs_c": "c.1676G>A",
"hgvs_p": "p.Gly559Glu",
"transcript": "XM_047449177.1",
"protein_id": "XP_047305133.1",
"transcript_support_level": null,
"aa_start": 559,
"aa_end": null,
"aa_length": 1151,
"cds_start": 1676,
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"cdna_start": 1851,
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"cdna_length": 4228,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "G",
"aa_alt": "E",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 9,
"exon_rank_end": null,
"exon_count": 19,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "BOC",
"gene_hgnc_id": 17173,
"hgvs_c": "c.1670G>A",
"hgvs_p": "p.Gly557Glu",
"transcript": "XM_047449178.1",
"protein_id": "XP_047305134.1",
"transcript_support_level": null,
"aa_start": 557,
"aa_end": null,
"aa_length": 1149,
"cds_start": 1670,
"cds_end": null,
"cds_length": 3450,
"cdna_start": 1845,
"cdna_end": null,
"cdna_length": 4222,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "G",
"aa_alt": "E",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 10,
"exon_rank_end": null,
"exon_count": 20,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "BOC",
"gene_hgnc_id": 17173,
"hgvs_c": "c.1670G>A",
"hgvs_p": "p.Gly557Glu",
"transcript": "XM_047449179.1",
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}