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GeneBe API Showcase
This page demonstrates how to use the GeneBe API to query variant information. The API provides programmatic access to genomic annotations and variant data.
API presented here should be used for checking single variants. If you want to check many variants at once, please use other API endpoints that you will find in the documentation.
Documentation & Advanced Usage
• Complete API documentation:docs.genebe.net/docs/api/overview/
• Interactive endpoint tester:api.genebe.net/cloud/gb-api-doc/swagger-ui/
• Python client for pandas:pypi.org/project/genebe/
• Java CLI for VCF files:github.com/pstawinski/genebe-cli
• All tools documented at:docs.genebe.net
API Request Examples for Variant: 3-113611133-G-C (hg38)
Bash / cURL Example
bash
curl "https://api.genebe.net/cloud/api-public/v1/variant?chr=3&pos=113611133&ref=G&alt=C&genome=hg38&allGenes=true"API Response
json
{
"variants": [
{
"chr": "3",
"pos": 113611133,
"ref": "G",
"alt": "C",
"effect": "missense_variant",
"transcript": "ENST00000264852.9",
"consequences": [
{
"aa_ref": "V",
"aa_alt": "L",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 18,
"exon_rank_end": null,
"exon_count": 25,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "SIDT1",
"gene_hgnc_id": 25967,
"hgvs_c": "c.1846G>C",
"hgvs_p": "p.Val616Leu",
"transcript": "NM_017699.3",
"protein_id": "NP_060169.2",
"transcript_support_level": null,
"aa_start": 616,
"aa_end": null,
"aa_length": 827,
"cds_start": 1846,
"cds_end": null,
"cds_length": 2484,
"cdna_start": 2313,
"cdna_end": null,
"cdna_length": 4818,
"mane_select": "ENST00000264852.9",
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "V",
"aa_alt": "L",
"canonical": true,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 18,
"exon_rank_end": null,
"exon_count": 25,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "SIDT1",
"gene_hgnc_id": 25967,
"hgvs_c": "c.1846G>C",
"hgvs_p": "p.Val616Leu",
"transcript": "ENST00000264852.9",
"protein_id": "ENSP00000264852.4",
"transcript_support_level": 2,
"aa_start": 616,
"aa_end": null,
"aa_length": 827,
"cds_start": 1846,
"cds_end": null,
"cds_length": 2484,
"cdna_start": 2313,
"cdna_end": null,
"cdna_length": 4818,
"mane_select": "NM_017699.3",
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "V",
"aa_alt": "L",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 18,
"exon_rank_end": null,
"exon_count": 26,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "SIDT1",
"gene_hgnc_id": 25967,
"hgvs_c": "c.1846G>C",
"hgvs_p": "p.Val616Leu",
"transcript": "ENST00000393830.5",
"protein_id": "ENSP00000377416.4",
"transcript_support_level": 1,
"aa_start": 616,
"aa_end": null,
"aa_length": 832,
"cds_start": 1846,
"cds_end": null,
"cds_length": 2499,
"cdna_start": 1885,
"cdna_end": null,
"cdna_length": 4544,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "V",
"aa_alt": "L",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 18,
"exon_rank_end": null,
"exon_count": 26,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "SIDT1",
"gene_hgnc_id": 25967,
"hgvs_c": "c.1846G>C",
"hgvs_p": "p.Val616Leu",
"transcript": "NM_001322294.2",
"protein_id": "NP_001309223.1",
"transcript_support_level": null,
"aa_start": 616,
"aa_end": null,
"aa_length": 833,
"cds_start": 1846,
"cds_end": null,
"cds_length": 2502,
"cdna_start": 2313,
"cdna_end": null,
"cdna_length": 4836,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "V",
"aa_alt": "L",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 18,
"exon_rank_end": null,
"exon_count": 26,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "SIDT1",
"gene_hgnc_id": 25967,
"hgvs_c": "c.1846G>C",
"hgvs_p": "p.Val616Leu",
"transcript": "NM_001308350.2",
"protein_id": "NP_001295279.1",
"transcript_support_level": null,
"aa_start": 616,
"aa_end": null,
"aa_length": 832,
"cds_start": 1846,
"cds_end": null,
"cds_length": 2499,
"cdna_start": 2313,
"cdna_end": null,
"cdna_length": 4833,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "V",
"aa_alt": "L",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 17,
"exon_rank_end": null,
"exon_count": 25,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "SIDT1",
"gene_hgnc_id": 25967,
"hgvs_c": "c.1762G>C",
"hgvs_p": "p.Val588Leu",
"transcript": "NM_001322295.2",
"protein_id": "NP_001309224.1",
"transcript_support_level": null,
"aa_start": 588,
"aa_end": null,
"aa_length": 804,
"cds_start": 1762,
"cds_end": null,
"cds_length": 2415,
"cdna_start": 2229,
"cdna_end": null,
"cdna_length": 4749,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "V",
"aa_alt": "L",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 16,
"exon_rank_end": null,
"exon_count": 24,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "SIDT1",
"gene_hgnc_id": 25967,
"hgvs_c": "c.1660G>C",
"hgvs_p": "p.Val554Leu",
"transcript": "NM_001322296.2",
"protein_id": "NP_001309225.1",
"transcript_support_level": null,
"aa_start": 554,
"aa_end": null,
"aa_length": 770,
"cds_start": 1660,
"cds_end": null,
"cds_length": 2313,
"cdna_start": 2127,
"cdna_end": null,
"cdna_length": 4647,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "V",
"aa_alt": "L",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 17,
"exon_rank_end": null,
"exon_count": 25,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "SIDT1",
"gene_hgnc_id": 25967,
"hgvs_c": "c.1393G>C",
"hgvs_p": "p.Val465Leu",
"transcript": "NM_001322297.2",
"protein_id": "NP_001309226.1",
"transcript_support_level": null,
"aa_start": 465,
"aa_end": null,
"aa_length": 681,
"cds_start": 1393,
"cds_end": null,
"cds_length": 2046,
"cdna_start": 2191,
"cdna_end": null,
"cdna_length": 4711,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "V",
"aa_alt": "L",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 17,
"exon_rank_end": null,
"exon_count": 25,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "SIDT1",
"gene_hgnc_id": 25967,
"hgvs_c": "c.1303G>C",
"hgvs_p": "p.Val435Leu",
"transcript": "NM_001322298.2",
"protein_id": "NP_001309227.1",
"transcript_support_level": null,
"aa_start": 435,
"aa_end": null,
"aa_length": 651,
"cds_start": 1303,
"cds_end": null,
"cds_length": 1956,
"cdna_start": 2290,
"cdna_end": null,
"cdna_length": 4810,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "V",
"aa_alt": "L",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 18,
"exon_rank_end": null,
"exon_count": 25,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "SIDT1",
"gene_hgnc_id": 25967,
"hgvs_c": "c.1105G>C",
"hgvs_p": "p.Val369Leu",
"transcript": "NM_001322299.2",
"protein_id": "NP_001309228.1",
"transcript_support_level": null,
"aa_start": 369,
"aa_end": null,
"aa_length": 580,
"cds_start": 1105,
"cds_end": null,
"cds_length": 1743,
"cdna_start": 2332,
"cdna_end": null,
"cdna_length": 4837,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "V",
"aa_alt": "L",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 17,
"exon_rank_end": null,
"exon_count": 25,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "SIDT1",
"gene_hgnc_id": 25967,
"hgvs_c": "c.565G>C",
"hgvs_p": "p.Val189Leu",
"transcript": "NM_001322300.2",
"protein_id": "NP_001309229.1",
"transcript_support_level": null,
"aa_start": 189,
"aa_end": null,
"aa_length": 405,
"cds_start": 565,
"cds_end": null,
"cds_length": 1218,
"cdna_start": 2210,
"cdna_end": null,
"cdna_length": 4730,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "V",
"aa_alt": "L",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 18,
"exon_rank_end": null,
"exon_count": 25,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "SIDT1",
"gene_hgnc_id": 25967,
"hgvs_c": "c.1846G>C",
"hgvs_p": "p.Val616Leu",
"transcript": "XM_011512939.4",
"protein_id": "XP_011511241.1",
"transcript_support_level": null,
"aa_start": 616,
"aa_end": null,
"aa_length": 828,
"cds_start": 1846,
"cds_end": null,
"cds_length": 2487,
"cdna_start": 2313,
"cdna_end": null,
"cdna_length": 4821,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "V",
"aa_alt": "L",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 18,
"exon_rank_end": null,
"exon_count": 26,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "SIDT1",
"gene_hgnc_id": 25967,
"hgvs_c": "c.1846G>C",
"hgvs_p": "p.Val616Leu",
"transcript": "XM_047448376.1",
"protein_id": "XP_047304332.1",
"transcript_support_level": null,
"aa_start": 616,
"aa_end": null,
"aa_length": 828,
"cds_start": 1846,
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"cds_length": 2487,
"cdna_start": 2313,
"cdna_end": null,
"cdna_length": 3228,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "V",
"aa_alt": "L",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 17,
"exon_rank_end": null,
"exon_count": 24,
"intron_rank": null,
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"gene_symbol": "SIDT1",
"gene_hgnc_id": 25967,
"hgvs_c": "c.1762G>C",
"hgvs_p": "p.Val588Leu",
"transcript": "XM_047448377.1",
"protein_id": "XP_047304333.1",
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"aa_end": null,
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"cds_start": 1762,
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"mane_select": null,
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"feature": null
},
{
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"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 17,
"exon_rank_end": null,
"exon_count": 24,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "SIDT1",
"gene_hgnc_id": 25967,
"hgvs_c": "c.1762G>C",
"hgvs_p": "p.Val588Leu",
"transcript": "XM_047448378.1",
"protein_id": "XP_047304334.1",
"transcript_support_level": null,
"aa_start": 588,
"aa_end": null,
"aa_length": 799,
"cds_start": 1762,
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"cds_length": 2400,
"cdna_start": 2229,
"cdna_end": null,
"cdna_length": 4734,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "V",
"aa_alt": "L",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 18,
"exon_rank_end": null,
"exon_count": 25,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "SIDT1",
"gene_hgnc_id": 25967,
"hgvs_c": "c.1846G>C",
"hgvs_p": "p.Val616Leu",
"transcript": "XM_011512941.4",
"protein_id": "XP_011511243.1",
"transcript_support_level": null,
"aa_start": 616,
"aa_end": null,
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"mane_select": null,
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"biotype": null,
"feature": null
},
{
"aa_ref": "V",
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"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 18,
"exon_rank_end": null,
"exon_count": 24,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "SIDT1",
"gene_hgnc_id": 25967,
"hgvs_c": "c.1846G>C",
"hgvs_p": "p.Val616Leu",
"transcript": "XM_047448379.1",
"protein_id": "XP_047304335.1",
"transcript_support_level": null,
"aa_start": 616,
"aa_end": null,
"aa_length": 790,
"cds_start": 1846,
"cds_end": null,
"cds_length": 2373,
"cdna_start": 2313,
"cdna_end": null,
"cdna_length": 4707,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "V",
"aa_alt": "L",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 18,
"exon_rank_end": null,
"exon_count": 24,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "SIDT1",
"gene_hgnc_id": 25967,
"hgvs_c": "c.1846G>C",
"hgvs_p": "p.Val616Leu",
"transcript": "XM_047448380.1",
"protein_id": "XP_047304336.1",
"transcript_support_level": null,
"aa_start": 616,
"aa_end": null,
"aa_length": 789,
"cds_start": 1846,
"cds_end": null,
"cds_length": 2370,
"cdna_start": 2313,
"cdna_end": null,
"cdna_length": 4704,
"mane_select": null,
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"biotype": null,
"feature": null
},
{
"aa_ref": "V",
"aa_alt": "L",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
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],
"exon_rank": 16,
"exon_rank_end": null,
"exon_count": 23,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "SIDT1",
"gene_hgnc_id": 25967,
"hgvs_c": "c.1660G>C",
"hgvs_p": "p.Val554Leu",
"transcript": "XM_047448381.1",
"protein_id": "XP_047304337.1",
"transcript_support_level": null,
"aa_start": 554,
"aa_end": null,
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"feature": null
},
{
"aa_ref": "V",
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"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 16,
"exon_rank_end": null,
"exon_count": 23,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "SIDT1",
"gene_hgnc_id": 25967,
"hgvs_c": "c.1660G>C",
"hgvs_p": "p.Val554Leu",
"transcript": "XM_047448382.1",
"protein_id": "XP_047304338.1",
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"aa_start": 554,
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"biotype": null,
"feature": null
},
{
"aa_ref": "V",
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"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 17,
"exon_rank_end": null,
"exon_count": 23,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "SIDT1",
"gene_hgnc_id": 25967,
"hgvs_c": "c.1762G>C",
"hgvs_p": "p.Val588Leu",
"transcript": "XM_047448383.1",
"protein_id": "XP_047304339.1",
"transcript_support_level": null,
"aa_start": 588,
"aa_end": null,
"aa_length": 762,
"cds_start": 1762,
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"cds_length": 2289,
"cdna_start": 2229,
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"cdna_length": 4623,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "V",
"aa_alt": "L",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 17,
"exon_rank_end": null,
"exon_count": 23,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "SIDT1",
"gene_hgnc_id": 25967,
"hgvs_c": "c.1762G>C",
"hgvs_p": "p.Val588Leu",
"transcript": "XM_047448384.1",
"protein_id": "XP_047304340.1",
"transcript_support_level": null,
"aa_start": 588,
"aa_end": null,
"aa_length": 761,
"cds_start": 1762,
"cds_end": null,
"cds_length": 2286,
"cdna_start": 2229,
"cdna_end": null,
"cdna_length": 4620,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "V",
"aa_alt": "L",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 16,
"exon_rank_end": null,
"exon_count": 22,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "SIDT1",
"gene_hgnc_id": 25967,
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}