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GeneBe API Showcase
This page demonstrates how to use the GeneBe API to query variant information. The API provides programmatic access to genomic annotations and variant data.
API presented here should be used for checking single variants. If you want to check many variants at once, please use other API endpoints that you will find in the documentation.
Documentation & Advanced Usage
• Complete API documentation:docs.genebe.net/docs/api/overview/
• Interactive endpoint tester:api.genebe.net/cloud/gb-api-doc/swagger-ui/
• Python client for pandas:pypi.org/project/genebe/
• Java CLI for VCF files:github.com/pstawinski/genebe-cli
• All tools documented at:docs.genebe.net
API Request Examples for Variant: 3-113615386-A-T (hg38)
Bash / cURL Example
bash
curl "https://api.genebe.net/cloud/api-public/v1/variant?chr=3&pos=113615386&ref=A&alt=T&genome=hg38&allGenes=true"API Response
json
{
"variants": [
{
"chr": "3",
"pos": 113615386,
"ref": "A",
"alt": "T",
"effect": "intron_variant",
"transcript": "ENST00000264852.9",
"consequences": [
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 25,
"intron_rank": 19,
"intron_rank_end": null,
"gene_symbol": "SIDT1",
"gene_hgnc_id": 25967,
"hgvs_c": "c.1967-714A>T",
"hgvs_p": null,
"transcript": "NM_017699.3",
"protein_id": "NP_060169.2",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 827,
"cds_start": -4,
"cds_end": null,
"cds_length": 2484,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 4818,
"mane_select": "ENST00000264852.9",
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": true,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 25,
"intron_rank": 19,
"intron_rank_end": null,
"gene_symbol": "SIDT1",
"gene_hgnc_id": 25967,
"hgvs_c": "c.1967-714A>T",
"hgvs_p": null,
"transcript": "ENST00000264852.9",
"protein_id": "ENSP00000264852.4",
"transcript_support_level": 2,
"aa_start": null,
"aa_end": null,
"aa_length": 827,
"cds_start": -4,
"cds_end": null,
"cds_length": 2484,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 4818,
"mane_select": "NM_017699.3",
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 26,
"intron_rank": 20,
"intron_rank_end": null,
"gene_symbol": "SIDT1",
"gene_hgnc_id": 25967,
"hgvs_c": "c.1981+309A>T",
"hgvs_p": null,
"transcript": "ENST00000393830.5",
"protein_id": "ENSP00000377416.4",
"transcript_support_level": 1,
"aa_start": null,
"aa_end": null,
"aa_length": 832,
"cds_start": -4,
"cds_end": null,
"cds_length": 2499,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 4544,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 26,
"intron_rank": 20,
"intron_rank_end": null,
"gene_symbol": "SIDT1",
"gene_hgnc_id": 25967,
"hgvs_c": "c.1981+309A>T",
"hgvs_p": null,
"transcript": "NM_001322294.2",
"protein_id": "NP_001309223.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 833,
"cds_start": -4,
"cds_end": null,
"cds_length": 2502,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 4836,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 26,
"intron_rank": 20,
"intron_rank_end": null,
"gene_symbol": "SIDT1",
"gene_hgnc_id": 25967,
"hgvs_c": "c.1981+309A>T",
"hgvs_p": null,
"transcript": "NM_001308350.2",
"protein_id": "NP_001295279.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 832,
"cds_start": -4,
"cds_end": null,
"cds_length": 2499,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 4833,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 25,
"intron_rank": 19,
"intron_rank_end": null,
"gene_symbol": "SIDT1",
"gene_hgnc_id": 25967,
"hgvs_c": "c.1897+309A>T",
"hgvs_p": null,
"transcript": "NM_001322295.2",
"protein_id": "NP_001309224.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 804,
"cds_start": -4,
"cds_end": null,
"cds_length": 2415,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 4749,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 24,
"intron_rank": 18,
"intron_rank_end": null,
"gene_symbol": "SIDT1",
"gene_hgnc_id": 25967,
"hgvs_c": "c.1795+309A>T",
"hgvs_p": null,
"transcript": "NM_001322296.2",
"protein_id": "NP_001309225.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 770,
"cds_start": -4,
"cds_end": null,
"cds_length": 2313,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 4647,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 25,
"intron_rank": 19,
"intron_rank_end": null,
"gene_symbol": "SIDT1",
"gene_hgnc_id": 25967,
"hgvs_c": "c.1528+309A>T",
"hgvs_p": null,
"transcript": "NM_001322297.2",
"protein_id": "NP_001309226.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 681,
"cds_start": -4,
"cds_end": null,
"cds_length": 2046,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 4711,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 25,
"intron_rank": 19,
"intron_rank_end": null,
"gene_symbol": "SIDT1",
"gene_hgnc_id": 25967,
"hgvs_c": "c.1438+309A>T",
"hgvs_p": null,
"transcript": "NM_001322298.2",
"protein_id": "NP_001309227.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 651,
"cds_start": -4,
"cds_end": null,
"cds_length": 1956,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 4810,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
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"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 25,
"intron_rank": 19,
"intron_rank_end": null,
"gene_symbol": "SIDT1",
"gene_hgnc_id": 25967,
"hgvs_c": "c.1226-714A>T",
"hgvs_p": null,
"transcript": "NM_001322299.2",
"protein_id": "NP_001309228.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 580,
"cds_start": -4,
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"cdna_start": null,
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"mane_select": null,
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"feature": null
},
{
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"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 25,
"intron_rank": 19,
"intron_rank_end": null,
"gene_symbol": "SIDT1",
"gene_hgnc_id": 25967,
"hgvs_c": "c.700+309A>T",
"hgvs_p": null,
"transcript": "NM_001322300.2",
"protein_id": "NP_001309229.1",
"transcript_support_level": null,
"aa_start": null,
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"cds_start": -4,
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},
{
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"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
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"exon_count": 15,
"intron_rank": 9,
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"gene_symbol": "SIDT1",
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"hgvs_c": "n.817+309A>T",
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"transcript": "ENST00000463226.1",
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},
{
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"strand": true,
"consequences": [
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],
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"intron_rank": 20,
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"gene_symbol": "SIDT1",
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"transcript": "NR_136280.2",
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},
{
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"strand": true,
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],
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"gene_symbol": "SIDT1",
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"transcript": "NR_136281.2",
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},
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"strand": true,
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],
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},
{
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],
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"gene_symbol": "SIDT1",
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},
{
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],
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},
{
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],
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"intron_rank": 15,
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"gene_symbol": "SIDT1",
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"hgvs_c": "n.2007+309A>T",
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"transcript": "NR_136285.2",
"protein_id": null,
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},
{
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"strand": true,
"consequences": [
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],
"exon_rank": null,
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"exon_count": 25,
"intron_rank": 19,
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"gene_symbol": "SIDT1",
"gene_hgnc_id": 25967,
"hgvs_c": "c.1967-711A>T",
"hgvs_p": null,
"transcript": "XM_011512939.4",
"protein_id": "XP_011511241.1",
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],
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],
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},
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],
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"gene_symbol": "SIDT1",
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"hgvs_c": "c.1883-714A>T",
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"transcript": "XM_047448378.1",
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},
{
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"strand": true,
"consequences": [
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],
"exon_rank": null,
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"exon_count": 25,
"intron_rank": 20,
"intron_rank_end": null,
"gene_symbol": "SIDT1",
"gene_hgnc_id": 25967,
"hgvs_c": "c.1981+309A>T",
"hgvs_p": null,
"transcript": "XM_011512941.4",
"protein_id": "XP_011511243.1",
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},
{
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"consequences": [
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}