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GeneBe API Showcase
This page demonstrates how to use the GeneBe API to query variant information. The API provides programmatic access to genomic annotations and variant data.
API presented here should be used for checking single variants. If you want to check many variants at once, please use other API endpoints that you will find in the documentation.
Documentation & Advanced Usage
• Complete API documentation:docs.genebe.net/docs/api/overview/
• Interactive endpoint tester:api.genebe.net/cloud/gb-api-doc/swagger-ui/
• Python client for pandas:pypi.org/project/genebe/
• Java CLI for VCF files:github.com/pstawinski/genebe-cli
• All tools documented at:docs.genebe.net
API Request Examples for Variant: 3-119908400-T-C (hg38)
Bash / cURL Example
bash
curl "https://api.genebe.net/cloud/api-public/v1/variant?chr=3&pos=119908400&ref=T&alt=C&genome=hg38&allGenes=true"API Response
json
{
"variants": [
{
"chr": "3",
"pos": 119908400,
"ref": "T",
"alt": "C",
"effect": "intron_variant",
"transcript": "ENST00000264235.13",
"consequences": [
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 11,
"intron_rank": 6,
"intron_rank_end": null,
"gene_symbol": "GSK3B",
"gene_hgnc_id": 4617,
"hgvs_c": "c.716-2548A>G",
"hgvs_p": null,
"transcript": "NM_001146156.2",
"protein_id": "NP_001139628.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 420,
"cds_start": -4,
"cds_end": null,
"cds_length": 1263,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 7743,
"mane_select": "ENST00000264235.13",
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": true,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 11,
"intron_rank": 6,
"intron_rank_end": null,
"gene_symbol": "GSK3B",
"gene_hgnc_id": 4617,
"hgvs_c": "c.716-2548A>G",
"hgvs_p": null,
"transcript": "ENST00000264235.13",
"protein_id": "ENSP00000264235.9",
"transcript_support_level": 1,
"aa_start": null,
"aa_end": null,
"aa_length": 420,
"cds_start": -4,
"cds_end": null,
"cds_length": 1263,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 7743,
"mane_select": "NM_001146156.2",
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 12,
"intron_rank": 6,
"intron_rank_end": null,
"gene_symbol": "GSK3B",
"gene_hgnc_id": 4617,
"hgvs_c": "c.716-2548A>G",
"hgvs_p": null,
"transcript": "ENST00000316626.6",
"protein_id": "ENSP00000324806.5",
"transcript_support_level": 1,
"aa_start": null,
"aa_end": null,
"aa_length": 433,
"cds_start": -4,
"cds_end": null,
"cds_length": 1302,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 7000,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 12,
"intron_rank": 6,
"intron_rank_end": null,
"gene_symbol": "GSK3B",
"gene_hgnc_id": 4617,
"hgvs_c": "c.716-2548A>G",
"hgvs_p": null,
"transcript": "ENST00000678439.1",
"protein_id": "ENSP00000503868.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 470,
"cds_start": -4,
"cds_end": null,
"cds_length": 1413,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 6714,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 12,
"intron_rank": 6,
"intron_rank_end": null,
"gene_symbol": "GSK3B",
"gene_hgnc_id": 4617,
"hgvs_c": "c.716-2548A>G",
"hgvs_p": null,
"transcript": "NM_002093.4",
"protein_id": "NP_002084.2",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 433,
"cds_start": -4,
"cds_end": null,
"cds_length": 1302,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 7782,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 10,
"intron_rank": 6,
"intron_rank_end": null,
"gene_symbol": "GSK3B",
"gene_hgnc_id": 4617,
"hgvs_c": "c.716-2548A>G",
"hgvs_p": null,
"transcript": "NM_001354596.2",
"protein_id": "NP_001341525.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 387,
"cds_start": -4,
"cds_end": null,
"cds_length": 1164,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 7644,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 10,
"intron_rank": 6,
"intron_rank_end": null,
"gene_symbol": "GSK3B",
"gene_hgnc_id": 4617,
"hgvs_c": "c.716-2548A>G",
"hgvs_p": null,
"transcript": "ENST00000650344.2",
"protein_id": "ENSP00000497956.2",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 387,
"cds_start": -4,
"cds_end": null,
"cds_length": 1164,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 1731,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 6,
"intron_rank": 4,
"intron_rank_end": null,
"gene_symbol": "GSK3B",
"gene_hgnc_id": 4617,
"hgvs_c": "c.389-2548A>G",
"hgvs_p": null,
"transcript": "ENST00000678561.1",
"protein_id": "ENSP00000503494.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 223,
"cds_start": -4,
"cds_end": null,
"cds_length": 673,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 673,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 2,
"intron_rank": 1,
"intron_rank_end": null,
"gene_symbol": "GSK3B",
"gene_hgnc_id": 4617,
"hgvs_c": "c.193-31892A>G",
"hgvs_p": null,
"transcript": "ENST00000678787.1",
"protein_id": "ENSP00000503398.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 95,
"cds_start": -4,
"cds_end": null,
"cds_length": 288,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 290,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 2,
"intron_rank": 1,
"intron_rank_end": null,
"gene_symbol": "GSK3B",
"gene_hgnc_id": 4617,
"hgvs_c": "c.84+38868A>G",
"hgvs_p": null,
"transcript": "ENST00000678181.1",
"protein_id": "ENSP00000504266.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 89,
"cds_start": -4,
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"cds_length": 271,
"cdna_start": null,
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"cdna_length": 271,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
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"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 2,
"intron_rank": 1,
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"gene_symbol": "GSK3B",
"gene_hgnc_id": 4617,
"hgvs_c": "c.111+14973A>G",
"hgvs_p": null,
"transcript": "ENST00000679188.1",
"protein_id": "ENSP00000504252.1",
"transcript_support_level": null,
"aa_start": null,
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"aa_length": 68,
"cds_start": -4,
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"cdna_start": null,
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"mane_select": null,
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"feature": null
},
{
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"protein_coding": true,
"strand": false,
"consequences": [
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],
"exon_rank": null,
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"exon_count": 2,
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"gene_symbol": "GSK3B",
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"hgvs_c": "c.106+4304A>G",
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"transcript": "ENST00000677362.1",
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},
{
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"strand": false,
"consequences": [
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],
"exon_rank": null,
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"exon_count": 2,
"intron_rank": 1,
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"gene_symbol": "GSK3B",
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"hgvs_c": "c.85-31892A>G",
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"transcript": "ENST00000679066.1",
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"aa_start": null,
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},
{
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],
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"exon_count": 2,
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"gene_symbol": "GSK3B",
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"hgvs_c": "c.131+7644A>G",
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"transcript": "ENST00000679206.1",
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},
{
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],
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"gene_symbol": "GSK3B",
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"transcript": "ENST00000676566.1",
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},
{
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"strand": false,
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],
"exon_rank": null,
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"exon_count": 3,
"intron_rank": 2,
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"gene_symbol": "GSK3B",
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"hgvs_c": "n.*108-2548A>G",
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"transcript": "ENST00000676733.1",
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},
{
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],
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"gene_symbol": "GSK3B",
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"hgvs_c": "n.131+7644A>G",
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"transcript": "ENST00000676887.1",
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},
{
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"strand": false,
"consequences": [
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],
"exon_rank": null,
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"intron_rank": 1,
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"gene_symbol": "GSK3B",
"gene_hgnc_id": 4617,
"hgvs_c": "n.108-1137A>G",
"hgvs_p": null,
"transcript": "ENST00000677067.1",
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},
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"strand": false,
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],
"exon_rank": null,
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"intron_rank": 5,
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"gene_symbol": "GSK3B",
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"hgvs_c": "n.499-2548A>G",
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},
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],
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},
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],
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"gene_symbol": "GSK3B",
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},
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"strand": false,
"consequences": [
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],
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"intron_rank": 2,
"intron_rank_end": null,
"gene_symbol": "GSK3B",
"gene_hgnc_id": 4617,
"hgvs_c": "n.*34-2548A>G",
"hgvs_p": null,
"transcript": "ENST00000677995.1",
"protein_id": "ENSP00000504203.1",
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"mane_select": null,
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"biotype": null,
"feature": null
},
{
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"canonical": false,
"protein_coding": false,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 7,
"intron_rank": 6,
"intron_rank_end": null,
"gene_symbol": "GSK3B",
"gene_hgnc_id": 4617,
"hgvs_c": "n.1173-2548A>G",
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"transcript": "ENST00000678245.1",
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"mane_select": null,
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},
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{
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}
],
"message": null
}