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GeneBe API Showcase
This page demonstrates how to use the GeneBe API to query variant information. The API provides programmatic access to genomic annotations and variant data.
API presented here should be used for checking single variants. If you want to check many variants at once, please use other API endpoints that you will find in the documentation.
Documentation & Advanced Usage
• Complete API documentation:docs.genebe.net/docs/api/overview/
• Interactive endpoint tester:api.genebe.net/cloud/gb-api-doc/swagger-ui/
• Python client for pandas:pypi.org/project/genebe/
• Java CLI for VCF files:github.com/pstawinski/genebe-cli
• All tools documented at:docs.genebe.net
API Request Examples for Variant: 3-122535922-G-A (hg38)
Bash / cURL Example
bash
curl "https://api.genebe.net/cloud/api-public/v1/variant?chr=3&pos=122535922&ref=G&alt=A&genome=hg38&allGenes=true"API Response
json
{
"variants": [
{
"chr": "3",
"pos": 122535922,
"ref": "G",
"alt": "A",
"effect": "intron_variant",
"transcript": "ENST00000682323.1",
"consequences": [
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"3_prime_UTR_variant"
],
"exon_rank": 10,
"exon_rank_end": null,
"exon_count": 10,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "PARP9",
"gene_hgnc_id": 24118,
"hgvs_c": "c.*193C>T",
"hgvs_p": null,
"transcript": "ENST00000462315.5",
"protein_id": "ENSP00000418894.1",
"transcript_support_level": 1,
"aa_start": null,
"aa_end": null,
"aa_length": 710,
"cds_start": -4,
"cds_end": null,
"cds_length": 2133,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 6769,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 11,
"intron_rank": 10,
"intron_rank_end": null,
"gene_symbol": "PARP9",
"gene_hgnc_id": 24118,
"hgvs_c": "c.2080+246C>T",
"hgvs_p": null,
"transcript": "NM_001146105.2",
"protein_id": "NP_001139577.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 819,
"cds_start": -4,
"cds_end": null,
"cds_length": 2460,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 3045,
"mane_select": "ENST00000682323.1",
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": true,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 11,
"intron_rank": 10,
"intron_rank_end": null,
"gene_symbol": "PARP9",
"gene_hgnc_id": 24118,
"hgvs_c": "c.2080+246C>T",
"hgvs_p": null,
"transcript": "ENST00000682323.1",
"protein_id": "ENSP00000507390.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 819,
"cds_start": -4,
"cds_end": null,
"cds_length": 2460,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 3045,
"mane_select": "NM_001146105.2",
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 11,
"intron_rank": 10,
"intron_rank_end": null,
"gene_symbol": "PARP9",
"gene_hgnc_id": 24118,
"hgvs_c": "c.2185+246C>T",
"hgvs_p": null,
"transcript": "ENST00000360356.6",
"protein_id": "ENSP00000353512.2",
"transcript_support_level": 1,
"aa_start": null,
"aa_end": null,
"aa_length": 854,
"cds_start": -4,
"cds_end": null,
"cds_length": 2565,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 3198,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 11,
"intron_rank": 10,
"intron_rank_end": null,
"gene_symbol": "PARP9",
"gene_hgnc_id": 24118,
"hgvs_c": "c.2080+246C>T",
"hgvs_p": null,
"transcript": "ENST00000477522.6",
"protein_id": "ENSP00000419506.1",
"transcript_support_level": 1,
"aa_start": null,
"aa_end": null,
"aa_length": 819,
"cds_start": -4,
"cds_end": null,
"cds_length": 2460,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 3128,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 9,
"intron_rank": 8,
"intron_rank_end": null,
"gene_symbol": "PARP9",
"gene_hgnc_id": 24118,
"hgvs_c": "c.820+246C>T",
"hgvs_p": null,
"transcript": "ENST00000492382.5",
"protein_id": "ENSP00000417664.1",
"transcript_support_level": 1,
"aa_start": null,
"aa_end": null,
"aa_length": 399,
"cds_start": -4,
"cds_end": null,
"cds_length": 1200,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 1837,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": false,
"strand": false,
"consequences": [
"non_coding_transcript_exon_variant"
],
"exon_rank": 10,
"exon_rank_end": null,
"exon_count": 10,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "PARP9",
"gene_hgnc_id": 24118,
"hgvs_c": "n.2593C>T",
"hgvs_p": null,
"transcript": "NR_170863.1",
"protein_id": null,
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": null,
"cds_start": -4,
"cds_end": null,
"cds_length": null,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 6743,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"3_prime_UTR_variant"
],
"exon_rank": 10,
"exon_rank_end": null,
"exon_count": 10,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "PARP9",
"gene_hgnc_id": 24118,
"hgvs_c": "c.*193C>T",
"hgvs_p": null,
"transcript": "NM_001387880.1",
"protein_id": "NP_001374809.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 745,
"cds_start": -4,
"cds_end": null,
"cds_length": 2238,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 6726,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"3_prime_UTR_variant"
],
"exon_rank": 10,
"exon_rank_end": null,
"exon_count": 10,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "PARP9",
"gene_hgnc_id": 24118,
"hgvs_c": "c.*193C>T",
"hgvs_p": null,
"transcript": "NM_001146106.3",
"protein_id": "NP_001139578.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 710,
"cds_start": -4,
"cds_end": null,
"cds_length": 2133,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 6755,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"3_prime_UTR_variant"
],
"exon_rank": 10,
"exon_rank_end": null,
"exon_count": 10,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "PARP9",
"gene_hgnc_id": 24118,
"hgvs_c": "c.*193C>T",
"hgvs_p": null,
"transcript": "NM_001387885.1",
"protein_id": "NP_001374814.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 710,
"cds_start": -4,
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"cdna_start": null,
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"mane_select": null,
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"biotype": null,
"feature": null
},
{
"aa_ref": null,
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"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"3_prime_UTR_variant"
],
"exon_rank": 10,
"exon_rank_end": null,
"exon_count": 10,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "PARP9",
"gene_hgnc_id": 24118,
"hgvs_c": "c.*193C>T",
"hgvs_p": null,
"transcript": "NM_001387886.1",
"protein_id": "NP_001374815.1",
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"aa_start": null,
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"cds_start": -4,
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"feature": null
},
{
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"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"3_prime_UTR_variant"
],
"exon_rank": 10,
"exon_rank_end": null,
"exon_count": 10,
"intron_rank": null,
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"gene_symbol": "PARP9",
"gene_hgnc_id": 24118,
"hgvs_c": "c.*193C>T",
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"transcript": "NM_001387887.1",
"protein_id": "NP_001374816.1",
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},
{
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"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
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"exon_count": 11,
"intron_rank": 10,
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"gene_symbol": "PARP9",
"gene_hgnc_id": 24118,
"hgvs_c": "c.2185+246C>T",
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"transcript": "NM_001146102.2",
"protein_id": "NP_001139574.1",
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},
{
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"strand": false,
"consequences": [
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],
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"intron_rank": 10,
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"gene_symbol": "PARP9",
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"hgvs_c": "c.2185+246C>T",
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"transcript": "NM_001387871.1",
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},
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],
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"gene_symbol": "PARP9",
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},
{
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],
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"exon_count": 11,
"intron_rank": 10,
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"gene_symbol": "PARP9",
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"hgvs_c": "c.2185+246C>T",
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},
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],
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"gene_symbol": "PARP9",
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"transcript": "NM_001387873.1",
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},
{
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"consequences": [
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],
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"exon_count": 11,
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"gene_symbol": "PARP9",
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"hgvs_c": "c.2119+246C>T",
"hgvs_p": null,
"transcript": "NM_001387874.1",
"protein_id": "NP_001374803.1",
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},
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"consequences": [
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],
"exon_rank": null,
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"intron_rank": 10,
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"gene_symbol": "PARP9",
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"transcript": "NM_001146103.2",
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],
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},
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],
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},
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"strand": false,
"consequences": [
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],
"exon_rank": null,
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"intron_rank": 10,
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"gene_symbol": "PARP9",
"gene_hgnc_id": 24118,
"hgvs_c": "c.2080+246C>T",
"hgvs_p": null,
"transcript": "NM_001387876.1",
"protein_id": "NP_001374805.1",
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"mane_select": null,
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"feature": null
},
{
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"protein_coding": true,
"strand": false,
"consequences": [
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],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 11,
"intron_rank": 10,
"intron_rank_end": null,
"gene_symbol": "PARP9",
"gene_hgnc_id": 24118,
"hgvs_c": "c.2080+246C>T",
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"transcript": "NM_001387877.1",
"protein_id": "NP_001374806.1",
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