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GeneBe API Showcase
This page demonstrates how to use the GeneBe API to query variant information. The API provides programmatic access to genomic annotations and variant data.
API presented here should be used for checking single variants. If you want to check many variants at once, please use other API endpoints that you will find in the documentation.
Documentation & Advanced Usage
• Complete API documentation:docs.genebe.net/docs/api/overview/
• Interactive endpoint tester:api.genebe.net/cloud/gb-api-doc/swagger-ui/
• Python client for pandas:pypi.org/project/genebe/
• Java CLI for VCF files:github.com/pstawinski/genebe-cli
• All tools documented at:docs.genebe.net
API Request Examples for Variant: 3-13498834-G-A (hg38)
Bash / cURL Example
bash
curl "https://api.genebe.net/cloud/api-public/v1/variant?chr=3&pos=13498834&ref=G&alt=A&genome=hg38&allGenes=true"API Response
json
{
"variants": [
{
"chr": "3",
"pos": 13498834,
"ref": "G",
"alt": "A",
"effect": "intron_variant",
"transcript": "NM_024827.4",
"consequences": [
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 10,
"intron_rank": 5,
"intron_rank_end": null,
"gene_symbol": "HDAC11",
"gene_hgnc_id": 19086,
"hgvs_c": "c.412+279G>A",
"hgvs_p": null,
"transcript": "NM_024827.4",
"protein_id": "NP_079103.2",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 347,
"cds_start": null,
"cds_end": null,
"cds_length": 1044,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": "ENST00000295757.8",
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_024827.4"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": true,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 10,
"intron_rank": 5,
"intron_rank_end": null,
"gene_symbol": "HDAC11",
"gene_hgnc_id": 19086,
"hgvs_c": "c.412+279G>A",
"hgvs_p": null,
"transcript": "ENST00000295757.8",
"protein_id": "ENSP00000295757.3",
"transcript_support_level": 1,
"aa_start": null,
"aa_end": null,
"aa_length": 347,
"cds_start": null,
"cds_end": null,
"cds_length": 1044,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": "NM_024827.4",
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000295757.8"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 9,
"intron_rank": 4,
"intron_rank_end": null,
"gene_symbol": "HDAC11",
"gene_hgnc_id": 19086,
"hgvs_c": "c.328+279G>A",
"hgvs_p": null,
"transcript": "ENST00000437379.2",
"protein_id": "ENSP00000395188.2",
"transcript_support_level": 1,
"aa_start": null,
"aa_end": null,
"aa_length": 319,
"cds_start": null,
"cds_end": null,
"cds_length": 960,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000437379.2"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 9,
"intron_rank": 4,
"intron_rank_end": null,
"gene_symbol": "HDAC11",
"gene_hgnc_id": 19086,
"hgvs_c": "c.286-1879G>A",
"hgvs_p": null,
"transcript": "ENST00000433119.5",
"protein_id": "ENSP00000412514.1",
"transcript_support_level": 1,
"aa_start": null,
"aa_end": null,
"aa_length": 236,
"cds_start": null,
"cds_end": null,
"cds_length": 711,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000433119.5"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 11,
"intron_rank": 5,
"intron_rank_end": null,
"gene_symbol": "HDAC11",
"gene_hgnc_id": 19086,
"hgvs_c": "c.412+279G>A",
"hgvs_p": null,
"transcript": "ENST00000861271.1",
"protein_id": "ENSP00000531330.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 372,
"cds_start": null,
"cds_end": null,
"cds_length": 1119,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000861271.1"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 11,
"intron_rank": 5,
"intron_rank_end": null,
"gene_symbol": "HDAC11",
"gene_hgnc_id": 19086,
"hgvs_c": "c.412+279G>A",
"hgvs_p": null,
"transcript": "ENST00000861272.1",
"protein_id": "ENSP00000531331.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 370,
"cds_start": null,
"cds_end": null,
"cds_length": 1113,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000861272.1"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 10,
"intron_rank": 5,
"intron_rank_end": null,
"gene_symbol": "HDAC11",
"gene_hgnc_id": 19086,
"hgvs_c": "c.412+279G>A",
"hgvs_p": null,
"transcript": "ENST00000967010.1",
"protein_id": "ENSP00000637069.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 368,
"cds_start": null,
"cds_end": null,
"cds_length": 1107,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000967010.1"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 10,
"intron_rank": 5,
"intron_rank_end": null,
"gene_symbol": "HDAC11",
"gene_hgnc_id": 19086,
"hgvs_c": "c.409+279G>A",
"hgvs_p": null,
"transcript": "ENST00000861269.1",
"protein_id": "ENSP00000531328.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 346,
"cds_start": null,
"cds_end": null,
"cds_length": 1041,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000861269.1"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 10,
"intron_rank": 5,
"intron_rank_end": null,
"gene_symbol": "HDAC11",
"gene_hgnc_id": 19086,
"hgvs_c": "c.412+279G>A",
"hgvs_p": null,
"transcript": "ENST00000861270.1",
"protein_id": "ENSP00000531329.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 325,
"cds_start": null,
"cds_end": null,
"cds_length": 978,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000861270.1"
},
{
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"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 9,
"intron_rank": 4,
"intron_rank_end": null,
"gene_symbol": "HDAC11",
"gene_hgnc_id": 19086,
"hgvs_c": "c.295+279G>A",
"hgvs_p": null,
"transcript": "ENST00000861268.1",
"protein_id": "ENSP00000531327.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 308,
"cds_start": null,
"cds_end": null,
"cds_length": 927,
"cdna_start": null,
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"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000861268.1"
},
{
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"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 10,
"intron_rank": 5,
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"gene_symbol": "HDAC11",
"gene_hgnc_id": 19086,
"hgvs_c": "c.259+279G>A",
"hgvs_p": null,
"transcript": "NM_001136041.3",
"protein_id": "NP_001129513.1",
"transcript_support_level": null,
"aa_start": null,
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"cds_start": null,
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"cdna_start": null,
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},
{
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],
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"gene_symbol": "HDAC11",
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"hgvs_c": "c.259+279G>A",
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"transcript": "ENST00000522202.5",
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},
{
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"consequences": [
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],
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"gene_symbol": "HDAC11",
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"hgvs_c": "c.369+1982G>A",
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"transcript": "ENST00000861266.1",
"protein_id": "ENSP00000531325.1",
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},
{
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"strand": true,
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],
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"gene_symbol": "HDAC11",
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"hgvs_c": "c.253-3037G>A",
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"transcript": "NM_001330636.2",
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},
{
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],
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"gene_symbol": "HDAC11",
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"hgvs_c": "c.253-3037G>A",
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"transcript": "ENST00000402271.5",
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},
{
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],
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"gene_symbol": "HDAC11",
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},
{
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],
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"gene_symbol": "HDAC11",
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"hgvs_c": "c.250-3037G>A",
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"transcript": "ENST00000967009.1",
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},
{
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],
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"exon_count": 6,
"intron_rank": 3,
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"gene_symbol": "HDAC11",
"gene_hgnc_id": 19086,
"hgvs_c": "c.253-4050G>A",
"hgvs_p": null,
"transcript": "ENST00000404040.5",
"protein_id": "ENSP00000385475.1",
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},
{
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],
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"gene_symbol": "HDAC11",
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"hgvs_c": "c.286-1879G>A",
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},
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],
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},
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],
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"gene_symbol": "HDAC11",
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"biotype": "protein_coding",
"feature": "ENST00000402259.5"
},
{
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"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
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"exon_count": 6,
"intron_rank": 3,
"intron_rank_end": null,
"gene_symbol": "HDAC11",
"gene_hgnc_id": 19086,
"hgvs_c": "c.310-1879G>A",
"hgvs_p": null,
"transcript": "ENST00000434848.5",
"protein_id": "ENSP00000398651.1",
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"mane_select": null,
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"biotype": "protein_coding",
"feature": "ENST00000434848.5"
},
{
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"protein_coding": true,
"strand": true,
"consequences": [
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],
"exon_rank": null,
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"exon_count": 7,
"intron_rank": 4,
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}