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GeneBe API Showcase
This page demonstrates how to use the GeneBe API to query variant information. The API provides programmatic access to genomic annotations and variant data.
API presented here should be used for checking single variants. If you want to check many variants at once, please use other API endpoints that you will find in the documentation.
Documentation & Advanced Usage
• Complete API documentation:docs.genebe.net/docs/api/overview/
• Interactive endpoint tester:api.genebe.net/cloud/gb-api-doc/swagger-ui/
• Python client for pandas:pypi.org/project/genebe/
• Java CLI for VCF files:github.com/pstawinski/genebe-cli
• All tools documented at:docs.genebe.net
API Request Examples for Variant: 3-141292788-C-G (hg38)
Bash / cURL Example
bash
curl "https://api.genebe.net/cloud/api-public/v1/variant?chr=3&pos=141292788&ref=C&alt=G&genome=hg38&allGenes=true"API Response
json
{
"variants": [
{
"chr": "3",
"pos": 141292788,
"ref": "C",
"alt": "G",
"effect": "missense_variant",
"transcript": "ENST00000286353.9",
"consequences": [
{
"aa_ref": "F",
"aa_alt": "L",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 6,
"exon_rank_end": null,
"exon_count": 6,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "PXYLP1",
"gene_hgnc_id": 26303,
"hgvs_c": "c.1026C>G",
"hgvs_p": "p.Phe342Leu",
"transcript": "NM_001037172.3",
"protein_id": "NP_001032249.1",
"transcript_support_level": null,
"aa_start": 342,
"aa_end": null,
"aa_length": 480,
"cds_start": 1026,
"cds_end": null,
"cds_length": 1443,
"cdna_start": 1166,
"cdna_end": null,
"cdna_length": 3302,
"mane_select": "ENST00000286353.9",
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "F",
"aa_alt": "L",
"canonical": true,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 6,
"exon_rank_end": null,
"exon_count": 6,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "PXYLP1",
"gene_hgnc_id": 26303,
"hgvs_c": "c.1026C>G",
"hgvs_p": "p.Phe342Leu",
"transcript": "ENST00000286353.9",
"protein_id": "ENSP00000286353.4",
"transcript_support_level": 1,
"aa_start": 342,
"aa_end": null,
"aa_length": 480,
"cds_start": 1026,
"cds_end": null,
"cds_length": 1443,
"cdna_start": 1166,
"cdna_end": null,
"cdna_length": 3302,
"mane_select": "NM_001037172.3",
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "F",
"aa_alt": "L",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 8,
"exon_rank_end": null,
"exon_count": 8,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "PXYLP1",
"gene_hgnc_id": 26303,
"hgvs_c": "c.1026C>G",
"hgvs_p": "p.Phe342Leu",
"transcript": "ENST00000393010.6",
"protein_id": "ENSP00000376733.2",
"transcript_support_level": 1,
"aa_start": 342,
"aa_end": null,
"aa_length": 480,
"cds_start": 1026,
"cds_end": null,
"cds_length": 1443,
"cdna_start": 1304,
"cdna_end": null,
"cdna_length": 3160,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "F",
"aa_alt": "L",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 5,
"exon_rank_end": null,
"exon_count": 5,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "PXYLP1",
"gene_hgnc_id": 26303,
"hgvs_c": "c.999C>G",
"hgvs_p": "p.Phe333Leu",
"transcript": "ENST00000508812.1",
"protein_id": "ENSP00000422901.1",
"transcript_support_level": 1,
"aa_start": 333,
"aa_end": null,
"aa_length": 471,
"cds_start": 999,
"cds_end": null,
"cds_length": 1416,
"cdna_start": 2906,
"cdna_end": null,
"cdna_length": 4158,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "F",
"aa_alt": "L",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 8,
"exon_rank_end": null,
"exon_count": 8,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "PXYLP1",
"gene_hgnc_id": 26303,
"hgvs_c": "c.1026C>G",
"hgvs_p": "p.Phe342Leu",
"transcript": "NM_152282.5",
"protein_id": "NP_689495.1",
"transcript_support_level": null,
"aa_start": 342,
"aa_end": null,
"aa_length": 480,
"cds_start": 1026,
"cds_end": null,
"cds_length": 1443,
"cdna_start": 1340,
"cdna_end": null,
"cdna_length": 3476,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "F",
"aa_alt": "L",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 5,
"exon_rank_end": null,
"exon_count": 5,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "PXYLP1",
"gene_hgnc_id": 26303,
"hgvs_c": "c.975C>G",
"hgvs_p": "p.Phe325Leu",
"transcript": "ENST00000504264.5",
"protein_id": "ENSP00000426877.1",
"transcript_support_level": 2,
"aa_start": 325,
"aa_end": null,
"aa_length": 463,
"cds_start": 975,
"cds_end": null,
"cds_length": 1392,
"cdna_start": 1057,
"cdna_end": null,
"cdna_length": 1773,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "F",
"aa_alt": "L",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 7,
"exon_rank_end": null,
"exon_count": 7,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "PXYLP1",
"gene_hgnc_id": 26303,
"hgvs_c": "c.912C>G",
"hgvs_p": "p.Phe304Leu",
"transcript": "NM_001282728.2",
"protein_id": "NP_001269657.1",
"transcript_support_level": null,
"aa_start": 304,
"aa_end": null,
"aa_length": 442,
"cds_start": 912,
"cds_end": null,
"cds_length": 1329,
"cdna_start": 1264,
"cdna_end": null,
"cdna_length": 3400,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "F",
"aa_alt": "L",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 7,
"exon_rank_end": null,
"exon_count": 7,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "PXYLP1",
"gene_hgnc_id": 26303,
"hgvs_c": "c.912C>G",
"hgvs_p": "p.Phe304Leu",
"transcript": "ENST00000502783.5",
"protein_id": "ENSP00000422558.1",
"transcript_support_level": 2,
"aa_start": 304,
"aa_end": null,
"aa_length": 442,
"cds_start": 912,
"cds_end": null,
"cds_length": 1329,
"cdna_start": 1249,
"cdna_end": null,
"cdna_length": 2066,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "F",
"aa_alt": "L",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 8,
"exon_rank_end": null,
"exon_count": 8,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "PXYLP1",
"gene_hgnc_id": 26303,
"hgvs_c": "c.1026C>G",
"hgvs_p": "p.Phe342Leu",
"transcript": "XM_047449209.1",
"protein_id": "XP_047305165.1",
"transcript_support_level": null,
"aa_start": 342,
"aa_end": null,
"aa_length": 480,
"cds_start": 1026,
"cds_end": null,
"cds_length": 1443,
"cdna_start": 1864,
"cdna_end": null,
"cdna_length": 4000,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "F",
"aa_alt": "L",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 9,
"exon_rank_end": null,
"exon_count": 9,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "PXYLP1",
"gene_hgnc_id": 26303,
"hgvs_c": "c.1026C>G",
"hgvs_p": "p.Phe342Leu",
"transcript": "XM_047449210.1",
"protein_id": "XP_047305166.1",
"transcript_support_level": null,
"aa_start": 342,
"aa_end": null,
"aa_length": 480,
"cds_start": 1026,
"cds_end": null,
"cds_length": 1443,
"cdna_start": 1492,
"cdna_end": null,
"cdna_length": 3628,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "F",
"aa_alt": "L",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 8,
"exon_rank_end": null,
"exon_count": 8,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "PXYLP1",
"gene_hgnc_id": 26303,
"hgvs_c": "c.1026C>G",
"hgvs_p": "p.Phe342Leu",
"transcript": "XM_047449211.1",
"protein_id": "XP_047305167.1",
"transcript_support_level": null,
"aa_start": 342,
"aa_end": null,
"aa_length": 480,
"cds_start": 1026,
"cds_end": null,
"cds_length": 1443,
"cdna_start": 1344,
"cdna_end": null,
"cdna_length": 3480,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "F",
"aa_alt": "L",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 8,
"exon_rank_end": null,
"exon_count": 8,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "PXYLP1",
"gene_hgnc_id": 26303,
"hgvs_c": "c.1026C>G",
"hgvs_p": "p.Phe342Leu",
"transcript": "XM_047449212.1",
"protein_id": "XP_047305168.1",
"transcript_support_level": null,
"aa_start": 342,
"aa_end": null,
"aa_length": 480,
"cds_start": 1026,
"cds_end": null,
"cds_length": 1443,
"cdna_start": 1357,
"cdna_end": null,
"cdna_length": 3493,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "F",
"aa_alt": "L",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 7,
"exon_rank_end": null,
"exon_count": 7,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "PXYLP1",
"gene_hgnc_id": 26303,
"hgvs_c": "c.1026C>G",
"hgvs_p": "p.Phe342Leu",
"transcript": "XM_047449213.1",
"protein_id": "XP_047305169.1",
"transcript_support_level": null,
"aa_start": 342,
"aa_end": null,
"aa_length": 480,
"cds_start": 1026,
"cds_end": null,
"cds_length": 1443,
"cdna_start": 1661,
"cdna_end": null,
"cdna_length": 3797,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "F",
"aa_alt": "L",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 6,
"exon_rank_end": null,
"exon_count": 6,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "PXYLP1",
"gene_hgnc_id": 26303,
"hgvs_c": "c.1026C>G",
"hgvs_p": "p.Phe342Leu",
"transcript": "XM_047449214.1",
"protein_id": "XP_047305170.1",
"transcript_support_level": null,
"aa_start": 342,
"aa_end": null,
"aa_length": 480,
"cds_start": 1026,
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"cdna_start": 1690,
"cdna_end": null,
"cdna_length": 3826,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "F",
"aa_alt": "L",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 7,
"exon_rank_end": null,
"exon_count": 7,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "PXYLP1",
"gene_hgnc_id": 26303,
"hgvs_c": "c.1026C>G",
"hgvs_p": "p.Phe342Leu",
"transcript": "XM_047449215.1",
"protein_id": "XP_047305171.1",
"transcript_support_level": null,
"aa_start": 342,
"aa_end": null,
"aa_length": 480,
"cds_start": 1026,
"cds_end": null,
"cds_length": 1443,
"cdna_start": 1302,
"cdna_end": null,
"cdna_length": 3438,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "F",
"aa_alt": "L",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 9,
"exon_rank_end": null,
"exon_count": 9,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "PXYLP1",
"gene_hgnc_id": 26303,
"hgvs_c": "c.1026C>G",
"hgvs_p": "p.Phe342Leu",
"transcript": "XM_047449216.1",
"protein_id": "XP_047305172.1",
"transcript_support_level": null,
"aa_start": 342,
"aa_end": null,
"aa_length": 480,
"cds_start": 1026,
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"cdna_start": 1476,
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"cdna_length": 3612,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "F",
"aa_alt": "L",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 6,
"exon_rank_end": null,
"exon_count": 6,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "PXYLP1",
"gene_hgnc_id": 26303,
"hgvs_c": "c.1026C>G",
"hgvs_p": "p.Phe342Leu",
"transcript": "XM_047449217.1",
"protein_id": "XP_047305173.1",
"transcript_support_level": null,
"aa_start": 342,
"aa_end": null,
"aa_length": 480,
"cds_start": 1026,
"cds_end": null,
"cds_length": 1443,
"cdna_start": 1240,
"cdna_end": null,
"cdna_length": 3376,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "F",
"aa_alt": "L",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 7,
"exon_rank_end": null,
"exon_count": 7,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "PXYLP1",
"gene_hgnc_id": 26303,
"hgvs_c": "c.1026C>G",
"hgvs_p": "p.Phe342Leu",
"transcript": "XM_047449218.1",
"protein_id": "XP_047305174.1",
"transcript_support_level": null,
"aa_start": 342,
"aa_end": null,
"aa_length": 480,
"cds_start": 1026,
"cds_end": null,
"cds_length": 1443,
"cdna_start": 1269,
"cdna_end": null,
"cdna_length": 3405,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "F",
"aa_alt": "L",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 11,
"exon_rank_end": null,
"exon_count": 11,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "PXYLP1",
"gene_hgnc_id": 26303,
"hgvs_c": "c.1026C>G",
"hgvs_p": "p.Phe342Leu",
"transcript": "XM_047449219.1",
"protein_id": "XP_047305175.1",
"transcript_support_level": null,
"aa_start": 342,
"aa_end": null,
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"cds_start": 1026,
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"mane_select": null,
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"biotype": null,
"feature": null
},
{
"aa_ref": "F",
"aa_alt": "L",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 11,
"exon_rank_end": null,
"exon_count": 11,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "PXYLP1",
"gene_hgnc_id": 26303,
"hgvs_c": "c.1026C>G",
"hgvs_p": "p.Phe342Leu",
"transcript": "XM_047449220.1",
"protein_id": "XP_047305176.1",
"transcript_support_level": null,
"aa_start": 342,
"aa_end": null,
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"cds_start": 1026,
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"cdna_start": 4120,
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"mane_select": null,
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"biotype": null,
"feature": null
},
{
"aa_ref": "F",
"aa_alt": "L",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 10,
"exon_rank_end": null,
"exon_count": 10,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "PXYLP1",
"gene_hgnc_id": 26303,
"hgvs_c": "c.1026C>G",
"hgvs_p": "p.Phe342Leu",
"transcript": "XM_047449221.1",
"protein_id": "XP_047305177.1",
"transcript_support_level": null,
"aa_start": 342,
"aa_end": null,
"aa_length": 480,
"cds_start": 1026,
"cds_end": null,
"cds_length": 1443,
"cdna_start": 3373,
"cdna_end": null,
"cdna_length": 5509,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "F",
"aa_alt": "L",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 10,
"exon_rank_end": null,
"exon_count": 10,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "PXYLP1",
"gene_hgnc_id": 26303,
"hgvs_c": "c.1026C>G",
"hgvs_p": "p.Phe342Leu",
"transcript": "XM_047449222.1",
"protein_id": "XP_047305178.1",
"transcript_support_level": null,
"aa_start": 342,
"aa_end": null,
"aa_length": 480,
"cds_start": 1026,
"cds_end": null,
"cds_length": 1443,
"cdna_start": 3948,
"cdna_end": null,
"cdna_length": 6084,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "F",
"aa_alt": "L",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 10,
"exon_rank_end": null,
"exon_count": 10,
"intron_rank": null,
"intron_rank_end": null,
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}