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GeneBe API Showcase
This page demonstrates how to use the GeneBe API to query variant information. The API provides programmatic access to genomic annotations and variant data.
API presented here should be used for checking single variants. If you want to check many variants at once, please use other API endpoints that you will find in the documentation.
Documentation & Advanced Usage
• Complete API documentation:docs.genebe.net/docs/api/overview/
• Interactive endpoint tester:api.genebe.net/cloud/gb-api-doc/swagger-ui/
• Python client for pandas:pypi.org/project/genebe/
• Java CLI for VCF files:github.com/pstawinski/genebe-cli
• All tools documented at:docs.genebe.net
API Request Examples for Variant: 3-142784763-G-A (hg38)
Bash / cURL Example
bash
curl "https://api.genebe.net/cloud/api-public/v1/variant?chr=3&pos=142784763&ref=G&alt=A&genome=hg38&allGenes=true"API Response
json
{
"variants": [
{
"chr": "3",
"pos": 142784763,
"ref": "G",
"alt": "A",
"effect": "synonymous_variant",
"transcript": "ENST00000476941.6",
"consequences": [
{
"aa_ref": "S",
"aa_alt": "S",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 7,
"exon_rank_end": null,
"exon_count": 13,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "TRPC1",
"gene_hgnc_id": 12333,
"hgvs_c": "c.1020G>A",
"hgvs_p": "p.Ser340Ser",
"transcript": "NM_001251845.2",
"protein_id": "NP_001238774.1",
"transcript_support_level": null,
"aa_start": 340,
"aa_end": null,
"aa_length": 793,
"cds_start": 1020,
"cds_end": null,
"cds_length": 2382,
"cdna_start": 1546,
"cdna_end": null,
"cdna_length": 4561,
"mane_select": "ENST00000476941.6",
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "S",
"aa_alt": "S",
"canonical": true,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 7,
"exon_rank_end": null,
"exon_count": 13,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "TRPC1",
"gene_hgnc_id": 12333,
"hgvs_c": "c.1020G>A",
"hgvs_p": "p.Ser340Ser",
"transcript": "ENST00000476941.6",
"protein_id": "ENSP00000419313.1",
"transcript_support_level": 1,
"aa_start": 340,
"aa_end": null,
"aa_length": 793,
"cds_start": 1020,
"cds_end": null,
"cds_length": 2382,
"cdna_start": 1546,
"cdna_end": null,
"cdna_length": 4561,
"mane_select": "NM_001251845.2",
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "S",
"aa_alt": "S",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 6,
"exon_rank_end": null,
"exon_count": 12,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "TRPC1",
"gene_hgnc_id": 12333,
"hgvs_c": "c.918G>A",
"hgvs_p": "p.Ser306Ser",
"transcript": "ENST00000273482.10",
"protein_id": "ENSP00000273482.6",
"transcript_support_level": 1,
"aa_start": 306,
"aa_end": null,
"aa_length": 759,
"cds_start": 918,
"cds_end": null,
"cds_length": 2280,
"cdna_start": 1309,
"cdna_end": null,
"cdna_length": 4324,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "S",
"aa_alt": "S",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 7,
"exon_rank_end": null,
"exon_count": 13,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "TRPC1",
"gene_hgnc_id": 12333,
"hgvs_c": "c.1329G>A",
"hgvs_p": "p.Ser443Ser",
"transcript": "ENST00000698238.1",
"protein_id": "ENSP00000513620.1",
"transcript_support_level": null,
"aa_start": 443,
"aa_end": null,
"aa_length": 896,
"cds_start": 1329,
"cds_end": null,
"cds_length": 2691,
"cdna_start": 1546,
"cdna_end": null,
"cdna_length": 4561,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "S",
"aa_alt": "S",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 6,
"exon_rank_end": null,
"exon_count": 12,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "TRPC1",
"gene_hgnc_id": 12333,
"hgvs_c": "c.918G>A",
"hgvs_p": "p.Ser306Ser",
"transcript": "NM_003304.5",
"protein_id": "NP_003295.1",
"transcript_support_level": null,
"aa_start": 306,
"aa_end": null,
"aa_length": 759,
"cds_start": 918,
"cds_end": null,
"cds_length": 2280,
"cdna_start": 1444,
"cdna_end": null,
"cdna_length": 4459,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "S",
"aa_alt": "S",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 6,
"exon_rank_end": null,
"exon_count": 12,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "TRPC1",
"gene_hgnc_id": 12333,
"hgvs_c": "c.870G>A",
"hgvs_p": "p.Ser290Ser",
"transcript": "NM_001413361.1",
"protein_id": "NP_001400290.1",
"transcript_support_level": null,
"aa_start": 290,
"aa_end": null,
"aa_length": 743,
"cds_start": 870,
"cds_end": null,
"cds_length": 2232,
"cdna_start": 3035,
"cdna_end": null,
"cdna_length": 6050,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "S",
"aa_alt": "S",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 5,
"exon_rank_end": null,
"exon_count": 11,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "TRPC1",
"gene_hgnc_id": 12333,
"hgvs_c": "c.786G>A",
"hgvs_p": "p.Ser262Ser",
"transcript": "NM_001413362.1",
"protein_id": "NP_001400291.1",
"transcript_support_level": null,
"aa_start": 262,
"aa_end": null,
"aa_length": 715,
"cds_start": 786,
"cds_end": null,
"cds_length": 2148,
"cdna_start": 1312,
"cdna_end": null,
"cdna_length": 4327,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "S",
"aa_alt": "S",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 6,
"exon_rank_end": null,
"exon_count": 11,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "TRPC1",
"gene_hgnc_id": 12333,
"hgvs_c": "c.918G>A",
"hgvs_p": "p.Ser306Ser",
"transcript": "NM_001413363.1",
"protein_id": "NP_001400292.1",
"transcript_support_level": null,
"aa_start": 306,
"aa_end": null,
"aa_length": 711,
"cds_start": 918,
"cds_end": null,
"cds_length": 2136,
"cdna_start": 1444,
"cdna_end": null,
"cdna_length": 4315,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "S",
"aa_alt": "S",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 5,
"exon_rank_end": null,
"exon_count": 11,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "TRPC1",
"gene_hgnc_id": 12333,
"hgvs_c": "c.768G>A",
"hgvs_p": "p.Ser256Ser",
"transcript": "NM_001413376.1",
"protein_id": "NP_001400305.1",
"transcript_support_level": null,
"aa_start": 256,
"aa_end": null,
"aa_length": 709,
"cds_start": 768,
"cds_end": null,
"cds_length": 2130,
"cdna_start": 2933,
"cdna_end": null,
"cdna_length": 5948,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "S",
"aa_alt": "S",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 6,
"exon_rank_end": null,
"exon_count": 12,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "TRPC1",
"gene_hgnc_id": 12333,
"hgvs_c": "c.726G>A",
"hgvs_p": "p.Ser242Ser",
"transcript": "NM_001413375.1",
"protein_id": "NP_001400304.1",
"transcript_support_level": null,
"aa_start": 242,
"aa_end": null,
"aa_length": 695,
"cds_start": 726,
"cds_end": null,
"cds_length": 2088,
"cdna_start": 1391,
"cdna_end": null,
"cdna_length": 4406,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "S",
"aa_alt": "S",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 5,
"exon_rank_end": null,
"exon_count": 11,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "TRPC1",
"gene_hgnc_id": 12333,
"hgvs_c": "c.624G>A",
"hgvs_p": "p.Ser208Ser",
"transcript": "NM_001413377.1",
"protein_id": "NP_001400306.1",
"transcript_support_level": null,
"aa_start": 208,
"aa_end": null,
"aa_length": 661,
"cds_start": 624,
"cds_end": null,
"cds_length": 1986,
"cdna_start": 1289,
"cdna_end": null,
"cdna_length": 4304,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "S",
"aa_alt": "S",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 6,
"exon_rank_end": null,
"exon_count": 11,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "TRPC1",
"gene_hgnc_id": 12333,
"hgvs_c": "c.726G>A",
"hgvs_p": "p.Ser242Ser",
"transcript": "NM_001413378.1",
"protein_id": "NP_001400307.1",
"transcript_support_level": null,
"aa_start": 242,
"aa_end": null,
"aa_length": 647,
"cds_start": 726,
"cds_end": null,
"cds_length": 1944,
"cdna_start": 1391,
"cdna_end": null,
"cdna_length": 4262,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "S",
"aa_alt": "S",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 5,
"exon_rank_end": null,
"exon_count": 10,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "TRPC1",
"gene_hgnc_id": 12333,
"hgvs_c": "c.624G>A",
"hgvs_p": "p.Ser208Ser",
"transcript": "NM_001413379.1",
"protein_id": "NP_001400308.1",
"transcript_support_level": null,
"aa_start": 208,
"aa_end": null,
"aa_length": 613,
"cds_start": 624,
"cds_end": null,
"cds_length": 1842,
"cdna_start": 1289,
"cdna_end": null,
"cdna_length": 4160,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "S",
"aa_alt": "S",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 4,
"exon_rank_end": null,
"exon_count": 9,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "TRPC1",
"gene_hgnc_id": 12333,
"hgvs_c": "c.492G>A",
"hgvs_p": "p.Ser164Ser",
"transcript": "NM_001413380.1",
"protein_id": "NP_001400309.1",
"transcript_support_level": null,
"aa_start": 164,
"aa_end": null,
"aa_length": 569,
"cds_start": 492,
"cds_end": null,
"cds_length": 1710,
"cdna_start": 1157,
"cdna_end": null,
"cdna_length": 4028,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "S",
"aa_alt": "S",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 7,
"exon_rank_end": null,
"exon_count": 13,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "TRPC1",
"gene_hgnc_id": 12333,
"hgvs_c": "c.837G>A",
"hgvs_p": "p.Ser279Ser",
"transcript": "XM_017007121.3",
"protein_id": "XP_016862610.1",
"transcript_support_level": null,
"aa_start": 279,
"aa_end": null,
"aa_length": 732,
"cds_start": 837,
"cds_end": null,
"cds_length": 2199,
"cdna_start": 2343,
"cdna_end": null,
"cdna_length": 5358,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "S",
"aa_alt": "S",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 6,
"exon_rank_end": null,
"exon_count": 12,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "TRPC1",
"gene_hgnc_id": 12333,
"hgvs_c": "c.735G>A",
"hgvs_p": "p.Ser245Ser",
"transcript": "XM_047448839.1",
"protein_id": "XP_047304795.1",
"transcript_support_level": null,
"aa_start": 245,
"aa_end": null,
"aa_length": 698,
"cds_start": 735,
"cds_end": null,
"cds_length": 2097,
"cdna_start": 2241,
"cdna_end": null,
"cdna_length": 5256,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "S",
"aa_alt": "S",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 7,
"exon_rank_end": null,
"exon_count": 11,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "TRPC1",
"gene_hgnc_id": 12333,
"hgvs_c": "c.1020G>A",
"hgvs_p": "p.Ser340Ser",
"transcript": "XM_047448840.1",
"protein_id": "XP_047304796.1",
"transcript_support_level": null,
"aa_start": 340,
"aa_end": null,
"aa_length": 537,
"cds_start": 1020,
"cds_end": null,
"cds_length": 1614,
"cdna_start": 1546,
"cdna_end": null,
"cdna_length": 2271,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "S",
"aa_alt": "S",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 6,
"exon_rank_end": null,
"exon_count": 10,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "TRPC1",
"gene_hgnc_id": 12333,
"hgvs_c": "c.918G>A",
"hgvs_p": "p.Ser306Ser",
"transcript": "XM_047448841.1",
"protein_id": "XP_047304797.1",
"transcript_support_level": null,
"aa_start": 306,
"aa_end": null,
"aa_length": 503,
"cds_start": 918,
"cds_end": null,
"cds_length": 1512,
"cdna_start": 1444,
"cdna_end": null,
"cdna_length": 2169,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "S",
"aa_alt": "S",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 7,
"exon_rank_end": null,
"exon_count": 8,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "TRPC1",
"gene_hgnc_id": 12333,
"hgvs_c": "c.1020G>A",
"hgvs_p": "p.Ser340Ser",
"transcript": "XM_047448842.1",
"protein_id": "XP_047304798.1",
"transcript_support_level": null,
"aa_start": 340,
"aa_end": null,
"aa_length": 464,
"cds_start": 1020,
"cds_end": null,
"cds_length": 1395,
"cdna_start": 1546,
"cdna_end": null,
"cdna_length": 1998,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": false,
"strand": true,
"consequences": [
"non_coding_transcript_exon_variant"
],
"exon_rank": 2,
"exon_rank_end": null,
"exon_count": 2,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "TRPC1",
"gene_hgnc_id": 12333,
"hgvs_c": "n.150G>A",
"hgvs_p": null,
"transcript": "ENST00000480101.1",
"protein_id": null,
"transcript_support_level": 3,
"aa_start": null,
"aa_end": null,
"aa_length": null,
"cds_start": -4,
"cds_end": null,
"cds_length": null,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 674,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": false,
"strand": true,
"consequences": [
"non_coding_transcript_exon_variant"
],
"exon_rank": 7,
"exon_rank_end": null,
"exon_count": 11,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "TRPC1",
"gene_hgnc_id": 12333,
"hgvs_c": "n.1546G>A",
"hgvs_p": null,
"transcript": "XR_007095722.1",
"protein_id": null,
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": null,
"cds_start": -4,
"cds_end": null,
"cds_length": null,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 2283,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": false,
"strand": true,
"consequences": [
"non_coding_transcript_exon_variant"
],
"exon_rank": 7,
"exon_rank_end": null,
"exon_count": 11,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "TRPC1",
"gene_hgnc_id": 12333,
"hgvs_c": "n.1546G>A",
"hgvs_p": null,
"transcript": "XR_007095723.1",
"protein_id": null,
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": null,
"cds_start": -4,
"cds_end": null,
"cds_length": null,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 2317,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 9,
"intron_rank": 5,
"intron_rank_end": null,
"gene_symbol": "TRPC1",
"gene_hgnc_id": 12333,
"hgvs_c": "c.858+3734G>A",
"hgvs_p": null,
"transcript": "NM_001413381.1",
"protein_id": "NP_001400310.1",
"transcript_support_level": null,
"aa_start": null,
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}
],
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}