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GeneBe API Showcase
This page demonstrates how to use the GeneBe API to query variant information. The API provides programmatic access to genomic annotations and variant data.
API presented here should be used for checking single variants. If you want to check many variants at once, please use other API endpoints that you will find in the documentation.
Documentation & Advanced Usage
• Complete API documentation:docs.genebe.net/docs/api/overview/
• Interactive endpoint tester:api.genebe.net/cloud/gb-api-doc/swagger-ui/
• Python client for pandas:pypi.org/project/genebe/
• Java CLI for VCF files:github.com/pstawinski/genebe-cli
• All tools documented at:docs.genebe.net
API Request Examples for Variant: 3-148741411-C-G (hg38)
Bash / cURL Example
bash
curl "https://api.genebe.net/cloud/api-public/v1/variant?chr=3&pos=148741411&ref=C&alt=G&genome=hg38&allGenes=true"API Response
json
{
"variants": [
{
"chr": "3",
"pos": 148741411,
"ref": "C",
"alt": "G",
"effect": "missense_variant",
"transcript": "NM_000685.5",
"consequences": [
{
"aa_ref": "R",
"aa_alt": "G",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 3,
"exon_rank_end": null,
"exon_count": 3,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "AGTR1",
"gene_hgnc_id": 336,
"hgvs_c": "c.376C>G",
"hgvs_p": "p.Arg126Gly",
"transcript": "NM_000685.5",
"protein_id": "NP_000676.1",
"transcript_support_level": null,
"aa_start": 126,
"aa_end": null,
"aa_length": 359,
"cds_start": 376,
"cds_end": null,
"cds_length": 1080,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": "ENST00000349243.8",
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_000685.5"
},
{
"aa_ref": "R",
"aa_alt": "G",
"canonical": true,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 3,
"exon_rank_end": null,
"exon_count": 3,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "AGTR1",
"gene_hgnc_id": 336,
"hgvs_c": "c.376C>G",
"hgvs_p": "p.Arg126Gly",
"transcript": "ENST00000349243.8",
"protein_id": "ENSP00000273430.3",
"transcript_support_level": 1,
"aa_start": 126,
"aa_end": null,
"aa_length": 359,
"cds_start": 376,
"cds_end": null,
"cds_length": 1080,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": "NM_000685.5",
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000349243.8"
},
{
"aa_ref": "R",
"aa_alt": "G",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 2,
"exon_rank_end": null,
"exon_count": 2,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "AGTR1",
"gene_hgnc_id": 336,
"hgvs_c": "c.376C>G",
"hgvs_p": "p.Arg126Gly",
"transcript": "ENST00000404754.2",
"protein_id": "ENSP00000385612.2",
"transcript_support_level": 1,
"aa_start": 126,
"aa_end": null,
"aa_length": 359,
"cds_start": 376,
"cds_end": null,
"cds_length": 1080,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000404754.2"
},
{
"aa_ref": "R",
"aa_alt": "G",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 2,
"exon_rank_end": null,
"exon_count": 2,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "AGTR1",
"gene_hgnc_id": 336,
"hgvs_c": "c.376C>G",
"hgvs_p": "p.Arg126Gly",
"transcript": "ENST00000497524.5",
"protein_id": "ENSP00000419422.1",
"transcript_support_level": 1,
"aa_start": 126,
"aa_end": null,
"aa_length": 359,
"cds_start": 376,
"cds_end": null,
"cds_length": 1080,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000497524.5"
},
{
"aa_ref": "R",
"aa_alt": "G",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 2,
"exon_rank_end": null,
"exon_count": 2,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "AGTR1",
"gene_hgnc_id": 336,
"hgvs_c": "c.376C>G",
"hgvs_p": "p.Arg126Gly",
"transcript": "NM_001382736.1",
"protein_id": "NP_001369665.1",
"transcript_support_level": null,
"aa_start": 126,
"aa_end": null,
"aa_length": 359,
"cds_start": 376,
"cds_end": null,
"cds_length": 1080,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001382736.1"
},
{
"aa_ref": "R",
"aa_alt": "G",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 3,
"exon_rank_end": null,
"exon_count": 3,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "AGTR1",
"gene_hgnc_id": 336,
"hgvs_c": "c.376C>G",
"hgvs_p": "p.Arg126Gly",
"transcript": "NM_001382737.1",
"protein_id": "NP_001369666.1",
"transcript_support_level": null,
"aa_start": 126,
"aa_end": null,
"aa_length": 359,
"cds_start": 376,
"cds_end": null,
"cds_length": 1080,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001382737.1"
},
{
"aa_ref": "R",
"aa_alt": "G",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 3,
"exon_rank_end": null,
"exon_count": 3,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "AGTR1",
"gene_hgnc_id": 336,
"hgvs_c": "c.376C>G",
"hgvs_p": "p.Arg126Gly",
"transcript": "NM_004835.5",
"protein_id": "NP_004826.6",
"transcript_support_level": null,
"aa_start": 126,
"aa_end": null,
"aa_length": 359,
"cds_start": 376,
"cds_end": null,
"cds_length": 1080,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_004835.5"
},
{
"aa_ref": "R",
"aa_alt": "G",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 2,
"exon_rank_end": null,
"exon_count": 2,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "AGTR1",
"gene_hgnc_id": 336,
"hgvs_c": "c.376C>G",
"hgvs_p": "p.Arg126Gly",
"transcript": "NM_009585.4",
"protein_id": "NP_033611.1",
"transcript_support_level": null,
"aa_start": 126,
"aa_end": null,
"aa_length": 359,
"cds_start": 376,
"cds_end": null,
"cds_length": 1080,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_009585.4"
},
{
"aa_ref": "R",
"aa_alt": "G",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 4,
"exon_rank_end": null,
"exon_count": 4,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "AGTR1",
"gene_hgnc_id": 336,
"hgvs_c": "c.376C>G",
"hgvs_p": "p.Arg126Gly",
"transcript": "NM_031850.4",
"protein_id": "NP_114038.5",
"transcript_support_level": null,
"aa_start": 126,
"aa_end": null,
"aa_length": 359,
"cds_start": 376,
"cds_end": null,
"cds_length": 1080,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_031850.4"
},
{
"aa_ref": "R",
"aa_alt": "G",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 4,
"exon_rank_end": null,
"exon_count": 4,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "AGTR1",
"gene_hgnc_id": 336,
"hgvs_c": "c.376C>G",
"hgvs_p": "p.Arg126Gly",
"transcript": "NM_032049.4",
"protein_id": "NP_114438.3",
"transcript_support_level": null,
"aa_start": 126,
"aa_end": null,
"aa_length": 359,
"cds_start": 376,
"cds_end": null,
"cds_length": 1080,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_032049.4"
},
{
"aa_ref": "R",
"aa_alt": "G",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 2,
"exon_rank_end": null,
"exon_count": 2,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "AGTR1",
"gene_hgnc_id": 336,
"hgvs_c": "c.376C>G",
"hgvs_p": "p.Arg126Gly",
"transcript": "ENST00000402260.2",
"protein_id": "ENSP00000385641.3",
"transcript_support_level": 5,
"aa_start": 126,
"aa_end": null,
"aa_length": 359,
"cds_start": 376,
"cds_end": null,
"cds_length": 1080,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000402260.2"
},
{
"aa_ref": "R",
"aa_alt": "G",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 3,
"exon_rank_end": null,
"exon_count": 3,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "AGTR1",
"gene_hgnc_id": 336,
"hgvs_c": "c.376C>G",
"hgvs_p": "p.Arg126Gly",
"transcript": "ENST00000418473.7",
"protein_id": "ENSP00000398832.4",
"transcript_support_level": 5,
"aa_start": 126,
"aa_end": null,
"aa_length": 359,
"cds_start": 376,
"cds_end": null,
"cds_length": 1080,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000418473.7"
},
{
"aa_ref": "R",
"aa_alt": "G",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 3,
"exon_rank_end": null,
"exon_count": 3,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "AGTR1",
"gene_hgnc_id": 336,
"hgvs_c": "c.376C>G",
"hgvs_p": "p.Arg126Gly",
"transcript": "ENST00000461609.1",
"protein_id": "ENSP00000418851.1",
"transcript_support_level": 3,
"aa_start": 126,
"aa_end": null,
"aa_length": 359,
"cds_start": 376,
"cds_end": null,
"cds_length": 1080,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000461609.1"
},
{
"aa_ref": "R",
"aa_alt": "G",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 3,
"exon_rank_end": null,
"exon_count": 3,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "AGTR1",
"gene_hgnc_id": 336,
"hgvs_c": "c.376C>G",
"hgvs_p": "p.Arg126Gly",
"transcript": "ENST00000474935.5",
"protein_id": "ENSP00000418084.1",
"transcript_support_level": 3,
"aa_start": 126,
"aa_end": null,
"aa_length": 359,
"cds_start": 376,
"cds_end": null,
"cds_length": 1080,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000474935.5"
},
{
"aa_ref": "R",
"aa_alt": "G",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 2,
"exon_rank_end": null,
"exon_count": 2,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "AGTR1",
"gene_hgnc_id": 336,
"hgvs_c": "c.376C>G",
"hgvs_p": "p.Arg126Gly",
"transcript": "ENST00000475347.5",
"protein_id": "ENSP00000419783.1",
"transcript_support_level": 3,
"aa_start": 126,
"aa_end": null,
"aa_length": 359,
"cds_start": 376,
"cds_end": null,
"cds_length": 1080,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000475347.5"
},
{
"aa_ref": "R",
"aa_alt": "G",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 4,
"exon_rank_end": null,
"exon_count": 4,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "AGTR1",
"gene_hgnc_id": 336,
"hgvs_c": "c.376C>G",
"hgvs_p": "p.Arg126Gly",
"transcript": "ENST00000892854.1",
"protein_id": "ENSP00000562913.1",
"transcript_support_level": null,
"aa_start": 126,
"aa_end": null,
"aa_length": 359,
"cds_start": 376,
"cds_end": null,
"cds_length": 1080,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000892854.1"
},
{
"aa_ref": "R",
"aa_alt": "G",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 3,
"exon_rank_end": null,
"exon_count": 3,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "AGTR1",
"gene_hgnc_id": 336,
"hgvs_c": "c.376C>G",
"hgvs_p": "p.Arg126Gly",
"transcript": "ENST00000892855.1",
"protein_id": "ENSP00000562914.1",
"transcript_support_level": null,
"aa_start": 126,
"aa_end": null,
"aa_length": 359,
"cds_start": 376,
"cds_end": null,
"cds_length": 1080,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000892855.1"
},
{
"aa_ref": "R",
"aa_alt": "G",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 5,
"exon_rank_end": null,
"exon_count": 5,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "AGTR1",
"gene_hgnc_id": 336,
"hgvs_c": "c.376C>G",
"hgvs_p": "p.Arg126Gly",
"transcript": "ENST00000892856.1",
"protein_id": "ENSP00000562915.1",
"transcript_support_level": null,
"aa_start": 126,
"aa_end": null,
"aa_length": 359,
"cds_start": 376,
"cds_end": null,
"cds_length": 1080,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000892856.1"
},
{
"aa_ref": "R",
"aa_alt": "G",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 3,
"exon_rank_end": null,
"exon_count": 3,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "AGTR1",
"gene_hgnc_id": 336,
"hgvs_c": "c.376C>G",
"hgvs_p": "p.Arg126Gly",
"transcript": "ENST00000892857.1",
"protein_id": "ENSP00000562916.1",
"transcript_support_level": null,
"aa_start": 126,
"aa_end": null,
"aa_length": 359,
"cds_start": 376,
"cds_end": null,
"cds_length": 1080,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000892857.1"
},
{
"aa_ref": "R",
"aa_alt": "G",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 4,
"exon_rank_end": null,
"exon_count": 4,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "AGTR1",
"gene_hgnc_id": 336,
"hgvs_c": "c.376C>G",
"hgvs_p": "p.Arg126Gly",
"transcript": "ENST00000892858.1",
"protein_id": "ENSP00000562917.1",
"transcript_support_level": null,
"aa_start": 126,
"aa_end": null,
"aa_length": 359,
"cds_start": 376,
"cds_end": null,
"cds_length": 1080,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000892858.1"
},
{
"aa_ref": "R",
"aa_alt": "G",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 4,
"exon_rank_end": null,
"exon_count": 4,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "AGTR1",
"gene_hgnc_id": 336,
"hgvs_c": "c.376C>G",
"hgvs_p": "p.Arg126Gly",
"transcript": "ENST00000892859.1",
"protein_id": "ENSP00000562918.1",
"transcript_support_level": null,
"aa_start": 126,
"aa_end": null,
"aa_length": 359,
"cds_start": 376,
"cds_end": null,
"cds_length": 1080,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000892859.1"
},
{
"aa_ref": "R",
"aa_alt": "G",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 2,
"exon_rank_end": null,
"exon_count": 2,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "AGTR1",
"gene_hgnc_id": 336,
"hgvs_c": "c.376C>G",
"hgvs_p": "p.Arg126Gly",
"transcript": "ENST00000892860.1",
"protein_id": "ENSP00000562919.1",
"transcript_support_level": null,
"aa_start": 126,
"aa_end": null,
"aa_length": 359,
"cds_start": 376,
"cds_end": null,
"cds_length": 1080,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000892860.1"
},
{
"aa_ref": "R",
"aa_alt": "G",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
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}