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GeneBe API Showcase
This page demonstrates how to use the GeneBe API to query variant information. The API provides programmatic access to genomic annotations and variant data.
API presented here should be used for checking single variants. If you want to check many variants at once, please use other API endpoints that you will find in the documentation.
Documentation & Advanced Usage
• Complete API documentation:docs.genebe.net/docs/api/overview/
• Interactive endpoint tester:api.genebe.net/cloud/gb-api-doc/swagger-ui/
• Python client for pandas:pypi.org/project/genebe/
• Java CLI for VCF files:github.com/pstawinski/genebe-cli
• All tools documented at:docs.genebe.net
API Request Examples for Variant: 3-15016159-C-A (hg38)
Bash / cURL Example
bash
curl "https://api.genebe.net/cloud/api-public/v1/variant?chr=3&pos=15016159&ref=C&alt=A&genome=hg38&allGenes=true"API Response
json
{
"variants": [
{
"chr": "3",
"pos": 15016159,
"ref": "C",
"alt": "A",
"effect": "missense_variant",
"transcript": "NM_003298.5",
"consequences": [
{
"aa_ref": "T",
"aa_alt": "K",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 4,
"exon_rank_end": null,
"exon_count": 14,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "NR2C2",
"gene_hgnc_id": 7972,
"hgvs_c": "c.281C>A",
"hgvs_p": "p.Thr94Lys",
"transcript": "NM_001291694.2",
"protein_id": "NP_001278623.1",
"transcript_support_level": null,
"aa_start": 94,
"aa_end": null,
"aa_length": 596,
"cds_start": 281,
"cds_end": null,
"cds_length": 1791,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": "ENST00000425241.6",
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001291694.2"
},
{
"aa_ref": "T",
"aa_alt": "K",
"canonical": true,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 4,
"exon_rank_end": null,
"exon_count": 14,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "NR2C2",
"gene_hgnc_id": 7972,
"hgvs_c": "c.281C>A",
"hgvs_p": "p.Thr94Lys",
"transcript": "ENST00000425241.6",
"protein_id": "ENSP00000388387.1",
"transcript_support_level": 2,
"aa_start": 94,
"aa_end": null,
"aa_length": 596,
"cds_start": 281,
"cds_end": null,
"cds_length": 1791,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": "NM_001291694.2",
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000425241.6"
},
{
"aa_ref": "T",
"aa_alt": "K",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 5,
"exon_rank_end": null,
"exon_count": 15,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "NR2C2",
"gene_hgnc_id": 7972,
"hgvs_c": "c.338C>A",
"hgvs_p": "p.Thr113Lys",
"transcript": "ENST00000323373.10",
"protein_id": "ENSP00000320447.6",
"transcript_support_level": 1,
"aa_start": 113,
"aa_end": null,
"aa_length": 615,
"cds_start": 338,
"cds_end": null,
"cds_length": 1848,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000323373.10"
},
{
"aa_ref": "T",
"aa_alt": "K",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 5,
"exon_rank_end": null,
"exon_count": 15,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "NR2C2",
"gene_hgnc_id": 7972,
"hgvs_c": "c.338C>A",
"hgvs_p": "p.Thr113Lys",
"transcript": "NM_003298.5",
"protein_id": "NP_003289.2",
"transcript_support_level": null,
"aa_start": 113,
"aa_end": null,
"aa_length": 615,
"cds_start": 338,
"cds_end": null,
"cds_length": 1848,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_003298.5"
},
{
"aa_ref": "T",
"aa_alt": "K",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 6,
"exon_rank_end": null,
"exon_count": 16,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "NR2C2",
"gene_hgnc_id": 7972,
"hgvs_c": "c.338C>A",
"hgvs_p": "p.Thr113Lys",
"transcript": "ENST00000859246.1",
"protein_id": "ENSP00000529305.1",
"transcript_support_level": null,
"aa_start": 113,
"aa_end": null,
"aa_length": 615,
"cds_start": 338,
"cds_end": null,
"cds_length": 1848,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000859246.1"
},
{
"aa_ref": "T",
"aa_alt": "K",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 9,
"exon_rank_end": null,
"exon_count": 19,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "NR2C2",
"gene_hgnc_id": 7972,
"hgvs_c": "c.338C>A",
"hgvs_p": "p.Thr113Lys",
"transcript": "ENST00000859250.1",
"protein_id": "ENSP00000529309.1",
"transcript_support_level": null,
"aa_start": 113,
"aa_end": null,
"aa_length": 615,
"cds_start": 338,
"cds_end": null,
"cds_length": 1848,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000859250.1"
},
{
"aa_ref": "T",
"aa_alt": "K",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 5,
"exon_rank_end": null,
"exon_count": 15,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "NR2C2",
"gene_hgnc_id": 7972,
"hgvs_c": "c.338C>A",
"hgvs_p": "p.Thr113Lys",
"transcript": "ENST00000859253.1",
"protein_id": "ENSP00000529312.1",
"transcript_support_level": null,
"aa_start": 113,
"aa_end": null,
"aa_length": 615,
"cds_start": 338,
"cds_end": null,
"cds_length": 1848,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000859253.1"
},
{
"aa_ref": "T",
"aa_alt": "K",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 8,
"exon_rank_end": null,
"exon_count": 18,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "NR2C2",
"gene_hgnc_id": 7972,
"hgvs_c": "c.338C>A",
"hgvs_p": "p.Thr113Lys",
"transcript": "ENST00000911529.1",
"protein_id": "ENSP00000581588.1",
"transcript_support_level": null,
"aa_start": 113,
"aa_end": null,
"aa_length": 615,
"cds_start": 338,
"cds_end": null,
"cds_length": 1848,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000911529.1"
},
{
"aa_ref": "T",
"aa_alt": "K",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 6,
"exon_rank_end": null,
"exon_count": 16,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "NR2C2",
"gene_hgnc_id": 7972,
"hgvs_c": "c.338C>A",
"hgvs_p": "p.Thr113Lys",
"transcript": "ENST00000968198.1",
"protein_id": "ENSP00000638257.1",
"transcript_support_level": null,
"aa_start": 113,
"aa_end": null,
"aa_length": 615,
"cds_start": 338,
"cds_end": null,
"cds_length": 1848,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000968198.1"
},
{
"aa_ref": "T",
"aa_alt": "K",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 8,
"exon_rank_end": null,
"exon_count": 18,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "NR2C2",
"gene_hgnc_id": 7972,
"hgvs_c": "c.338C>A",
"hgvs_p": "p.Thr113Lys",
"transcript": "ENST00000968199.1",
"protein_id": "ENSP00000638258.1",
"transcript_support_level": null,
"aa_start": 113,
"aa_end": null,
"aa_length": 615,
"cds_start": 338,
"cds_end": null,
"cds_length": 1848,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000968199.1"
},
{
"aa_ref": "T",
"aa_alt": "K",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 4,
"exon_rank_end": null,
"exon_count": 14,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "NR2C2",
"gene_hgnc_id": 7972,
"hgvs_c": "c.281C>A",
"hgvs_p": "p.Thr94Lys",
"transcript": "ENST00000393102.7",
"protein_id": "ENSP00000376814.3",
"transcript_support_level": 5,
"aa_start": 94,
"aa_end": null,
"aa_length": 596,
"cds_start": 281,
"cds_end": null,
"cds_length": 1791,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000393102.7"
},
{
"aa_ref": "T",
"aa_alt": "K",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 7,
"exon_rank_end": null,
"exon_count": 17,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "NR2C2",
"gene_hgnc_id": 7972,
"hgvs_c": "c.281C>A",
"hgvs_p": "p.Thr94Lys",
"transcript": "ENST00000859248.1",
"protein_id": "ENSP00000529307.1",
"transcript_support_level": null,
"aa_start": 94,
"aa_end": null,
"aa_length": 596,
"cds_start": 281,
"cds_end": null,
"cds_length": 1791,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000859248.1"
},
{
"aa_ref": "T",
"aa_alt": "K",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 5,
"exon_rank_end": null,
"exon_count": 15,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "NR2C2",
"gene_hgnc_id": 7972,
"hgvs_c": "c.281C>A",
"hgvs_p": "p.Thr94Lys",
"transcript": "ENST00000859249.1",
"protein_id": "ENSP00000529308.1",
"transcript_support_level": null,
"aa_start": 94,
"aa_end": null,
"aa_length": 596,
"cds_start": 281,
"cds_end": null,
"cds_length": 1791,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000859249.1"
},
{
"aa_ref": "T",
"aa_alt": "K",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 7,
"exon_rank_end": null,
"exon_count": 17,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "NR2C2",
"gene_hgnc_id": 7972,
"hgvs_c": "c.281C>A",
"hgvs_p": "p.Thr94Lys",
"transcript": "ENST00000859251.1",
"protein_id": "ENSP00000529310.1",
"transcript_support_level": null,
"aa_start": 94,
"aa_end": null,
"aa_length": 596,
"cds_start": 281,
"cds_end": null,
"cds_length": 1791,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000859251.1"
},
{
"aa_ref": "T",
"aa_alt": "K",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 5,
"exon_rank_end": null,
"exon_count": 15,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "NR2C2",
"gene_hgnc_id": 7972,
"hgvs_c": "c.281C>A",
"hgvs_p": "p.Thr94Lys",
"transcript": "ENST00000859252.1",
"protein_id": "ENSP00000529311.1",
"transcript_support_level": null,
"aa_start": 94,
"aa_end": null,
"aa_length": 596,
"cds_start": 281,
"cds_end": null,
"cds_length": 1791,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000859252.1"
},
{
"aa_ref": "T",
"aa_alt": "K",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 6,
"exon_rank_end": null,
"exon_count": 16,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "NR2C2",
"gene_hgnc_id": 7972,
"hgvs_c": "c.281C>A",
"hgvs_p": "p.Thr94Lys",
"transcript": "ENST00000968197.1",
"protein_id": "ENSP00000638256.1",
"transcript_support_level": null,
"aa_start": 94,
"aa_end": null,
"aa_length": 596,
"cds_start": 281,
"cds_end": null,
"cds_length": 1791,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000968197.1"
},
{
"aa_ref": "T",
"aa_alt": "K",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 4,
"exon_rank_end": null,
"exon_count": 14,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "NR2C2",
"gene_hgnc_id": 7972,
"hgvs_c": "c.281C>A",
"hgvs_p": "p.Thr94Lys",
"transcript": "ENST00000968201.1",
"protein_id": "ENSP00000638260.1",
"transcript_support_level": null,
"aa_start": 94,
"aa_end": null,
"aa_length": 596,
"cds_start": 281,
"cds_end": null,
"cds_length": 1791,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000968201.1"
},
{
"aa_ref": "T",
"aa_alt": "K",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 4,
"exon_rank_end": null,
"exon_count": 14,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "NR2C2",
"gene_hgnc_id": 7972,
"hgvs_c": "c.137C>A",
"hgvs_p": "p.Thr46Lys",
"transcript": "ENST00000859247.1",
"protein_id": "ENSP00000529306.1",
"transcript_support_level": null,
"aa_start": 46,
"aa_end": null,
"aa_length": 548,
"cds_start": 137,
"cds_end": null,
"cds_length": 1647,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000859247.1"
},
{
"aa_ref": "T",
"aa_alt": "K",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 3,
"exon_rank_end": null,
"exon_count": 13,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "NR2C2",
"gene_hgnc_id": 7972,
"hgvs_c": "c.80C>A",
"hgvs_p": "p.Thr27Lys",
"transcript": "ENST00000968200.1",
"protein_id": "ENSP00000638259.1",
"transcript_support_level": null,
"aa_start": 27,
"aa_end": null,
"aa_length": 529,
"cds_start": 80,
"cds_end": null,
"cds_length": 1590,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000968200.1"
},
{
"aa_ref": "T",
"aa_alt": "K",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 5,
"exon_rank_end": null,
"exon_count": 6,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "NR2C2",
"gene_hgnc_id": 7972,
"hgvs_c": "c.338C>A",
"hgvs_p": "p.Thr113Lys",
"transcript": "ENST00000437120.5",
"protein_id": "ENSP00000401807.1",
"transcript_support_level": 3,
"aa_start": 113,
"aa_end": null,
"aa_length": 204,
"cds_start": 338,
"cds_end": null,
"cds_length": 616,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000437120.5"
},
{
"aa_ref": "T",
"aa_alt": "K",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 8,
"exon_rank_end": null,
"exon_count": 18,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "NR2C2",
"gene_hgnc_id": 7972,
"hgvs_c": "c.437C>A",
"hgvs_p": "p.Thr146Lys",
"transcript": "XM_011534058.4",
"protein_id": "XP_011532360.1",
"transcript_support_level": null,
"aa_start": 146,
"aa_end": null,
"aa_length": 648,
"cds_start": 437,
"cds_end": null,
"cds_length": 1947,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "XM_011534058.4"
},
{
"aa_ref": "T",
"aa_alt": "K",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 8,
"exon_rank_end": null,
"exon_count": 18,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "NR2C2",
"gene_hgnc_id": 7972,
"hgvs_c": "c.437C>A",
"hgvs_p": "p.Thr146Lys",
"transcript": "XM_011534059.3",
"protein_id": "XP_011532361.1",
"transcript_support_level": null,
"aa_start": 146,
"aa_end": null,
"aa_length": 648,
"cds_start": 437,
"cds_end": null,
"cds_length": 1947,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
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{
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}
],
"message": null
}