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GeneBe API Showcase
This page demonstrates how to use the GeneBe API to query variant information. The API provides programmatic access to genomic annotations and variant data.
API presented here should be used for checking single variants. If you want to check many variants at once, please use other API endpoints that you will find in the documentation.
Documentation & Advanced Usage
• Complete API documentation:docs.genebe.net/docs/api/overview/
• Interactive endpoint tester:api.genebe.net/cloud/gb-api-doc/swagger-ui/
• Python client for pandas:pypi.org/project/genebe/
• Java CLI for VCF files:github.com/pstawinski/genebe-cli
• All tools documented at:docs.genebe.net
API Request Examples for Variant: 3-15017449-A-G (hg38)
Bash / cURL Example
bash
curl "https://api.genebe.net/cloud/api-public/v1/variant?chr=3&pos=15017449&ref=A&alt=G&genome=hg38&allGenes=true"API Response
json
{
"variants": [
{
"chr": "3",
"pos": 15017449,
"ref": "A",
"alt": "G",
"effect": "intron_variant",
"transcript": "ENST00000425241.6",
"consequences": [
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 14,
"intron_rank": 4,
"intron_rank_end": null,
"gene_symbol": "NR2C2",
"gene_hgnc_id": 7972,
"hgvs_c": "c.376+1195A>G",
"hgvs_p": null,
"transcript": "NM_001291694.2",
"protein_id": "NP_001278623.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 596,
"cds_start": -4,
"cds_end": null,
"cds_length": 1791,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 8419,
"mane_select": "ENST00000425241.6",
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": true,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 14,
"intron_rank": 4,
"intron_rank_end": null,
"gene_symbol": "NR2C2",
"gene_hgnc_id": 7972,
"hgvs_c": "c.376+1195A>G",
"hgvs_p": null,
"transcript": "ENST00000425241.6",
"protein_id": "ENSP00000388387.1",
"transcript_support_level": 2,
"aa_start": null,
"aa_end": null,
"aa_length": 596,
"cds_start": -4,
"cds_end": null,
"cds_length": 1791,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 8419,
"mane_select": "NM_001291694.2",
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 15,
"intron_rank": 5,
"intron_rank_end": null,
"gene_symbol": "NR2C2",
"gene_hgnc_id": 7972,
"hgvs_c": "c.433+1195A>G",
"hgvs_p": null,
"transcript": "ENST00000323373.10",
"protein_id": "ENSP00000320447.6",
"transcript_support_level": 1,
"aa_start": null,
"aa_end": null,
"aa_length": 615,
"cds_start": -4,
"cds_end": null,
"cds_length": 1848,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 2406,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 14,
"intron_rank": 4,
"intron_rank_end": null,
"gene_symbol": "NR2C2",
"gene_hgnc_id": 7972,
"hgvs_c": "c.433+1195A>G",
"hgvs_p": null,
"transcript": "ENST00000617312.4",
"protein_id": "ENSP00000483059.1",
"transcript_support_level": 1,
"aa_start": null,
"aa_end": null,
"aa_length": 615,
"cds_start": -4,
"cds_end": null,
"cds_length": 1848,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 8113,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 13,
"intron_rank": 3,
"intron_rank_end": null,
"gene_symbol": "NR2C2",
"gene_hgnc_id": 7972,
"hgvs_c": "c.376+1195A>G",
"hgvs_p": null,
"transcript": "ENST00000406272.6",
"protein_id": "ENSP00000384463.2",
"transcript_support_level": 1,
"aa_start": null,
"aa_end": null,
"aa_length": 596,
"cds_start": -4,
"cds_end": null,
"cds_length": 1791,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 1791,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 15,
"intron_rank": 5,
"intron_rank_end": null,
"gene_symbol": "NR2C2",
"gene_hgnc_id": 7972,
"hgvs_c": "c.433+1195A>G",
"hgvs_p": null,
"transcript": "NM_003298.5",
"protein_id": "NP_003289.2",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 615,
"cds_start": -4,
"cds_end": null,
"cds_length": 1848,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 8476,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 14,
"intron_rank": 4,
"intron_rank_end": null,
"gene_symbol": "NR2C2",
"gene_hgnc_id": 7972,
"hgvs_c": "c.376+1195A>G",
"hgvs_p": null,
"transcript": "ENST00000393102.7",
"protein_id": "ENSP00000376814.3",
"transcript_support_level": 5,
"aa_start": null,
"aa_end": null,
"aa_length": 596,
"cds_start": -4,
"cds_end": null,
"cds_length": 1791,
"cdna_start": null,
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"cdna_length": 1937,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 6,
"intron_rank": 5,
"intron_rank_end": null,
"gene_symbol": "NR2C2",
"gene_hgnc_id": 7972,
"hgvs_c": "c.433+1195A>G",
"hgvs_p": null,
"transcript": "ENST00000437120.5",
"protein_id": "ENSP00000401807.1",
"transcript_support_level": 3,
"aa_start": null,
"aa_end": null,
"aa_length": 204,
"cds_start": -4,
"cds_end": null,
"cds_length": 616,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 739,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": false,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 14,
"intron_rank": 5,
"intron_rank_end": null,
"gene_symbol": "NR2C2",
"gene_hgnc_id": 7972,
"hgvs_c": "n.568+1195A>G",
"hgvs_p": null,
"transcript": "ENST00000475707.5",
"protein_id": null,
"transcript_support_level": 2,
"aa_start": null,
"aa_end": null,
"aa_length": null,
"cds_start": -4,
"cds_end": null,
"cds_length": null,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 3308,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
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"canonical": false,
"protein_coding": false,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 4,
"intron_rank": 3,
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"gene_symbol": "MRPS25",
"gene_hgnc_id": 14511,
"hgvs_c": "n.*140+9T>C",
"hgvs_p": null,
"transcript": "ENST00000695375.1",
"protein_id": "ENSP00000511848.1",
"transcript_support_level": null,
"aa_start": null,
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"aa_length": null,
"cds_start": -4,
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"mane_select": null,
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"feature": null
},
{
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"canonical": false,
"protein_coding": false,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 7,
"intron_rank": 5,
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"gene_symbol": "MRPS25",
"gene_hgnc_id": 14511,
"hgvs_c": "n.*2962+9T>C",
"hgvs_p": null,
"transcript": "ENST00000695376.1",
"protein_id": "ENSP00000511849.1",
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},
{
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"strand": false,
"consequences": [
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],
"exon_rank": null,
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"exon_count": 6,
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"gene_symbol": "MRPS25",
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},
{
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"consequences": [
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],
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"exon_count": 4,
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"gene_symbol": "MRPS25",
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"hgvs_c": "n.*140+9T>C",
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"transcript": "ENST00000695378.1",
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},
{
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],
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"gene_symbol": "MRPS25",
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"hgvs_c": "n.*2962+9T>C",
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},
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],
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},
{
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"consequences": [
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],
"exon_rank": null,
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"intron_rank": 8,
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"gene_symbol": "NR2C2",
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"hgvs_c": "c.532+1195A>G",
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"transcript": "XM_011534058.4",
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},
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],
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"gene_symbol": "NR2C2",
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"hgvs_c": "c.532+1195A>G",
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"transcript": "XM_011534059.3",
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},
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],
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"intron_rank": 6,
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"gene_symbol": "NR2C2",
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"hgvs_c": "c.532+1195A>G",
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"transcript": "XM_011534061.4",
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],
"exon_rank": null,
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"intron_rank": 8,
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"hgvs_c": "c.532+1195A>G",
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],
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},
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],
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"gene_symbol": "NR2C2",
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"hgvs_c": "c.532+1195A>G",
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"transcript": "XM_047448827.1",
"protein_id": "XP_047304783.1",
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},
{
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],
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"exon_count": 16,
"intron_rank": 6,
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"gene_symbol": "NR2C2",
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