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GeneBe API Showcase
This page demonstrates how to use the GeneBe API to query variant information. The API provides programmatic access to genomic annotations and variant data.
API presented here should be used for checking single variants. If you want to check many variants at once, please use other API endpoints that you will find in the documentation.
Documentation & Advanced Usage
• Complete API documentation:docs.genebe.net/docs/api/overview/
• Interactive endpoint tester:api.genebe.net/cloud/gb-api-doc/swagger-ui/
• Python client for pandas:pypi.org/project/genebe/
• Java CLI for VCF files:github.com/pstawinski/genebe-cli
• All tools documented at:docs.genebe.net
API Request Examples for Variant: 3-15039189-G-A (hg38)
Bash / cURL Example
bash
curl "https://api.genebe.net/cloud/api-public/v1/variant?chr=3&pos=15039189&ref=G&alt=A&genome=hg38&allGenes=true"API Response
json
{
"variants": [
{
"chr": "3",
"pos": 15039189,
"ref": "G",
"alt": "A",
"effect": "synonymous_variant",
"transcript": "ENST00000425241.6",
"consequences": [
{
"aa_ref": "Q",
"aa_alt": "Q",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 13,
"exon_rank_end": null,
"exon_count": 14,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "NR2C2",
"gene_hgnc_id": 7972,
"hgvs_c": "c.1578G>A",
"hgvs_p": "p.Gln526Gln",
"transcript": "NM_001291694.2",
"protein_id": "NP_001278623.1",
"transcript_support_level": null,
"aa_start": 526,
"aa_end": null,
"aa_length": 596,
"cds_start": 1578,
"cds_end": null,
"cds_length": 1791,
"cdna_start": 1941,
"cdna_end": null,
"cdna_length": 8419,
"mane_select": "ENST00000425241.6",
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "Q",
"aa_alt": "Q",
"canonical": true,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 13,
"exon_rank_end": null,
"exon_count": 14,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "NR2C2",
"gene_hgnc_id": 7972,
"hgvs_c": "c.1578G>A",
"hgvs_p": "p.Gln526Gln",
"transcript": "ENST00000425241.6",
"protein_id": "ENSP00000388387.1",
"transcript_support_level": 2,
"aa_start": 526,
"aa_end": null,
"aa_length": 596,
"cds_start": 1578,
"cds_end": null,
"cds_length": 1791,
"cdna_start": 1941,
"cdna_end": null,
"cdna_length": 8419,
"mane_select": "NM_001291694.2",
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "Q",
"aa_alt": "Q",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 14,
"exon_rank_end": null,
"exon_count": 15,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "NR2C2",
"gene_hgnc_id": 7972,
"hgvs_c": "c.1635G>A",
"hgvs_p": "p.Gln545Gln",
"transcript": "ENST00000323373.10",
"protein_id": "ENSP00000320447.6",
"transcript_support_level": 1,
"aa_start": 545,
"aa_end": null,
"aa_length": 615,
"cds_start": 1635,
"cds_end": null,
"cds_length": 1848,
"cdna_start": 1852,
"cdna_end": null,
"cdna_length": 2406,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "Q",
"aa_alt": "Q",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 13,
"exon_rank_end": null,
"exon_count": 14,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "NR2C2",
"gene_hgnc_id": 7972,
"hgvs_c": "c.1635G>A",
"hgvs_p": "p.Gln545Gln",
"transcript": "ENST00000617312.4",
"protein_id": "ENSP00000483059.1",
"transcript_support_level": 1,
"aa_start": 545,
"aa_end": null,
"aa_length": 615,
"cds_start": 1635,
"cds_end": null,
"cds_length": 1848,
"cdna_start": 1635,
"cdna_end": null,
"cdna_length": 8113,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "Q",
"aa_alt": "Q",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 12,
"exon_rank_end": null,
"exon_count": 13,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "NR2C2",
"gene_hgnc_id": 7972,
"hgvs_c": "c.1578G>A",
"hgvs_p": "p.Gln526Gln",
"transcript": "ENST00000406272.6",
"protein_id": "ENSP00000384463.2",
"transcript_support_level": 1,
"aa_start": 526,
"aa_end": null,
"aa_length": 596,
"cds_start": 1578,
"cds_end": null,
"cds_length": 1791,
"cdna_start": 1578,
"cdna_end": null,
"cdna_length": 1791,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "Q",
"aa_alt": "Q",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 14,
"exon_rank_end": null,
"exon_count": 15,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "NR2C2",
"gene_hgnc_id": 7972,
"hgvs_c": "c.1635G>A",
"hgvs_p": "p.Gln545Gln",
"transcript": "NM_003298.5",
"protein_id": "NP_003289.2",
"transcript_support_level": null,
"aa_start": 545,
"aa_end": null,
"aa_length": 615,
"cds_start": 1635,
"cds_end": null,
"cds_length": 1848,
"cdna_start": 1998,
"cdna_end": null,
"cdna_length": 8476,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "Q",
"aa_alt": "Q",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 13,
"exon_rank_end": null,
"exon_count": 14,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "NR2C2",
"gene_hgnc_id": 7972,
"hgvs_c": "c.1578G>A",
"hgvs_p": "p.Gln526Gln",
"transcript": "ENST00000393102.7",
"protein_id": "ENSP00000376814.3",
"transcript_support_level": 5,
"aa_start": 526,
"aa_end": null,
"aa_length": 596,
"cds_start": 1578,
"cds_end": null,
"cds_length": 1791,
"cdna_start": 1703,
"cdna_end": null,
"cdna_length": 1937,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "Q",
"aa_alt": "Q",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 4,
"exon_rank_end": null,
"exon_count": 5,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "NR2C2",
"gene_hgnc_id": 7972,
"hgvs_c": "c.420G>A",
"hgvs_p": "p.Gln140Gln",
"transcript": "ENST00000439011.5",
"protein_id": "ENSP00000412473.1",
"transcript_support_level": 3,
"aa_start": 140,
"aa_end": null,
"aa_length": 222,
"cds_start": 420,
"cds_end": null,
"cds_length": 669,
"cdna_start": 420,
"cdna_end": null,
"cdna_length": 698,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "Q",
"aa_alt": "Q",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 3,
"exon_rank_end": null,
"exon_count": 4,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "NR2C2",
"gene_hgnc_id": 7972,
"hgvs_c": "c.363G>A",
"hgvs_p": "p.Gln121Gln",
"transcript": "ENST00000413194.1",
"protein_id": "ENSP00000413438.1",
"transcript_support_level": 3,
"aa_start": 121,
"aa_end": null,
"aa_length": 173,
"cds_start": 363,
"cds_end": null,
"cds_length": 522,
"cdna_start": 363,
"cdna_end": null,
"cdna_length": 551,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "Q",
"aa_alt": "Q",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 17,
"exon_rank_end": null,
"exon_count": 18,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "NR2C2",
"gene_hgnc_id": 7972,
"hgvs_c": "c.1734G>A",
"hgvs_p": "p.Gln578Gln",
"transcript": "XM_011534058.4",
"protein_id": "XP_011532360.1",
"transcript_support_level": null,
"aa_start": 578,
"aa_end": null,
"aa_length": 648,
"cds_start": 1734,
"cds_end": null,
"cds_length": 1947,
"cdna_start": 2228,
"cdna_end": null,
"cdna_length": 8706,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "Q",
"aa_alt": "Q",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 17,
"exon_rank_end": null,
"exon_count": 18,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "NR2C2",
"gene_hgnc_id": 7972,
"hgvs_c": "c.1734G>A",
"hgvs_p": "p.Gln578Gln",
"transcript": "XM_011534059.3",
"protein_id": "XP_011532361.1",
"transcript_support_level": null,
"aa_start": 578,
"aa_end": null,
"aa_length": 648,
"cds_start": 1734,
"cds_end": null,
"cds_length": 1947,
"cdna_start": 2997,
"cdna_end": null,
"cdna_length": 9475,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "Q",
"aa_alt": "Q",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 15,
"exon_rank_end": null,
"exon_count": 16,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "NR2C2",
"gene_hgnc_id": 7972,
"hgvs_c": "c.1734G>A",
"hgvs_p": "p.Gln578Gln",
"transcript": "XM_011534061.4",
"protein_id": "XP_011532363.1",
"transcript_support_level": null,
"aa_start": 578,
"aa_end": null,
"aa_length": 648,
"cds_start": 1734,
"cds_end": null,
"cds_length": 1947,
"cdna_start": 2082,
"cdna_end": null,
"cdna_length": 8560,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "Q",
"aa_alt": "Q",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 17,
"exon_rank_end": null,
"exon_count": 18,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "NR2C2",
"gene_hgnc_id": 7972,
"hgvs_c": "c.1734G>A",
"hgvs_p": "p.Gln578Gln",
"transcript": "XM_047448824.1",
"protein_id": "XP_047304780.1",
"transcript_support_level": null,
"aa_start": 578,
"aa_end": null,
"aa_length": 648,
"cds_start": 1734,
"cds_end": null,
"cds_length": 1947,
"cdna_start": 2000,
"cdna_end": null,
"cdna_length": 8478,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "Q",
"aa_alt": "Q",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 17,
"exon_rank_end": null,
"exon_count": 18,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "NR2C2",
"gene_hgnc_id": 7972,
"hgvs_c": "c.1734G>A",
"hgvs_p": "p.Gln578Gln",
"transcript": "XM_047448825.1",
"protein_id": "XP_047304781.1",
"transcript_support_level": null,
"aa_start": 578,
"aa_end": null,
"aa_length": 648,
"cds_start": 1734,
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"cdna_start": 2325,
"cdna_end": null,
"cdna_length": 8803,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "Q",
"aa_alt": "Q",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 16,
"exon_rank_end": null,
"exon_count": 17,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "NR2C2",
"gene_hgnc_id": 7972,
"hgvs_c": "c.1734G>A",
"hgvs_p": "p.Gln578Gln",
"transcript": "XM_047448826.1",
"protein_id": "XP_047304782.1",
"transcript_support_level": null,
"aa_start": 578,
"aa_end": null,
"aa_length": 648,
"cds_start": 1734,
"cds_end": null,
"cds_length": 1947,
"cdna_start": 2567,
"cdna_end": null,
"cdna_length": 9045,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "Q",
"aa_alt": "Q",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 17,
"exon_rank_end": null,
"exon_count": 18,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "NR2C2",
"gene_hgnc_id": 7972,
"hgvs_c": "c.1734G>A",
"hgvs_p": "p.Gln578Gln",
"transcript": "XM_047448827.1",
"protein_id": "XP_047304783.1",
"transcript_support_level": null,
"aa_start": 578,
"aa_end": null,
"aa_length": 648,
"cds_start": 1734,
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"cdna_start": 2125,
"cdna_end": null,
"cdna_length": 8603,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "Q",
"aa_alt": "Q",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 15,
"exon_rank_end": null,
"exon_count": 16,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "NR2C2",
"gene_hgnc_id": 7972,
"hgvs_c": "c.1734G>A",
"hgvs_p": "p.Gln578Gln",
"transcript": "XM_047448828.1",
"protein_id": "XP_047304784.1",
"transcript_support_level": null,
"aa_start": 578,
"aa_end": null,
"aa_length": 648,
"cds_start": 1734,
"cds_end": null,
"cds_length": 1947,
"cdna_start": 2851,
"cdna_end": null,
"cdna_length": 9329,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "Q",
"aa_alt": "Q",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 17,
"exon_rank_end": null,
"exon_count": 18,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "NR2C2",
"gene_hgnc_id": 7972,
"hgvs_c": "c.1734G>A",
"hgvs_p": "p.Gln578Gln",
"transcript": "XM_047448829.1",
"protein_id": "XP_047304785.1",
"transcript_support_level": null,
"aa_start": 578,
"aa_end": null,
"aa_length": 630,
"cds_start": 1734,
"cds_end": null,
"cds_length": 1893,
"cdna_start": 2228,
"cdna_end": null,
"cdna_length": 11334,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "Q",
"aa_alt": "Q",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 16,
"exon_rank_end": null,
"exon_count": 17,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "NR2C2",
"gene_hgnc_id": 7972,
"hgvs_c": "c.1677G>A",
"hgvs_p": "p.Gln559Gln",
"transcript": "XM_011534063.4",
"protein_id": "XP_011532365.1",
"transcript_support_level": null,
"aa_start": 559,
"aa_end": null,
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"cds_start": 1677,
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"cdna_start": 2171,
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"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "Q",
"aa_alt": "Q",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 16,
"exon_rank_end": null,
"exon_count": 17,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "NR2C2",
"gene_hgnc_id": 7972,
"hgvs_c": "c.1677G>A",
"hgvs_p": "p.Gln559Gln",
"transcript": "XM_047448830.1",
"protein_id": "XP_047304786.1",
"transcript_support_level": null,
"aa_start": 559,
"aa_end": null,
"aa_length": 629,
"cds_start": 1677,
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"cdna_start": 2268,
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"cdna_length": 8746,
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"biotype": null,
"feature": null
},
{
"aa_ref": "Q",
"aa_alt": "Q",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 16,
"exon_rank_end": null,
"exon_count": 17,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "NR2C2",
"gene_hgnc_id": 7972,
"hgvs_c": "c.1677G>A",
"hgvs_p": "p.Gln559Gln",
"transcript": "XM_047448831.1",
"protein_id": "XP_047304787.1",
"transcript_support_level": null,
"aa_start": 559,
"aa_end": null,
"aa_length": 629,
"cds_start": 1677,
"cds_end": null,
"cds_length": 1890,
"cdna_start": 2940,
"cdna_end": null,
"cdna_length": 9418,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "Q",
"aa_alt": "Q",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 14,
"exon_rank_end": null,
"exon_count": 15,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "NR2C2",
"gene_hgnc_id": 7972,
"hgvs_c": "c.1677G>A",
"hgvs_p": "p.Gln559Gln",
"transcript": "XM_047448832.1",
"protein_id": "XP_047304788.1",
"transcript_support_level": null,
"aa_start": 559,
"aa_end": null,
"aa_length": 629,
"cds_start": 1677,
"cds_end": null,
"cds_length": 1890,
"cdna_start": 2025,
"cdna_end": null,
"cdna_length": 8503,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "Q",
"aa_alt": "Q",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 14,
"exon_rank_end": null,
"exon_count": 15,
"intron_rank": null,
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