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GeneBe API Showcase
This page demonstrates how to use the GeneBe API to query variant information. The API provides programmatic access to genomic annotations and variant data.
API presented here should be used for checking single variants. If you want to check many variants at once, please use other API endpoints that you will find in the documentation.
Documentation & Advanced Usage
• Complete API documentation:docs.genebe.net/docs/api/overview/
• Interactive endpoint tester:api.genebe.net/cloud/gb-api-doc/swagger-ui/
• Python client for pandas:pypi.org/project/genebe/
• Java CLI for VCF files:github.com/pstawinski/genebe-cli
• All tools documented at:docs.genebe.net
API Request Examples for Variant: 3-155160412-G-A (hg38)
Bash / cURL Example
bash
curl "https://api.genebe.net/cloud/api-public/v1/variant?chr=3&pos=155160412&ref=G&alt=A&genome=hg38&allGenes=true"API Response
json
{
"variants": [
{
"chr": "3",
"pos": 155160412,
"ref": "G",
"alt": "A",
"effect": "missense_variant",
"transcript": "NM_000902.5",
"consequences": [
{
"aa_ref": "V",
"aa_alt": "I",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 17,
"exon_rank_end": null,
"exon_count": 23,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "MME",
"gene_hgnc_id": 7154,
"hgvs_c": "c.1624G>A",
"hgvs_p": "p.Val542Ile",
"transcript": "NM_007289.4",
"protein_id": "NP_009220.2",
"transcript_support_level": null,
"aa_start": 542,
"aa_end": null,
"aa_length": 750,
"cds_start": 1624,
"cds_end": null,
"cds_length": 2253,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": "ENST00000360490.7",
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_007289.4"
},
{
"aa_ref": "V",
"aa_alt": "I",
"canonical": true,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 17,
"exon_rank_end": null,
"exon_count": 23,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "MME",
"gene_hgnc_id": 7154,
"hgvs_c": "c.1624G>A",
"hgvs_p": "p.Val542Ile",
"transcript": "ENST00000360490.7",
"protein_id": "ENSP00000353679.2",
"transcript_support_level": 1,
"aa_start": 542,
"aa_end": null,
"aa_length": 750,
"cds_start": 1624,
"cds_end": null,
"cds_length": 2253,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": "NM_007289.4",
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000360490.7"
},
{
"aa_ref": "V",
"aa_alt": "I",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 18,
"exon_rank_end": null,
"exon_count": 24,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "MME",
"gene_hgnc_id": 7154,
"hgvs_c": "c.1714G>A",
"hgvs_p": "p.Val572Ile",
"transcript": "ENST00000615825.2",
"protein_id": "ENSP00000478173.2",
"transcript_support_level": 1,
"aa_start": 572,
"aa_end": null,
"aa_length": 780,
"cds_start": 1714,
"cds_end": null,
"cds_length": 2343,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000615825.2"
},
{
"aa_ref": "V",
"aa_alt": "I",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 17,
"exon_rank_end": null,
"exon_count": 23,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "MME",
"gene_hgnc_id": 7154,
"hgvs_c": "c.1624G>A",
"hgvs_p": "p.Val542Ile",
"transcript": "ENST00000460393.6",
"protein_id": "ENSP00000418525.1",
"transcript_support_level": 1,
"aa_start": 542,
"aa_end": null,
"aa_length": 750,
"cds_start": 1624,
"cds_end": null,
"cds_length": 2253,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000460393.6"
},
{
"aa_ref": "V",
"aa_alt": "I",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 17,
"exon_rank_end": null,
"exon_count": 23,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "MME",
"gene_hgnc_id": 7154,
"hgvs_c": "c.1624G>A",
"hgvs_p": "p.Val542Ile",
"transcript": "ENST00000493237.5",
"protein_id": "ENSP00000417079.1",
"transcript_support_level": 1,
"aa_start": 542,
"aa_end": null,
"aa_length": 750,
"cds_start": 1624,
"cds_end": null,
"cds_length": 2253,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000493237.5"
},
{
"aa_ref": "V",
"aa_alt": "I",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 18,
"exon_rank_end": null,
"exon_count": 24,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "MME",
"gene_hgnc_id": 7154,
"hgvs_c": "c.1714G>A",
"hgvs_p": "p.Val572Ile",
"transcript": "ENST00000871485.1",
"protein_id": "ENSP00000541544.1",
"transcript_support_level": null,
"aa_start": 572,
"aa_end": null,
"aa_length": 780,
"cds_start": 1714,
"cds_end": null,
"cds_length": 2343,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000871485.1"
},
{
"aa_ref": "V",
"aa_alt": "I",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 18,
"exon_rank_end": null,
"exon_count": 24,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "MME",
"gene_hgnc_id": 7154,
"hgvs_c": "c.1714G>A",
"hgvs_p": "p.Val572Ile",
"transcript": "ENST00000915243.1",
"protein_id": "ENSP00000585302.1",
"transcript_support_level": null,
"aa_start": 572,
"aa_end": null,
"aa_length": 780,
"cds_start": 1714,
"cds_end": null,
"cds_length": 2343,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000915243.1"
},
{
"aa_ref": "V",
"aa_alt": "I",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 17,
"exon_rank_end": null,
"exon_count": 23,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "MME",
"gene_hgnc_id": 7154,
"hgvs_c": "c.1624G>A",
"hgvs_p": "p.Val542Ile",
"transcript": "NM_000902.5",
"protein_id": "NP_000893.2",
"transcript_support_level": null,
"aa_start": 542,
"aa_end": null,
"aa_length": 750,
"cds_start": 1624,
"cds_end": null,
"cds_length": 2253,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_000902.5"
},
{
"aa_ref": "V",
"aa_alt": "I",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 17,
"exon_rank_end": null,
"exon_count": 23,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "MME",
"gene_hgnc_id": 7154,
"hgvs_c": "c.1624G>A",
"hgvs_p": "p.Val542Ile",
"transcript": "NM_001354642.2",
"protein_id": "NP_001341571.1",
"transcript_support_level": null,
"aa_start": 542,
"aa_end": null,
"aa_length": 750,
"cds_start": 1624,
"cds_end": null,
"cds_length": 2253,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001354642.2"
},
{
"aa_ref": "V",
"aa_alt": "I",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 17,
"exon_rank_end": null,
"exon_count": 23,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "MME",
"gene_hgnc_id": 7154,
"hgvs_c": "c.1624G>A",
"hgvs_p": "p.Val542Ile",
"transcript": "NM_001354643.1",
"protein_id": "NP_001341572.1",
"transcript_support_level": null,
"aa_start": 542,
"aa_end": null,
"aa_length": 750,
"cds_start": 1624,
"cds_end": null,
"cds_length": 2253,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001354643.1"
},
{
"aa_ref": "V",
"aa_alt": "I",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 17,
"exon_rank_end": null,
"exon_count": 23,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "MME",
"gene_hgnc_id": 7154,
"hgvs_c": "c.1624G>A",
"hgvs_p": "p.Val542Ile",
"transcript": "NM_007287.4",
"protein_id": "NP_009218.2",
"transcript_support_level": null,
"aa_start": 542,
"aa_end": null,
"aa_length": 750,
"cds_start": 1624,
"cds_end": null,
"cds_length": 2253,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_007287.4"
},
{
"aa_ref": "V",
"aa_alt": "I",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 17,
"exon_rank_end": null,
"exon_count": 23,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "MME",
"gene_hgnc_id": 7154,
"hgvs_c": "c.1624G>A",
"hgvs_p": "p.Val542Ile",
"transcript": "NM_007288.3",
"protein_id": "NP_009219.2",
"transcript_support_level": null,
"aa_start": 542,
"aa_end": null,
"aa_length": 750,
"cds_start": 1624,
"cds_end": null,
"cds_length": 2253,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_007288.3"
},
{
"aa_ref": "V",
"aa_alt": "I",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 17,
"exon_rank_end": null,
"exon_count": 23,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "MME",
"gene_hgnc_id": 7154,
"hgvs_c": "c.1624G>A",
"hgvs_p": "p.Val542Ile",
"transcript": "ENST00000462745.5",
"protein_id": "ENSP00000419653.1",
"transcript_support_level": 5,
"aa_start": 542,
"aa_end": null,
"aa_length": 750,
"cds_start": 1624,
"cds_end": null,
"cds_length": 2253,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000462745.5"
},
{
"aa_ref": "V",
"aa_alt": "I",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 17,
"exon_rank_end": null,
"exon_count": 23,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "MME",
"gene_hgnc_id": 7154,
"hgvs_c": "c.1624G>A",
"hgvs_p": "p.Val542Ile",
"transcript": "ENST00000473730.6",
"protein_id": "ENSP00000420542.2",
"transcript_support_level": 3,
"aa_start": 542,
"aa_end": null,
"aa_length": 750,
"cds_start": 1624,
"cds_end": null,
"cds_length": 2253,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000473730.6"
},
{
"aa_ref": "V",
"aa_alt": "I",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 17,
"exon_rank_end": null,
"exon_count": 23,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "MME",
"gene_hgnc_id": 7154,
"hgvs_c": "c.1624G>A",
"hgvs_p": "p.Val542Ile",
"transcript": "ENST00000491026.6",
"protein_id": "ENSP00000418791.2",
"transcript_support_level": 4,
"aa_start": 542,
"aa_end": null,
"aa_length": 750,
"cds_start": 1624,
"cds_end": null,
"cds_length": 2253,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000491026.6"
},
{
"aa_ref": "V",
"aa_alt": "I",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 17,
"exon_rank_end": null,
"exon_count": 23,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "MME",
"gene_hgnc_id": 7154,
"hgvs_c": "c.1624G>A",
"hgvs_p": "p.Val542Ile",
"transcript": "ENST00000492661.5",
"protein_id": "ENSP00000420389.1",
"transcript_support_level": 2,
"aa_start": 542,
"aa_end": null,
"aa_length": 750,
"cds_start": 1624,
"cds_end": null,
"cds_length": 2253,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000492661.5"
},
{
"aa_ref": "V",
"aa_alt": "I",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 17,
"exon_rank_end": null,
"exon_count": 23,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "MME",
"gene_hgnc_id": 7154,
"hgvs_c": "c.1624G>A",
"hgvs_p": "p.Val542Ile",
"transcript": "ENST00000675418.2",
"protein_id": "ENSP00000502021.2",
"transcript_support_level": null,
"aa_start": 542,
"aa_end": null,
"aa_length": 750,
"cds_start": 1624,
"cds_end": null,
"cds_length": 2253,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000675418.2"
},
{
"aa_ref": "V",
"aa_alt": "I",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 17,
"exon_rank_end": null,
"exon_count": 23,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "MME",
"gene_hgnc_id": 7154,
"hgvs_c": "c.1624G>A",
"hgvs_p": "p.Val542Ile",
"transcript": "ENST00000680057.1",
"protein_id": "ENSP00000505211.1",
"transcript_support_level": null,
"aa_start": 542,
"aa_end": null,
"aa_length": 750,
"cds_start": 1624,
"cds_end": null,
"cds_length": 2253,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000680057.1"
},
{
"aa_ref": "V",
"aa_alt": "I",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 17,
"exon_rank_end": null,
"exon_count": 23,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "MME",
"gene_hgnc_id": 7154,
"hgvs_c": "c.1624G>A",
"hgvs_p": "p.Val542Ile",
"transcript": "ENST00000680282.1",
"protein_id": "ENSP00000505690.1",
"transcript_support_level": null,
"aa_start": 542,
"aa_end": null,
"aa_length": 750,
"cds_start": 1624,
"cds_end": null,
"cds_length": 2253,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000680282.1"
},
{
"aa_ref": "V",
"aa_alt": "I",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 17,
"exon_rank_end": null,
"exon_count": 23,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "MME",
"gene_hgnc_id": 7154,
"hgvs_c": "c.1624G>A",
"hgvs_p": "p.Val542Ile",
"transcript": "ENST00000871479.1",
"protein_id": "ENSP00000541538.1",
"transcript_support_level": null,
"aa_start": 542,
"aa_end": null,
"aa_length": 750,
"cds_start": 1624,
"cds_end": null,
"cds_length": 2253,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000871479.1"
},
{
"aa_ref": "V",
"aa_alt": "I",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 17,
"exon_rank_end": null,
"exon_count": 23,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "MME",
"gene_hgnc_id": 7154,
"hgvs_c": "c.1624G>A",
"hgvs_p": "p.Val542Ile",
"transcript": "ENST00000871481.1",
"protein_id": "ENSP00000541540.1",
"transcript_support_level": null,
"aa_start": 542,
"aa_end": null,
"aa_length": 750,
"cds_start": 1624,
"cds_end": null,
"cds_length": 2253,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000871481.1"
},
{
"aa_ref": "V",
"aa_alt": "I",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 17,
"exon_rank_end": null,
"exon_count": 23,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "MME",
"gene_hgnc_id": 7154,
"hgvs_c": "c.1624G>A",
"hgvs_p": "p.Val542Ile",
"transcript": "ENST00000871482.1",
"protein_id": "ENSP00000541541.1",
"transcript_support_level": null,
"aa_start": 542,
"aa_end": null,
"aa_length": 750,
"cds_start": 1624,
"cds_end": null,
"cds_length": 2253,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
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