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GeneBe API Showcase

This page demonstrates how to use the GeneBe API to query variant information. The API provides programmatic access to genomic annotations and variant data.

API presented here should be used for checking single variants. If you want to check many variants at once, please use other API endpoints that you will find in the documentation.

Documentation & Advanced Usage

Complete API documentation:docs.genebe.net/docs/api/overview/

Interactive endpoint tester:api.genebe.net/cloud/gb-api-doc/swagger-ui/

Python client for pandas:pypi.org/project/genebe/

Java CLI for VCF files:github.com/pstawinski/genebe-cli

All tools documented at:docs.genebe.net

API Request Examples for Variant: 3-183807041-C-A (hg38)

Bash / cURL Example

bash
curl "https://api.genebe.net/cloud/api-public/v1/variant?chr=3&pos=183807041&ref=C&alt=A&genome=hg38&allGenes=true"

API Response

json
{
  "variants": [
    {
      "chr": "3",
      "pos": 183807041,
      "ref": "C",
      "alt": "A",
      "effect": "missense_variant",
      "transcript": "NM_001351370.2",
      "consequences": [
        {
          "aa_ref": "F",
          "aa_alt": "L",
          "canonical": false,
          "protein_coding": true,
          "strand": true,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 28,
          "exon_rank_end": null,
          "exon_count": 31,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "YEATS2",
          "gene_hgnc_id": 25489,
          "hgvs_c": "c.3960C>A",
          "hgvs_p": "p.Phe1320Leu",
          "transcript": "NM_018023.5",
          "protein_id": "NP_060493.3",
          "transcript_support_level": null,
          "aa_start": 1320,
          "aa_end": null,
          "aa_length": 1422,
          "cds_start": 3960,
          "cds_end": null,
          "cds_length": 4269,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": "ENST00000305135.10",
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "NM_018023.5"
        },
        {
          "aa_ref": "F",
          "aa_alt": "L",
          "canonical": true,
          "protein_coding": true,
          "strand": true,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 28,
          "exon_rank_end": null,
          "exon_count": 31,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "YEATS2",
          "gene_hgnc_id": 25489,
          "hgvs_c": "c.3960C>A",
          "hgvs_p": "p.Phe1320Leu",
          "transcript": "ENST00000305135.10",
          "protein_id": "ENSP00000306983.5",
          "transcript_support_level": 1,
          "aa_start": 1320,
          "aa_end": null,
          "aa_length": 1422,
          "cds_start": 3960,
          "cds_end": null,
          "cds_length": 4269,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": "NM_018023.5",
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000305135.10"
        },
        {
          "aa_ref": "F",
          "aa_alt": "L",
          "canonical": false,
          "protein_coding": true,
          "strand": true,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 28,
          "exon_rank_end": null,
          "exon_count": 31,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "YEATS2",
          "gene_hgnc_id": 25489,
          "hgvs_c": "c.3963C>A",
          "hgvs_p": "p.Phe1321Leu",
          "transcript": "NM_001351370.2",
          "protein_id": "NP_001338299.1",
          "transcript_support_level": null,
          "aa_start": 1321,
          "aa_end": null,
          "aa_length": 1423,
          "cds_start": 3963,
          "cds_end": null,
          "cds_length": 4272,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "NM_001351370.2"
        },
        {
          "aa_ref": "F",
          "aa_alt": "L",
          "canonical": false,
          "protein_coding": true,
          "strand": true,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 28,
          "exon_rank_end": null,
          "exon_count": 31,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "YEATS2",
          "gene_hgnc_id": 25489,
          "hgvs_c": "c.3963C>A",
          "hgvs_p": "p.Phe1321Leu",
          "transcript": "ENST00000884732.1",
          "protein_id": "ENSP00000554791.1",
          "transcript_support_level": null,
          "aa_start": 1321,
          "aa_end": null,
          "aa_length": 1423,
          "cds_start": 3963,
          "cds_end": null,
          "cds_length": 4272,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000884732.1"
        },
        {
          "aa_ref": "F",
          "aa_alt": "L",
          "canonical": false,
          "protein_coding": true,
          "strand": true,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 29,
          "exon_rank_end": null,
          "exon_count": 32,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "YEATS2",
          "gene_hgnc_id": 25489,
          "hgvs_c": "c.3963C>A",
          "hgvs_p": "p.Phe1321Leu",
          "transcript": "ENST00000884736.1",
          "protein_id": "ENSP00000554795.1",
          "transcript_support_level": null,
          "aa_start": 1321,
          "aa_end": null,
          "aa_length": 1423,
          "cds_start": 3963,
          "cds_end": null,
          "cds_length": 4272,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000884736.1"
        },
        {
          "aa_ref": "F",
          "aa_alt": "L",
          "canonical": false,
          "protein_coding": true,
          "strand": true,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 28,
          "exon_rank_end": null,
          "exon_count": 31,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "YEATS2",
          "gene_hgnc_id": 25489,
          "hgvs_c": "c.3963C>A",
          "hgvs_p": "p.Phe1321Leu",
          "transcript": "ENST00000927066.1",
          "protein_id": "ENSP00000597125.1",
          "transcript_support_level": null,
          "aa_start": 1321,
          "aa_end": null,
          "aa_length": 1423,
          "cds_start": 3963,
          "cds_end": null,
          "cds_length": 4272,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000927066.1"
        },
        {
          "aa_ref": "F",
          "aa_alt": "L",
          "canonical": false,
          "protein_coding": true,
          "strand": true,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 28,
          "exon_rank_end": null,
          "exon_count": 31,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "YEATS2",
          "gene_hgnc_id": 25489,
          "hgvs_c": "c.3960C>A",
          "hgvs_p": "p.Phe1320Leu",
          "transcript": "NM_001351369.2",
          "protein_id": "NP_001338298.1",
          "transcript_support_level": null,
          "aa_start": 1320,
          "aa_end": null,
          "aa_length": 1422,
          "cds_start": 3960,
          "cds_end": null,
          "cds_length": 4269,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "NM_001351369.2"
        },
        {
          "aa_ref": "F",
          "aa_alt": "L",
          "canonical": false,
          "protein_coding": true,
          "strand": true,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 29,
          "exon_rank_end": null,
          "exon_count": 32,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "YEATS2",
          "gene_hgnc_id": 25489,
          "hgvs_c": "c.3960C>A",
          "hgvs_p": "p.Phe1320Leu",
          "transcript": "ENST00000884734.1",
          "protein_id": "ENSP00000554793.1",
          "transcript_support_level": null,
          "aa_start": 1320,
          "aa_end": null,
          "aa_length": 1422,
          "cds_start": 3960,
          "cds_end": null,
          "cds_length": 4269,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000884734.1"
        },
        {
          "aa_ref": "F",
          "aa_alt": "L",
          "canonical": false,
          "protein_coding": true,
          "strand": true,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 28,
          "exon_rank_end": null,
          "exon_count": 31,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "YEATS2",
          "gene_hgnc_id": 25489,
          "hgvs_c": "c.3960C>A",
          "hgvs_p": "p.Phe1320Leu",
          "transcript": "ENST00000884737.1",
          "protein_id": "ENSP00000554796.1",
          "transcript_support_level": null,
          "aa_start": 1320,
          "aa_end": null,
          "aa_length": 1422,
          "cds_start": 3960,
          "cds_end": null,
          "cds_length": 4269,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000884737.1"
        },
        {
          "aa_ref": "F",
          "aa_alt": "L",
          "canonical": false,
          "protein_coding": true,
          "strand": true,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 29,
          "exon_rank_end": null,
          "exon_count": 32,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "YEATS2",
          "gene_hgnc_id": 25489,
          "hgvs_c": "c.3960C>A",
          "hgvs_p": "p.Phe1320Leu",
          "transcript": "ENST00000927064.1",
          "protein_id": "ENSP00000597123.1",
          "transcript_support_level": null,
          "aa_start": 1320,
          "aa_end": null,
          "aa_length": 1422,
          "cds_start": 3960,
          "cds_end": null,
          "cds_length": 4269,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000927064.1"
        },
        {
          "aa_ref": "F",
          "aa_alt": "L",
          "canonical": false,
          "protein_coding": true,
          "strand": true,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 28,
          "exon_rank_end": null,
          "exon_count": 31,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "YEATS2",
          "gene_hgnc_id": 25489,
          "hgvs_c": "c.3960C>A",
          "hgvs_p": "p.Phe1320Leu",
          "transcript": "ENST00000927067.1",
          "protein_id": "ENSP00000597126.1",
          "transcript_support_level": null,
          "aa_start": 1320,
          "aa_end": null,
          "aa_length": 1422,
          "cds_start": 3960,
          "cds_end": null,
          "cds_length": 4269,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000927067.1"
        },
        {
          "aa_ref": "F",
          "aa_alt": "L",
          "canonical": false,
          "protein_coding": true,
          "strand": true,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 28,
          "exon_rank_end": null,
          "exon_count": 31,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "YEATS2",
          "gene_hgnc_id": 25489,
          "hgvs_c": "c.3957C>A",
          "hgvs_p": "p.Phe1319Leu",
          "transcript": "ENST00000927062.1",
          "protein_id": "ENSP00000597121.1",
          "transcript_support_level": null,
          "aa_start": 1319,
          "aa_end": null,
          "aa_length": 1421,
          "cds_start": 3957,
          "cds_end": null,
          "cds_length": 4266,
          "cdna_start": null,
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          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000927062.1"
        },
        {
          "aa_ref": "F",
          "aa_alt": "L",
          "canonical": false,
          "protein_coding": true,
          "strand": true,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 27,
          "exon_rank_end": null,
          "exon_count": 30,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "YEATS2",
          "gene_hgnc_id": 25489,
          "hgvs_c": "c.3801C>A",
          "hgvs_p": "p.Phe1267Leu",
          "transcript": "ENST00000927063.1",
          "protein_id": "ENSP00000597122.1",
          "transcript_support_level": null,
          "aa_start": 1267,
          "aa_end": null,
          "aa_length": 1369,
          "cds_start": 3801,
          "cds_end": null,
          "cds_length": 4110,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000927063.1"
        },
        {
          "aa_ref": "F",
          "aa_alt": "L",
          "canonical": false,
          "protein_coding": true,
          "strand": true,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 27,
          "exon_rank_end": null,
          "exon_count": 30,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "YEATS2",
          "gene_hgnc_id": 25489,
          "hgvs_c": "c.3801C>A",
          "hgvs_p": "p.Phe1267Leu",
          "transcript": "ENST00000927065.1",
          "protein_id": "ENSP00000597124.1",
          "transcript_support_level": null,
          "aa_start": 1267,
          "aa_end": null,
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          "cds_start": 3801,
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          "biotype": "protein_coding",
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        },
        {
          "aa_ref": "F",
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          "canonical": false,
          "protein_coding": true,
          "strand": true,
          "consequences": [
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          ],
          "exon_rank": 28,
          "exon_rank_end": null,
          "exon_count": 31,
          "intron_rank": null,
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          "gene_symbol": "YEATS2",
          "gene_hgnc_id": 25489,
          "hgvs_c": "c.3798C>A",
          "hgvs_p": "p.Phe1266Leu",
          "transcript": "ENST00000884733.1",
          "protein_id": "ENSP00000554792.1",
          "transcript_support_level": null,
          "aa_start": 1266,
          "aa_end": null,
          "aa_length": 1368,
          "cds_start": 3798,
          "cds_end": null,
          "cds_length": 4107,
          "cdna_start": null,
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          "cdna_length": null,
          "mane_select": null,
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          "biotype": "protein_coding",
          "feature": "ENST00000884733.1"
        },
        {
          "aa_ref": "F",
          "aa_alt": "L",
          "canonical": false,
          "protein_coding": true,
          "strand": true,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 27,
          "exon_rank_end": null,
          "exon_count": 30,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "YEATS2",
          "gene_hgnc_id": 25489,
          "hgvs_c": "c.3798C>A",
          "hgvs_p": "p.Phe1266Leu",
          "transcript": "ENST00000927061.1",
          "protein_id": "ENSP00000597120.1",
          "transcript_support_level": null,
          "aa_start": 1266,
          "aa_end": null,
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          "cds_start": 3798,
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          "cds_length": 4107,
          "cdna_start": null,
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          "cdna_length": null,
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          "biotype": "protein_coding",
          "feature": "ENST00000927061.1"
        },
        {
          "aa_ref": "F",
          "aa_alt": "L",
          "canonical": false,
          "protein_coding": true,
          "strand": true,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 26,
          "exon_rank_end": null,
          "exon_count": 29,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "YEATS2",
          "gene_hgnc_id": 25489,
          "hgvs_c": "c.3669C>A",
          "hgvs_p": "p.Phe1223Leu",
          "transcript": "ENST00000927068.1",
          "protein_id": "ENSP00000597127.1",
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          "biotype": "protein_coding",
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        },
        {
          "aa_ref": "F",
          "aa_alt": "L",
          "canonical": false,
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          ],
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          "exon_rank_end": null,
          "exon_count": 29,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "YEATS2",
          "gene_hgnc_id": 25489,
          "hgvs_c": "c.3669C>A",
          "hgvs_p": "p.Phe1223Leu",
          "transcript": "ENST00000941369.1",
          "protein_id": "ENSP00000611428.1",
          "transcript_support_level": null,
          "aa_start": 1223,
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          "aa_length": 1325,
          "cds_start": 3669,
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          "cds_length": 3978,
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          "biotype": "protein_coding",
          "feature": "ENST00000941369.1"
        },
        {
          "aa_ref": "F",
          "aa_alt": "L",
          "canonical": false,
          "protein_coding": true,
          "strand": true,
          "consequences": [
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          ],
          "exon_rank": 25,
          "exon_rank_end": null,
          "exon_count": 28,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "YEATS2",
          "gene_hgnc_id": 25489,
          "hgvs_c": "c.3507C>A",
          "hgvs_p": "p.Phe1169Leu",
          "transcript": "ENST00000884735.1",
          "protein_id": "ENSP00000554794.1",
          "transcript_support_level": null,
          "aa_start": 1169,
          "aa_end": null,
          "aa_length": 1271,
          "cds_start": 3507,
          "cds_end": null,
          "cds_length": 3816,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000884735.1"
        },
        {
          "aa_ref": "F",
          "aa_alt": "L",
          "canonical": false,
          "protein_coding": true,
          "strand": true,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 13,
          "exon_rank_end": null,
          "exon_count": 16,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "YEATS2",
          "gene_hgnc_id": 25489,
          "hgvs_c": "c.1692C>A",
          "hgvs_p": "p.Phe564Leu",
          "transcript": "ENST00000884738.1",
          "protein_id": "ENSP00000554797.1",
          "transcript_support_level": null,
          "aa_start": 564,
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      "clinvar_review_status": "",
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      "custom_annotations": null
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}