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GeneBe API Showcase
This page demonstrates how to use the GeneBe API to query variant information. The API provides programmatic access to genomic annotations and variant data.
API presented here should be used for checking single variants. If you want to check many variants at once, please use other API endpoints that you will find in the documentation.
Documentation & Advanced Usage
• Complete API documentation:docs.genebe.net/docs/api/overview/
• Interactive endpoint tester:api.genebe.net/cloud/gb-api-doc/swagger-ui/
• Python client for pandas:pypi.org/project/genebe/
• Java CLI for VCF files:github.com/pstawinski/genebe-cli
• All tools documented at:docs.genebe.net
API Request Examples for Variant: 3-185609340-A-C (hg38)
Bash / cURL Example
bash
curl "https://api.genebe.net/cloud/api-public/v1/variant?chr=3&pos=185609340&ref=A&alt=C&genome=hg38&allGenes=true"API Response
json
{
"variants": [
{
"chr": "3",
"pos": 185609340,
"ref": "A",
"alt": "C",
"effect": "missense_variant",
"transcript": "NM_021627.3",
"consequences": [
{
"aa_ref": "N",
"aa_alt": "H",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 7,
"exon_rank_end": null,
"exon_count": 17,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "SENP2",
"gene_hgnc_id": 23116,
"hgvs_c": "c.712A>C",
"hgvs_p": "p.Asn238His",
"transcript": "NM_021627.3",
"protein_id": "NP_067640.2",
"transcript_support_level": null,
"aa_start": 238,
"aa_end": null,
"aa_length": 589,
"cds_start": 712,
"cds_end": null,
"cds_length": 1770,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": "ENST00000296257.10",
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_021627.3"
},
{
"aa_ref": "N",
"aa_alt": "H",
"canonical": true,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 7,
"exon_rank_end": null,
"exon_count": 17,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "SENP2",
"gene_hgnc_id": 23116,
"hgvs_c": "c.712A>C",
"hgvs_p": "p.Asn238His",
"transcript": "ENST00000296257.10",
"protein_id": "ENSP00000296257.5",
"transcript_support_level": 1,
"aa_start": 238,
"aa_end": null,
"aa_length": 589,
"cds_start": 712,
"cds_end": null,
"cds_length": 1770,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": "NM_021627.3",
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000296257.10"
},
{
"aa_ref": "N",
"aa_alt": "H",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 7,
"exon_rank_end": null,
"exon_count": 17,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "SENP2",
"gene_hgnc_id": 23116,
"hgvs_c": "c.712A>C",
"hgvs_p": "p.Asn238His",
"transcript": "ENST00000953470.1",
"protein_id": "ENSP00000623529.1",
"transcript_support_level": null,
"aa_start": 238,
"aa_end": null,
"aa_length": 588,
"cds_start": 712,
"cds_end": null,
"cds_length": 1767,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000953470.1"
},
{
"aa_ref": "N",
"aa_alt": "H",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 7,
"exon_rank_end": null,
"exon_count": 17,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "SENP2",
"gene_hgnc_id": 23116,
"hgvs_c": "c.712A>C",
"hgvs_p": "p.Asn238His",
"transcript": "ENST00000953471.1",
"protein_id": "ENSP00000623530.1",
"transcript_support_level": null,
"aa_start": 238,
"aa_end": null,
"aa_length": 587,
"cds_start": 712,
"cds_end": null,
"cds_length": 1764,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000953471.1"
},
{
"aa_ref": "N",
"aa_alt": "H",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 7,
"exon_rank_end": null,
"exon_count": 17,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "SENP2",
"gene_hgnc_id": 23116,
"hgvs_c": "c.712A>C",
"hgvs_p": "p.Asn238His",
"transcript": "ENST00000889617.1",
"protein_id": "ENSP00000559676.1",
"transcript_support_level": null,
"aa_start": 238,
"aa_end": null,
"aa_length": 586,
"cds_start": 712,
"cds_end": null,
"cds_length": 1761,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000889617.1"
},
{
"aa_ref": "N",
"aa_alt": "H",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 7,
"exon_rank_end": null,
"exon_count": 17,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "SENP2",
"gene_hgnc_id": 23116,
"hgvs_c": "c.712A>C",
"hgvs_p": "p.Asn238His",
"transcript": "ENST00000889616.1",
"protein_id": "ENSP00000559675.1",
"transcript_support_level": null,
"aa_start": 238,
"aa_end": null,
"aa_length": 583,
"cds_start": 712,
"cds_end": null,
"cds_length": 1752,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000889616.1"
},
{
"aa_ref": "N",
"aa_alt": "H",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 7,
"exon_rank_end": null,
"exon_count": 17,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "SENP2",
"gene_hgnc_id": 23116,
"hgvs_c": "c.694A>C",
"hgvs_p": "p.Asn232His",
"transcript": "ENST00000889624.1",
"protein_id": "ENSP00000559683.1",
"transcript_support_level": null,
"aa_start": 232,
"aa_end": null,
"aa_length": 583,
"cds_start": 694,
"cds_end": null,
"cds_length": 1752,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000889624.1"
},
{
"aa_ref": "N",
"aa_alt": "H",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 7,
"exon_rank_end": null,
"exon_count": 17,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "SENP2",
"gene_hgnc_id": 23116,
"hgvs_c": "c.712A>C",
"hgvs_p": "p.Asn238His",
"transcript": "ENST00000889619.1",
"protein_id": "ENSP00000559678.1",
"transcript_support_level": null,
"aa_start": 238,
"aa_end": null,
"aa_length": 580,
"cds_start": 712,
"cds_end": null,
"cds_length": 1743,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000889619.1"
},
{
"aa_ref": "N",
"aa_alt": "H",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 7,
"exon_rank_end": null,
"exon_count": 17,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "SENP2",
"gene_hgnc_id": 23116,
"hgvs_c": "c.664A>C",
"hgvs_p": "p.Asn222His",
"transcript": "ENST00000889612.1",
"protein_id": "ENSP00000559671.1",
"transcript_support_level": null,
"aa_start": 222,
"aa_end": null,
"aa_length": 573,
"cds_start": 664,
"cds_end": null,
"cds_length": 1722,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000889612.1"
},
{
"aa_ref": "N",
"aa_alt": "H",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 7,
"exon_rank_end": null,
"exon_count": 17,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "SENP2",
"gene_hgnc_id": 23116,
"hgvs_c": "c.712A>C",
"hgvs_p": "p.Asn238His",
"transcript": "ENST00000889618.1",
"protein_id": "ENSP00000559677.1",
"transcript_support_level": null,
"aa_start": 238,
"aa_end": null,
"aa_length": 567,
"cds_start": 712,
"cds_end": null,
"cds_length": 1704,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000889618.1"
},
{
"aa_ref": "N",
"aa_alt": "H",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 7,
"exon_rank_end": null,
"exon_count": 16,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "SENP2",
"gene_hgnc_id": 23116,
"hgvs_c": "c.712A>C",
"hgvs_p": "p.Asn238His",
"transcript": "ENST00000953476.1",
"protein_id": "ENSP00000623535.1",
"transcript_support_level": null,
"aa_start": 238,
"aa_end": null,
"aa_length": 557,
"cds_start": 712,
"cds_end": null,
"cds_length": 1674,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000953476.1"
},
{
"aa_ref": "N",
"aa_alt": "H",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 7,
"exon_rank_end": null,
"exon_count": 16,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "SENP2",
"gene_hgnc_id": 23116,
"hgvs_c": "c.712A>C",
"hgvs_p": "p.Asn238His",
"transcript": "ENST00000953474.1",
"protein_id": "ENSP00000623533.1",
"transcript_support_level": null,
"aa_start": 238,
"aa_end": null,
"aa_length": 539,
"cds_start": 712,
"cds_end": null,
"cds_length": 1620,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000953474.1"
},
{
"aa_ref": "N",
"aa_alt": "H",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 7,
"exon_rank_end": null,
"exon_count": 16,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "SENP2",
"gene_hgnc_id": 23116,
"hgvs_c": "c.712A>C",
"hgvs_p": "p.Asn238His",
"transcript": "ENST00000889614.1",
"protein_id": "ENSP00000559673.1",
"transcript_support_level": null,
"aa_start": 238,
"aa_end": null,
"aa_length": 530,
"cds_start": 712,
"cds_end": null,
"cds_length": 1593,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000889614.1"
},
{
"aa_ref": "N",
"aa_alt": "H",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 5,
"exon_rank_end": null,
"exon_count": 15,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "SENP2",
"gene_hgnc_id": 23116,
"hgvs_c": "c.511A>C",
"hgvs_p": "p.Asn171His",
"transcript": "ENST00000889623.1",
"protein_id": "ENSP00000559682.1",
"transcript_support_level": null,
"aa_start": 171,
"aa_end": null,
"aa_length": 522,
"cds_start": 511,
"cds_end": null,
"cds_length": 1569,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000889623.1"
},
{
"aa_ref": "N",
"aa_alt": "H",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 7,
"exon_rank_end": null,
"exon_count": 16,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "SENP2",
"gene_hgnc_id": 23116,
"hgvs_c": "c.712A>C",
"hgvs_p": "p.Asn238His",
"transcript": "ENST00000889615.1",
"protein_id": "ENSP00000559674.1",
"transcript_support_level": null,
"aa_start": 238,
"aa_end": null,
"aa_length": 521,
"cds_start": 712,
"cds_end": null,
"cds_length": 1566,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000889615.1"
},
{
"aa_ref": "N",
"aa_alt": "H",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 5,
"exon_rank_end": null,
"exon_count": 15,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "SENP2",
"gene_hgnc_id": 23116,
"hgvs_c": "c.511A>C",
"hgvs_p": "p.Asn171His",
"transcript": "ENST00000889621.1",
"protein_id": "ENSP00000559680.1",
"transcript_support_level": null,
"aa_start": 171,
"aa_end": null,
"aa_length": 519,
"cds_start": 511,
"cds_end": null,
"cds_length": 1560,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000889621.1"
},
{
"aa_ref": "N",
"aa_alt": "H",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 7,
"exon_rank_end": null,
"exon_count": 15,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "SENP2",
"gene_hgnc_id": 23116,
"hgvs_c": "c.712A>C",
"hgvs_p": "p.Asn238His",
"transcript": "ENST00000889613.1",
"protein_id": "ENSP00000559672.1",
"transcript_support_level": null,
"aa_start": 238,
"aa_end": null,
"aa_length": 486,
"cds_start": 712,
"cds_end": null,
"cds_length": 1461,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000889613.1"
},
{
"aa_ref": "N",
"aa_alt": "H",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 7,
"exon_rank_end": null,
"exon_count": 15,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "SENP2",
"gene_hgnc_id": 23116,
"hgvs_c": "c.712A>C",
"hgvs_p": "p.Asn238His",
"transcript": "ENST00000953475.1",
"protein_id": "ENSP00000623534.1",
"transcript_support_level": null,
"aa_start": 238,
"aa_end": null,
"aa_length": 483,
"cds_start": 712,
"cds_end": null,
"cds_length": 1452,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000953475.1"
},
{
"aa_ref": "N",
"aa_alt": "H",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 7,
"exon_rank_end": null,
"exon_count": 15,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "SENP2",
"gene_hgnc_id": 23116,
"hgvs_c": "c.712A>C",
"hgvs_p": "p.Asn238His",
"transcript": "ENST00000889620.1",
"protein_id": "ENSP00000559679.1",
"transcript_support_level": null,
"aa_start": 238,
"aa_end": null,
"aa_length": 477,
"cds_start": 712,
"cds_end": null,
"cds_length": 1434,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000889620.1"
},
{
"aa_ref": "N",
"aa_alt": "H",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 7,
"exon_rank_end": null,
"exon_count": 14,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "SENP2",
"gene_hgnc_id": 23116,
"hgvs_c": "c.712A>C",
"hgvs_p": "p.Asn238His",
"transcript": "ENST00000889622.1",
"protein_id": "ENSP00000559681.1",
"transcript_support_level": null,
"aa_start": 238,
"aa_end": null,
"aa_length": 466,
"cds_start": 712,
"cds_end": null,
"cds_length": 1401,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000889622.1"
},
{
"aa_ref": "N",
"aa_alt": "H",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 7,
"exon_rank_end": null,
"exon_count": 15,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "SENP2",
"gene_hgnc_id": 23116,
"hgvs_c": "c.712A>C",
"hgvs_p": "p.Asn238His",
"transcript": "ENST00000953473.1",
"protein_id": "ENSP00000623532.1",
"transcript_support_level": null,
"aa_start": 238,
"aa_end": null,
"aa_length": 462,
"cds_start": 712,
"cds_end": null,
"cds_length": 1389,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000953473.1"
},
{
"aa_ref": "N",
"aa_alt": "H",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 7,
"exon_rank_end": null,
"exon_count": 14,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "SENP2",
"gene_hgnc_id": 23116,
"hgvs_c": "c.712A>C",
"hgvs_p": "p.Asn238His",
"transcript": "ENST00000953472.1",
"protein_id": "ENSP00000623531.1",
"transcript_support_level": null,
"aa_start": 238,
"aa_end": null,
"aa_length": 418,
"cds_start": 712,
"cds_end": null,
"cds_length": 1257,
"cdna_start": null,
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{
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}
],
"message": null
}