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GeneBe API Showcase
This page demonstrates how to use the GeneBe API to query variant information. The API provides programmatic access to genomic annotations and variant data.
API presented here should be used for checking single variants. If you want to check many variants at once, please use other API endpoints that you will find in the documentation.
Documentation & Advanced Usage
• Complete API documentation:docs.genebe.net/docs/api/overview/
• Interactive endpoint tester:api.genebe.net/cloud/gb-api-doc/swagger-ui/
• Python client for pandas:pypi.org/project/genebe/
• Java CLI for VCF files:github.com/pstawinski/genebe-cli
• All tools documented at:docs.genebe.net
API Request Examples for Variant: 3-195867221-G-A (hg38)
Bash / cURL Example
bash
curl "https://api.genebe.net/cloud/api-public/v1/variant?chr=3&pos=195867221&ref=G&alt=A&genome=hg38&allGenes=true"API Response
json
{
"variants": [
{
"chr": "3",
"pos": 195867221,
"ref": "G",
"alt": "A",
"effect": "missense_variant",
"transcript": "NM_001387707.1",
"consequences": [
{
"aa_ref": "A",
"aa_alt": "V",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 14,
"exon_rank_end": null,
"exon_count": 16,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "TNK2",
"gene_hgnc_id": 19297,
"hgvs_c": "c.2981C>T",
"hgvs_p": "p.Ala994Val",
"transcript": "NM_001382273.1",
"protein_id": "NP_001369202.1",
"transcript_support_level": null,
"aa_start": 994,
"aa_end": null,
"aa_length": 1055,
"cds_start": 2981,
"cds_end": null,
"cds_length": 3168,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": "ENST00000672887.2",
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001382273.1"
},
{
"aa_ref": "A",
"aa_alt": "V",
"canonical": true,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 14,
"exon_rank_end": null,
"exon_count": 16,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "TNK2",
"gene_hgnc_id": 19297,
"hgvs_c": "c.2981C>T",
"hgvs_p": "p.Ala994Val",
"transcript": "ENST00000672887.2",
"protein_id": "ENSP00000499899.1",
"transcript_support_level": null,
"aa_start": 994,
"aa_end": null,
"aa_length": 1055,
"cds_start": 2981,
"cds_end": null,
"cds_length": 3168,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": "NM_001382273.1",
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000672887.2"
},
{
"aa_ref": "A",
"aa_alt": "V",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 13,
"exon_rank_end": null,
"exon_count": 15,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "TNK2",
"gene_hgnc_id": 19297,
"hgvs_c": "c.2930C>T",
"hgvs_p": "p.Ala977Val",
"transcript": "ENST00000333602.14",
"protein_id": "ENSP00000329425.6",
"transcript_support_level": 1,
"aa_start": 977,
"aa_end": null,
"aa_length": 1038,
"cds_start": 2930,
"cds_end": null,
"cds_length": 3117,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000333602.14"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 14,
"intron_rank": 12,
"intron_rank_end": null,
"gene_symbol": "TNK2",
"gene_hgnc_id": 19297,
"hgvs_c": "c.2988+140C>T",
"hgvs_p": null,
"transcript": "ENST00000428187.7",
"protein_id": "ENSP00000392546.1",
"transcript_support_level": 1,
"aa_start": null,
"aa_end": null,
"aa_length": 1040,
"cds_start": null,
"cds_end": null,
"cds_length": 3123,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000428187.7"
},
{
"aa_ref": "A",
"aa_alt": "V",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 14,
"exon_rank_end": null,
"exon_count": 16,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "TNK2",
"gene_hgnc_id": 19297,
"hgvs_c": "c.3077C>T",
"hgvs_p": "p.Ala1026Val",
"transcript": "NM_001387707.1",
"protein_id": "NP_001374636.1",
"transcript_support_level": null,
"aa_start": 1026,
"aa_end": null,
"aa_length": 1087,
"cds_start": 3077,
"cds_end": null,
"cds_length": 3264,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001387707.1"
},
{
"aa_ref": "A",
"aa_alt": "V",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 14,
"exon_rank_end": null,
"exon_count": 16,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "TNK2",
"gene_hgnc_id": 19297,
"hgvs_c": "c.3053C>T",
"hgvs_p": "p.Ala1018Val",
"transcript": "NM_001382272.1",
"protein_id": "NP_001369201.1",
"transcript_support_level": null,
"aa_start": 1018,
"aa_end": null,
"aa_length": 1079,
"cds_start": 3053,
"cds_end": null,
"cds_length": 3240,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001382272.1"
},
{
"aa_ref": "A",
"aa_alt": "V",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 14,
"exon_rank_end": null,
"exon_count": 16,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "TNK2",
"gene_hgnc_id": 19297,
"hgvs_c": "c.3050C>T",
"hgvs_p": "p.Ala1017Val",
"transcript": "ENST00000863906.1",
"protein_id": "ENSP00000533965.1",
"transcript_support_level": null,
"aa_start": 1017,
"aa_end": null,
"aa_length": 1078,
"cds_start": 3050,
"cds_end": null,
"cds_length": 3237,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000863906.1"
},
{
"aa_ref": "A",
"aa_alt": "V",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 14,
"exon_rank_end": null,
"exon_count": 16,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "TNK2",
"gene_hgnc_id": 19297,
"hgvs_c": "c.3050C>T",
"hgvs_p": "p.Ala1017Val",
"transcript": "ENST00000863912.1",
"protein_id": "ENSP00000533971.1",
"transcript_support_level": null,
"aa_start": 1017,
"aa_end": null,
"aa_length": 1078,
"cds_start": 3050,
"cds_end": null,
"cds_length": 3237,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000863912.1"
},
{
"aa_ref": "A",
"aa_alt": "V",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 13,
"exon_rank_end": null,
"exon_count": 15,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "TNK2",
"gene_hgnc_id": 19297,
"hgvs_c": "c.3032C>T",
"hgvs_p": "p.Ala1011Val",
"transcript": "NM_001382271.1",
"protein_id": "NP_001369200.1",
"transcript_support_level": null,
"aa_start": 1011,
"aa_end": null,
"aa_length": 1072,
"cds_start": 3032,
"cds_end": null,
"cds_length": 3219,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001382271.1"
},
{
"aa_ref": "A",
"aa_alt": "V",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 13,
"exon_rank_end": null,
"exon_count": 15,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "TNK2",
"gene_hgnc_id": 19297,
"hgvs_c": "c.3032C>T",
"hgvs_p": "p.Ala1011Val",
"transcript": "ENST00000673038.1",
"protein_id": "ENSP00000500452.1",
"transcript_support_level": null,
"aa_start": 1011,
"aa_end": null,
"aa_length": 1072,
"cds_start": 3032,
"cds_end": null,
"cds_length": 3219,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000673038.1"
},
{
"aa_ref": "A",
"aa_alt": "V",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 13,
"exon_rank_end": null,
"exon_count": 15,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "TNK2",
"gene_hgnc_id": 19297,
"hgvs_c": "c.3032C>T",
"hgvs_p": "p.Ala1011Val",
"transcript": "ENST00000678220.1",
"protein_id": "ENSP00000503221.1",
"transcript_support_level": null,
"aa_start": 1011,
"aa_end": null,
"aa_length": 1072,
"cds_start": 3032,
"cds_end": null,
"cds_length": 3219,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000678220.1"
},
{
"aa_ref": "A",
"aa_alt": "V",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 13,
"exon_rank_end": null,
"exon_count": 15,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "TNK2",
"gene_hgnc_id": 19297,
"hgvs_c": "c.3008C>T",
"hgvs_p": "p.Ala1003Val",
"transcript": "NM_001387708.1",
"protein_id": "NP_001374637.1",
"transcript_support_level": null,
"aa_start": 1003,
"aa_end": null,
"aa_length": 1064,
"cds_start": 3008,
"cds_end": null,
"cds_length": 3195,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001387708.1"
},
{
"aa_ref": "A",
"aa_alt": "V",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 14,
"exon_rank_end": null,
"exon_count": 16,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "TNK2",
"gene_hgnc_id": 19297,
"hgvs_c": "c.2981C>T",
"hgvs_p": "p.Ala994Val",
"transcript": "NM_001382274.1",
"protein_id": "NP_001369203.1",
"transcript_support_level": null,
"aa_start": 994,
"aa_end": null,
"aa_length": 1055,
"cds_start": 2981,
"cds_end": null,
"cds_length": 3168,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001382274.1"
},
{
"aa_ref": "A",
"aa_alt": "V",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 14,
"exon_rank_end": null,
"exon_count": 16,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "TNK2",
"gene_hgnc_id": 19297,
"hgvs_c": "c.2981C>T",
"hgvs_p": "p.Ala994Val",
"transcript": "ENST00000863904.1",
"protein_id": "ENSP00000533963.1",
"transcript_support_level": null,
"aa_start": 994,
"aa_end": null,
"aa_length": 1055,
"cds_start": 2981,
"cds_end": null,
"cds_length": 3168,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000863904.1"
},
{
"aa_ref": "A",
"aa_alt": "V",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 14,
"exon_rank_end": null,
"exon_count": 16,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "TNK2",
"gene_hgnc_id": 19297,
"hgvs_c": "c.2981C>T",
"hgvs_p": "p.Ala994Val",
"transcript": "ENST00000863911.1",
"protein_id": "ENSP00000533970.1",
"transcript_support_level": null,
"aa_start": 994,
"aa_end": null,
"aa_length": 1055,
"cds_start": 2981,
"cds_end": null,
"cds_length": 3168,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000863911.1"
},
{
"aa_ref": "A",
"aa_alt": "V",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 13,
"exon_rank_end": null,
"exon_count": 15,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "TNK2",
"gene_hgnc_id": 19297,
"hgvs_c": "c.2936C>T",
"hgvs_p": "p.Ala979Val",
"transcript": "NM_001386164.1",
"protein_id": "NP_001373093.1",
"transcript_support_level": null,
"aa_start": 979,
"aa_end": null,
"aa_length": 1040,
"cds_start": 2936,
"cds_end": null,
"cds_length": 3123,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001386164.1"
},
{
"aa_ref": "A",
"aa_alt": "V",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 13,
"exon_rank_end": null,
"exon_count": 15,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "TNK2",
"gene_hgnc_id": 19297,
"hgvs_c": "c.2936C>T",
"hgvs_p": "p.Ala979Val",
"transcript": "NM_001387709.1",
"protein_id": "NP_001374638.1",
"transcript_support_level": null,
"aa_start": 979,
"aa_end": null,
"aa_length": 1040,
"cds_start": 2936,
"cds_end": null,
"cds_length": 3123,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001387709.1"
},
{
"aa_ref": "A",
"aa_alt": "V",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 13,
"exon_rank_end": null,
"exon_count": 15,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "TNK2",
"gene_hgnc_id": 19297,
"hgvs_c": "c.2936C>T",
"hgvs_p": "p.Ala979Val",
"transcript": "NM_001387710.1",
"protein_id": "NP_001374639.1",
"transcript_support_level": null,
"aa_start": 979,
"aa_end": null,
"aa_length": 1040,
"cds_start": 2936,
"cds_end": null,
"cds_length": 3123,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001387710.1"
},
{
"aa_ref": "A",
"aa_alt": "V",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 13,
"exon_rank_end": null,
"exon_count": 15,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "TNK2",
"gene_hgnc_id": 19297,
"hgvs_c": "c.2936C>T",
"hgvs_p": "p.Ala979Val",
"transcript": "NM_001387711.1",
"protein_id": "NP_001374640.1",
"transcript_support_level": null,
"aa_start": 979,
"aa_end": null,
"aa_length": 1040,
"cds_start": 2936,
"cds_end": null,
"cds_length": 3123,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001387711.1"
},
{
"aa_ref": "A",
"aa_alt": "V",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 13,
"exon_rank_end": null,
"exon_count": 15,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "TNK2",
"gene_hgnc_id": 19297,
"hgvs_c": "c.2936C>T",
"hgvs_p": "p.Ala979Val",
"transcript": "NM_001387712.1",
"protein_id": "NP_001374641.1",
"transcript_support_level": null,
"aa_start": 979,
"aa_end": null,
"aa_length": 1040,
"cds_start": 2936,
"cds_end": null,
"cds_length": 3123,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001387712.1"
},
{
"aa_ref": "A",
"aa_alt": "V",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 13,
"exon_rank_end": null,
"exon_count": 15,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "TNK2",
"gene_hgnc_id": 19297,
"hgvs_c": "c.2936C>T",
"hgvs_p": "p.Ala979Val",
"transcript": "ENST00000673420.1",
"protein_id": "ENSP00000500887.1",
"transcript_support_level": null,
"aa_start": 979,
"aa_end": null,
"aa_length": 1040,
"cds_start": 2936,
"cds_end": null,
"cds_length": 3123,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000673420.1"
},
{
"aa_ref": "A",
"aa_alt": "V",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 13,
"exon_rank_end": null,
"exon_count": 15,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "TNK2",
"gene_hgnc_id": 19297,
"hgvs_c": "c.2936C>T",
"hgvs_p": "p.Ala979Val",
"transcript": "ENST00000863903.1",
"protein_id": "ENSP00000533962.1",
"transcript_support_level": null,
"aa_start": 979,
"aa_end": null,
"aa_length": 1040,
"cds_start": 2936,
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{
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{
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{
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{
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{
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],
"gene_symbol": "TNK2",
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"dbsnp": "rs571171423",
"frequency_reference_population": 0.000029757846,
"hom_count_reference_population": 0,
"allele_count_reference_population": 48,
"gnomad_exomes_af": 0.0000280689,
"gnomad_genomes_af": 0.0000459535,
"gnomad_exomes_ac": 41,
"gnomad_genomes_ac": 7,
"gnomad_exomes_homalt": 0,
"gnomad_genomes_homalt": 0,
"gnomad_mito_homoplasmic": null,
"gnomad_mito_heteroplasmic": null,
"computational_score_selected": 0.16257402300834656,
"computational_prediction_selected": "Benign",
"computational_source_selected": "MetaRNN",
"splice_score_selected": 0,
"splice_prediction_selected": "Benign",
"splice_source_selected": "max_spliceai",
"revel_score": 0.156,
"revel_prediction": "Benign",
"alphamissense_score": 0.114,
"alphamissense_prediction": null,
"bayesdelnoaf_score": -0.12,
"bayesdelnoaf_prediction": "Benign",
"phylop100way_score": 6.42,
"phylop100way_prediction": "Uncertain_significance",
"spliceai_max_score": 0,
"spliceai_max_prediction": "Benign",
"dbscsnv_ada_score": null,
"dbscsnv_ada_prediction": null,
"apogee2_score": null,
"apogee2_prediction": null,
"mitotip_score": null,
"mitotip_prediction": null,
"acmg_score": 0,
"acmg_classification": "Uncertain_significance",
"acmg_criteria": "PM2,BP4_Moderate",
"acmg_by_gene": [
{
"score": 0,
"benign_score": 2,
"pathogenic_score": 2,
"criteria": [
"PM2",
"BP4_Moderate"
],
"verdict": "Uncertain_significance",
"transcript": "NM_001387707.1",
"gene_symbol": "TNK2",
"hgnc_id": 19297,
"effects": [
"missense_variant"
],
"inheritance_mode": "AR",
"hgvs_c": "c.3077C>T",
"hgvs_p": "p.Ala1026Val"
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],
"clinvar_disease": "Parkinson disease",
"clinvar_classification": "Uncertain significance",
"clinvar_review_status": "criteria provided, single submitter",
"clinvar_submissions_summary": "US:1",
"phenotype_combined": "Parkinson disease",
"pathogenicity_classification_combined": "Uncertain significance",
"custom_annotations": null
}
],
"message": null
}