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GeneBe API Showcase
This page demonstrates how to use the GeneBe API to query variant information. The API provides programmatic access to genomic annotations and variant data.
API presented here should be used for checking single variants. If you want to check many variants at once, please use other API endpoints that you will find in the documentation.
Documentation & Advanced Usage
• Complete API documentation:docs.genebe.net/docs/api/overview/
• Interactive endpoint tester:api.genebe.net/cloud/gb-api-doc/swagger-ui/
• Python client for pandas:pypi.org/project/genebe/
• Java CLI for VCF files:github.com/pstawinski/genebe-cli
• All tools documented at:docs.genebe.net
API Request Examples for Variant: 3-21510900-T-C (hg38)
Bash / cURL Example
bash
curl "https://api.genebe.net/cloud/api-public/v1/variant?chr=3&pos=21510900&ref=T&alt=C&genome=hg38&allGenes=true"API Response
json
{
"variants": [
{
"chr": "3",
"pos": 21510900,
"ref": "T",
"alt": "C",
"effect": "missense_variant",
"transcript": "ENST00000281523.8",
"consequences": [
{
"aa_ref": "I",
"aa_alt": "V",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 4,
"exon_rank_end": null,
"exon_count": 8,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ZNF385D",
"gene_hgnc_id": 26191,
"hgvs_c": "c.400A>G",
"hgvs_p": "p.Ile134Val",
"transcript": "NM_024697.3",
"protein_id": "NP_078973.1",
"transcript_support_level": null,
"aa_start": 134,
"aa_end": null,
"aa_length": 395,
"cds_start": 400,
"cds_end": null,
"cds_length": 1188,
"cdna_start": 694,
"cdna_end": null,
"cdna_length": 10478,
"mane_select": "ENST00000281523.8",
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "I",
"aa_alt": "V",
"canonical": true,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 4,
"exon_rank_end": null,
"exon_count": 8,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ZNF385D",
"gene_hgnc_id": 26191,
"hgvs_c": "c.400A>G",
"hgvs_p": "p.Ile134Val",
"transcript": "ENST00000281523.8",
"protein_id": "ENSP00000281523.2",
"transcript_support_level": 1,
"aa_start": 134,
"aa_end": null,
"aa_length": 395,
"cds_start": 400,
"cds_end": null,
"cds_length": 1188,
"cdna_start": 694,
"cdna_end": null,
"cdna_length": 10478,
"mane_select": "NM_024697.3",
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": false,
"strand": false,
"consequences": [
"non_coding_transcript_exon_variant"
],
"exon_rank": 5,
"exon_rank_end": null,
"exon_count": 7,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ZNF385D",
"gene_hgnc_id": 26191,
"hgvs_c": "n.*210A>G",
"hgvs_p": null,
"transcript": "ENST00000494118.5",
"protein_id": "ENSP00000493727.1",
"transcript_support_level": 1,
"aa_start": null,
"aa_end": null,
"aa_length": null,
"cds_start": -4,
"cds_end": null,
"cds_length": null,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 1050,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": false,
"strand": false,
"consequences": [
"3_prime_UTR_variant"
],
"exon_rank": 5,
"exon_rank_end": null,
"exon_count": 7,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ZNF385D",
"gene_hgnc_id": 26191,
"hgvs_c": "n.*210A>G",
"hgvs_p": null,
"transcript": "ENST00000494118.5",
"protein_id": "ENSP00000493727.1",
"transcript_support_level": 1,
"aa_start": null,
"aa_end": null,
"aa_length": null,
"cds_start": -4,
"cds_end": null,
"cds_length": null,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 1050,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "I",
"aa_alt": "V",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 5,
"exon_rank_end": null,
"exon_count": 10,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ZNF385D",
"gene_hgnc_id": 26191,
"hgvs_c": "c.703A>G",
"hgvs_p": "p.Ile235Val",
"transcript": "ENST00000706131.1",
"protein_id": "ENSP00000516216.1",
"transcript_support_level": null,
"aa_start": 235,
"aa_end": null,
"aa_length": 515,
"cds_start": 703,
"cds_end": null,
"cds_length": 1548,
"cdna_start": 784,
"cdna_end": null,
"cdna_length": 4424,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "I",
"aa_alt": "V",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 6,
"exon_rank_end": null,
"exon_count": 10,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ZNF385D",
"gene_hgnc_id": 26191,
"hgvs_c": "c.703A>G",
"hgvs_p": "p.Ile235Val",
"transcript": "ENST00000494108.3",
"protein_id": "ENSP00000495609.3",
"transcript_support_level": 5,
"aa_start": 235,
"aa_end": null,
"aa_length": 496,
"cds_start": 703,
"cds_end": null,
"cds_length": 1491,
"cdna_start": 1124,
"cdna_end": null,
"cdna_length": 4707,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "I",
"aa_alt": "V",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 4,
"exon_rank_end": null,
"exon_count": 8,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ZNF385D",
"gene_hgnc_id": 26191,
"hgvs_c": "c.391A>G",
"hgvs_p": "p.Ile131Val",
"transcript": "ENST00000706134.1",
"protein_id": "ENSP00000516219.1",
"transcript_support_level": null,
"aa_start": 131,
"aa_end": null,
"aa_length": 392,
"cds_start": 391,
"cds_end": null,
"cds_length": 1179,
"cdna_start": 740,
"cdna_end": null,
"cdna_length": 1549,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "I",
"aa_alt": "V",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 1,
"exon_rank_end": null,
"exon_count": 3,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ZNF385D",
"gene_hgnc_id": 26191,
"hgvs_c": "c.85A>G",
"hgvs_p": "p.Ile29Val",
"transcript": "ENST00000495739.1",
"protein_id": "ENSP00000498106.1",
"transcript_support_level": 3,
"aa_start": 29,
"aa_end": null,
"aa_length": 156,
"cds_start": 85,
"cds_end": null,
"cds_length": 471,
"cdna_start": 87,
"cdna_end": null,
"cdna_length": 567,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "I",
"aa_alt": "V",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 5,
"exon_rank_end": null,
"exon_count": 10,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ZNF385D",
"gene_hgnc_id": 26191,
"hgvs_c": "c.703A>G",
"hgvs_p": "p.Ile235Val",
"transcript": "XM_017007191.2",
"protein_id": "XP_016862680.1",
"transcript_support_level": null,
"aa_start": 235,
"aa_end": null,
"aa_length": 515,
"cds_start": 703,
"cds_end": null,
"cds_length": 1548,
"cdna_start": 911,
"cdna_end": null,
"cdna_length": 6635,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "I",
"aa_alt": "V",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 5,
"exon_rank_end": null,
"exon_count": 9,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ZNF385D",
"gene_hgnc_id": 26191,
"hgvs_c": "c.703A>G",
"hgvs_p": "p.Ile235Val",
"transcript": "XM_017007192.2",
"protein_id": "XP_016862681.1",
"transcript_support_level": null,
"aa_start": 235,
"aa_end": null,
"aa_length": 496,
"cds_start": 703,
"cds_end": null,
"cds_length": 1491,
"cdna_start": 911,
"cdna_end": null,
"cdna_length": 6578,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "I",
"aa_alt": "V",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 5,
"exon_rank_end": null,
"exon_count": 10,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ZNF385D",
"gene_hgnc_id": 26191,
"hgvs_c": "c.490A>G",
"hgvs_p": "p.Ile164Val",
"transcript": "XM_017007193.2",
"protein_id": "XP_016862682.1",
"transcript_support_level": null,
"aa_start": 164,
"aa_end": null,
"aa_length": 444,
"cds_start": 490,
"cds_end": null,
"cds_length": 1335,
"cdna_start": 781,
"cdna_end": null,
"cdna_length": 6505,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "I",
"aa_alt": "V",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 5,
"exon_rank_end": null,
"exon_count": 10,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ZNF385D",
"gene_hgnc_id": 26191,
"hgvs_c": "c.451A>G",
"hgvs_p": "p.Ile151Val",
"transcript": "XM_047448956.1",
"protein_id": "XP_047304912.1",
"transcript_support_level": null,
"aa_start": 151,
"aa_end": null,
"aa_length": 431,
"cds_start": 451,
"cds_end": null,
"cds_length": 1296,
"cdna_start": 535,
"cdna_end": null,
"cdna_length": 6259,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "I",
"aa_alt": "V",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 4,
"exon_rank_end": null,
"exon_count": 9,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ZNF385D",
"gene_hgnc_id": 26191,
"hgvs_c": "c.445A>G",
"hgvs_p": "p.Ile149Val",
"transcript": "XM_017007195.2",
"protein_id": "XP_016862684.1",
"transcript_support_level": null,
"aa_start": 149,
"aa_end": null,
"aa_length": 429,
"cds_start": 445,
"cds_end": null,
"cds_length": 1290,
"cdna_start": 484,
"cdna_end": null,
"cdna_length": 6208,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "I",
"aa_alt": "V",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 4,
"exon_rank_end": null,
"exon_count": 9,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ZNF385D",
"gene_hgnc_id": 26191,
"hgvs_c": "c.400A>G",
"hgvs_p": "p.Ile134Val",
"transcript": "XM_017007196.2",
"protein_id": "XP_016862685.1",
"transcript_support_level": null,
"aa_start": 134,
"aa_end": null,
"aa_length": 414,
"cds_start": 400,
"cds_end": null,
"cds_length": 1245,
"cdna_start": 694,
"cdna_end": null,
"cdna_length": 6418,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "I",
"aa_alt": "V",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 4,
"exon_rank_end": null,
"exon_count": 9,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ZNF385D",
"gene_hgnc_id": 26191,
"hgvs_c": "c.391A>G",
"hgvs_p": "p.Ile131Val",
"transcript": "XM_017007197.2",
"protein_id": "XP_016862686.1",
"transcript_support_level": null,
"aa_start": 131,
"aa_end": null,
"aa_length": 411,
"cds_start": 391,
"cds_end": null,
"cds_length": 1236,
"cdna_start": 1200,
"cdna_end": null,
"cdna_length": 6924,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "I",
"aa_alt": "V",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 4,
"exon_rank_end": null,
"exon_count": 9,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ZNF385D",
"gene_hgnc_id": 26191,
"hgvs_c": "c.388A>G",
"hgvs_p": "p.Ile130Val",
"transcript": "XM_017007198.2",
"protein_id": "XP_016862687.1",
"transcript_support_level": null,
"aa_start": 130,
"aa_end": null,
"aa_length": 410,
"cds_start": 388,
"cds_end": null,
"cds_length": 1233,
"cdna_start": 553,
"cdna_end": null,
"cdna_length": 6277,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "I",
"aa_alt": "V",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 4,
"exon_rank_end": null,
"exon_count": 8,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ZNF385D",
"gene_hgnc_id": 26191,
"hgvs_c": "c.445A>G",
"hgvs_p": "p.Ile149Val",
"transcript": "XM_047448958.1",
"protein_id": "XP_047304914.1",
"transcript_support_level": null,
"aa_start": 149,
"aa_end": null,
"aa_length": 410,
"cds_start": 445,
"cds_end": null,
"cds_length": 1233,
"cdna_start": 481,
"cdna_end": null,
"cdna_length": 6148,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "I",
"aa_alt": "V",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 4,
"exon_rank_end": null,
"exon_count": 8,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ZNF385D",
"gene_hgnc_id": 26191,
"hgvs_c": "c.391A>G",
"hgvs_p": "p.Ile131Val",
"transcript": "XM_047448959.1",
"protein_id": "XP_047304915.1",
"transcript_support_level": null,
"aa_start": 131,
"aa_end": null,
"aa_length": 392,
"cds_start": 391,
"cds_end": null,
"cds_length": 1179,
"cdna_start": 1196,
"cdna_end": null,
"cdna_length": 6863,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "I",
"aa_alt": "V",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 4,
"exon_rank_end": null,
"exon_count": 8,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ZNF385D",
"gene_hgnc_id": 26191,
"hgvs_c": "c.388A>G",
"hgvs_p": "p.Ile130Val",
"transcript": "XM_047448960.1",
"protein_id": "XP_047304916.1",
"transcript_support_level": null,
"aa_start": 130,
"aa_end": null,
"aa_length": 391,
"cds_start": 388,
"cds_end": null,
"cds_length": 1176,
"cdna_start": 553,
"cdna_end": null,
"cdna_length": 6220,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "I",
"aa_alt": "V",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 3,
"exon_rank_end": null,
"exon_count": 8,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ZNF385D",
"gene_hgnc_id": 26191,
"hgvs_c": "c.244A>G",
"hgvs_p": "p.Ile82Val",
"transcript": "XM_017007199.2",
"protein_id": "XP_016862688.1",
"transcript_support_level": null,
"aa_start": 82,
"aa_end": null,
"aa_length": 362,
"cds_start": 244,
"cds_end": null,
"cds_length": 1089,
"cdna_start": 328,
"cdna_end": null,
"cdna_length": 6052,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "I",
"aa_alt": "V",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 3,
"exon_rank_end": null,
"exon_count": 8,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ZNF385D",
"gene_hgnc_id": 26191,
"hgvs_c": "c.235A>G",
"hgvs_p": "p.Ile79Val",
"transcript": "XM_017007200.3",
"protein_id": "XP_016862689.1",
"transcript_support_level": null,
"aa_start": 79,
"aa_end": null,
"aa_length": 359,
"cds_start": 235,
"cds_end": null,
"cds_length": 1080,
"cdna_start": 7845,
"cdna_end": null,
"cdna_length": 13569,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "I",
"aa_alt": "V",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 3,
"exon_rank_end": null,
"exon_count": 8,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ZNF385D",
"gene_hgnc_id": 26191,
"hgvs_c": "c.61A>G",
"hgvs_p": "p.Ile21Val",
"transcript": "XM_017007201.2",
"protein_id": "XP_016862690.1",
"transcript_support_level": null,
"aa_start": 21,
"aa_end": null,
"aa_length": 301,
"cds_start": 61,
"cds_end": null,
"cds_length": 906,
"cdna_start": 331,
"cdna_end": null,
"cdna_length": 6055,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "I",
"aa_alt": "V",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 5,
"exon_rank_end": null,
"exon_count": 7,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ZNF385D",
"gene_hgnc_id": 26191,
"hgvs_c": "c.703A>G",
"hgvs_p": "p.Ile235Val",
"transcript": "XM_011534122.3",
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"phenotype_combined": "not specified",
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}
],
"message": null
}