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GeneBe API Showcase
This page demonstrates how to use the GeneBe API to query variant information. The API provides programmatic access to genomic annotations and variant data.
API presented here should be used for checking single variants. If you want to check many variants at once, please use other API endpoints that you will find in the documentation.
Documentation & Advanced Usage
• Complete API documentation:docs.genebe.net/docs/api/overview/
• Interactive endpoint tester:api.genebe.net/cloud/gb-api-doc/swagger-ui/
• Python client for pandas:pypi.org/project/genebe/
• Java CLI for VCF files:github.com/pstawinski/genebe-cli
• All tools documented at:docs.genebe.net
API Request Examples for Variant: 3-23901014-T-A (hg38)
Bash / cURL Example
bash
curl "https://api.genebe.net/cloud/api-public/v1/variant?chr=3&pos=23901014&ref=T&alt=A&genome=hg38&allGenes=true"API Response
json
{
"variants": [
{
"chr": "3",
"pos": 23901014,
"ref": "T",
"alt": "A",
"effect": "missense_variant",
"transcript": "NM_020345.4",
"consequences": [
{
"aa_ref": "M",
"aa_alt": "L",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 4,
"exon_rank_end": null,
"exon_count": 5,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "NKIRAS1",
"gene_hgnc_id": 17899,
"hgvs_c": "c.130A>T",
"hgvs_p": "p.Met44Leu",
"transcript": "NM_020345.4",
"protein_id": "NP_065078.1",
"transcript_support_level": null,
"aa_start": 44,
"aa_end": null,
"aa_length": 192,
"cds_start": 130,
"cds_end": null,
"cds_length": 579,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": "ENST00000425478.7",
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_020345.4"
},
{
"aa_ref": "M",
"aa_alt": "L",
"canonical": true,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 4,
"exon_rank_end": null,
"exon_count": 5,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "NKIRAS1",
"gene_hgnc_id": 17899,
"hgvs_c": "c.130A>T",
"hgvs_p": "p.Met44Leu",
"transcript": "ENST00000425478.7",
"protein_id": "ENSP00000400385.2",
"transcript_support_level": 1,
"aa_start": 44,
"aa_end": null,
"aa_length": 192,
"cds_start": 130,
"cds_end": null,
"cds_length": 579,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": "NM_020345.4",
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000425478.7"
},
{
"aa_ref": "M",
"aa_alt": "L",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 2,
"exon_rank_end": null,
"exon_count": 3,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "NKIRAS1",
"gene_hgnc_id": 17899,
"hgvs_c": "c.130A>T",
"hgvs_p": "p.Met44Leu",
"transcript": "ENST00000614374.4",
"protein_id": "ENSP00000483749.1",
"transcript_support_level": 1,
"aa_start": 44,
"aa_end": null,
"aa_length": 192,
"cds_start": 130,
"cds_end": null,
"cds_length": 579,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000614374.4"
},
{
"aa_ref": "M",
"aa_alt": "L",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 4,
"exon_rank_end": null,
"exon_count": 6,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "NKIRAS1",
"gene_hgnc_id": 17899,
"hgvs_c": "c.130A>T",
"hgvs_p": "p.Met44Leu",
"transcript": "ENST00000941384.1",
"protein_id": "ENSP00000611443.1",
"transcript_support_level": null,
"aa_start": 44,
"aa_end": null,
"aa_length": 231,
"cds_start": 130,
"cds_end": null,
"cds_length": 696,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000941384.1"
},
{
"aa_ref": "M",
"aa_alt": "L",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 3,
"exon_rank_end": null,
"exon_count": 4,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "NKIRAS1",
"gene_hgnc_id": 17899,
"hgvs_c": "c.130A>T",
"hgvs_p": "p.Met44Leu",
"transcript": "NM_001377351.1",
"protein_id": "NP_001364280.1",
"transcript_support_level": null,
"aa_start": 44,
"aa_end": null,
"aa_length": 192,
"cds_start": 130,
"cds_end": null,
"cds_length": 579,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001377351.1"
},
{
"aa_ref": "M",
"aa_alt": "L",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 4,
"exon_rank_end": null,
"exon_count": 5,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "NKIRAS1",
"gene_hgnc_id": 17899,
"hgvs_c": "c.130A>T",
"hgvs_p": "p.Met44Leu",
"transcript": "NM_001377352.1",
"protein_id": "NP_001364281.1",
"transcript_support_level": null,
"aa_start": 44,
"aa_end": null,
"aa_length": 192,
"cds_start": 130,
"cds_end": null,
"cds_length": 579,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001377352.1"
},
{
"aa_ref": "M",
"aa_alt": "L",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 4,
"exon_rank_end": null,
"exon_count": 5,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "NKIRAS1",
"gene_hgnc_id": 17899,
"hgvs_c": "c.130A>T",
"hgvs_p": "p.Met44Leu",
"transcript": "NM_001377353.1",
"protein_id": "NP_001364282.1",
"transcript_support_level": null,
"aa_start": 44,
"aa_end": null,
"aa_length": 192,
"cds_start": 130,
"cds_end": null,
"cds_length": 579,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001377353.1"
},
{
"aa_ref": "M",
"aa_alt": "L",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 4,
"exon_rank_end": null,
"exon_count": 5,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "NKIRAS1",
"gene_hgnc_id": 17899,
"hgvs_c": "c.130A>T",
"hgvs_p": "p.Met44Leu",
"transcript": "NM_001377354.1",
"protein_id": "NP_001364283.1",
"transcript_support_level": null,
"aa_start": 44,
"aa_end": null,
"aa_length": 192,
"cds_start": 130,
"cds_end": null,
"cds_length": 579,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001377354.1"
},
{
"aa_ref": "M",
"aa_alt": "L",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 3,
"exon_rank_end": null,
"exon_count": 4,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "NKIRAS1",
"gene_hgnc_id": 17899,
"hgvs_c": "c.130A>T",
"hgvs_p": "p.Met44Leu",
"transcript": "NM_001377355.1",
"protein_id": "NP_001364284.1",
"transcript_support_level": null,
"aa_start": 44,
"aa_end": null,
"aa_length": 192,
"cds_start": 130,
"cds_end": null,
"cds_length": 579,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001377355.1"
},
{
"aa_ref": "M",
"aa_alt": "L",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 5,
"exon_rank_end": null,
"exon_count": 6,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "NKIRAS1",
"gene_hgnc_id": 17899,
"hgvs_c": "c.130A>T",
"hgvs_p": "p.Met44Leu",
"transcript": "NM_001377356.1",
"protein_id": "NP_001364285.1",
"transcript_support_level": null,
"aa_start": 44,
"aa_end": null,
"aa_length": 192,
"cds_start": 130,
"cds_end": null,
"cds_length": 579,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001377356.1"
},
{
"aa_ref": "M",
"aa_alt": "L",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 5,
"exon_rank_end": null,
"exon_count": 6,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "NKIRAS1",
"gene_hgnc_id": 17899,
"hgvs_c": "c.130A>T",
"hgvs_p": "p.Met44Leu",
"transcript": "NM_001377357.1",
"protein_id": "NP_001364286.1",
"transcript_support_level": null,
"aa_start": 44,
"aa_end": null,
"aa_length": 192,
"cds_start": 130,
"cds_end": null,
"cds_length": 579,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001377357.1"
},
{
"aa_ref": "M",
"aa_alt": "L",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 5,
"exon_rank_end": null,
"exon_count": 6,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "NKIRAS1",
"gene_hgnc_id": 17899,
"hgvs_c": "c.130A>T",
"hgvs_p": "p.Met44Leu",
"transcript": "NM_001377358.1",
"protein_id": "NP_001364287.1",
"transcript_support_level": null,
"aa_start": 44,
"aa_end": null,
"aa_length": 192,
"cds_start": 130,
"cds_end": null,
"cds_length": 579,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001377358.1"
},
{
"aa_ref": "M",
"aa_alt": "L",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 6,
"exon_rank_end": null,
"exon_count": 7,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "NKIRAS1",
"gene_hgnc_id": 17899,
"hgvs_c": "c.130A>T",
"hgvs_p": "p.Met44Leu",
"transcript": "NM_001377359.1",
"protein_id": "NP_001364288.1",
"transcript_support_level": null,
"aa_start": 44,
"aa_end": null,
"aa_length": 192,
"cds_start": 130,
"cds_end": null,
"cds_length": 579,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001377359.1"
},
{
"aa_ref": "M",
"aa_alt": "L",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 4,
"exon_rank_end": null,
"exon_count": 5,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "NKIRAS1",
"gene_hgnc_id": 17899,
"hgvs_c": "c.130A>T",
"hgvs_p": "p.Met44Leu",
"transcript": "NM_001377360.1",
"protein_id": "NP_001364289.1",
"transcript_support_level": null,
"aa_start": 44,
"aa_end": null,
"aa_length": 192,
"cds_start": 130,
"cds_end": null,
"cds_length": 579,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001377360.1"
},
{
"aa_ref": "M",
"aa_alt": "L",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 4,
"exon_rank_end": null,
"exon_count": 5,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "NKIRAS1",
"gene_hgnc_id": 17899,
"hgvs_c": "c.130A>T",
"hgvs_p": "p.Met44Leu",
"transcript": "NM_001377361.1",
"protein_id": "NP_001364290.1",
"transcript_support_level": null,
"aa_start": 44,
"aa_end": null,
"aa_length": 192,
"cds_start": 130,
"cds_end": null,
"cds_length": 579,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001377361.1"
},
{
"aa_ref": "M",
"aa_alt": "L",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 4,
"exon_rank_end": null,
"exon_count": 5,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "NKIRAS1",
"gene_hgnc_id": 17899,
"hgvs_c": "c.130A>T",
"hgvs_p": "p.Met44Leu",
"transcript": "NM_001377362.1",
"protein_id": "NP_001364291.1",
"transcript_support_level": null,
"aa_start": 44,
"aa_end": null,
"aa_length": 192,
"cds_start": 130,
"cds_end": null,
"cds_length": 579,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001377362.1"
},
{
"aa_ref": "M",
"aa_alt": "L",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 3,
"exon_rank_end": null,
"exon_count": 4,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "NKIRAS1",
"gene_hgnc_id": 17899,
"hgvs_c": "c.130A>T",
"hgvs_p": "p.Met44Leu",
"transcript": "NM_001377363.1",
"protein_id": "NP_001364292.1",
"transcript_support_level": null,
"aa_start": 44,
"aa_end": null,
"aa_length": 192,
"cds_start": 130,
"cds_end": null,
"cds_length": 579,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001377363.1"
},
{
"aa_ref": "M",
"aa_alt": "L",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 5,
"exon_rank_end": null,
"exon_count": 6,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "NKIRAS1",
"gene_hgnc_id": 17899,
"hgvs_c": "c.130A>T",
"hgvs_p": "p.Met44Leu",
"transcript": "NM_001377364.1",
"protein_id": "NP_001364293.1",
"transcript_support_level": null,
"aa_start": 44,
"aa_end": null,
"aa_length": 192,
"cds_start": 130,
"cds_end": null,
"cds_length": 579,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001377364.1"
},
{
"aa_ref": "M",
"aa_alt": "L",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 4,
"exon_rank_end": null,
"exon_count": 5,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "NKIRAS1",
"gene_hgnc_id": 17899,
"hgvs_c": "c.130A>T",
"hgvs_p": "p.Met44Leu",
"transcript": "NM_001377380.1",
"protein_id": "NP_001364309.1",
"transcript_support_level": null,
"aa_start": 44,
"aa_end": null,
"aa_length": 192,
"cds_start": 130,
"cds_end": null,
"cds_length": 579,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001377380.1"
},
{
"aa_ref": "M",
"aa_alt": "L",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 4,
"exon_rank_end": null,
"exon_count": 5,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "NKIRAS1",
"gene_hgnc_id": 17899,
"hgvs_c": "c.130A>T",
"hgvs_p": "p.Met44Leu",
"transcript": "ENST00000388759.7",
"protein_id": "ENSP00000373411.3",
"transcript_support_level": 3,
"aa_start": 44,
"aa_end": null,
"aa_length": 192,
"cds_start": 130,
"cds_end": null,
"cds_length": 579,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000388759.7"
},
{
"aa_ref": "M",
"aa_alt": "L",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 4,
"exon_rank_end": null,
"exon_count": 5,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "NKIRAS1",
"gene_hgnc_id": 17899,
"hgvs_c": "c.130A>T",
"hgvs_p": "p.Met44Leu",
"transcript": "ENST00000412028.5",
"protein_id": "ENSP00000396063.1",
"transcript_support_level": 5,
"aa_start": 44,
"aa_end": null,
"aa_length": 192,
"cds_start": 130,
"cds_end": null,
"cds_length": 579,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000412028.5"
},
{
"aa_ref": "M",
"aa_alt": "L",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 4,
"exon_rank_end": null,
"exon_count": 5,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "NKIRAS1",
"gene_hgnc_id": 17899,
"hgvs_c": "c.130A>T",
"hgvs_p": "p.Met44Leu",
"transcript": "ENST00000415901.6",
"protein_id": "ENSP00000415225.2",
"transcript_support_level": 5,
"aa_start": 44,
"aa_end": null,
"aa_length": 192,
"cds_start": 130,
"cds_end": null,
"cds_length": 579,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000415901.6"
},
{
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}