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GeneBe API Showcase
This page demonstrates how to use the GeneBe API to query variant information. The API provides programmatic access to genomic annotations and variant data.
API presented here should be used for checking single variants. If you want to check many variants at once, please use other API endpoints that you will find in the documentation.
Documentation & Advanced Usage
• Complete API documentation:docs.genebe.net/docs/api/overview/
• Interactive endpoint tester:api.genebe.net/cloud/gb-api-doc/swagger-ui/
• Python client for pandas:pypi.org/project/genebe/
• Java CLI for VCF files:github.com/pstawinski/genebe-cli
• All tools documented at:docs.genebe.net
API Request Examples for Variant: 3-24118060-G-A (hg38)
Bash / cURL Example
bash
curl "https://api.genebe.net/cloud/api-public/v1/variant?chr=3&pos=24118060&ref=G&alt=A&genome=hg38&allGenes=true"API Response
json
{
"variants": [
{
"chr": "3",
"pos": 24118060,
"ref": "G",
"alt": "A",
"effect": "3_prime_UTR_variant",
"transcript": "NM_001354712.2",
"consequences": [
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"3_prime_UTR_variant"
],
"exon_rank": 11,
"exon_rank_end": null,
"exon_count": 11,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "THRB",
"gene_hgnc_id": 11799,
"hgvs_c": "c.*4824C>T",
"hgvs_p": null,
"transcript": "NM_001354712.2",
"protein_id": "NP_001341641.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 461,
"cds_start": -4,
"cds_end": null,
"cds_length": 1386,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 7576,
"mane_select": "ENST00000646209.2",
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": true,
"protein_coding": true,
"strand": false,
"consequences": [
"3_prime_UTR_variant"
],
"exon_rank": 11,
"exon_rank_end": null,
"exon_count": 11,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "THRB",
"gene_hgnc_id": 11799,
"hgvs_c": "c.*4824C>T",
"hgvs_p": null,
"transcript": "ENST00000646209.2",
"protein_id": "ENSP00000496686.2",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 461,
"cds_start": -4,
"cds_end": null,
"cds_length": 1386,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 7576,
"mane_select": "NM_001354712.2",
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"3_prime_UTR_variant"
],
"exon_rank": 10,
"exon_rank_end": null,
"exon_count": 10,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "THRB",
"gene_hgnc_id": 11799,
"hgvs_c": "c.*4824C>T",
"hgvs_p": null,
"transcript": "NM_000461.5",
"protein_id": "NP_000452.2",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 461,
"cds_start": -4,
"cds_end": null,
"cds_length": 1386,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 7430,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"3_prime_UTR_variant"
],
"exon_rank": 11,
"exon_rank_end": null,
"exon_count": 11,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "THRB",
"gene_hgnc_id": 11799,
"hgvs_c": "c.*4824C>T",
"hgvs_p": null,
"transcript": "NM_001128176.3",
"protein_id": "NP_001121648.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 461,
"cds_start": -4,
"cds_end": null,
"cds_length": 1386,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 7541,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"3_prime_UTR_variant"
],
"exon_rank": 11,
"exon_rank_end": null,
"exon_count": 11,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "THRB",
"gene_hgnc_id": 11799,
"hgvs_c": "c.*4824C>T",
"hgvs_p": null,
"transcript": "NM_001128177.2",
"protein_id": "NP_001121649.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 461,
"cds_start": -4,
"cds_end": null,
"cds_length": 1386,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 7567,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"3_prime_UTR_variant"
],
"exon_rank": 12,
"exon_rank_end": null,
"exon_count": 12,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "THRB",
"gene_hgnc_id": 11799,
"hgvs_c": "c.*4824C>T",
"hgvs_p": null,
"transcript": "NM_001252634.2",
"protein_id": "NP_001239563.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 461,
"cds_start": -4,
"cds_end": null,
"cds_length": 1386,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 7665,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"3_prime_UTR_variant"
],
"exon_rank": 10,
"exon_rank_end": null,
"exon_count": 10,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "THRB",
"gene_hgnc_id": 11799,
"hgvs_c": "c.*4824C>T",
"hgvs_p": null,
"transcript": "NM_001354708.2",
"protein_id": "NP_001341637.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 461,
"cds_start": -4,
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"cdna_start": null,
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"cdna_length": 7807,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"3_prime_UTR_variant"
],
"exon_rank": 11,
"exon_rank_end": null,
"exon_count": 11,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "THRB",
"gene_hgnc_id": 11799,
"hgvs_c": "c.*4824C>T",
"hgvs_p": null,
"transcript": "NM_001354709.2",
"protein_id": "NP_001341638.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 461,
"cds_start": -4,
"cds_end": null,
"cds_length": 1386,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 7344,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"3_prime_UTR_variant"
],
"exon_rank": 11,
"exon_rank_end": null,
"exon_count": 11,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "THRB",
"gene_hgnc_id": 11799,
"hgvs_c": "c.*4824C>T",
"hgvs_p": null,
"transcript": "NM_001354710.2",
"protein_id": "NP_001341639.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 461,
"cds_start": -4,
"cds_end": null,
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"cdna_start": null,
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"cdna_length": 7433,
"mane_select": null,
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"biotype": null,
"feature": null
},
{
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"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"3_prime_UTR_variant"
],
"exon_rank": 10,
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"exon_count": 10,
"intron_rank": null,
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"gene_symbol": "THRB",
"gene_hgnc_id": 11799,
"hgvs_c": "c.*4824C>T",
"hgvs_p": null,
"transcript": "NM_001354711.2",
"protein_id": "NP_001341640.1",
"transcript_support_level": null,
"aa_start": null,
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"aa_length": 461,
"cds_start": -4,
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"cdna_start": null,
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"feature": null
},
{
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"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"3_prime_UTR_variant"
],
"exon_rank": 10,
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"exon_count": 10,
"intron_rank": null,
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"gene_symbol": "THRB",
"gene_hgnc_id": 11799,
"hgvs_c": "c.*4824C>T",
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"transcript": "NM_001354713.2",
"protein_id": "NP_001341642.1",
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},
{
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"strand": false,
"consequences": [
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],
"exon_rank": 10,
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"gene_symbol": "THRB",
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},
{
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],
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"gene_symbol": "THRB",
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"hgvs_c": "c.*4824C>T",
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},
{
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],
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"intron_rank": null,
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"gene_symbol": "THRB",
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},
{
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],
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},
{
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],
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"intron_rank": null,
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"gene_symbol": "THRB",
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},
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],
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"hgvs_c": "c.*4824C>T",
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"transcript": "ENST00000396671.7",
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},
{
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],
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"intron_rank": null,
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"gene_symbol": "THRB",
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"hgvs_c": "c.*4824C>T",
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"transcript": "NM_001354714.2",
"protein_id": "NP_001341643.1",
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},
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],
"exon_rank": 9,
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"intron_rank": null,
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"gene_symbol": "THRB",
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],
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},
{
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],
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},
{
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"consequences": [
"3_prime_UTR_variant"
],
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"gene_symbol": "THRB",
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"hgvs_c": "c.*4824C>T",
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"transcript": "XM_011534050.3",
"protein_id": "XP_011532352.1",
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},
{
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"strand": false,
"consequences": [
"3_prime_UTR_variant"
],
"exon_rank": 12,
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"intron_rank": null,
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"gene_symbol": "THRB",
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"transcript": "XM_024453734.2",
"protein_id": "XP_024309502.1",
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}
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}