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GeneBe API Showcase
This page demonstrates how to use the GeneBe API to query variant information. The API provides programmatic access to genomic annotations and variant data.
API presented here should be used for checking single variants. If you want to check many variants at once, please use other API endpoints that you will find in the documentation.
Documentation & Advanced Usage
• Complete API documentation:docs.genebe.net/docs/api/overview/
• Interactive endpoint tester:api.genebe.net/cloud/gb-api-doc/swagger-ui/
• Python client for pandas:pypi.org/project/genebe/
• Java CLI for VCF files:github.com/pstawinski/genebe-cli
• All tools documented at:docs.genebe.net
API Request Examples for Variant: 3-25525589-G-A (hg38)
Bash / cURL Example
bash
curl "https://api.genebe.net/cloud/api-public/v1/variant?chr=3&pos=25525589&ref=G&alt=A&genome=hg38&allGenes=true"API Response
json
{
"variants": [
{
"chr": "3",
"pos": 25525589,
"ref": "G",
"alt": "A",
"effect": "intron_variant",
"transcript": "ENST00000330688.9",
"consequences": [
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 8,
"intron_rank": 3,
"intron_rank_end": null,
"gene_symbol": "RARB",
"gene_hgnc_id": 9865,
"hgvs_c": "c.448+24266G>A",
"hgvs_p": null,
"transcript": "NM_000965.5",
"protein_id": "NP_000956.2",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 448,
"cds_start": -4,
"cds_end": null,
"cds_length": 1347,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 3132,
"mane_select": "ENST00000330688.9",
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": true,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 8,
"intron_rank": 3,
"intron_rank_end": null,
"gene_symbol": "RARB",
"gene_hgnc_id": 9865,
"hgvs_c": "c.448+24266G>A",
"hgvs_p": null,
"transcript": "ENST00000330688.9",
"protein_id": "ENSP00000332296.4",
"transcript_support_level": 1,
"aa_start": null,
"aa_end": null,
"aa_length": 448,
"cds_start": -4,
"cds_end": null,
"cds_length": 1347,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 3132,
"mane_select": "NM_000965.5",
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 8,
"intron_rank": 3,
"intron_rank_end": null,
"gene_symbol": "RARB",
"gene_hgnc_id": 9865,
"hgvs_c": "c.112+24266G>A",
"hgvs_p": null,
"transcript": "ENST00000437042.7",
"protein_id": "ENSP00000398840.2",
"transcript_support_level": 1,
"aa_start": null,
"aa_end": null,
"aa_length": 336,
"cds_start": -4,
"cds_end": null,
"cds_length": 1011,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 2600,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 8,
"intron_rank": 3,
"intron_rank_end": null,
"gene_symbol": "RARB",
"gene_hgnc_id": 9865,
"hgvs_c": "c.112+24266G>A",
"hgvs_p": null,
"transcript": "ENST00000458646.2",
"protein_id": "ENSP00000391391.1",
"transcript_support_level": 1,
"aa_start": null,
"aa_end": null,
"aa_length": 336,
"cds_start": -4,
"cds_end": null,
"cds_length": 1011,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 2587,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 11,
"intron_rank": 6,
"intron_rank_end": null,
"gene_symbol": "RARB",
"gene_hgnc_id": 9865,
"hgvs_c": "c.469+24266G>A",
"hgvs_p": null,
"transcript": "NM_001290216.3",
"protein_id": "NP_001277145.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 455,
"cds_start": -4,
"cds_end": null,
"cds_length": 1368,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 3177,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 12,
"intron_rank": 7,
"intron_rank_end": null,
"gene_symbol": "RARB",
"gene_hgnc_id": 9865,
"hgvs_c": "c.469+24266G>A",
"hgvs_p": null,
"transcript": "ENST00000383772.9",
"protein_id": "ENSP00000373282.5",
"transcript_support_level": 5,
"aa_start": null,
"aa_end": null,
"aa_length": 455,
"cds_start": -4,
"cds_end": null,
"cds_length": 1368,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 3034,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 12,
"intron_rank": 7,
"intron_rank_end": null,
"gene_symbol": "RARB",
"gene_hgnc_id": 9865,
"hgvs_c": "c.469+24266G>A",
"hgvs_p": null,
"transcript": "ENST00000686715.1",
"protein_id": "ENSP00000510539.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 455,
"cds_start": -4,
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"cdna_start": null,
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"cdna_length": 3135,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 13,
"intron_rank": 8,
"intron_rank_end": null,
"gene_symbol": "RARB",
"gene_hgnc_id": 9865,
"hgvs_c": "c.469+24266G>A",
"hgvs_p": null,
"transcript": "ENST00000687353.1",
"protein_id": "ENSP00000508588.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 455,
"cds_start": -4,
"cds_end": null,
"cds_length": 1368,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 3341,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 12,
"intron_rank": 7,
"intron_rank_end": null,
"gene_symbol": "RARB",
"gene_hgnc_id": 9865,
"hgvs_c": "c.469+24266G>A",
"hgvs_p": null,
"transcript": "ENST00000687676.1",
"protein_id": "ENSP00000510313.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 455,
"cds_start": -4,
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"cds_length": 1368,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 3221,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
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"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
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"exon_count": 11,
"intron_rank": 6,
"intron_rank_end": null,
"gene_symbol": "RARB",
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"hgvs_c": "c.469+24266G>A",
"hgvs_p": null,
"transcript": "ENST00000688892.1",
"protein_id": "ENSP00000510650.1",
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"aa_start": null,
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"cds_start": -4,
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"cdna_start": null,
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"mane_select": null,
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"feature": null
},
{
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"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
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"exon_count": 8,
"intron_rank": 3,
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"gene_symbol": "RARB",
"gene_hgnc_id": 9865,
"hgvs_c": "c.319+24266G>A",
"hgvs_p": null,
"transcript": "NM_001290300.2",
"protein_id": "NP_001277229.1",
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},
{
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],
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"gene_symbol": "RARB",
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},
{
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],
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"gene_symbol": "RARB",
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"hgvs_c": "c.448+24266G>A",
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},
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],
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"gene_symbol": "RARB",
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},
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],
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},
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],
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"gene_symbol": "RARB",
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],
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"gene_symbol": "RARB",
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"hgvs_c": "c.112+24266G>A",
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"transcript": "NM_016152.4",
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},
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],
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"gene_symbol": "RARB",
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"hgvs_c": "c.112+24266G>A",
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"transcript": "ENST00000693261.1",
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],
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"exon_count": 6,
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"gene_symbol": "RARB",
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"hgvs_c": "c.448+24266G>A",
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],
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],
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"gene_symbol": "RARB",
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"hgvs_c": "n.448+24266G>A",
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},
{
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"strand": true,
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],
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"intron_rank": 3,
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"gene_symbol": "RARB",
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"hgvs_c": "n.*284+24266G>A",
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},
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}
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}