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GeneBe API Showcase
This page demonstrates how to use the GeneBe API to query variant information. The API provides programmatic access to genomic annotations and variant data.
API presented here should be used for checking single variants. If you want to check many variants at once, please use other API endpoints that you will find in the documentation.
Documentation & Advanced Usage
• Complete API documentation:docs.genebe.net/docs/api/overview/
• Interactive endpoint tester:api.genebe.net/cloud/gb-api-doc/swagger-ui/
• Python client for pandas:pypi.org/project/genebe/
• Java CLI for VCF files:github.com/pstawinski/genebe-cli
• All tools documented at:docs.genebe.net
API Request Examples for Variant: 3-31533139-C-G (hg38)
Bash / cURL Example
bash
curl "https://api.genebe.net/cloud/api-public/v1/variant?chr=3&pos=31533139&ref=C&alt=G&genome=hg38&allGenes=true"API Response
json
{
"variants": [
{
"chr": "3",
"pos": 31533139,
"ref": "C",
"alt": "G",
"effect": "synonymous_variant",
"transcript": "NM_178862.3",
"consequences": [
{
"aa_ref": "G",
"aa_alt": "G",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 1,
"exon_rank_end": null,
"exon_count": 16,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "STT3B",
"gene_hgnc_id": 30611,
"hgvs_c": "c.141C>G",
"hgvs_p": "p.Gly47Gly",
"transcript": "NM_178862.3",
"protein_id": "NP_849193.1",
"transcript_support_level": null,
"aa_start": 47,
"aa_end": null,
"aa_length": 826,
"cds_start": 141,
"cds_end": null,
"cds_length": 2481,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": "ENST00000295770.4",
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_178862.3"
},
{
"aa_ref": "G",
"aa_alt": "G",
"canonical": true,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 1,
"exon_rank_end": null,
"exon_count": 16,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "STT3B",
"gene_hgnc_id": 30611,
"hgvs_c": "c.141C>G",
"hgvs_p": "p.Gly47Gly",
"transcript": "ENST00000295770.4",
"protein_id": "ENSP00000295770.2",
"transcript_support_level": 1,
"aa_start": 47,
"aa_end": null,
"aa_length": 826,
"cds_start": 141,
"cds_end": null,
"cds_length": 2481,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": "NM_178862.3",
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000295770.4"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": false,
"strand": true,
"consequences": [
"non_coding_transcript_exon_variant"
],
"exon_rank": 1,
"exon_rank_end": null,
"exon_count": 10,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "STT3B",
"gene_hgnc_id": 30611,
"hgvs_c": "n.502C>G",
"hgvs_p": null,
"transcript": "ENST00000453168.5",
"protein_id": null,
"transcript_support_level": 1,
"aa_start": null,
"aa_end": null,
"aa_length": null,
"cds_start": null,
"cds_end": null,
"cds_length": null,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "pseudogene",
"feature": "ENST00000453168.5"
},
{
"aa_ref": "G",
"aa_alt": "G",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 1,
"exon_rank_end": null,
"exon_count": 16,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "STT3B",
"gene_hgnc_id": 30611,
"hgvs_c": "c.141C>G",
"hgvs_p": "p.Gly47Gly",
"transcript": "ENST00000935233.1",
"protein_id": "ENSP00000605292.1",
"transcript_support_level": null,
"aa_start": 47,
"aa_end": null,
"aa_length": 824,
"cds_start": 141,
"cds_end": null,
"cds_length": 2475,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000935233.1"
},
{
"aa_ref": "G",
"aa_alt": "G",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 1,
"exon_rank_end": null,
"exon_count": 15,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "STT3B",
"gene_hgnc_id": 30611,
"hgvs_c": "c.141C>G",
"hgvs_p": "p.Gly47Gly",
"transcript": "ENST00000868023.1",
"protein_id": "ENSP00000538082.1",
"transcript_support_level": null,
"aa_start": 47,
"aa_end": null,
"aa_length": 804,
"cds_start": 141,
"cds_end": null,
"cds_length": 2415,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000868023.1"
},
{
"aa_ref": "G",
"aa_alt": "G",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 1,
"exon_rank_end": null,
"exon_count": 15,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "STT3B",
"gene_hgnc_id": 30611,
"hgvs_c": "c.141C>G",
"hgvs_p": "p.Gly47Gly",
"transcript": "ENST00000935235.1",
"protein_id": "ENSP00000605294.1",
"transcript_support_level": null,
"aa_start": 47,
"aa_end": null,
"aa_length": 793,
"cds_start": 141,
"cds_end": null,
"cds_length": 2382,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000935235.1"
},
{
"aa_ref": "G",
"aa_alt": "G",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 1,
"exon_rank_end": null,
"exon_count": 15,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "STT3B",
"gene_hgnc_id": 30611,
"hgvs_c": "c.141C>G",
"hgvs_p": "p.Gly47Gly",
"transcript": "ENST00000935232.1",
"protein_id": "ENSP00000605291.1",
"transcript_support_level": null,
"aa_start": 47,
"aa_end": null,
"aa_length": 788,
"cds_start": 141,
"cds_end": null,
"cds_length": 2367,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000935232.1"
},
{
"aa_ref": "G",
"aa_alt": "G",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 1,
"exon_rank_end": null,
"exon_count": 15,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "STT3B",
"gene_hgnc_id": 30611,
"hgvs_c": "c.141C>G",
"hgvs_p": "p.Gly47Gly",
"transcript": "ENST00000945188.1",
"protein_id": "ENSP00000615247.1",
"transcript_support_level": null,
"aa_start": 47,
"aa_end": null,
"aa_length": 777,
"cds_start": 141,
"cds_end": null,
"cds_length": 2334,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000945188.1"
},
{
"aa_ref": "G",
"aa_alt": "G",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 1,
"exon_rank_end": null,
"exon_count": 15,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "STT3B",
"gene_hgnc_id": 30611,
"hgvs_c": "c.141C>G",
"hgvs_p": "p.Gly47Gly",
"transcript": "ENST00000945187.1",
"protein_id": "ENSP00000615246.1",
"transcript_support_level": null,
"aa_start": 47,
"aa_end": null,
"aa_length": 774,
"cds_start": 141,
"cds_end": null,
"cds_length": 2325,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000945187.1"
},
{
"aa_ref": "G",
"aa_alt": "G",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 1,
"exon_rank_end": null,
"exon_count": 15,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "STT3B",
"gene_hgnc_id": 30611,
"hgvs_c": "c.141C>G",
"hgvs_p": "p.Gly47Gly",
"transcript": "ENST00000935234.1",
"protein_id": "ENSP00000605293.1",
"transcript_support_level": null,
"aa_start": 47,
"aa_end": null,
"aa_length": 773,
"cds_start": 141,
"cds_end": null,
"cds_length": 2322,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000935234.1"
},
{
"aa_ref": "G",
"aa_alt": "G",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 1,
"exon_rank_end": null,
"exon_count": 14,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "STT3B",
"gene_hgnc_id": 30611,
"hgvs_c": "c.141C>G",
"hgvs_p": "p.Gly47Gly",
"transcript": "ENST00000945185.1",
"protein_id": "ENSP00000615244.1",
"transcript_support_level": null,
"aa_start": 47,
"aa_end": null,
"aa_length": 758,
"cds_start": 141,
"cds_end": null,
"cds_length": 2277,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000945185.1"
},
{
"aa_ref": "G",
"aa_alt": "G",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 1,
"exon_rank_end": null,
"exon_count": 15,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "STT3B",
"gene_hgnc_id": 30611,
"hgvs_c": "c.141C>G",
"hgvs_p": "p.Gly47Gly",
"transcript": "ENST00000868024.1",
"protein_id": "ENSP00000538083.1",
"transcript_support_level": null,
"aa_start": 47,
"aa_end": null,
"aa_length": 755,
"cds_start": 141,
"cds_end": null,
"cds_length": 2268,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000868024.1"
},
{
"aa_ref": "G",
"aa_alt": "G",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 1,
"exon_rank_end": null,
"exon_count": 15,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "STT3B",
"gene_hgnc_id": 30611,
"hgvs_c": "c.141C>G",
"hgvs_p": "p.Gly47Gly",
"transcript": "ENST00000868025.1",
"protein_id": "ENSP00000538084.1",
"transcript_support_level": null,
"aa_start": 47,
"aa_end": null,
"aa_length": 754,
"cds_start": 141,
"cds_end": null,
"cds_length": 2265,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000868025.1"
},
{
"aa_ref": "G",
"aa_alt": "G",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 1,
"exon_rank_end": null,
"exon_count": 14,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "STT3B",
"gene_hgnc_id": 30611,
"hgvs_c": "c.141C>G",
"hgvs_p": "p.Gly47Gly",
"transcript": "ENST00000945186.1",
"protein_id": "ENSP00000615245.1",
"transcript_support_level": null,
"aa_start": 47,
"aa_end": null,
"aa_length": 745,
"cds_start": 141,
"cds_end": null,
"cds_length": 2238,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000945186.1"
},
{
"aa_ref": "G",
"aa_alt": "G",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 1,
"exon_rank_end": null,
"exon_count": 14,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "STT3B",
"gene_hgnc_id": 30611,
"hgvs_c": "c.141C>G",
"hgvs_p": "p.Gly47Gly",
"transcript": "ENST00000945184.1",
"protein_id": "ENSP00000615243.1",
"transcript_support_level": null,
"aa_start": 47,
"aa_end": null,
"aa_length": 733,
"cds_start": 141,
"cds_end": null,
"cds_length": 2202,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000945184.1"
},
{
"aa_ref": "G",
"aa_alt": "G",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 1,
"exon_rank_end": null,
"exon_count": 15,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "STT3B",
"gene_hgnc_id": 30611,
"hgvs_c": "c.141C>G",
"hgvs_p": "p.Gly47Gly",
"transcript": "ENST00000718294.1",
"protein_id": "ENSP00000520727.1",
"transcript_support_level": null,
"aa_start": 47,
"aa_end": null,
"aa_length": 730,
"cds_start": 141,
"cds_end": null,
"cds_length": 2193,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000718294.1"
},
{
"aa_ref": "G",
"aa_alt": "G",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 1,
"exon_rank_end": null,
"exon_count": 10,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "STT3B",
"gene_hgnc_id": 30611,
"hgvs_c": "c.141C>G",
"hgvs_p": "p.Gly47Gly",
"transcript": "XM_011533465.2",
"protein_id": "XP_011531767.1",
"transcript_support_level": null,
"aa_start": 47,
"aa_end": null,
"aa_length": 444,
"cds_start": 141,
"cds_end": null,
"cds_length": 1335,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "XM_011533465.2"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": false,
"strand": true,
"consequences": [
"non_coding_transcript_exon_variant"
],
"exon_rank": 1,
"exon_rank_end": null,
"exon_count": 10,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "STT3B",
"gene_hgnc_id": 30611,
"hgvs_c": "n.168C>G",
"hgvs_p": null,
"transcript": "ENST00000423527.5",
"protein_id": null,
"transcript_support_level": 2,
"aa_start": null,
"aa_end": null,
"aa_length": null,
"cds_start": null,
"cds_end": null,
"cds_length": null,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "pseudogene",
"feature": "ENST00000423527.5"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": false,
"strand": true,
"consequences": [
"upstream_gene_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 1,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ENSG00000288926",
"gene_hgnc_id": null,
"hgvs_c": "n.-206G>C",
"hgvs_p": null,
"transcript": "ENST00000686326.3",
"protein_id": null,
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": null,
"cds_start": null,
"cds_end": null,
"cds_length": null,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "pseudogene",
"feature": "ENST00000686326.3"
}
],
"gene_symbol": "STT3B",
"gene_hgnc_id": 30611,
"dbsnp": "rs367626371",
"frequency_reference_population": 0.0000038584417,
"hom_count_reference_population": 0,
"allele_count_reference_population": 5,
"gnomad_exomes_af": 8.73643e-7,
"gnomad_genomes_af": 0.0000264501,
"gnomad_exomes_ac": 1,
"gnomad_genomes_ac": 4,
"gnomad_exomes_homalt": 0,
"gnomad_genomes_homalt": 0,
"gnomad_mito_homoplasmic": null,
"gnomad_mito_heteroplasmic": null,
"computational_score_selected": -0.4699999988079071,
"computational_prediction_selected": "Benign",
"computational_source_selected": "BayesDel_noAF",
"splice_score_selected": 0,
"splice_prediction_selected": "Benign",
"splice_source_selected": "max_spliceai",
"revel_score": null,
"revel_prediction": null,
"alphamissense_score": null,
"alphamissense_prediction": null,
"bayesdelnoaf_score": -0.47,
"bayesdelnoaf_prediction": "Benign",
"phylop100way_score": 0.934,
"phylop100way_prediction": "Benign",
"spliceai_max_score": 0,
"spliceai_max_prediction": "Benign",
"dbscsnv_ada_score": null,
"dbscsnv_ada_prediction": null,
"apogee2_score": null,
"apogee2_prediction": null,
"mitotip_score": null,
"mitotip_prediction": null,
"acmg_score": -3,
"acmg_classification": "Likely_benign",
"acmg_criteria": "PM2,BP4_Strong,BP7",
"acmg_by_gene": [
{
"score": -3,
"benign_score": 5,
"pathogenic_score": 2,
"criteria": [
"PM2",
"BP4_Strong",
"BP7"
],
"verdict": "Likely_benign",
"transcript": "NM_178862.3",
"gene_symbol": "STT3B",
"hgnc_id": 30611,
"effects": [
"synonymous_variant"
],
"inheritance_mode": "AR,Unknown",
"hgvs_c": "c.141C>G",
"hgvs_p": "p.Gly47Gly"
},
{
"score": -2,
"benign_score": 4,
"pathogenic_score": 2,
"criteria": [
"PM2",
"BP4_Strong"
],
"verdict": "Likely_benign",
"transcript": "ENST00000686326.3",
"gene_symbol": "ENSG00000288926",
"hgnc_id": null,
"effects": [
"upstream_gene_variant"
],
"inheritance_mode": "",
"hgvs_c": "n.-206G>C",
"hgvs_p": null
}
],
"clinvar_disease": "",
"clinvar_classification": "",
"clinvar_review_status": "",
"clinvar_submissions_summary": "",
"phenotype_combined": null,
"pathogenicity_classification_combined": null,
"custom_annotations": null
}
],
"message": null
}