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GeneBe API Showcase

This page demonstrates how to use the GeneBe API to query variant information. The API provides programmatic access to genomic annotations and variant data.

API presented here should be used for checking single variants. If you want to check many variants at once, please use other API endpoints that you will find in the documentation.

Documentation & Advanced Usage

Complete API documentation:docs.genebe.net/docs/api/overview/

Interactive endpoint tester:api.genebe.net/cloud/gb-api-doc/swagger-ui/

Python client for pandas:pypi.org/project/genebe/

Java CLI for VCF files:github.com/pstawinski/genebe-cli

All tools documented at:docs.genebe.net

API Request Examples for Variant: 3-39143660-C-T (hg38)

Bash / cURL Example

bash
curl "https://api.genebe.net/cloud/api-public/v1/variant?chr=3&pos=39143660&ref=C&alt=T&genome=hg38&allGenes=true"

API Response

json
{
  "variants": [
    {
      "chr": "3",
      "pos": 39143660,
      "ref": "C",
      "alt": "T",
      "effect": "missense_variant",
      "transcript": "NM_001320559.2",
      "consequences": [
        {
          "aa_ref": "D",
          "aa_alt": "N",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 5,
          "exon_rank_end": null,
          "exon_count": 5,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "CSRNP1",
          "gene_hgnc_id": 14300,
          "hgvs_c": "c.1165G>A",
          "hgvs_p": "p.Asp389Asn",
          "transcript": "NM_033027.4",
          "protein_id": "NP_149016.2",
          "transcript_support_level": null,
          "aa_start": 389,
          "aa_end": null,
          "aa_length": 589,
          "cds_start": 1165,
          "cds_end": null,
          "cds_length": 1770,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": "ENST00000273153.10",
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "NM_033027.4"
        },
        {
          "aa_ref": "D",
          "aa_alt": "N",
          "canonical": true,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 5,
          "exon_rank_end": null,
          "exon_count": 5,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "CSRNP1",
          "gene_hgnc_id": 14300,
          "hgvs_c": "c.1165G>A",
          "hgvs_p": "p.Asp389Asn",
          "transcript": "ENST00000273153.10",
          "protein_id": "ENSP00000273153.5",
          "transcript_support_level": 1,
          "aa_start": 389,
          "aa_end": null,
          "aa_length": 589,
          "cds_start": 1165,
          "cds_end": null,
          "cds_length": 1770,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": "NM_033027.4",
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000273153.10"
        },
        {
          "aa_ref": "D",
          "aa_alt": "N",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 5,
          "exon_rank_end": null,
          "exon_count": 5,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "CSRNP1",
          "gene_hgnc_id": 14300,
          "hgvs_c": "c.1165G>A",
          "hgvs_p": "p.Asp389Asn",
          "transcript": "ENST00000514182.1",
          "protein_id": "ENSP00000422532.1",
          "transcript_support_level": 1,
          "aa_start": 389,
          "aa_end": null,
          "aa_length": 589,
          "cds_start": 1165,
          "cds_end": null,
          "cds_length": 1770,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000514182.1"
        },
        {
          "aa_ref": "D",
          "aa_alt": "N",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 5,
          "exon_rank_end": null,
          "exon_count": 5,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "CSRNP1",
          "gene_hgnc_id": 14300,
          "hgvs_c": "c.1225G>A",
          "hgvs_p": "p.Asp409Asn",
          "transcript": "NM_001320559.2",
          "protein_id": "NP_001307488.1",
          "transcript_support_level": null,
          "aa_start": 409,
          "aa_end": null,
          "aa_length": 609,
          "cds_start": 1225,
          "cds_end": null,
          "cds_length": 1830,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "NM_001320559.2"
        },
        {
          "aa_ref": "D",
          "aa_alt": "N",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 5,
          "exon_rank_end": null,
          "exon_count": 5,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "CSRNP1",
          "gene_hgnc_id": 14300,
          "hgvs_c": "c.1165G>A",
          "hgvs_p": "p.Asp389Asn",
          "transcript": "NM_001320560.2",
          "protein_id": "NP_001307489.1",
          "transcript_support_level": null,
          "aa_start": 389,
          "aa_end": null,
          "aa_length": 589,
          "cds_start": 1165,
          "cds_end": null,
          "cds_length": 1770,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "NM_001320560.2"
        },
        {
          "aa_ref": "D",
          "aa_alt": "N",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 5,
          "exon_rank_end": null,
          "exon_count": 5,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "CSRNP1",
          "gene_hgnc_id": 14300,
          "hgvs_c": "c.1165G>A",
          "hgvs_p": "p.Asp389Asn",
          "transcript": "ENST00000909282.1",
          "protein_id": "ENSP00000579341.1",
          "transcript_support_level": null,
          "aa_start": 389,
          "aa_end": null,
          "aa_length": 589,
          "cds_start": 1165,
          "cds_end": null,
          "cds_length": 1770,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000909282.1"
        },
        {
          "aa_ref": "D",
          "aa_alt": "N",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 5,
          "exon_rank_end": null,
          "exon_count": 5,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "CSRNP1",
          "gene_hgnc_id": 14300,
          "hgvs_c": "c.1165G>A",
          "hgvs_p": "p.Asp389Asn",
          "transcript": "ENST00000909283.1",
          "protein_id": "ENSP00000579342.1",
          "transcript_support_level": null,
          "aa_start": 389,
          "aa_end": null,
          "aa_length": 589,
          "cds_start": 1165,
          "cds_end": null,
          "cds_length": 1770,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000909283.1"
        },
        {
          "aa_ref": "D",
          "aa_alt": "N",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 5,
          "exon_rank_end": null,
          "exon_count": 5,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "CSRNP1",
          "gene_hgnc_id": 14300,
          "hgvs_c": "c.1165G>A",
          "hgvs_p": "p.Asp389Asn",
          "transcript": "ENST00000909284.1",
          "protein_id": "ENSP00000579343.1",
          "transcript_support_level": null,
          "aa_start": 389,
          "aa_end": null,
          "aa_length": 589,
          "cds_start": 1165,
          "cds_end": null,
          "cds_length": 1770,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000909284.1"
        },
        {
          "aa_ref": "D",
          "aa_alt": "N",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 6,
          "exon_rank_end": null,
          "exon_count": 6,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "CSRNP1",
          "gene_hgnc_id": 14300,
          "hgvs_c": "c.1165G>A",
          "hgvs_p": "p.Asp389Asn",
          "transcript": "ENST00000909285.1",
          "protein_id": "ENSP00000579344.1",
          "transcript_support_level": null,
          "aa_start": 389,
          "aa_end": null,
          "aa_length": 589,
          "cds_start": 1165,
          "cds_end": null,
          "cds_length": 1770,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000909285.1"
        },
        {
          "aa_ref": "D",
          "aa_alt": "N",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 5,
          "exon_rank_end": null,
          "exon_count": 5,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "CSRNP1",
          "gene_hgnc_id": 14300,
          "hgvs_c": "c.1165G>A",
          "hgvs_p": "p.Asp389Asn",
          "transcript": "ENST00000909286.1",
          "protein_id": "ENSP00000579345.1",
          "transcript_support_level": null,
          "aa_start": 389,
          "aa_end": null,
          "aa_length": 589,
          "cds_start": 1165,
          "cds_end": null,
          "cds_length": 1770,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000909286.1"
        },
        {
          "aa_ref": "D",
          "aa_alt": "N",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 5,
          "exon_rank_end": null,
          "exon_count": 5,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "CSRNP1",
          "gene_hgnc_id": 14300,
          "hgvs_c": "c.1165G>A",
          "hgvs_p": "p.Asp389Asn",
          "transcript": "ENST00000909288.1",
          "protein_id": "ENSP00000579347.1",
          "transcript_support_level": null,
          "aa_start": 389,
          "aa_end": null,
          "aa_length": 589,
          "cds_start": 1165,
          "cds_end": null,
          "cds_length": 1770,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000909288.1"
        },
        {
          "aa_ref": "D",
          "aa_alt": "N",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 5,
          "exon_rank_end": null,
          "exon_count": 5,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "CSRNP1",
          "gene_hgnc_id": 14300,
          "hgvs_c": "c.1165G>A",
          "hgvs_p": "p.Asp389Asn",
          "transcript": "ENST00000909289.1",
          "protein_id": "ENSP00000579348.1",
          "transcript_support_level": null,
          "aa_start": 389,
          "aa_end": null,
          "aa_length": 589,
          "cds_start": 1165,
          "cds_end": null,
          "cds_length": 1770,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000909289.1"
        },
        {
          "aa_ref": "D",
          "aa_alt": "N",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 5,
          "exon_rank_end": null,
          "exon_count": 5,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "CSRNP1",
          "gene_hgnc_id": 14300,
          "hgvs_c": "c.1165G>A",
          "hgvs_p": "p.Asp389Asn",
          "transcript": "ENST00000909290.1",
          "protein_id": "ENSP00000579349.1",
          "transcript_support_level": null,
          "aa_start": 389,
          "aa_end": null,
          "aa_length": 589,
          "cds_start": 1165,
          "cds_end": null,
          "cds_length": 1770,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000909290.1"
        },
        {
          "aa_ref": "D",
          "aa_alt": "N",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 5,
          "exon_rank_end": null,
          "exon_count": 5,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "CSRNP1",
          "gene_hgnc_id": 14300,
          "hgvs_c": "c.1165G>A",
          "hgvs_p": "p.Asp389Asn",
          "transcript": "ENST00000938863.1",
          "protein_id": "ENSP00000608922.1",
          "transcript_support_level": null,
          "aa_start": 389,
          "aa_end": null,
          "aa_length": 589,
          "cds_start": 1165,
          "cds_end": null,
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          "cdna_start": null,
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          "cdna_length": null,
          "mane_select": null,
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          "biotype": "protein_coding",
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        },
        {
          "aa_ref": "D",
          "aa_alt": "N",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 5,
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          "exon_count": 5,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "CSRNP1",
          "gene_hgnc_id": 14300,
          "hgvs_c": "c.1165G>A",
          "hgvs_p": "p.Asp389Asn",
          "transcript": "ENST00000958140.1",
          "protein_id": "ENSP00000628199.1",
          "transcript_support_level": null,
          "aa_start": 389,
          "aa_end": null,
          "aa_length": 589,
          "cds_start": 1165,
          "cds_end": null,
          "cds_length": 1770,
          "cdna_start": null,
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          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000958140.1"
        },
        {
          "aa_ref": "D",
          "aa_alt": "N",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 6,
          "exon_rank_end": null,
          "exon_count": 6,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "CSRNP1",
          "gene_hgnc_id": 14300,
          "hgvs_c": "c.1165G>A",
          "hgvs_p": "p.Asp389Asn",
          "transcript": "ENST00000958141.1",
          "protein_id": "ENSP00000628200.1",
          "transcript_support_level": null,
          "aa_start": 389,
          "aa_end": null,
          "aa_length": 589,
          "cds_start": 1165,
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          "cdna_start": null,
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          "cdna_length": null,
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          "biotype": "protein_coding",
          "feature": "ENST00000958141.1"
        },
        {
          "aa_ref": "D",
          "aa_alt": "N",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 5,
          "exon_rank_end": null,
          "exon_count": 5,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "CSRNP1",
          "gene_hgnc_id": 14300,
          "hgvs_c": "c.1165G>A",
          "hgvs_p": "p.Asp389Asn",
          "transcript": "ENST00000958142.1",
          "protein_id": "ENSP00000628201.1",
          "transcript_support_level": null,
          "aa_start": 389,
          "aa_end": null,
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          "cdna_start": null,
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          "biotype": "protein_coding",
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        },
        {
          "aa_ref": "D",
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          "consequences": [
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          ],
          "exon_rank": 5,
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          "intron_rank": null,
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          "gene_symbol": "CSRNP1",
          "gene_hgnc_id": 14300,
          "hgvs_c": "c.1165G>A",
          "hgvs_p": "p.Asp389Asn",
          "transcript": "ENST00000958143.1",
          "protein_id": "ENSP00000628202.1",
          "transcript_support_level": null,
          "aa_start": 389,
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          "cds_start": 1165,
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          "cdna_start": null,
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          "cdna_length": null,
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          "biotype": "protein_coding",
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        },
        {
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          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
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          ],
          "exon_rank": 4,
          "exon_rank_end": null,
          "exon_count": 4,
          "intron_rank": null,
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          "gene_symbol": "CSRNP1",
          "gene_hgnc_id": 14300,
          "hgvs_c": "c.850G>A",
          "hgvs_p": "p.Asp284Asn",
          "transcript": "ENST00000909287.1",
          "protein_id": "ENSP00000579346.1",
          "transcript_support_level": null,
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          "cds_start": 850,
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          "cdna_start": null,
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          "cdna_length": null,
          "mane_select": null,
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          "biotype": "protein_coding",
          "feature": "ENST00000909287.1"
        },
        {
          "aa_ref": "D",
          "aa_alt": "N",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 4,
          "exon_rank_end": null,
          "exon_count": 4,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "CSRNP1",
          "gene_hgnc_id": 14300,
          "hgvs_c": "c.850G>A",
          "hgvs_p": "p.Asp284Asn",
          "transcript": "ENST00000938864.1",
          "protein_id": "ENSP00000608923.1",
          "transcript_support_level": null,
          "aa_start": 284,
          "aa_end": null,
          "aa_length": 484,
          "cds_start": 850,
          "cds_end": null,
          "cds_length": 1455,
          "cdna_start": null,
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          "mane_select": null,
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          "biotype": "protein_coding",
          "feature": "ENST00000938864.1"
        },
        {
          "aa_ref": "D",
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          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
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          ],
          "exon_rank": 4,
          "exon_rank_end": null,
          "exon_count": 4,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "CSRNP1",
          "gene_hgnc_id": 14300,
          "hgvs_c": "c.850G>A",
          "hgvs_p": "p.Asp284Asn",
          "transcript": "ENST00000938865.1",
          "protein_id": "ENSP00000608924.1",
          "transcript_support_level": null,
          "aa_start": 284,
          "aa_end": null,
          "aa_length": 484,
          "cds_start": 850,
          "cds_end": null,
          "cds_length": 1455,
          "cdna_start": null,
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          "cdna_length": null,
          "mane_select": null,
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          "biotype": "protein_coding",
          "feature": "ENST00000938865.1"
        },
        {
          "aa_ref": "D",
          "aa_alt": "N",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 5,
          "exon_rank_end": null,
          "exon_count": 5,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "CSRNP1",
          "gene_hgnc_id": 14300,
          "hgvs_c": "c.1318G>A",
          "hgvs_p": "p.Asp440Asn",
          "transcript": "XM_047448721.1",
          "protein_id": "XP_047304677.1",
          "transcript_support_level": null,
          "aa_start": 440,
          "aa_end": null,
          "aa_length": 640,
          "cds_start": 1318,
          "cds_end": null,
          "cds_length": 1923,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "XM_047448721.1"
        },
        {
          "aa_ref": "D",
          "aa_alt": "N",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 5,
          "exon_rank_end": null,
          "exon_count": 5,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "CSRNP1",
          "gene_hgnc_id": 14300,
          "hgvs_c": "c.1165G>A",
          "hgvs_p": "p.Asp389Asn",
          "transcript": "XM_047448723.1",
          "protein_id": "XP_047304679.1",
          "transcript_support_level": null,
          "aa_start": 389,
          "aa_end": null,
          "aa_length": 589,
          "cds_start": 1165,
          "cds_end": null,
          "cds_length": 1770,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "XM_047448723.1"
        },
        {
          "aa_ref": "D",
          "aa_alt": "N",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 5,
          "exon_rank_end": null,
          "exon_count": 5,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "CSRNP1",
          "gene_hgnc_id": 14300,
          "hgvs_c": "c.1165G>A",
          "hgvs_p": "p.Asp389Asn",
          "transcript": "XM_047448724.1",
          "protein_id": "XP_047304680.1",
          "transcript_support_level": null,
          "aa_start": 389,
          "aa_end": null,
          "aa_length": 589,
          "cds_start": 1165,
          "cds_end": null,
          "cds_length": 1770,
          "cdna_start": null,
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          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "XM_047448724.1"
        },
        {
          "aa_ref": "D",
          "aa_alt": "N",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 3,
          "exon_rank_end": null,
          "exon_count": 3,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "CSRNP1",
          "gene_hgnc_id": 14300,
          "hgvs_c": "c.385G>A",
          "hgvs_p": "p.Asp129Asn",
          "transcript": "XM_017007049.2",
          "protein_id": "XP_016862538.1",
          "transcript_support_level": null,
          "aa_start": 129,
          "aa_end": null,
          "aa_length": 329,
          "cds_start": 385,
          "cds_end": null,
          "cds_length": 990,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "XM_017007049.2"
        }
      ],
      "gene_symbol": "CSRNP1",
      "gene_hgnc_id": 14300,
      "dbsnp": "rs141310941",
      "frequency_reference_population": 0.00008302138,
      "hom_count_reference_population": 0,
      "allele_count_reference_population": 134,
      "gnomad_exomes_af": 0.0000848223,
      "gnomad_genomes_af": 0.0000657194,
      "gnomad_exomes_ac": 124,
      "gnomad_genomes_ac": 10,
      "gnomad_exomes_homalt": 0,
      "gnomad_genomes_homalt": 0,
      "gnomad_mito_homoplasmic": null,
      "gnomad_mito_heteroplasmic": null,
      "computational_score_selected": 0.14942818880081177,
      "computational_prediction_selected": "Benign",
      "computational_source_selected": "MetaRNN",
      "splice_score_selected": 0,
      "splice_prediction_selected": "Benign",
      "splice_source_selected": "max_spliceai",
      "revel_score": 0.133,
      "revel_prediction": "Benign",
      "alphamissense_score": 0.0925,
      "alphamissense_prediction": null,
      "bayesdelnoaf_score": -0.6,
      "bayesdelnoaf_prediction": "Benign",
      "phylop100way_score": 2.913,
      "phylop100way_prediction": "Benign",
      "spliceai_max_score": 0,
      "spliceai_max_prediction": "Benign",
      "dbscsnv_ada_score": null,
      "dbscsnv_ada_prediction": null,
      "apogee2_score": null,
      "apogee2_prediction": null,
      "mitotip_score": null,
      "mitotip_prediction": null,
      "acmg_score": 0,
      "acmg_classification": "Uncertain_significance",
      "acmg_criteria": "PM2,BP4_Moderate",
      "acmg_by_gene": [
        {
          "score": 0,
          "benign_score": 2,
          "pathogenic_score": 2,
          "criteria": [
            "PM2",
            "BP4_Moderate"
          ],
          "verdict": "Uncertain_significance",
          "transcript": "NM_001320559.2",
          "gene_symbol": "CSRNP1",
          "hgnc_id": 14300,
          "effects": [
            "missense_variant"
          ],
          "inheritance_mode": "AR",
          "hgvs_c": "c.1225G>A",
          "hgvs_p": "p.Asp409Asn"
        }
      ],
      "clinvar_disease": "not specified",
      "clinvar_classification": "Uncertain significance",
      "clinvar_review_status": "criteria provided, single submitter",
      "clinvar_submissions_summary": "US:1",
      "phenotype_combined": "not specified",
      "pathogenicity_classification_combined": "Uncertain significance",
      "custom_annotations": null
    }
  ],
  "message": null
}