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GeneBe API Showcase
This page demonstrates how to use the GeneBe API to query variant information. The API provides programmatic access to genomic annotations and variant data.
API presented here should be used for checking single variants. If you want to check many variants at once, please use other API endpoints that you will find in the documentation.
Documentation & Advanced Usage
• Complete API documentation:docs.genebe.net/docs/api/overview/
• Interactive endpoint tester:api.genebe.net/cloud/gb-api-doc/swagger-ui/
• Python client for pandas:pypi.org/project/genebe/
• Java CLI for VCF files:github.com/pstawinski/genebe-cli
• All tools documented at:docs.genebe.net
API Request Examples for Variant: 3-42513800-G-T (hg38)
Bash / cURL Example
bash
curl "https://api.genebe.net/cloud/api-public/v1/variant?chr=3&pos=42513800&ref=G&alt=T&genome=hg38&allGenes=true"API Response
json
{
"variants": [
{
"chr": "3",
"pos": 42513800,
"ref": "G",
"alt": "T",
"effect": "stop_gained",
"transcript": "NM_004624.4",
"consequences": [
{
"aa_ref": "E",
"aa_alt": "*",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"stop_gained"
],
"exon_rank": 2,
"exon_rank_end": null,
"exon_count": 13,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "VIPR1",
"gene_hgnc_id": 12694,
"hgvs_c": "c.130G>T",
"hgvs_p": "p.Glu44*",
"transcript": "NM_004624.4",
"protein_id": "NP_004615.2",
"transcript_support_level": null,
"aa_start": 44,
"aa_end": null,
"aa_length": 457,
"cds_start": 130,
"cds_end": null,
"cds_length": 1374,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": "ENST00000325123.5",
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_004624.4"
},
{
"aa_ref": "E",
"aa_alt": "*",
"canonical": true,
"protein_coding": true,
"strand": true,
"consequences": [
"stop_gained"
],
"exon_rank": 2,
"exon_rank_end": null,
"exon_count": 13,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "VIPR1",
"gene_hgnc_id": 12694,
"hgvs_c": "c.130G>T",
"hgvs_p": "p.Glu44*",
"transcript": "ENST00000325123.5",
"protein_id": "ENSP00000327246.4",
"transcript_support_level": 1,
"aa_start": 44,
"aa_end": null,
"aa_length": 457,
"cds_start": 130,
"cds_end": null,
"cds_length": 1374,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": "NM_004624.4",
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000325123.5"
},
{
"aa_ref": "E",
"aa_alt": "*",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"stop_gained"
],
"exon_rank": 2,
"exon_rank_end": null,
"exon_count": 13,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "VIPR1",
"gene_hgnc_id": 12694,
"hgvs_c": "c.130G>T",
"hgvs_p": "p.Glu44*",
"transcript": "ENST00000883021.1",
"protein_id": "ENSP00000553080.1",
"transcript_support_level": null,
"aa_start": 44,
"aa_end": null,
"aa_length": 467,
"cds_start": 130,
"cds_end": null,
"cds_length": 1404,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000883021.1"
},
{
"aa_ref": "E",
"aa_alt": "*",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"stop_gained"
],
"exon_rank": 2,
"exon_rank_end": null,
"exon_count": 13,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "VIPR1",
"gene_hgnc_id": 12694,
"hgvs_c": "c.130G>T",
"hgvs_p": "p.Glu44*",
"transcript": "ENST00000883016.1",
"protein_id": "ENSP00000553075.1",
"transcript_support_level": null,
"aa_start": 44,
"aa_end": null,
"aa_length": 456,
"cds_start": 130,
"cds_end": null,
"cds_length": 1371,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000883016.1"
},
{
"aa_ref": "E",
"aa_alt": "*",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"stop_gained"
],
"exon_rank": 2,
"exon_rank_end": null,
"exon_count": 13,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "VIPR1",
"gene_hgnc_id": 12694,
"hgvs_c": "c.130G>T",
"hgvs_p": "p.Glu44*",
"transcript": "ENST00000883017.1",
"protein_id": "ENSP00000553076.1",
"transcript_support_level": null,
"aa_start": 44,
"aa_end": null,
"aa_length": 456,
"cds_start": 130,
"cds_end": null,
"cds_length": 1371,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000883017.1"
},
{
"aa_ref": "E",
"aa_alt": "*",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"stop_gained"
],
"exon_rank": 2,
"exon_rank_end": null,
"exon_count": 13,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "VIPR1",
"gene_hgnc_id": 12694,
"hgvs_c": "c.130G>T",
"hgvs_p": "p.Glu44*",
"transcript": "ENST00000883018.1",
"protein_id": "ENSP00000553077.1",
"transcript_support_level": null,
"aa_start": 44,
"aa_end": null,
"aa_length": 455,
"cds_start": 130,
"cds_end": null,
"cds_length": 1368,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000883018.1"
},
{
"aa_ref": "E",
"aa_alt": "*",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"stop_gained"
],
"exon_rank": 2,
"exon_rank_end": null,
"exon_count": 13,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "VIPR1",
"gene_hgnc_id": 12694,
"hgvs_c": "c.130G>T",
"hgvs_p": "p.Glu44*",
"transcript": "ENST00000883020.1",
"protein_id": "ENSP00000553079.1",
"transcript_support_level": null,
"aa_start": 44,
"aa_end": null,
"aa_length": 455,
"cds_start": 130,
"cds_end": null,
"cds_length": 1368,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000883020.1"
},
{
"aa_ref": "E",
"aa_alt": "*",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"stop_gained"
],
"exon_rank": 2,
"exon_rank_end": null,
"exon_count": 13,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "VIPR1",
"gene_hgnc_id": 12694,
"hgvs_c": "c.130G>T",
"hgvs_p": "p.Glu44*",
"transcript": "ENST00000883025.1",
"protein_id": "ENSP00000553084.1",
"transcript_support_level": null,
"aa_start": 44,
"aa_end": null,
"aa_length": 455,
"cds_start": 130,
"cds_end": null,
"cds_length": 1368,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000883025.1"
},
{
"aa_ref": "E",
"aa_alt": "*",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"stop_gained"
],
"exon_rank": 2,
"exon_rank_end": null,
"exon_count": 13,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "VIPR1",
"gene_hgnc_id": 12694,
"hgvs_c": "c.130G>T",
"hgvs_p": "p.Glu44*",
"transcript": "ENST00000883022.1",
"protein_id": "ENSP00000553081.1",
"transcript_support_level": null,
"aa_start": 44,
"aa_end": null,
"aa_length": 454,
"cds_start": 130,
"cds_end": null,
"cds_length": 1365,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000883022.1"
},
{
"aa_ref": "E",
"aa_alt": "*",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"stop_gained"
],
"exon_rank": 2,
"exon_rank_end": null,
"exon_count": 12,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "VIPR1",
"gene_hgnc_id": 12694,
"hgvs_c": "c.130G>T",
"hgvs_p": "p.Glu44*",
"transcript": "ENST00000883023.1",
"protein_id": "ENSP00000553082.1",
"transcript_support_level": null,
"aa_start": 44,
"aa_end": null,
"aa_length": 443,
"cds_start": 130,
"cds_end": null,
"cds_length": 1332,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000883023.1"
},
{
"aa_ref": "E",
"aa_alt": "*",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"stop_gained"
],
"exon_rank": 2,
"exon_rank_end": null,
"exon_count": 13,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "VIPR1",
"gene_hgnc_id": 12694,
"hgvs_c": "c.130G>T",
"hgvs_p": "p.Glu44*",
"transcript": "ENST00000883024.1",
"protein_id": "ENSP00000553083.1",
"transcript_support_level": null,
"aa_start": 44,
"aa_end": null,
"aa_length": 442,
"cds_start": 130,
"cds_end": null,
"cds_length": 1329,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000883024.1"
},
{
"aa_ref": "E",
"aa_alt": "*",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"stop_gained"
],
"exon_rank": 2,
"exon_rank_end": null,
"exon_count": 13,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "VIPR1",
"gene_hgnc_id": 12694,
"hgvs_c": "c.130G>T",
"hgvs_p": "p.Glu44*",
"transcript": "ENST00000883027.1",
"protein_id": "ENSP00000553086.1",
"transcript_support_level": null,
"aa_start": 44,
"aa_end": null,
"aa_length": 437,
"cds_start": 130,
"cds_end": null,
"cds_length": 1314,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000883027.1"
},
{
"aa_ref": "E",
"aa_alt": "*",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"stop_gained"
],
"exon_rank": 2,
"exon_rank_end": null,
"exon_count": 13,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "VIPR1",
"gene_hgnc_id": 12694,
"hgvs_c": "c.49G>T",
"hgvs_p": "p.Glu17*",
"transcript": "NM_001251885.2",
"protein_id": "NP_001238814.1",
"transcript_support_level": null,
"aa_start": 17,
"aa_end": null,
"aa_length": 430,
"cds_start": 49,
"cds_end": null,
"cds_length": 1293,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001251885.2"
},
{
"aa_ref": "E",
"aa_alt": "*",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"stop_gained"
],
"exon_rank": 2,
"exon_rank_end": null,
"exon_count": 12,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "VIPR1",
"gene_hgnc_id": 12694,
"hgvs_c": "c.130G>T",
"hgvs_p": "p.Glu44*",
"transcript": "ENST00000883030.1",
"protein_id": "ENSP00000553089.1",
"transcript_support_level": null,
"aa_start": 44,
"aa_end": null,
"aa_length": 430,
"cds_start": 130,
"cds_end": null,
"cds_length": 1293,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000883030.1"
},
{
"aa_ref": "E",
"aa_alt": "*",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"stop_gained"
],
"exon_rank": 2,
"exon_rank_end": null,
"exon_count": 12,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "VIPR1",
"gene_hgnc_id": 12694,
"hgvs_c": "c.130G>T",
"hgvs_p": "p.Glu44*",
"transcript": "ENST00000883029.1",
"protein_id": "ENSP00000553088.1",
"transcript_support_level": null,
"aa_start": 44,
"aa_end": null,
"aa_length": 421,
"cds_start": 130,
"cds_end": null,
"cds_length": 1266,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000883029.1"
},
{
"aa_ref": "E",
"aa_alt": "*",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"stop_gained"
],
"exon_rank": 3,
"exon_rank_end": null,
"exon_count": 14,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "VIPR1",
"gene_hgnc_id": 12694,
"hgvs_c": "c.7G>T",
"hgvs_p": "p.Glu3*",
"transcript": "NM_001251882.2",
"protein_id": "NP_001238811.1",
"transcript_support_level": null,
"aa_start": 3,
"aa_end": null,
"aa_length": 416,
"cds_start": 7,
"cds_end": null,
"cds_length": 1251,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001251882.2"
},
{
"aa_ref": "E",
"aa_alt": "*",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"stop_gained"
],
"exon_rank": 3,
"exon_rank_end": null,
"exon_count": 14,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "VIPR1",
"gene_hgnc_id": 12694,
"hgvs_c": "c.7G>T",
"hgvs_p": "p.Glu3*",
"transcript": "ENST00000433647.5",
"protein_id": "ENSP00000394950.1",
"transcript_support_level": 2,
"aa_start": 3,
"aa_end": null,
"aa_length": 416,
"cds_start": 7,
"cds_end": null,
"cds_length": 1251,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000433647.5"
},
{
"aa_ref": "E",
"aa_alt": "*",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"stop_gained"
],
"exon_rank": 2,
"exon_rank_end": null,
"exon_count": 12,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "VIPR1",
"gene_hgnc_id": 12694,
"hgvs_c": "c.130G>T",
"hgvs_p": "p.Glu44*",
"transcript": "ENST00000883019.1",
"protein_id": "ENSP00000553078.1",
"transcript_support_level": null,
"aa_start": 44,
"aa_end": null,
"aa_length": 406,
"cds_start": 130,
"cds_end": null,
"cds_length": 1221,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000883019.1"
},
{
"aa_ref": "E",
"aa_alt": "*",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"stop_gained"
],
"exon_rank": 2,
"exon_rank_end": null,
"exon_count": 11,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "VIPR1",
"gene_hgnc_id": 12694,
"hgvs_c": "c.130G>T",
"hgvs_p": "p.Glu44*",
"transcript": "ENST00000883026.1",
"protein_id": "ENSP00000553085.1",
"transcript_support_level": null,
"aa_start": 44,
"aa_end": null,
"aa_length": 383,
"cds_start": 130,
"cds_end": null,
"cds_length": 1152,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000883026.1"
},
{
"aa_ref": "E",
"aa_alt": "*",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"stop_gained"
],
"exon_rank": 2,
"exon_rank_end": null,
"exon_count": 11,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "VIPR1",
"gene_hgnc_id": 12694,
"hgvs_c": "c.130G>T",
"hgvs_p": "p.Glu44*",
"transcript": "ENST00000883028.1",
"protein_id": "ENSP00000553087.1",
"transcript_support_level": null,
"aa_start": 44,
"aa_end": null,
"aa_length": 378,
"cds_start": 130,
"cds_end": null,
"cds_length": 1137,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000883028.1"
},
{
"aa_ref": "E",
"aa_alt": "*",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"stop_gained"
],
"exon_rank": 2,
"exon_rank_end": null,
"exon_count": 10,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "VIPR1",
"gene_hgnc_id": 12694,
"hgvs_c": "c.130G>T",
"hgvs_p": "p.Glu44*",
"transcript": "ENST00000913982.1",
"protein_id": "ENSP00000584041.1",
"transcript_support_level": null,
"aa_start": 44,
"aa_end": null,
"aa_length": 341,
"cds_start": 130,
"cds_end": null,
"cds_length": 1026,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000913982.1"
},
{
"aa_ref": "E",
"aa_alt": "*",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"stop_gained"
],
"exon_rank": 2,
"exon_rank_end": null,
"exon_count": 10,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "VIPR1",
"gene_hgnc_id": 12694,
"hgvs_c": "c.130G>T",
"hgvs_p": "p.Glu44*",
"transcript": "ENST00000954073.1",
"protein_id": "ENSP00000624132.1",
"transcript_support_level": null,
"aa_start": 44,
"aa_end": null,
"aa_length": 340,
"cds_start": 130,
"cds_end": null,
"cds_length": 1023,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000954073.1"
},
{
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}