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GeneBe API Showcase
This page demonstrates how to use the GeneBe API to query variant information. The API provides programmatic access to genomic annotations and variant data.
API presented here should be used for checking single variants. If you want to check many variants at once, please use other API endpoints that you will find in the documentation.
Documentation & Advanced Usage
• Complete API documentation:docs.genebe.net/docs/api/overview/
• Interactive endpoint tester:api.genebe.net/cloud/gb-api-doc/swagger-ui/
• Python client for pandas:pypi.org/project/genebe/
• Java CLI for VCF files:github.com/pstawinski/genebe-cli
• All tools documented at:docs.genebe.net
API Request Examples for Variant: 3-45524062-A-C (hg38)
Bash / cURL Example
bash
curl "https://api.genebe.net/cloud/api-public/v1/variant?chr=3&pos=45524062&ref=A&alt=C&genome=hg38&allGenes=true"API Response
json
{
"variants": [
{
"chr": "3",
"pos": 45524062,
"ref": "A",
"alt": "C",
"effect": "synonymous_variant",
"transcript": "NM_015340.4",
"consequences": [
{
"aa_ref": "V",
"aa_alt": "V",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 20,
"exon_rank_end": null,
"exon_count": 22,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "LARS2",
"gene_hgnc_id": 17095,
"hgvs_c": "c.2358A>C",
"hgvs_p": "p.Val786Val",
"transcript": "NM_015340.4",
"protein_id": "NP_056155.1",
"transcript_support_level": null,
"aa_start": 786,
"aa_end": null,
"aa_length": 903,
"cds_start": 2358,
"cds_end": null,
"cds_length": 2712,
"cdna_start": 2550,
"cdna_end": null,
"cdna_length": 4781,
"mane_select": "ENST00000645846.2",
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_015340.4"
},
{
"aa_ref": "V",
"aa_alt": "V",
"canonical": true,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 20,
"exon_rank_end": null,
"exon_count": 22,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "LARS2",
"gene_hgnc_id": 17095,
"hgvs_c": "c.2358A>C",
"hgvs_p": "p.Val786Val",
"transcript": "ENST00000645846.2",
"protein_id": "ENSP00000495093.1",
"transcript_support_level": null,
"aa_start": 786,
"aa_end": null,
"aa_length": 903,
"cds_start": 2358,
"cds_end": null,
"cds_length": 2712,
"cdna_start": 2550,
"cdna_end": null,
"cdna_length": 4781,
"mane_select": "NM_015340.4",
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000645846.2"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": false,
"strand": true,
"consequences": [
"non_coding_transcript_exon_variant"
],
"exon_rank": 21,
"exon_rank_end": null,
"exon_count": 23,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "LARS2",
"gene_hgnc_id": 17095,
"hgvs_c": "n.*748A>C",
"hgvs_p": null,
"transcript": "ENST00000265537.8",
"protein_id": "ENSP00000265537.4",
"transcript_support_level": 1,
"aa_start": null,
"aa_end": null,
"aa_length": null,
"cds_start": null,
"cds_end": null,
"cds_length": null,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 4169,
"mane_select": null,
"mane_plus": null,
"biotype": "nonsense_mediated_decay",
"feature": "ENST00000265537.8"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": false,
"strand": true,
"consequences": [
"3_prime_UTR_variant"
],
"exon_rank": 21,
"exon_rank_end": null,
"exon_count": 23,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "LARS2",
"gene_hgnc_id": 17095,
"hgvs_c": "n.*748A>C",
"hgvs_p": null,
"transcript": "ENST00000265537.8",
"protein_id": "ENSP00000265537.4",
"transcript_support_level": 1,
"aa_start": null,
"aa_end": null,
"aa_length": null,
"cds_start": null,
"cds_end": null,
"cds_length": null,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 4169,
"mane_select": null,
"mane_plus": null,
"biotype": "nonsense_mediated_decay",
"feature": "ENST00000265537.8"
},
{
"aa_ref": "V",
"aa_alt": "V",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 21,
"exon_rank_end": null,
"exon_count": 23,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "LARS2",
"gene_hgnc_id": 17095,
"hgvs_c": "c.2460A>C",
"hgvs_p": "p.Val820Val",
"transcript": "ENST00000935381.1",
"protein_id": "ENSP00000605440.1",
"transcript_support_level": null,
"aa_start": 820,
"aa_end": null,
"aa_length": 937,
"cds_start": 2460,
"cds_end": null,
"cds_length": 2814,
"cdna_start": 2652,
"cdna_end": null,
"cdna_length": 4313,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000935381.1"
},
{
"aa_ref": "V",
"aa_alt": "V",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 19,
"exon_rank_end": null,
"exon_count": 21,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "LARS2",
"gene_hgnc_id": 17095,
"hgvs_c": "c.2358A>C",
"hgvs_p": "p.Val786Val",
"transcript": "NM_001368263.1",
"protein_id": "NP_001355192.1",
"transcript_support_level": null,
"aa_start": 786,
"aa_end": null,
"aa_length": 903,
"cds_start": 2358,
"cds_end": null,
"cds_length": 2712,
"cdna_start": 2484,
"cdna_end": null,
"cdna_length": 4715,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001368263.1"
},
{
"aa_ref": "V",
"aa_alt": "V",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 20,
"exon_rank_end": null,
"exon_count": 22,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "LARS2",
"gene_hgnc_id": 17095,
"hgvs_c": "c.2358A>C",
"hgvs_p": "p.Val786Val",
"transcript": "ENST00000642274.1",
"protein_id": "ENSP00000495707.1",
"transcript_support_level": null,
"aa_start": 786,
"aa_end": null,
"aa_length": 903,
"cds_start": 2358,
"cds_end": null,
"cds_length": 2712,
"cdna_start": 2716,
"cdna_end": null,
"cdna_length": 4139,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000642274.1"
},
{
"aa_ref": "V",
"aa_alt": "V",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 19,
"exon_rank_end": null,
"exon_count": 21,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "LARS2",
"gene_hgnc_id": 17095,
"hgvs_c": "c.2358A>C",
"hgvs_p": "p.Val786Val",
"transcript": "ENST00000650792.2",
"protein_id": "ENSP00000498867.1",
"transcript_support_level": null,
"aa_start": 786,
"aa_end": null,
"aa_length": 903,
"cds_start": 2358,
"cds_end": null,
"cds_length": 2712,
"cdna_start": 2499,
"cdna_end": null,
"cdna_length": 10049,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000650792.2"
},
{
"aa_ref": "V",
"aa_alt": "V",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 19,
"exon_rank_end": null,
"exon_count": 21,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "LARS2",
"gene_hgnc_id": 17095,
"hgvs_c": "c.2358A>C",
"hgvs_p": "p.Val786Val",
"transcript": "ENST00000872207.1",
"protein_id": "ENSP00000542266.1",
"transcript_support_level": null,
"aa_start": 786,
"aa_end": null,
"aa_length": 903,
"cds_start": 2358,
"cds_end": null,
"cds_length": 2712,
"cdna_start": 2473,
"cdna_end": null,
"cdna_length": 4704,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000872207.1"
},
{
"aa_ref": "V",
"aa_alt": "V",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 21,
"exon_rank_end": null,
"exon_count": 23,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "LARS2",
"gene_hgnc_id": 17095,
"hgvs_c": "c.2358A>C",
"hgvs_p": "p.Val786Val",
"transcript": "ENST00000872209.1",
"protein_id": "ENSP00000542268.1",
"transcript_support_level": null,
"aa_start": 786,
"aa_end": null,
"aa_length": 903,
"cds_start": 2358,
"cds_end": null,
"cds_length": 2712,
"cdna_start": 2674,
"cdna_end": null,
"cdna_length": 4328,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000872209.1"
},
{
"aa_ref": "V",
"aa_alt": "V",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 20,
"exon_rank_end": null,
"exon_count": 22,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "LARS2",
"gene_hgnc_id": 17095,
"hgvs_c": "c.2358A>C",
"hgvs_p": "p.Val786Val",
"transcript": "ENST00000935377.1",
"protein_id": "ENSP00000605436.1",
"transcript_support_level": null,
"aa_start": 786,
"aa_end": null,
"aa_length": 903,
"cds_start": 2358,
"cds_end": null,
"cds_length": 2712,
"cdna_start": 2661,
"cdna_end": null,
"cdna_length": 4886,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000935377.1"
},
{
"aa_ref": "V",
"aa_alt": "V",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 20,
"exon_rank_end": null,
"exon_count": 22,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "LARS2",
"gene_hgnc_id": 17095,
"hgvs_c": "c.2358A>C",
"hgvs_p": "p.Val786Val",
"transcript": "ENST00000935379.1",
"protein_id": "ENSP00000605438.1",
"transcript_support_level": null,
"aa_start": 786,
"aa_end": null,
"aa_length": 903,
"cds_start": 2358,
"cds_end": null,
"cds_length": 2712,
"cdna_start": 2576,
"cdna_end": null,
"cdna_length": 4237,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000935379.1"
},
{
"aa_ref": "V",
"aa_alt": "V",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 20,
"exon_rank_end": null,
"exon_count": 22,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "LARS2",
"gene_hgnc_id": 17095,
"hgvs_c": "c.2358A>C",
"hgvs_p": "p.Val786Val",
"transcript": "ENST00000935382.1",
"protein_id": "ENSP00000605441.1",
"transcript_support_level": null,
"aa_start": 786,
"aa_end": null,
"aa_length": 903,
"cds_start": 2358,
"cds_end": null,
"cds_length": 2712,
"cdna_start": 2530,
"cdna_end": null,
"cdna_length": 4190,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000935382.1"
},
{
"aa_ref": "V",
"aa_alt": "V",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 21,
"exon_rank_end": null,
"exon_count": 23,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "LARS2",
"gene_hgnc_id": 17095,
"hgvs_c": "c.2358A>C",
"hgvs_p": "p.Val786Val",
"transcript": "ENST00000935384.1",
"protein_id": "ENSP00000605443.1",
"transcript_support_level": null,
"aa_start": 786,
"aa_end": null,
"aa_length": 903,
"cds_start": 2358,
"cds_end": null,
"cds_length": 2712,
"cdna_start": 2601,
"cdna_end": null,
"cdna_length": 4262,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000935384.1"
},
{
"aa_ref": "V",
"aa_alt": "V",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 21,
"exon_rank_end": null,
"exon_count": 23,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "LARS2",
"gene_hgnc_id": 17095,
"hgvs_c": "c.2358A>C",
"hgvs_p": "p.Val786Val",
"transcript": "ENST00000953712.1",
"protein_id": "ENSP00000623771.1",
"transcript_support_level": null,
"aa_start": 786,
"aa_end": null,
"aa_length": 903,
"cds_start": 2358,
"cds_end": null,
"cds_length": 2712,
"cdna_start": 2664,
"cdna_end": null,
"cdna_length": 4321,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000953712.1"
},
{
"aa_ref": "V",
"aa_alt": "V",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 21,
"exon_rank_end": null,
"exon_count": 23,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "LARS2",
"gene_hgnc_id": 17095,
"hgvs_c": "c.2358A>C",
"hgvs_p": "p.Val786Val",
"transcript": "ENST00000953713.1",
"protein_id": "ENSP00000623772.1",
"transcript_support_level": null,
"aa_start": 786,
"aa_end": null,
"aa_length": 903,
"cds_start": 2358,
"cds_end": null,
"cds_length": 2712,
"cdna_start": 2654,
"cdna_end": null,
"cdna_length": 4310,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000953713.1"
},
{
"aa_ref": "V",
"aa_alt": "V",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 20,
"exon_rank_end": null,
"exon_count": 22,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "LARS2",
"gene_hgnc_id": 17095,
"hgvs_c": "c.2307A>C",
"hgvs_p": "p.Val769Val",
"transcript": "ENST00000953714.1",
"protein_id": "ENSP00000623773.1",
"transcript_support_level": null,
"aa_start": 769,
"aa_end": null,
"aa_length": 886,
"cds_start": 2307,
"cds_end": null,
"cds_length": 2661,
"cdna_start": 2495,
"cdna_end": null,
"cdna_length": 4153,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000953714.1"
},
{
"aa_ref": "V",
"aa_alt": "V",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 19,
"exon_rank_end": null,
"exon_count": 21,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "LARS2",
"gene_hgnc_id": 17095,
"hgvs_c": "c.2280A>C",
"hgvs_p": "p.Val760Val",
"transcript": "ENST00000872206.1",
"protein_id": "ENSP00000542265.1",
"transcript_support_level": null,
"aa_start": 760,
"aa_end": null,
"aa_length": 877,
"cds_start": 2280,
"cds_end": null,
"cds_length": 2634,
"cdna_start": 2500,
"cdna_end": null,
"cdna_length": 4749,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000872206.1"
},
{
"aa_ref": "V",
"aa_alt": "V",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 18,
"exon_rank_end": null,
"exon_count": 20,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "LARS2",
"gene_hgnc_id": 17095,
"hgvs_c": "c.2280A>C",
"hgvs_p": "p.Val760Val",
"transcript": "ENST00000872212.1",
"protein_id": "ENSP00000542271.1",
"transcript_support_level": null,
"aa_start": 760,
"aa_end": null,
"aa_length": 877,
"cds_start": 2280,
"cds_end": null,
"cds_length": 2634,
"cdna_start": 2403,
"cdna_end": null,
"cdna_length": 4064,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000872212.1"
},
{
"aa_ref": "V",
"aa_alt": "V",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 19,
"exon_rank_end": null,
"exon_count": 21,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "LARS2",
"gene_hgnc_id": 17095,
"hgvs_c": "c.2268A>C",
"hgvs_p": "p.Val756Val",
"transcript": "ENST00000872211.1",
"protein_id": "ENSP00000542270.1",
"transcript_support_level": null,
"aa_start": 756,
"aa_end": null,
"aa_length": 873,
"cds_start": 2268,
"cds_end": null,
"cds_length": 2622,
"cdna_start": 2460,
"cdna_end": null,
"cdna_length": 4121,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000872211.1"
},
{
"aa_ref": "V",
"aa_alt": "V",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 18,
"exon_rank_end": null,
"exon_count": 20,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "LARS2",
"gene_hgnc_id": 17095,
"hgvs_c": "c.2268A>C",
"hgvs_p": "p.Val756Val",
"transcript": "ENST00000935378.1",
"protein_id": "ENSP00000605437.1",
"transcript_support_level": null,
"aa_start": 756,
"aa_end": null,
"aa_length": 873,
"cds_start": 2268,
"cds_end": null,
"cds_length": 2622,
"cdna_start": 2443,
"cdna_end": null,
"cdna_length": 4099,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000935378.1"
},
{
"aa_ref": "V",
"aa_alt": "V",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 19,
"exon_rank_end": null,
"exon_count": 21,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "LARS2",
"gene_hgnc_id": 17095,
"hgvs_c": "c.2250A>C",
"hgvs_p": "p.Val750Val",
"transcript": "ENST00000872210.1",
"protein_id": "ENSP00000542269.1",
"transcript_support_level": null,
"aa_start": 750,
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