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GeneBe API Showcase
This page demonstrates how to use the GeneBe API to query variant information. The API provides programmatic access to genomic annotations and variant data.
API presented here should be used for checking single variants. If you want to check many variants at once, please use other API endpoints that you will find in the documentation.
Documentation & Advanced Usage
• Complete API documentation:docs.genebe.net/docs/api/overview/
• Interactive endpoint tester:api.genebe.net/cloud/gb-api-doc/swagger-ui/
• Python client for pandas:pypi.org/project/genebe/
• Java CLI for VCF files:github.com/pstawinski/genebe-cli
• All tools documented at:docs.genebe.net
API Request Examples for Variant: 3-47588231-G-A (hg38)
Bash / cURL Example
bash
curl "https://api.genebe.net/cloud/api-public/v1/variant?chr=3&pos=47588231&ref=G&alt=A&genome=hg38&allGenes=true"API Response
json
{
"variants": [
{
"chr": "3",
"pos": 47588231,
"ref": "G",
"alt": "A",
"effect": "missense_variant",
"transcript": "NM_003074.4",
"consequences": [
{
"aa_ref": "P",
"aa_alt": "L",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 28,
"exon_rank_end": null,
"exon_count": 28,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "SMARCC1",
"gene_hgnc_id": 11104,
"hgvs_c": "c.3296C>T",
"hgvs_p": "p.Pro1099Leu",
"transcript": "NM_003074.4",
"protein_id": "NP_003065.3",
"transcript_support_level": null,
"aa_start": 1099,
"aa_end": null,
"aa_length": 1105,
"cds_start": 3296,
"cds_end": null,
"cds_length": 3318,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": "ENST00000254480.10",
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_003074.4"
},
{
"aa_ref": "P",
"aa_alt": "L",
"canonical": true,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 28,
"exon_rank_end": null,
"exon_count": 28,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "SMARCC1",
"gene_hgnc_id": 11104,
"hgvs_c": "c.3296C>T",
"hgvs_p": "p.Pro1099Leu",
"transcript": "ENST00000254480.10",
"protein_id": "ENSP00000254480.5",
"transcript_support_level": 1,
"aa_start": 1099,
"aa_end": null,
"aa_length": 1105,
"cds_start": 3296,
"cds_end": null,
"cds_length": 3318,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": "NM_003074.4",
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000254480.10"
},
{
"aa_ref": "P",
"aa_alt": "L",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 29,
"exon_rank_end": null,
"exon_count": 29,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "SMARCC1",
"gene_hgnc_id": 11104,
"hgvs_c": "c.3428C>T",
"hgvs_p": "p.Pro1143Leu",
"transcript": "ENST00000938791.1",
"protein_id": "ENSP00000608850.1",
"transcript_support_level": null,
"aa_start": 1143,
"aa_end": null,
"aa_length": 1149,
"cds_start": 3428,
"cds_end": null,
"cds_length": 3450,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000938791.1"
},
{
"aa_ref": "P",
"aa_alt": "L",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 29,
"exon_rank_end": null,
"exon_count": 29,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "SMARCC1",
"gene_hgnc_id": 11104,
"hgvs_c": "c.3389C>T",
"hgvs_p": "p.Pro1130Leu",
"transcript": "ENST00000855763.1",
"protein_id": "ENSP00000525822.1",
"transcript_support_level": null,
"aa_start": 1130,
"aa_end": null,
"aa_length": 1136,
"cds_start": 3389,
"cds_end": null,
"cds_length": 3411,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000855763.1"
},
{
"aa_ref": "P",
"aa_alt": "L",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 29,
"exon_rank_end": null,
"exon_count": 29,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "SMARCC1",
"gene_hgnc_id": 11104,
"hgvs_c": "c.3389C>T",
"hgvs_p": "p.Pro1130Leu",
"transcript": "ENST00000938807.1",
"protein_id": "ENSP00000608866.1",
"transcript_support_level": null,
"aa_start": 1130,
"aa_end": null,
"aa_length": 1136,
"cds_start": 3389,
"cds_end": null,
"cds_length": 3411,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000938807.1"
},
{
"aa_ref": "P",
"aa_alt": "L",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 29,
"exon_rank_end": null,
"exon_count": 29,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "SMARCC1",
"gene_hgnc_id": 11104,
"hgvs_c": "c.3386C>T",
"hgvs_p": "p.Pro1129Leu",
"transcript": "ENST00000938787.1",
"protein_id": "ENSP00000608846.1",
"transcript_support_level": null,
"aa_start": 1129,
"aa_end": null,
"aa_length": 1135,
"cds_start": 3386,
"cds_end": null,
"cds_length": 3408,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000938787.1"
},
{
"aa_ref": "P",
"aa_alt": "L",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 28,
"exon_rank_end": null,
"exon_count": 28,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "SMARCC1",
"gene_hgnc_id": 11104,
"hgvs_c": "c.3326C>T",
"hgvs_p": "p.Pro1109Leu",
"transcript": "ENST00000938802.1",
"protein_id": "ENSP00000608861.1",
"transcript_support_level": null,
"aa_start": 1109,
"aa_end": null,
"aa_length": 1115,
"cds_start": 3326,
"cds_end": null,
"cds_length": 3348,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000938802.1"
},
{
"aa_ref": "P",
"aa_alt": "L",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 28,
"exon_rank_end": null,
"exon_count": 28,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "SMARCC1",
"gene_hgnc_id": 11104,
"hgvs_c": "c.3293C>T",
"hgvs_p": "p.Pro1098Leu",
"transcript": "ENST00000855762.1",
"protein_id": "ENSP00000525821.1",
"transcript_support_level": null,
"aa_start": 1098,
"aa_end": null,
"aa_length": 1104,
"cds_start": 3293,
"cds_end": null,
"cds_length": 3315,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000855762.1"
},
{
"aa_ref": "P",
"aa_alt": "L",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 28,
"exon_rank_end": null,
"exon_count": 28,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "SMARCC1",
"gene_hgnc_id": 11104,
"hgvs_c": "c.3293C>T",
"hgvs_p": "p.Pro1098Leu",
"transcript": "ENST00000855764.1",
"protein_id": "ENSP00000525823.1",
"transcript_support_level": null,
"aa_start": 1098,
"aa_end": null,
"aa_length": 1104,
"cds_start": 3293,
"cds_end": null,
"cds_length": 3315,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000855764.1"
},
{
"aa_ref": "P",
"aa_alt": "L",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 28,
"exon_rank_end": null,
"exon_count": 28,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "SMARCC1",
"gene_hgnc_id": 11104,
"hgvs_c": "c.3293C>T",
"hgvs_p": "p.Pro1098Leu",
"transcript": "ENST00000938799.1",
"protein_id": "ENSP00000608858.1",
"transcript_support_level": null,
"aa_start": 1098,
"aa_end": null,
"aa_length": 1104,
"cds_start": 3293,
"cds_end": null,
"cds_length": 3315,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000938799.1"
},
{
"aa_ref": "P",
"aa_alt": "L",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 28,
"exon_rank_end": null,
"exon_count": 28,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "SMARCC1",
"gene_hgnc_id": 11104,
"hgvs_c": "c.3290C>T",
"hgvs_p": "p.Pro1097Leu",
"transcript": "ENST00000938801.1",
"protein_id": "ENSP00000608860.1",
"transcript_support_level": null,
"aa_start": 1097,
"aa_end": null,
"aa_length": 1103,
"cds_start": 3290,
"cds_end": null,
"cds_length": 3312,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000938801.1"
},
{
"aa_ref": "P",
"aa_alt": "L",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 28,
"exon_rank_end": null,
"exon_count": 28,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "SMARCC1",
"gene_hgnc_id": 11104,
"hgvs_c": "c.3290C>T",
"hgvs_p": "p.Pro1097Leu",
"transcript": "ENST00000938805.1",
"protein_id": "ENSP00000608864.1",
"transcript_support_level": null,
"aa_start": 1097,
"aa_end": null,
"aa_length": 1103,
"cds_start": 3290,
"cds_end": null,
"cds_length": 3312,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000938805.1"
},
{
"aa_ref": "P",
"aa_alt": "L",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 28,
"exon_rank_end": null,
"exon_count": 28,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "SMARCC1",
"gene_hgnc_id": 11104,
"hgvs_c": "c.3287C>T",
"hgvs_p": "p.Pro1096Leu",
"transcript": "ENST00000938793.1",
"protein_id": "ENSP00000608852.1",
"transcript_support_level": null,
"aa_start": 1096,
"aa_end": null,
"aa_length": 1102,
"cds_start": 3287,
"cds_end": null,
"cds_length": 3309,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000938793.1"
},
{
"aa_ref": "P",
"aa_alt": "L",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 28,
"exon_rank_end": null,
"exon_count": 28,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "SMARCC1",
"gene_hgnc_id": 11104,
"hgvs_c": "c.3278C>T",
"hgvs_p": "p.Pro1093Leu",
"transcript": "ENST00000938790.1",
"protein_id": "ENSP00000608849.1",
"transcript_support_level": null,
"aa_start": 1093,
"aa_end": null,
"aa_length": 1099,
"cds_start": 3278,
"cds_end": null,
"cds_length": 3300,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000938790.1"
},
{
"aa_ref": "P",
"aa_alt": "L",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 28,
"exon_rank_end": null,
"exon_count": 28,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "SMARCC1",
"gene_hgnc_id": 11104,
"hgvs_c": "c.3269C>T",
"hgvs_p": "p.Pro1090Leu",
"transcript": "ENST00000938789.1",
"protein_id": "ENSP00000608848.1",
"transcript_support_level": null,
"aa_start": 1090,
"aa_end": null,
"aa_length": 1096,
"cds_start": 3269,
"cds_end": null,
"cds_length": 3291,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000938789.1"
},
{
"aa_ref": "P",
"aa_alt": "L",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 27,
"exon_rank_end": null,
"exon_count": 27,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "SMARCC1",
"gene_hgnc_id": 11104,
"hgvs_c": "c.3236C>T",
"hgvs_p": "p.Pro1079Leu",
"transcript": "ENST00000855770.1",
"protein_id": "ENSP00000525829.1",
"transcript_support_level": null,
"aa_start": 1079,
"aa_end": null,
"aa_length": 1085,
"cds_start": 3236,
"cds_end": null,
"cds_length": 3258,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000855770.1"
},
{
"aa_ref": "P",
"aa_alt": "L",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 28,
"exon_rank_end": null,
"exon_count": 28,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "SMARCC1",
"gene_hgnc_id": 11104,
"hgvs_c": "c.3212C>T",
"hgvs_p": "p.Pro1071Leu",
"transcript": "ENST00000938792.1",
"protein_id": "ENSP00000608851.1",
"transcript_support_level": null,
"aa_start": 1071,
"aa_end": null,
"aa_length": 1077,
"cds_start": 3212,
"cds_end": null,
"cds_length": 3234,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000938792.1"
},
{
"aa_ref": "P",
"aa_alt": "L",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 27,
"exon_rank_end": null,
"exon_count": 27,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "SMARCC1",
"gene_hgnc_id": 11104,
"hgvs_c": "c.3182C>T",
"hgvs_p": "p.Pro1061Leu",
"transcript": "ENST00000855765.1",
"protein_id": "ENSP00000525824.1",
"transcript_support_level": null,
"aa_start": 1061,
"aa_end": null,
"aa_length": 1067,
"cds_start": 3182,
"cds_end": null,
"cds_length": 3204,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000855765.1"
},
{
"aa_ref": "P",
"aa_alt": "L",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 27,
"exon_rank_end": null,
"exon_count": 27,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "SMARCC1",
"gene_hgnc_id": 11104,
"hgvs_c": "c.3182C>T",
"hgvs_p": "p.Pro1061Leu",
"transcript": "ENST00000938803.1",
"protein_id": "ENSP00000608862.1",
"transcript_support_level": null,
"aa_start": 1061,
"aa_end": null,
"aa_length": 1067,
"cds_start": 3182,
"cds_end": null,
"cds_length": 3204,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000938803.1"
},
{
"aa_ref": "P",
"aa_alt": "L",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 27,
"exon_rank_end": null,
"exon_count": 27,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "SMARCC1",
"gene_hgnc_id": 11104,
"hgvs_c": "c.3179C>T",
"hgvs_p": "p.Pro1060Leu",
"transcript": "ENST00000938795.1",
"protein_id": "ENSP00000608854.1",
"transcript_support_level": null,
"aa_start": 1060,
"aa_end": null,
"aa_length": 1066,
"cds_start": 3179,
"cds_end": null,
"cds_length": 3201,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000938795.1"
},
{
"aa_ref": "P",
"aa_alt": "L",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 27,
"exon_rank_end": null,
"exon_count": 27,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "SMARCC1",
"gene_hgnc_id": 11104,
"hgvs_c": "c.3176C>T",
"hgvs_p": "p.Pro1059Leu",
"transcript": "ENST00000855767.1",
"protein_id": "ENSP00000525826.1",
"transcript_support_level": null,
"aa_start": 1059,
"aa_end": null,
"aa_length": 1065,
"cds_start": 3176,
"cds_end": null,
"cds_length": 3198,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000855767.1"
},
{
"aa_ref": "P",
"aa_alt": "L",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 27,
"exon_rank_end": null,
"exon_count": 27,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "SMARCC1",
"gene_hgnc_id": 11104,
"hgvs_c": "c.3170C>T",
"hgvs_p": "p.Pro1057Leu",
"transcript": "ENST00000938794.1",
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}