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GeneBe API Showcase

This page demonstrates how to use the GeneBe API to query variant information. The API provides programmatic access to genomic annotations and variant data.

API presented here should be used for checking single variants. If you want to check many variants at once, please use other API endpoints that you will find in the documentation.

Documentation & Advanced Usage

Complete API documentation:docs.genebe.net/docs/api/overview/

Interactive endpoint tester:api.genebe.net/cloud/gb-api-doc/swagger-ui/

Python client for pandas:pypi.org/project/genebe/

Java CLI for VCF files:github.com/pstawinski/genebe-cli

All tools documented at:docs.genebe.net

API Request Examples for Variant: 3-47829056-C-T (hg38)

Bash / cURL Example

bash
curl "https://api.genebe.net/cloud/api-public/v1/variant?chr=3&pos=47829056&ref=C&alt=T&genome=hg38&allGenes=true"

API Response

json
{
  "variants": [
    {
      "chr": "3",
      "pos": 47829056,
      "ref": "C",
      "alt": "T",
      "effect": "synonymous_variant",
      "transcript": "NM_138615.3",
      "consequences": [
        {
          "aa_ref": "S",
          "aa_alt": "S",
          "canonical": false,
          "protein_coding": true,
          "strand": true,
          "consequences": [
            "synonymous_variant"
          ],
          "exon_rank": 6,
          "exon_rank_end": null,
          "exon_count": 22,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "DHX30",
          "gene_hgnc_id": 16716,
          "hgvs_c": "c.288C>T",
          "hgvs_p": "p.Ser96Ser",
          "transcript": "NM_138615.3",
          "protein_id": "NP_619520.1",
          "transcript_support_level": null,
          "aa_start": 96,
          "aa_end": null,
          "aa_length": 1194,
          "cds_start": 288,
          "cds_end": null,
          "cds_length": 3585,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": "ENST00000445061.6",
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "NM_138615.3"
        },
        {
          "aa_ref": "S",
          "aa_alt": "S",
          "canonical": true,
          "protein_coding": true,
          "strand": true,
          "consequences": [
            "synonymous_variant"
          ],
          "exon_rank": 6,
          "exon_rank_end": null,
          "exon_count": 22,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "DHX30",
          "gene_hgnc_id": 16716,
          "hgvs_c": "c.288C>T",
          "hgvs_p": "p.Ser96Ser",
          "transcript": "ENST00000445061.6",
          "protein_id": "ENSP00000405620.1",
          "transcript_support_level": 1,
          "aa_start": 96,
          "aa_end": null,
          "aa_length": 1194,
          "cds_start": 288,
          "cds_end": null,
          "cds_length": 3585,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": "NM_138615.3",
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000445061.6"
        },
        {
          "aa_ref": null,
          "aa_alt": null,
          "canonical": false,
          "protein_coding": false,
          "strand": true,
          "consequences": [
            "non_coding_transcript_exon_variant"
          ],
          "exon_rank": 7,
          "exon_rank_end": null,
          "exon_count": 23,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "DHX30",
          "gene_hgnc_id": 16716,
          "hgvs_c": "n.*188C>T",
          "hgvs_p": null,
          "transcript": "ENST00000395745.6",
          "protein_id": "ENSP00000379094.2",
          "transcript_support_level": 1,
          "aa_start": null,
          "aa_end": null,
          "aa_length": null,
          "cds_start": null,
          "cds_end": null,
          "cds_length": null,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "nonsense_mediated_decay",
          "feature": "ENST00000395745.6"
        },
        {
          "aa_ref": null,
          "aa_alt": null,
          "canonical": false,
          "protein_coding": false,
          "strand": true,
          "consequences": [
            "3_prime_UTR_variant"
          ],
          "exon_rank": 7,
          "exon_rank_end": null,
          "exon_count": 23,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "DHX30",
          "gene_hgnc_id": 16716,
          "hgvs_c": "n.*188C>T",
          "hgvs_p": null,
          "transcript": "ENST00000395745.6",
          "protein_id": "ENSP00000379094.2",
          "transcript_support_level": 1,
          "aa_start": null,
          "aa_end": null,
          "aa_length": null,
          "cds_start": null,
          "cds_end": null,
          "cds_length": null,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "nonsense_mediated_decay",
          "feature": "ENST00000395745.6"
        },
        {
          "aa_ref": "S",
          "aa_alt": "S",
          "canonical": false,
          "protein_coding": true,
          "strand": true,
          "consequences": [
            "synonymous_variant"
          ],
          "exon_rank": 3,
          "exon_rank_end": null,
          "exon_count": 19,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "DHX30",
          "gene_hgnc_id": 16716,
          "hgvs_c": "c.372C>T",
          "hgvs_p": "p.Ser124Ser",
          "transcript": "ENST00000457607.1",
          "protein_id": "ENSP00000394682.1",
          "transcript_support_level": 5,
          "aa_start": 124,
          "aa_end": null,
          "aa_length": 1222,
          "cds_start": 372,
          "cds_end": null,
          "cds_length": 3669,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000457607.1"
        },
        {
          "aa_ref": "S",
          "aa_alt": "S",
          "canonical": false,
          "protein_coding": true,
          "strand": true,
          "consequences": [
            "synonymous_variant"
          ],
          "exon_rank": 6,
          "exon_rank_end": null,
          "exon_count": 22,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "DHX30",
          "gene_hgnc_id": 16716,
          "hgvs_c": "c.288C>T",
          "hgvs_p": "p.Ser96Ser",
          "transcript": "ENST00000954991.1",
          "protein_id": "ENSP00000625050.1",
          "transcript_support_level": null,
          "aa_start": 96,
          "aa_end": null,
          "aa_length": 1212,
          "cds_start": 288,
          "cds_end": null,
          "cds_length": 3639,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000954991.1"
        },
        {
          "aa_ref": "S",
          "aa_alt": "S",
          "canonical": false,
          "protein_coding": true,
          "strand": true,
          "consequences": [
            "synonymous_variant"
          ],
          "exon_rank": 6,
          "exon_rank_end": null,
          "exon_count": 22,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "DHX30",
          "gene_hgnc_id": 16716,
          "hgvs_c": "c.288C>T",
          "hgvs_p": "p.Ser96Ser",
          "transcript": "ENST00000954992.1",
          "protein_id": "ENSP00000625051.1",
          "transcript_support_level": null,
          "aa_start": 96,
          "aa_end": null,
          "aa_length": 1199,
          "cds_start": 288,
          "cds_end": null,
          "cds_length": 3600,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000954992.1"
        },
        {
          "aa_ref": "S",
          "aa_alt": "S",
          "canonical": false,
          "protein_coding": true,
          "strand": true,
          "consequences": [
            "synonymous_variant"
          ],
          "exon_rank": 6,
          "exon_rank_end": null,
          "exon_count": 22,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "DHX30",
          "gene_hgnc_id": 16716,
          "hgvs_c": "c.288C>T",
          "hgvs_p": "p.Ser96Ser",
          "transcript": "ENST00000876607.1",
          "protein_id": "ENSP00000546666.1",
          "transcript_support_level": null,
          "aa_start": 96,
          "aa_end": null,
          "aa_length": 1194,
          "cds_start": 288,
          "cds_end": null,
          "cds_length": 3585,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000876607.1"
        },
        {
          "aa_ref": "S",
          "aa_alt": "S",
          "canonical": false,
          "protein_coding": true,
          "strand": true,
          "consequences": [
            "synonymous_variant"
          ],
          "exon_rank": 5,
          "exon_rank_end": null,
          "exon_count": 21,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "DHX30",
          "gene_hgnc_id": 16716,
          "hgvs_c": "c.288C>T",
          "hgvs_p": "p.Ser96Ser",
          "transcript": "ENST00000876610.1",
          "protein_id": "ENSP00000546669.1",
          "transcript_support_level": null,
          "aa_start": 96,
          "aa_end": null,
          "aa_length": 1194,
          "cds_start": 288,
          "cds_end": null,
          "cds_length": 3585,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000876610.1"
        },
        {
          "aa_ref": "S",
          "aa_alt": "S",
          "canonical": false,
          "protein_coding": true,
          "strand": true,
          "consequences": [
            "synonymous_variant"
          ],
          "exon_rank": 6,
          "exon_rank_end": null,
          "exon_count": 22,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "DHX30",
          "gene_hgnc_id": 16716,
          "hgvs_c": "c.288C>T",
          "hgvs_p": "p.Ser96Ser",
          "transcript": "ENST00000876611.1",
          "protein_id": "ENSP00000546670.1",
          "transcript_support_level": null,
          "aa_start": 96,
          "aa_end": null,
          "aa_length": 1194,
          "cds_start": 288,
          "cds_end": null,
          "cds_length": 3585,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000876611.1"
        },
        {
          "aa_ref": "S",
          "aa_alt": "S",
          "canonical": false,
          "protein_coding": true,
          "strand": true,
          "consequences": [
            "synonymous_variant"
          ],
          "exon_rank": 5,
          "exon_rank_end": null,
          "exon_count": 21,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "DHX30",
          "gene_hgnc_id": 16716,
          "hgvs_c": "c.288C>T",
          "hgvs_p": "p.Ser96Ser",
          "transcript": "ENST00000876614.1",
          "protein_id": "ENSP00000546673.1",
          "transcript_support_level": null,
          "aa_start": 96,
          "aa_end": null,
          "aa_length": 1194,
          "cds_start": 288,
          "cds_end": null,
          "cds_length": 3585,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000876614.1"
        },
        {
          "aa_ref": "S",
          "aa_alt": "S",
          "canonical": false,
          "protein_coding": true,
          "strand": true,
          "consequences": [
            "synonymous_variant"
          ],
          "exon_rank": 6,
          "exon_rank_end": null,
          "exon_count": 22,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "DHX30",
          "gene_hgnc_id": 16716,
          "hgvs_c": "c.288C>T",
          "hgvs_p": "p.Ser96Ser",
          "transcript": "ENST00000876615.1",
          "protein_id": "ENSP00000546674.1",
          "transcript_support_level": null,
          "aa_start": 96,
          "aa_end": null,
          "aa_length": 1194,
          "cds_start": 288,
          "cds_end": null,
          "cds_length": 3585,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000876615.1"
        },
        {
          "aa_ref": "S",
          "aa_alt": "S",
          "canonical": false,
          "protein_coding": true,
          "strand": true,
          "consequences": [
            "synonymous_variant"
          ],
          "exon_rank": 6,
          "exon_rank_end": null,
          "exon_count": 22,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "DHX30",
          "gene_hgnc_id": 16716,
          "hgvs_c": "c.288C>T",
          "hgvs_p": "p.Ser96Ser",
          "transcript": "ENST00000876617.1",
          "protein_id": "ENSP00000546676.1",
          "transcript_support_level": null,
          "aa_start": 96,
          "aa_end": null,
          "aa_length": 1194,
          "cds_start": 288,
          "cds_end": null,
          "cds_length": 3585,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000876617.1"
        },
        {
          "aa_ref": "S",
          "aa_alt": "S",
          "canonical": false,
          "protein_coding": true,
          "strand": true,
          "consequences": [
            "synonymous_variant"
          ],
          "exon_rank": 6,
          "exon_rank_end": null,
          "exon_count": 22,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "DHX30",
          "gene_hgnc_id": 16716,
          "hgvs_c": "c.288C>T",
          "hgvs_p": "p.Ser96Ser",
          "transcript": "ENST00000923019.1",
          "protein_id": "ENSP00000593078.1",
          "transcript_support_level": null,
          "aa_start": 96,
          "aa_end": null,
          "aa_length": 1194,
          "cds_start": 288,
          "cds_end": null,
          "cds_length": 3585,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000923019.1"
        },
        {
          "aa_ref": "S",
          "aa_alt": "S",
          "canonical": false,
          "protein_coding": true,
          "strand": true,
          "consequences": [
            "synonymous_variant"
          ],
          "exon_rank": 5,
          "exon_rank_end": null,
          "exon_count": 21,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "DHX30",
          "gene_hgnc_id": 16716,
          "hgvs_c": "c.288C>T",
          "hgvs_p": "p.Ser96Ser",
          "transcript": "ENST00000954993.1",
          "protein_id": "ENSP00000625052.1",
          "transcript_support_level": null,
          "aa_start": 96,
          "aa_end": null,
          "aa_length": 1194,
          "cds_start": 288,
          "cds_end": null,
          "cds_length": 3585,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000954993.1"
        },
        {
          "aa_ref": "S",
          "aa_alt": "S",
          "canonical": false,
          "protein_coding": true,
          "strand": true,
          "consequences": [
            "synonymous_variant"
          ],
          "exon_rank": 7,
          "exon_rank_end": null,
          "exon_count": 23,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "DHX30",
          "gene_hgnc_id": 16716,
          "hgvs_c": "c.204C>T",
          "hgvs_p": "p.Ser68Ser",
          "transcript": "NM_001330990.2",
          "protein_id": "NP_001317919.1",
          "transcript_support_level": null,
          "aa_start": 68,
          "aa_end": null,
          "aa_length": 1166,
          "cds_start": 204,
          "cds_end": null,
          "cds_length": 3501,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "NM_001330990.2"
        },
        {
          "aa_ref": "S",
          "aa_alt": "S",
          "canonical": false,
          "protein_coding": true,
          "strand": true,
          "consequences": [
            "synonymous_variant"
          ],
          "exon_rank": 7,
          "exon_rank_end": null,
          "exon_count": 23,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "DHX30",
          "gene_hgnc_id": 16716,
          "hgvs_c": "c.204C>T",
          "hgvs_p": "p.Ser68Ser",
          "transcript": "ENST00000348968.8",
          "protein_id": "ENSP00000343442.4",
          "transcript_support_level": 5,
          "aa_start": 68,
          "aa_end": null,
          "aa_length": 1166,
          "cds_start": 204,
          "cds_end": null,
          "cds_length": 3501,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000348968.8"
        },
        {
          "aa_ref": "S",
          "aa_alt": "S",
          "canonical": false,
          "protein_coding": true,
          "strand": true,
          "consequences": [
            "synonymous_variant"
          ],
          "exon_rank": 5,
          "exon_rank_end": null,
          "exon_count": 21,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "DHX30",
          "gene_hgnc_id": 16716,
          "hgvs_c": "c.192C>T",
          "hgvs_p": "p.Ser64Ser",
          "transcript": "ENST00000876608.1",
          "protein_id": "ENSP00000546667.1",
          "transcript_support_level": null,
          "aa_start": 64,
          "aa_end": null,
          "aa_length": 1162,
          "cds_start": 192,
          "cds_end": null,
          "cds_length": 3489,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000876608.1"
        },
        {
          "aa_ref": "S",
          "aa_alt": "S",
          "canonical": false,
          "protein_coding": true,
          "strand": true,
          "consequences": [
            "synonymous_variant"
          ],
          "exon_rank": 5,
          "exon_rank_end": null,
          "exon_count": 21,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "DHX30",
          "gene_hgnc_id": 16716,
          "hgvs_c": "c.192C>T",
          "hgvs_p": "p.Ser64Ser",
          "transcript": "ENST00000923018.1",
          "protein_id": "ENSP00000593077.1",
          "transcript_support_level": null,
          "aa_start": 64,
          "aa_end": null,
          "aa_length": 1162,
          "cds_start": 192,
          "cds_end": null,
          "cds_length": 3489,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000923018.1"
        },
        {
          "aa_ref": "S",
          "aa_alt": "S",
          "canonical": false,
          "protein_coding": true,
          "strand": true,
          "consequences": [
            "synonymous_variant"
          ],
          "exon_rank": 5,
          "exon_rank_end": null,
          "exon_count": 21,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "DHX30",
          "gene_hgnc_id": 16716,
          "hgvs_c": "c.192C>T",
          "hgvs_p": "p.Ser64Ser",
          "transcript": "ENST00000954988.1",
          "protein_id": "ENSP00000625047.1",
          "transcript_support_level": null,
          "aa_start": 64,
          "aa_end": null,
          "aa_length": 1162,
          "cds_start": 192,
          "cds_end": null,
          "cds_length": 3489,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000954988.1"
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      "phylop100way_prediction": "Benign",
      "spliceai_max_score": 0,
      "spliceai_max_prediction": "Benign",
      "dbscsnv_ada_score": null,
      "dbscsnv_ada_prediction": null,
      "apogee2_score": null,
      "apogee2_prediction": null,
      "mitotip_score": null,
      "mitotip_prediction": null,
      "acmg_score": -9,
      "acmg_classification": "Benign",
      "acmg_criteria": "BP4_Moderate,BP6_Moderate,BP7,BS2",
      "acmg_by_gene": [
        {
          "score": -9,
          "benign_score": 9,
          "pathogenic_score": 0,
          "criteria": [
            "BP4_Moderate",
            "BP6_Moderate",
            "BP7",
            "BS2"
          ],
          "verdict": "Benign",
          "transcript": "NM_138615.3",
          "gene_symbol": "DHX30",
          "hgnc_id": 16716,
          "effects": [
            "synonymous_variant"
          ],
          "inheritance_mode": "AD",
          "hgvs_c": "c.288C>T",
          "hgvs_p": "p.Ser96Ser"
        }
      ],
      "clinvar_disease": "not provided",
      "clinvar_classification": "Likely benign",
      "clinvar_review_status": "criteria provided, single submitter",
      "clinvar_submissions_summary": "LB:1",
      "phenotype_combined": "not provided",
      "pathogenicity_classification_combined": "Likely benign",
      "custom_annotations": null
    }
  ],
  "message": null
}