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GeneBe API Showcase

This page demonstrates how to use the GeneBe API to query variant information. The API provides programmatic access to genomic annotations and variant data.

API presented here should be used for checking single variants. If you want to check many variants at once, please use other API endpoints that you will find in the documentation.

Documentation & Advanced Usage

Complete API documentation:docs.genebe.net/docs/api/overview/

Interactive endpoint tester:api.genebe.net/cloud/gb-api-doc/swagger-ui/

Python client for pandas:pypi.org/project/genebe/

Java CLI for VCF files:github.com/pstawinski/genebe-cli

All tools documented at:docs.genebe.net

API Request Examples for Variant: 3-49016066-GAA-ACT (hg38)

Bash / cURL Example

bash
curl "https://api.genebe.net/cloud/api-public/v1/variant?chr=3&pos=49016066&ref=GAA&alt=ACT&genome=hg38&allGenes=true"

API Response

json
{
  "message": null,
  "variants": [
    {
      "acmg_by_gene": [
        {
          "benign_score": 0,
          "criteria": [
            "PP3"
          ],
          "effects": [
            "missense_variant"
          ],
          "gene_symbol": "DALRD3",
          "hgnc_id": 25536,
          "hgvs_c": "c.1348_1350delTTCinsAGT",
          "hgvs_p": "p.Phe450Ser",
          "inheritance_mode": "AR,AD,Unknown",
          "pathogenic_score": 1,
          "score": 1,
          "transcript": "NM_001009996.3",
          "verdict": "Uncertain_significance"
        },
        {
          "benign_score": 0,
          "criteria": [
            "PP3"
          ],
          "effects": [
            "downstream_gene_variant"
          ],
          "gene_symbol": "WDR6",
          "hgnc_id": 12758,
          "hgvs_c": "c.*778_*780delGAAinsACT",
          "hgvs_p": null,
          "inheritance_mode": "AR",
          "pathogenic_score": 1,
          "score": 1,
          "transcript": "NM_018031.6",
          "verdict": "Uncertain_significance"
        }
      ],
      "acmg_classification": "Uncertain_significance",
      "acmg_criteria": "PP3",
      "acmg_score": 1,
      "allele_count_reference_population": 0,
      "alphamissense_prediction": null,
      "alphamissense_score": null,
      "alt": "ACT",
      "apogee2_prediction": null,
      "apogee2_score": null,
      "bayesdelnoaf_prediction": null,
      "bayesdelnoaf_score": null,
      "chr": "3",
      "clinvar_classification": "",
      "clinvar_disease": "",
      "clinvar_review_status": "",
      "clinvar_submissions_summary": "",
      "computational_prediction_selected": null,
      "computational_score_selected": null,
      "computational_source_selected": null,
      "consequences": [
        {
          "aa_alt": "S",
          "aa_end": null,
          "aa_length": 543,
          "aa_ref": "F",
          "aa_start": 450,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 1748,
          "cdna_start": 1366,
          "cds_end": null,
          "cds_length": 1632,
          "cds_start": 1348,
          "consequences": [
            "missense_variant"
          ],
          "exon_count": 12,
          "exon_rank": null,
          "exon_rank_end": null,
          "feature": "NM_001009996.3",
          "gene_hgnc_id": 25536,
          "gene_symbol": "DALRD3",
          "hgvs_c": "c.1348_1350delTTCinsAGT",
          "hgvs_p": "p.Phe450Ser",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": "ENST00000341949.9",
          "protein_coding": true,
          "protein_id": "NP_001009996.1",
          "strand": false,
          "transcript": "NM_001009996.3",
          "transcript_support_level": null
        },
        {
          "aa_alt": "S",
          "aa_end": null,
          "aa_length": 543,
          "aa_ref": "F",
          "aa_start": 450,
          "biotype": "protein_coding",
          "canonical": true,
          "cdna_end": null,
          "cdna_length": 1748,
          "cdna_start": 1366,
          "cds_end": null,
          "cds_length": 1632,
          "cds_start": 1348,
          "consequences": [
            "missense_variant"
          ],
          "exon_count": 12,
          "exon_rank": null,
          "exon_rank_end": null,
          "feature": "ENST00000341949.9",
          "gene_hgnc_id": 25536,
          "gene_symbol": "DALRD3",
          "hgvs_c": "c.1348_1350delTTCinsAGT",
          "hgvs_p": "p.Phe450Ser",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": "NM_001009996.3",
          "protein_coding": true,
          "protein_id": "ENSP00000344989.4",
          "strand": false,
          "transcript": "ENST00000341949.9",
          "transcript_support_level": 1
        },
        {
          "aa_alt": "S",
          "aa_end": null,
          "aa_length": 386,
          "aa_ref": "F",
          "aa_start": 283,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 2014,
          "cdna_start": 1552,
          "cds_end": null,
          "cds_length": 1161,
          "cds_start": 847,
          "consequences": [
            "missense_variant"
          ],
          "exon_count": 12,
          "exon_rank": null,
          "exon_rank_end": null,
          "feature": "ENST00000440857.5",
          "gene_hgnc_id": 25536,
          "gene_symbol": "DALRD3",
          "hgvs_c": "c.847_849delTTCinsAGT",
          "hgvs_p": "p.Phe283Ser",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "ENSP00000403770.1",
          "strand": false,
          "transcript": "ENST00000440857.5",
          "transcript_support_level": 1
        },
        {
          "aa_alt": null,
          "aa_end": null,
          "aa_length": 516,
          "aa_ref": null,
          "aa_start": null,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 1706,
          "cdna_start": null,
          "cds_end": null,
          "cds_length": 1551,
          "cds_start": null,
          "consequences": [
            "splice_region_variant",
            "intron_variant"
          ],
          "exon_count": 12,
          "exon_rank": null,
          "exon_rank_end": null,
          "feature": "ENST00000441576.6",
          "gene_hgnc_id": 25536,
          "gene_symbol": "DALRD3",
          "hgvs_c": "c.1330-8_1330-6delTTCinsAGT",
          "hgvs_p": null,
          "intron_rank": 9,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "ENSP00000410623.2",
          "strand": false,
          "transcript": "ENST00000441576.6",
          "transcript_support_level": 1
        },
        {
          "aa_alt": null,
          "aa_end": null,
          "aa_length": null,
          "aa_ref": null,
          "aa_start": null,
          "biotype": "retained_intron",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 1886,
          "cdna_start": null,
          "cds_end": null,
          "cds_length": null,
          "cds_start": null,
          "consequences": [
            "non_coding_transcript_exon_variant"
          ],
          "exon_count": 10,
          "exon_rank": 8,
          "exon_rank_end": null,
          "feature": "ENST00000460505.5",
          "gene_hgnc_id": 25536,
          "gene_symbol": "DALRD3",
          "hgvs_c": "n.1502_1504delTTCinsAGT",
          "hgvs_p": null,
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": false,
          "protein_id": null,
          "strand": false,
          "transcript": "ENST00000460505.5",
          "transcript_support_level": 1
        },
        {
          "aa_alt": null,
          "aa_end": null,
          "aa_length": null,
          "aa_ref": null,
          "aa_start": null,
          "biotype": "retained_intron",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 1591,
          "cdna_start": null,
          "cds_end": null,
          "cds_length": null,
          "cds_start": null,
          "consequences": [
            "non_coding_transcript_exon_variant"
          ],
          "exon_count": 6,
          "exon_rank": 6,
          "exon_rank_end": null,
          "feature": "ENST00000467457.5",
          "gene_hgnc_id": 25536,
          "gene_symbol": "DALRD3",
          "hgvs_c": "n.1048_1050delTTCinsAGT",
          "hgvs_p": null,
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": false,
          "protein_id": null,
          "strand": false,
          "transcript": "ENST00000467457.5",
          "transcript_support_level": 1
        },
        {
          "aa_alt": "S",
          "aa_end": null,
          "aa_length": 542,
          "aa_ref": "F",
          "aa_start": 449,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 1746,
          "cdna_start": 1364,
          "cds_end": null,
          "cds_length": 1629,
          "cds_start": 1345,
          "consequences": [
            "missense_variant"
          ],
          "exon_count": 12,
          "exon_rank": null,
          "exon_rank_end": null,
          "feature": "ENST00000873682.1",
          "gene_hgnc_id": 25536,
          "gene_symbol": "DALRD3",
          "hgvs_c": "c.1345_1347delTTCinsAGT",
          "hgvs_p": "p.Phe449Ser",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "ENSP00000543741.1",
          "strand": false,
          "transcript": "ENST00000873682.1",
          "transcript_support_level": null
        },
        {
          "aa_alt": "S",
          "aa_end": null,
          "aa_length": 542,
          "aa_ref": "F",
          "aa_start": 450,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 1738,
          "cdna_start": 1362,
          "cds_end": null,
          "cds_length": 1629,
          "cds_start": 1348,
          "consequences": [
            "missense_variant"
          ],
          "exon_count": 12,
          "exon_rank": null,
          "exon_rank_end": null,
          "feature": "ENST00000969753.1",
          "gene_hgnc_id": 25536,
          "gene_symbol": "DALRD3",
          "hgvs_c": "c.1348_1350delTTCinsAGT",
          "hgvs_p": "p.Phe450Ser",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "ENSP00000639812.1",
          "strand": false,
          "transcript": "ENST00000969753.1",
          "transcript_support_level": null
        },
        {
          "aa_alt": "S",
          "aa_end": null,
          "aa_length": 540,
          "aa_ref": "F",
          "aa_start": 447,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 1737,
          "cdna_start": 1360,
          "cds_end": null,
          "cds_length": 1623,
          "cds_start": 1339,
          "consequences": [
            "missense_variant"
          ],
          "exon_count": 12,
          "exon_rank": null,
          "exon_rank_end": null,
          "feature": "ENST00000916246.1",
          "gene_hgnc_id": 25536,
          "gene_symbol": "DALRD3",
          "hgvs_c": "c.1339_1341delTTCinsAGT",
          "hgvs_p": "p.Phe447Ser",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "ENSP00000586305.1",
          "strand": false,
          "transcript": "ENST00000916246.1",
          "transcript_support_level": null
        },
        {
          "aa_alt": "S",
          "aa_end": null,
          "aa_length": 538,
          "aa_ref": "F",
          "aa_start": 450,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 1731,
          "cdna_start": 1366,
          "cds_end": null,
          "cds_length": 1617,
          "cds_start": 1348,
          "consequences": [
            "missense_variant"
          ],
          "exon_count": 12,
          "exon_rank": null,
          "exon_rank_end": null,
          "feature": "ENST00000969752.1",
          "gene_hgnc_id": 25536,
          "gene_symbol": "DALRD3",
          "hgvs_c": "c.1348_1350delTTCinsAGT",
          "hgvs_p": "p.Phe450Ser",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "ENSP00000639811.1",
          "strand": false,
          "transcript": "ENST00000969752.1",
          "transcript_support_level": null
        },
        {
          "aa_alt": "S",
          "aa_end": null,
          "aa_length": 537,
          "aa_ref": "F",
          "aa_start": 444,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 1721,
          "cdna_start": 1344,
          "cds_end": null,
          "cds_length": 1614,
          "cds_start": 1330,
          "consequences": [
            "missense_variant"
          ],
          "exon_count": 12,
          "exon_rank": null,
          "exon_rank_end": null,
          "feature": "ENST00000969754.1",
          "gene_hgnc_id": 25536,
          "gene_symbol": "DALRD3",
          "hgvs_c": "c.1330_1332delTTCinsAGT",
          "hgvs_p": "p.Phe444Ser",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "ENSP00000639813.1",
          "strand": false,
          "transcript": "ENST00000969754.1",
          "transcript_support_level": null
        },
        {
          "aa_alt": "S",
          "aa_end": null,
          "aa_length": 533,
          "aa_ref": "F",
          "aa_start": 450,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 1664,
          "cdna_start": 1363,
          "cds_end": null,
          "cds_length": 1602,
          "cds_start": 1348,
          "consequences": [
            "missense_variant"
          ],
          "exon_count": 12,
          "exon_rank": null,
          "exon_rank_end": null,
          "feature": "ENST00000969755.1",
          "gene_hgnc_id": 25536,
          "gene_symbol": "DALRD3",
          "hgvs_c": "c.1348_1350delTTCinsAGT",
          "hgvs_p": "p.Phe450Ser",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "ENSP00000639814.1",
          "strand": false,
          "transcript": "ENST00000969755.1",
          "transcript_support_level": null
        },
        {
          "aa_alt": "S",
          "aa_end": null,
          "aa_length": 376,
          "aa_ref": "F",
          "aa_start": 283,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 2227,
          "cdna_start": 1845,
          "cds_end": null,
          "cds_length": 1131,
          "cds_start": 847,
          "consequences": [
            "missense_variant"
          ],
          "exon_count": 12,
          "exon_rank": null,
          "exon_rank_end": null,
          "feature": "NM_018114.6",
          "gene_hgnc_id": 25536,
          "gene_symbol": "DALRD3",
          "hgvs_c": "c.847_849delTTCinsAGT",
          "hgvs_p": "p.Phe283Ser",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "NP_060584.3",
          "strand": false,
          "transcript": "NM_018114.6",
          "transcript_support_level": null
        },
        {
          "aa_alt": "S",
          "aa_end": null,
          "aa_length": 376,
          "aa_ref": "F",
          "aa_start": 283,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 1968,
          "cdna_start": 1591,
          "cds_end": null,
          "cds_length": 1131,
          "cds_start": 847,
          "consequences": [
            "missense_variant"
          ],
          "exon_count": 12,
          "exon_rank": null,
          "exon_rank_end": null,
          "feature": "ENST00000313778.9",
          "gene_hgnc_id": 25536,
          "gene_symbol": "DALRD3",
          "hgvs_c": "c.847_849delTTCinsAGT",
          "hgvs_p": "p.Phe283Ser",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "ENSP00000323265.5",
          "strand": false,
          "transcript": "ENST00000313778.9",
          "transcript_support_level": 2
        },
        {
          "aa_alt": "S",
          "aa_end": null,
          "aa_length": 183,
          "aa_ref": "F",
          "aa_start": 95,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 654,
          "cdna_start": 287,
          "cds_end": null,
          "cds_length": 552,
          "cds_start": 283,
          "consequences": [
            "missense_variant"
          ],
          "exon_count": 5,
          "exon_rank": null,
          "exon_rank_end": null,
          "feature": "ENST00000438585.5",
          "gene_hgnc_id": 25536,
          "gene_symbol": "DALRD3",
          "hgvs_c": "c.283_285delTTCinsAGT",
          "hgvs_p": "p.Phe95Ser",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "ENSP00000396650.2",
          "strand": false,
          "transcript": "ENST00000438585.5",
          "transcript_support_level": 5
        },
        {
          "aa_alt": "S",
          "aa_end": null,
          "aa_length": 575,
          "aa_ref": "F",
          "aa_start": 450,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 3359,
          "cdna_start": 2881,
          "cds_end": null,
          "cds_length": 1728,
          "cds_start": 1348,
          "consequences": [
            "missense_variant"
          ],
          "exon_count": 12,
          "exon_rank": null,
          "exon_rank_end": null,
          "feature": "XM_047448436.1",
          "gene_hgnc_id": 25536,
          "gene_symbol": "DALRD3",
          "hgvs_c": "c.1348_1350delTTCinsAGT",
          "hgvs_p": "p.Phe450Ser",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "XP_047304392.1",
          "strand": false,
          "transcript": "XM_047448436.1",
          "transcript_support_level": null
        },
        {
          "aa_alt": "S",
          "aa_end": null,
          "aa_length": 558,
          "aa_ref": "F",
          "aa_start": 450,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 1848,
          "cdna_start": 1366,
          "cds_end": null,
          "cds_length": 1677,
          "cds_start": 1348,
          "consequences": [
            "missense_variant"
          ],
          "exon_count": 11,
          "exon_rank": null,
          "exon_rank_end": null,
          "feature": "XM_011533891.3",
          "gene_hgnc_id": 25536,
          "gene_symbol": "DALRD3",
          "hgvs_c": "c.1348_1350delTTCinsAGT",
          "hgvs_p": "p.Phe450Ser",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "XP_011532193.1",
          "strand": false,
          "transcript": "XM_011533891.3",
          "transcript_support_level": null
        },
        {
          "aa_alt": "S",
          "aa_end": null,
          "aa_length": 543,
          "aa_ref": "F",
          "aa_start": 450,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 3263,
          "cdna_start": 2881,
          "cds_end": null,
          "cds_length": 1632,
          "cds_start": 1348,
          "consequences": [
            "missense_variant"
          ],
          "exon_count": 13,
          "exon_rank": null,
          "exon_rank_end": null,
          "feature": "XM_047448437.1",
          "gene_hgnc_id": 25536,
          "gene_symbol": "DALRD3",
          "hgvs_c": "c.1348_1350delTTCinsAGT",
          "hgvs_p": "p.Phe450Ser",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "XP_047304393.1",
          "strand": false,
          "transcript": "XM_047448437.1",
          "transcript_support_level": null
        },
        {
          "aa_alt": "S",
          "aa_end": null,
          "aa_length": 408,
          "aa_ref": "F",
          "aa_start": 283,
          "biotype": "protein_coding",
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For research and educational, non-commercial use only. Not for clinical or diagnostic use. GeneBe does not provide medical advice. Data use for AI modeling is prohibited: if used, the cost is $0.001 per byte of downloaded uncompressed data.