← Back to variant description

GeneBe API Showcase

This page demonstrates how to use the GeneBe API to query variant information. The API provides programmatic access to genomic annotations and variant data.

API presented here should be used for checking single variants. If you want to check many variants at once, please use other API endpoints that you will find in the documentation.

Documentation & Advanced Usage

Complete API documentation:docs.genebe.net/docs/api/overview/

Interactive endpoint tester:api.genebe.net/cloud/gb-api-doc/swagger-ui/

Python client for pandas:pypi.org/project/genebe/

Java CLI for VCF files:github.com/pstawinski/genebe-cli

All tools documented at:docs.genebe.net

API Request Examples for Variant: 3-49284535-G-C (hg38)

Bash / cURL Example

bash
curl "https://api.genebe.net/cloud/api-public/v1/variant?chr=3&pos=49284535&ref=G&alt=C&genome=hg38&allGenes=true"

API Response

json
{
  "variants": [
    {
      "chr": "3",
      "pos": 49284535,
      "ref": "G",
      "alt": "C",
      "effect": "missense_variant",
      "transcript": "NM_003363.4",
      "consequences": [
        {
          "aa_ref": "T",
          "aa_alt": "S",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 18,
          "exon_rank_end": null,
          "exon_count": 22,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "USP4",
          "gene_hgnc_id": 12627,
          "hgvs_c": "c.2321C>G",
          "hgvs_p": "p.Thr774Ser",
          "transcript": "NM_003363.4",
          "protein_id": "NP_003354.2",
          "transcript_support_level": null,
          "aa_start": 774,
          "aa_end": null,
          "aa_length": 963,
          "cds_start": 2321,
          "cds_end": null,
          "cds_length": 2892,
          "cdna_start": 2350,
          "cdna_end": null,
          "cdna_length": 4070,
          "mane_select": "ENST00000265560.9",
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "NM_003363.4"
        },
        {
          "aa_ref": "T",
          "aa_alt": "S",
          "canonical": true,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 18,
          "exon_rank_end": null,
          "exon_count": 22,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "USP4",
          "gene_hgnc_id": 12627,
          "hgvs_c": "c.2321C>G",
          "hgvs_p": "p.Thr774Ser",
          "transcript": "ENST00000265560.9",
          "protein_id": "ENSP00000265560.4",
          "transcript_support_level": 1,
          "aa_start": 774,
          "aa_end": null,
          "aa_length": 963,
          "cds_start": 2321,
          "cds_end": null,
          "cds_length": 2892,
          "cdna_start": 2350,
          "cdna_end": null,
          "cdna_length": 4070,
          "mane_select": "NM_003363.4",
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000265560.9"
        },
        {
          "aa_ref": "T",
          "aa_alt": "S",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 17,
          "exon_rank_end": null,
          "exon_count": 21,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "USP4",
          "gene_hgnc_id": 12627,
          "hgvs_c": "c.2180C>G",
          "hgvs_p": "p.Thr727Ser",
          "transcript": "ENST00000351842.8",
          "protein_id": "ENSP00000341028.4",
          "transcript_support_level": 1,
          "aa_start": 727,
          "aa_end": null,
          "aa_length": 916,
          "cds_start": 2180,
          "cds_end": null,
          "cds_length": 2751,
          "cdna_start": 2189,
          "cdna_end": null,
          "cdna_length": 3222,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000351842.8"
        },
        {
          "aa_ref": "T",
          "aa_alt": "S",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 19,
          "exon_rank_end": null,
          "exon_count": 23,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "USP4",
          "gene_hgnc_id": 12627,
          "hgvs_c": "c.2474C>G",
          "hgvs_p": "p.Thr825Ser",
          "transcript": "ENST00000911610.1",
          "protein_id": "ENSP00000581669.1",
          "transcript_support_level": null,
          "aa_start": 825,
          "aa_end": null,
          "aa_length": 1014,
          "cds_start": 2474,
          "cds_end": null,
          "cds_length": 3045,
          "cdna_start": 2632,
          "cdna_end": null,
          "cdna_length": 3937,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000911610.1"
        },
        {
          "aa_ref": "T",
          "aa_alt": "S",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 19,
          "exon_rank_end": null,
          "exon_count": 23,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "USP4",
          "gene_hgnc_id": 12627,
          "hgvs_c": "c.2450C>G",
          "hgvs_p": "p.Thr817Ser",
          "transcript": "ENST00000965332.1",
          "protein_id": "ENSP00000635391.1",
          "transcript_support_level": null,
          "aa_start": 817,
          "aa_end": null,
          "aa_length": 1006,
          "cds_start": 2450,
          "cds_end": null,
          "cds_length": 3021,
          "cdna_start": 2479,
          "cdna_end": null,
          "cdna_length": 3219,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000965332.1"
        },
        {
          "aa_ref": "T",
          "aa_alt": "S",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 19,
          "exon_rank_end": null,
          "exon_count": 23,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "USP4",
          "gene_hgnc_id": 12627,
          "hgvs_c": "c.2432C>G",
          "hgvs_p": "p.Thr811Ser",
          "transcript": "ENST00000965340.1",
          "protein_id": "ENSP00000635399.1",
          "transcript_support_level": null,
          "aa_start": 811,
          "aa_end": null,
          "aa_length": 1000,
          "cds_start": 2432,
          "cds_end": null,
          "cds_length": 3003,
          "cdna_start": 2473,
          "cdna_end": null,
          "cdna_length": 3181,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000965340.1"
        },
        {
          "aa_ref": "T",
          "aa_alt": "S",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 19,
          "exon_rank_end": null,
          "exon_count": 23,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "USP4",
          "gene_hgnc_id": 12627,
          "hgvs_c": "c.2399C>G",
          "hgvs_p": "p.Thr800Ser",
          "transcript": "ENST00000877491.1",
          "protein_id": "ENSP00000547550.1",
          "transcript_support_level": null,
          "aa_start": 800,
          "aa_end": null,
          "aa_length": 989,
          "cds_start": 2399,
          "cds_end": null,
          "cds_length": 2970,
          "cdna_start": 2414,
          "cdna_end": null,
          "cdna_length": 3135,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000877491.1"
        },
        {
          "aa_ref": "T",
          "aa_alt": "S",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 18,
          "exon_rank_end": null,
          "exon_count": 22,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "USP4",
          "gene_hgnc_id": 12627,
          "hgvs_c": "c.2342C>G",
          "hgvs_p": "p.Thr781Ser",
          "transcript": "ENST00000965341.1",
          "protein_id": "ENSP00000635400.1",
          "transcript_support_level": null,
          "aa_start": 781,
          "aa_end": null,
          "aa_length": 970,
          "cds_start": 2342,
          "cds_end": null,
          "cds_length": 2913,
          "cdna_start": 2371,
          "cdna_end": null,
          "cdna_length": 3066,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000965341.1"
        },
        {
          "aa_ref": "T",
          "aa_alt": "S",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 18,
          "exon_rank_end": null,
          "exon_count": 22,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "USP4",
          "gene_hgnc_id": 12627,
          "hgvs_c": "c.2333C>G",
          "hgvs_p": "p.Thr778Ser",
          "transcript": "ENST00000911611.1",
          "protein_id": "ENSP00000581670.1",
          "transcript_support_level": null,
          "aa_start": 778,
          "aa_end": null,
          "aa_length": 967,
          "cds_start": 2333,
          "cds_end": null,
          "cds_length": 2904,
          "cdna_start": 2528,
          "cdna_end": null,
          "cdna_length": 3765,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000911611.1"
        },
        {
          "aa_ref": "T",
          "aa_alt": "S",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 18,
          "exon_rank_end": null,
          "exon_count": 22,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "USP4",
          "gene_hgnc_id": 12627,
          "hgvs_c": "c.2318C>G",
          "hgvs_p": "p.Thr773Ser",
          "transcript": "ENST00000911612.1",
          "protein_id": "ENSP00000581671.1",
          "transcript_support_level": null,
          "aa_start": 773,
          "aa_end": null,
          "aa_length": 962,
          "cds_start": 2318,
          "cds_end": null,
          "cds_length": 2889,
          "cdna_start": 2355,
          "cdna_end": null,
          "cdna_length": 3606,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000911612.1"
        },
        {
          "aa_ref": "T",
          "aa_alt": "S",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 18,
          "exon_rank_end": null,
          "exon_count": 22,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "USP4",
          "gene_hgnc_id": 12627,
          "hgvs_c": "c.2318C>G",
          "hgvs_p": "p.Thr773Ser",
          "transcript": "ENST00000965324.1",
          "protein_id": "ENSP00000635383.1",
          "transcript_support_level": null,
          "aa_start": 773,
          "aa_end": null,
          "aa_length": 962,
          "cds_start": 2318,
          "cds_end": null,
          "cds_length": 2889,
          "cdna_start": 2366,
          "cdna_end": null,
          "cdna_length": 3682,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000965324.1"
        },
        {
          "aa_ref": "T",
          "aa_alt": "S",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 18,
          "exon_rank_end": null,
          "exon_count": 22,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "USP4",
          "gene_hgnc_id": 12627,
          "hgvs_c": "c.2315C>G",
          "hgvs_p": "p.Thr772Ser",
          "transcript": "ENST00000877475.1",
          "protein_id": "ENSP00000547534.1",
          "transcript_support_level": null,
          "aa_start": 772,
          "aa_end": null,
          "aa_length": 961,
          "cds_start": 2315,
          "cds_end": null,
          "cds_length": 2886,
          "cdna_start": 2363,
          "cdna_end": null,
          "cdna_length": 3689,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000877475.1"
        },
        {
          "aa_ref": "T",
          "aa_alt": "S",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 18,
          "exon_rank_end": null,
          "exon_count": 22,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "USP4",
          "gene_hgnc_id": 12627,
          "hgvs_c": "c.2288C>G",
          "hgvs_p": "p.Thr763Ser",
          "transcript": "ENST00000877488.1",
          "protein_id": "ENSP00000547547.1",
          "transcript_support_level": null,
          "aa_start": 763,
          "aa_end": null,
          "aa_length": 952,
          "cds_start": 2288,
          "cds_end": null,
          "cds_length": 2859,
          "cdna_start": 2303,
          "cdna_end": null,
          "cdna_length": 3041,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000877488.1"
        },
        {
          "aa_ref": "T",
          "aa_alt": "S",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 18,
          "exon_rank_end": null,
          "exon_count": 22,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "USP4",
          "gene_hgnc_id": 12627,
          "hgvs_c": "c.2279C>G",
          "hgvs_p": "p.Thr760Ser",
          "transcript": "ENST00000965327.1",
          "protein_id": "ENSP00000635386.1",
          "transcript_support_level": null,
          "aa_start": 760,
          "aa_end": null,
          "aa_length": 949,
          "cds_start": 2279,
          "cds_end": null,
          "cds_length": 2850,
          "cdna_start": 2329,
          "cdna_end": null,
          "cdna_length": 3362,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000965327.1"
        },
        {
          "aa_ref": "T",
          "aa_alt": "S",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 18,
          "exon_rank_end": null,
          "exon_count": 22,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "USP4",
          "gene_hgnc_id": 12627,
          "hgvs_c": "c.2267C>G",
          "hgvs_p": "p.Thr756Ser",
          "transcript": "ENST00000877477.1",
          "protein_id": "ENSP00000547536.1",
          "transcript_support_level": null,
          "aa_start": 756,
          "aa_end": null,
          "aa_length": 945,
          "cds_start": 2267,
          "cds_end": null,
          "cds_length": 2838,
          "cdna_start": 2296,
          "cdna_end": null,
          "cdna_length": 3621,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000877477.1"
        },
        {
          "aa_ref": "T",
          "aa_alt": "S",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 18,
          "exon_rank_end": null,
          "exon_count": 22,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "USP4",
          "gene_hgnc_id": 12627,
          "hgvs_c": "c.2252C>G",
          "hgvs_p": "p.Thr751Ser",
          "transcript": "ENST00000965330.1",
          "protein_id": "ENSP00000635389.1",
          "transcript_support_level": null,
          "aa_start": 751,
          "aa_end": null,
          "aa_length": 940,
          "cds_start": 2252,
          "cds_end": null,
          "cds_length": 2823,
          "cdna_start": 2265,
          "cdna_end": null,
          "cdna_length": 3298,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000965330.1"
        },
        {
          "aa_ref": "T",
          "aa_alt": "S",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 18,
          "exon_rank_end": null,
          "exon_count": 22,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "USP4",
          "gene_hgnc_id": 12627,
          "hgvs_c": "c.2207C>G",
          "hgvs_p": "p.Thr736Ser",
          "transcript": "ENST00000877480.1",
          "protein_id": "ENSP00000547539.1",
          "transcript_support_level": null,
          "aa_start": 736,
          "aa_end": null,
          "aa_length": 925,
          "cds_start": 2207,
          "cds_end": null,
          "cds_length": 2778,
          "cdna_start": 2216,
          "cdna_end": null,
          "cdna_length": 3444,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000877480.1"
        },
        {
          "aa_ref": "T",
          "aa_alt": "S",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 17,
          "exon_rank_end": null,
          "exon_count": 21,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "USP4",
          "gene_hgnc_id": 12627,
          "hgvs_c": "c.2180C>G",
          "hgvs_p": "p.Thr727Ser",
          "transcript": "NM_199443.3",
          "protein_id": "NP_955475.1",
          "transcript_support_level": null,
          "aa_start": 727,
          "aa_end": null,
          "aa_length": 916,
          "cds_start": 2180,
          "cds_end": null,
          "cds_length": 2751,
          "cdna_start": 2209,
          "cdna_end": null,
          "cdna_length": 3929,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "NM_199443.3"
        },
        {
          "aa_ref": "T",
          "aa_alt": "S",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 17,
          "exon_rank_end": null,
          "exon_count": 21,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "USP4",
          "gene_hgnc_id": 12627,
          "hgvs_c": "c.2177C>G",
          "hgvs_p": "p.Thr726Ser",
          "transcript": "ENST00000877484.1",
          "protein_id": "ENSP00000547543.1",
          "transcript_support_level": null,
          "aa_start": 726,
          "aa_end": null,
          "aa_length": 915,
          "cds_start": 2177,
          "cds_end": null,
          "cds_length": 2748,
          "cdna_start": 2248,
          "cdna_end": null,
          "cdna_length": 2985,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000877484.1"
        },
        {
          "aa_ref": "T",
          "aa_alt": "S",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 17,
          "exon_rank_end": null,
          "exon_count": 21,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "USP4",
          "gene_hgnc_id": 12627,
          "hgvs_c": "c.2174C>G",
          "hgvs_p": "p.Thr725Ser",
          "transcript": "ENST00000877485.1",
          "protein_id": "ENSP00000547544.1",
          "transcript_support_level": null,
          "aa_start": 725,
          "aa_end": null,
          "aa_length": 914,
          "cds_start": 2174,
          "cds_end": null,
          "cds_length": 2745,
          "cdna_start": 2215,
          "cdna_end": null,
          "cdna_length": 2951,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000877485.1"
        },
        {
          "aa_ref": "T",
          "aa_alt": "S",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 17,
          "exon_rank_end": null,
          "exon_count": 21,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "USP4",
          "gene_hgnc_id": 12627,
          "hgvs_c": "c.2162C>G",
          "hgvs_p": "p.Thr721Ser",
          "transcript": "ENST00000877473.1",
          "protein_id": "ENSP00000547532.1",
          "transcript_support_level": null,
          "aa_start": 721,
          "aa_end": null,
          "aa_length": 910,
          "cds_start": 2162,
          "cds_end": null,
          "cds_length": 2733,
          "cdna_start": 2206,
          "cdna_end": null,
          "cdna_length": 3639,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000877473.1"
        },
        {
          "aa_ref": "T",
          "aa_alt": "S",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 17,
          "exon_rank_end": null,
          "exon_count": 21,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "USP4",
          "gene_hgnc_id": 12627,
          "hgvs_c": "c.2147C>G",
          "hgvs_p": "p.Thr716Ser",
          "transcript": "ENST00000877492.1",
          "protein_id": "ENSP00000547551.1",
          "transcript_support_level": null,
          "aa_start": 716,
          "aa_end": null,
          "aa_length": 905,
          "cds_start": 2147,
          "cds_end": null,
          "cds_length": 2718,
          "cdna_start": 2162,
          "cdna_end": null,
          "cdna_length": 2883,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000877492.1"
        },
        {
          "aa_ref": "T",
          "aa_alt": "S",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 17,
          "exon_rank_end": null,
          "exon_count": 21,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "USP4",
          "gene_hgnc_id": 12627,
          "hgvs_c": "c.2138C>G",
          "hgvs_p": "p.Thr713Ser",
          "transcript": "ENST00000877487.1",
          "protein_id": "ENSP00000547546.1",
          "transcript_support_level": null,
          "aa_start": 713,
          "aa_end": null,
          "aa_length": 902,
          "cds_start": 2138,
          "cds_end": null,
          "cds_length": 2709,
          "cdna_start": 2163,
          "cdna_end": null,
          "cdna_length": 2901,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000877487.1"
        },
        {
          "aa_ref": "T",
          "aa_alt": "S",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 17,
          "exon_rank_end": null,
          "exon_count": 21,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "USP4",
          "gene_hgnc_id": 12627,
          "hgvs_c": "c.2129C>G",
          "hgvs_p": "p.Thr710Ser",
          "transcript": "ENST00000877483.1",
          "protein_id": "ENSP00000547542.1",
          "transcript_support_level": null,
          "aa_start": 710,
          "aa_end": null,
          "aa_length": 899,
          "cds_start": 2129,
          "cds_end": null,
          "cds_length": 2700,
          "cdna_start": 2266,
          "cdna_end": null,
          "cdna_length": 3011,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000877483.1"
        },
        {
          "aa_ref": "T",
          "aa_alt": "S",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 17,
          "exon_rank_end": null,
          "exon_count": 21,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "USP4",
          "gene_hgnc_id": 12627,
          "hgvs_c": "c.2126C>G",
          "hgvs_p": "p.Thr709Ser",
          "transcript": "ENST00000877490.1",
          "protein_id": "ENSP00000547549.1",
          "transcript_support_level": null,
          "aa_start": 709,
          "aa_end": null,
          "aa_length": 898,
          "cds_start": 2126,
          "cds_end": null,
          "cds_length": 2697,
          "cdna_start": 2155,
          "cdna_end": null,
          "cdna_length": 2876,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000877490.1"
        },
        {
          "aa_ref": "T",
          "aa_alt": "S",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 17,
          "exon_rank_end": null,
          "exon_count": 21,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "USP4",
          "gene_hgnc_id": 12627,
          "hgvs_c": "c.2096C>G",
          "hgvs_p": "p.Thr699Ser",
          "transcript": "ENST00000877472.1",
          "protein_id": "ENSP00000547531.1",
          "transcript_support_level": null,
          "aa_start": 699,
          "aa_end": null,
          "aa_length": 888,
          "cds_start": 2096,
          "cds_end": null,
          "cds_length": 2667,
          "cdna_start": 2142,
          "cdna_end": null,
          "cdna_length": 3575,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000877472.1"
        },
        {
          "aa_ref": "T",
          "aa_alt": "S",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 17,
          "exon_rank_end": null,
          "exon_count": 21,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "USP4",
          "gene_hgnc_id": 12627,
          "hgvs_c": "c.2093C>G",
          "hgvs_p": "p.Thr698Ser",
          "transcript": "ENST00000877476.1",
          "protein_id": "ENSP00000547535.1",
          "transcript_support_level": null,
          "aa_start": 698,
          "aa_end": null,
          "aa_length": 887,
          "cds_start": 2093,
          "cds_end": null,
          "cds_length": 2664,
          "cdna_start": 2122,
          "cdna_end": null,
          "cdna_length": 3448,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000877476.1"
        },
        {
          "aa_ref": "T",
          "aa_alt": "S",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 17,
          "exon_rank_end": null,
          "exon_count": 21,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "USP4",
          "gene_hgnc_id": 12627,
          "hgvs_c": "c.2066C>G",
          "hgvs_p": "p.Thr689Ser",
          "transcript": "ENST00000965335.1",
          "protein_id": "ENSP00000635394.1",
          "transcript_support_level": null,
          "aa_start": 689,
          "aa_end": null,
          "aa_length": 878,
          "cds_start": 2066,
          "cds_end": null,
          "cds_length": 2637,
          "cdna_start": 2095,
          "cdna_end": null,
          "cdna_length": 2833,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000965335.1"
        },
        {
          "aa_ref": "T",
          "aa_alt": "S",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 17,
          "exon_rank_end": null,
          "exon_count": 21,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "USP4",
          "gene_hgnc_id": 12627,
          "hgvs_c": "c.2060C>G",
          "hgvs_p": "p.Thr687Ser",
          "transcript": "ENST00000965337.1",
          "protein_id": "ENSP00000635396.1",
          "transcript_support_level": null,
          "aa_start": 687,
          "aa_end": null,
          "aa_length": 876,
          "cds_start": 2060,
          "cds_end": null,
          "cds_length": 2631,
          "cdna_start": 2071,
          "cdna_end": null,
          "cdna_length": 2811,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000965337.1"
        },
        {
          "aa_ref": "T",
          "aa_alt": "S",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 17,
          "exon_rank_end": null,
          "exon_count": 21,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "USP4",
          "gene_hgnc_id": 12627,
          "hgvs_c": "c.2042C>G",
          "hgvs_p": "p.Thr681Ser",
          "transcript": "ENST00000965328.1",
          "protein_id": "ENSP00000635387.1",
          "transcript_support_level": null,
          "aa_start": 681,
          "aa_end": null,
          "aa_length": 870,
          "cds_start": 2042,
          "cds_end": null,
          "cds_length": 2613,
          "cdna_start": 2065,
          "cdna_end": null,
          "cdna_length": 3098,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000965328.1"
        },
        {
          "aa_ref": "T",
          "aa_alt": "S",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 16,
          "exon_rank_end": null,
          "exon_count": 20,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "USP4",
          "gene_hgnc_id": 12627,
          "hgvs_c": "c.2021C>G",
          "hgvs_p": "p.Thr674Ser",
          "transcript": "ENST00000965325.1",
          "protein_id": "ENSP00000635384.1",
          "transcript_support_level": null,
          "aa_start": 674,
          "aa_end": null,
          "aa_length": 863,
          "cds_start": 2021,
          "cds_end": null,
          "cds_length": 2592,
          "cdna_start": 2050,
          "cdna_end": null,
          "cdna_length": 3378,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000965325.1"
        },
        {
          "aa_ref": "T",
          "aa_alt": "S",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 16,
          "exon_rank_end": null,
          "exon_count": 20,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "USP4",
          "gene_hgnc_id": 12627,
          "hgvs_c": "c.2006C>G",
          "hgvs_p": "p.Thr669Ser",
          "transcript": "ENST00000877474.1",
          "protein_id": "ENSP00000547533.1",
          "transcript_support_level": null,
          "aa_start": 669,
          "aa_end": null,
          "aa_length": 858,
          "cds_start": 2006,
          "cds_end": null,
          "cds_length": 2577,
          "cdna_start": 2036,
          "cdna_end": null,
          "cdna_length": 3469,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000877474.1"
        },
        {
          "aa_ref": "T",
          "aa_alt": "S",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 16,
          "exon_rank_end": null,
          "exon_count": 20,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "USP4",
          "gene_hgnc_id": 12627,
          "hgvs_c": "c.1988C>G",
          "hgvs_p": "p.Thr663Ser",
          "transcript": "ENST00000965338.1",
          "protein_id": "ENSP00000635397.1",
          "transcript_support_level": null,
          "aa_start": 663,
          "aa_end": null,
          "aa_length": 852,
          "cds_start": 1988,
          "cds_end": null,
          "cds_length": 2559,
          "cdna_start": 2017,
          "cdna_end": null,
          "cdna_length": 2738,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000965338.1"
        },
        {
          "aa_ref": "T",
          "aa_alt": "S",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 16,
          "exon_rank_end": null,
          "exon_count": 20,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "USP4",
          "gene_hgnc_id": 12627,
          "hgvs_c": "c.1955C>G",
          "hgvs_p": "p.Thr652Ser",
          "transcript": "ENST00000877478.1",
          "protein_id": "ENSP00000547537.1",
          "transcript_support_level": null,
          "aa_start": 652,
          "aa_end": null,
          "aa_length": 841,
          "cds_start": 1955,
          "cds_end": null,
          "cds_length": 2526,
          "cdna_start": 1985,
          "cdna_end": null,
          "cdna_length": 3302,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000877478.1"
        },
        {
          "aa_ref": "T",
          "aa_alt": "S",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 16,
          "exon_rank_end": null,
          "exon_count": 20,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "USP4",
          "gene_hgnc_id": 12627,
          "hgvs_c": "c.1952C>G",
          "hgvs_p": "p.Thr651Ser",
          "transcript": "ENST00000965331.1",
          "protein_id": "ENSP00000635390.1",
          "transcript_support_level": null,
          "aa_start": 651,
          "aa_end": null,
          "aa_length": 840,
          "cds_start": 1952,
          "cds_end": null,
          "cds_length": 2523,
          "cdna_start": 1999,
          "cdna_end": null,
          "cdna_length": 2730,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000965331.1"
        },
        {
          "aa_ref": "T",
          "aa_alt": "S",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 16,
          "exon_rank_end": null,
          "exon_count": 20,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "USP4",
          "gene_hgnc_id": 12627,
          "hgvs_c": "c.1937C>G",
          "hgvs_p": "p.Thr646Ser",
          "transcript": "ENST00000877486.1",
          "protein_id": "ENSP00000547545.1",
          "transcript_support_level": null,
          "aa_start": 646,
          "aa_end": null,
          "aa_length": 835,
          "cds_start": 1937,
          "cds_end": null,
          "cds_length": 2508,
          "cdna_start": 1966,
          "cdna_end": null,
          "cdna_length": 2706,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000877486.1"
        },
        {
          "aa_ref": "T",
          "aa_alt": "S",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 15,
          "exon_rank_end": null,
          "exon_count": 19,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "USP4",
          "gene_hgnc_id": 12627,
          "hgvs_c": "c.1922C>G",
          "hgvs_p": "p.Thr641Ser",
          "transcript": "ENST00000877481.1",
          "protein_id": "ENSP00000547540.1",
          "transcript_support_level": null,
          "aa_start": 641,
          "aa_end": null,
          "aa_length": 830,
          "cds_start": 1922,
          "cds_end": null,
          "cds_length": 2493,
          "cdna_start": 1937,
          "cdna_end": null,
          "cdna_length": 2969,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000877481.1"
        },
        {
          "aa_ref": "T",
          "aa_alt": "S",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 16,
          "exon_rank_end": null,
          "exon_count": 20,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "USP4",
          "gene_hgnc_id": 12627,
          "hgvs_c": "c.1922C>G",
          "hgvs_p": "p.Thr641Ser",
          "transcript": "ENST00000965323.1",
          "protein_id": "ENSP00000635382.1",
          "transcript_support_level": null,
          "aa_start": 641,
          "aa_end": null,
          "aa_length": 830,
          "cds_start": 1922,
          "cds_end": null,
          "cds_length": 2493,
          "cdna_start": 1950,
          "cdna_end": null,
          "cdna_length": 3380,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000965323.1"
        },
        {
          "aa_ref": "T",
          "aa_alt": "S",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 16,
          "exon_rank_end": null,
          "exon_count": 20,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "USP4",
          "gene_hgnc_id": 12627,
          "hgvs_c": "c.1919C>G",
          "hgvs_p": "p.Thr640Ser",
          "transcript": "ENST00000877482.1",
          "protein_id": "ENSP00000547541.1",
          "transcript_support_level": null,
          "aa_start": 640,
          "aa_end": null,
          "aa_length": 829,
          "cds_start": 1919,
          "cds_end": null,
          "cds_length": 2490,
          "cdna_start": 1926,
          "cdna_end": null,
          "cdna_length": 2958,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000877482.1"
        },
        {
          "aa_ref": "T",
          "aa_alt": "S",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 15,
          "exon_rank_end": null,
          "exon_count": 19,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "USP4",
          "gene_hgnc_id": 12627,
          "hgvs_c": "c.1907C>G",
          "hgvs_p": "p.Thr636Ser",
          "transcript": "ENST00000965339.1",
          "protein_id": "ENSP00000635398.1",
          "transcript_support_level": null,
          "aa_start": 636,
          "aa_end": null,
          "aa_length": 825,
          "cds_start": 1907,
          "cds_end": null,
          "cds_length": 2478,
          "cdna_start": 1921,
          "cdna_end": null,
          "cdna_length": 2657,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000965339.1"
        },
        {
          "aa_ref": "T",
          "aa_alt": "S",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 16,
          "exon_rank_end": null,
          "exon_count": 20,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "USP4",
          "gene_hgnc_id": 12627,
          "hgvs_c": "c.1904C>G",
          "hgvs_p": "p.Thr635Ser",
          "transcript": "ENST00000965336.1",
          "protein_id": "ENSP00000635395.1",
          "transcript_support_level": null,
          "aa_start": 635,
          "aa_end": null,
          "aa_length": 824,
          "cds_start": 1904,
          "cds_end": null,
          "cds_length": 2475,
          "cdna_start": 1934,
          "cdna_end": null,
          "cdna_length": 2670,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000965336.1"
        },
        {
          "aa_ref": "T",
          "aa_alt": "S",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 16,
          "exon_rank_end": null,
          "exon_count": 20,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "USP4",
          "gene_hgnc_id": 12627,
          "hgvs_c": "c.1868C>G",
          "hgvs_p": "p.Thr623Ser",
          "transcript": "ENST00000965342.1",
          "protein_id": "ENSP00000635401.1",
          "transcript_support_level": null,
          "aa_start": 623,
          "aa_end": null,
          "aa_length": 812,
          "cds_start": 1868,
          "cds_end": null,
          "cds_length": 2439,
          "cdna_start": 1888,
          "cdna_end": null,
          "cdna_length": 2582,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000965342.1"
        },
        {
          "aa_ref": "T",
          "aa_alt": "S",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 15,
          "exon_rank_end": null,
          "exon_count": 19,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "USP4",
          "gene_hgnc_id": 12627,
          "hgvs_c": "c.1847C>G",
          "hgvs_p": "p.Thr616Ser",
          "transcript": "ENST00000965343.1",
          "protein_id": "ENSP00000635402.1",
          "transcript_support_level": null,
          "aa_start": 616,
          "aa_end": null,
          "aa_length": 805,
          "cds_start": 1847,
          "cds_end": null,
          "cds_length": 2418,
          "cdna_start": 1861,
          "cdna_end": null,
          "cdna_length": 2557,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000965343.1"
        },
        {
          "aa_ref": "T",
          "aa_alt": "S",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 15,
          "exon_rank_end": null,
          "exon_count": 19,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "USP4",
          "gene_hgnc_id": 12627,
          "hgvs_c": "c.1814C>G",
          "hgvs_p": "p.Thr605Ser",
          "transcript": "ENST00000965329.1",
          "protein_id": "ENSP00000635388.1",
          "transcript_support_level": null,
          "aa_start": 605,
          "aa_end": null,
          "aa_length": 794,
          "cds_start": 1814,
          "cds_end": null,
          "cds_length": 2385,
          "cdna_start": 1827,
          "cdna_end": null,
          "cdna_length": 2862,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000965329.1"
        },
        {
          "aa_ref": "T",
          "aa_alt": "S",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 15,
          "exon_rank_end": null,
          "exon_count": 19,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "USP4",
          "gene_hgnc_id": 12627,
          "hgvs_c": "c.1796C>G",
          "hgvs_p": "p.Thr599Ser",
          "transcript": "ENST00000877493.1",
          "protein_id": "ENSP00000547552.1",
          "transcript_support_level": null,
          "aa_start": 599,
          "aa_end": null,
          "aa_length": 788,
          "cds_start": 1796,
          "cds_end": null,
          "cds_length": 2367,
          "cdna_start": 1821,
          "cdna_end": null,
          "cdna_length": 2525,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000877493.1"
        },
        {
          "aa_ref": "T",
          "aa_alt": "S",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 15,
          "exon_rank_end": null,
          "exon_count": 19,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "USP4",
          "gene_hgnc_id": 12627,
          "hgvs_c": "c.1727C>G",
          "hgvs_p": "p.Thr576Ser",
          "transcript": "ENST00000877479.1",
          "protein_id": "ENSP00000547538.1",
          "transcript_support_level": null,
          "aa_start": 576,
          "aa_end": null,
          "aa_length": 765,
          "cds_start": 1727,
          "cds_end": null,
          "cds_length": 2298,
          "cdna_start": 1751,
          "cdna_end": null,
          "cdna_length": 3058,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000877479.1"
        },
        {
          "aa_ref": "T",
          "aa_alt": "S",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 13,
          "exon_rank_end": null,
          "exon_count": 17,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "USP4",
          "gene_hgnc_id": 12627,
          "hgvs_c": "c.1727C>G",
          "hgvs_p": "p.Thr576Ser",
          "transcript": "ENST00000965334.1",
          "protein_id": "ENSP00000635393.1",
          "transcript_support_level": null,
          "aa_start": 576,
          "aa_end": null,
          "aa_length": 765,
          "cds_start": 1727,
          "cds_end": null,
          "cds_length": 2298,
          "cdna_start": 1757,
          "cdna_end": null,
          "cdna_length": 2495,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000965334.1"
        },
        {
          "aa_ref": "T",
          "aa_alt": "S",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 12,
          "exon_rank_end": null,
          "exon_count": 16,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "USP4",
          "gene_hgnc_id": 12627,
          "hgvs_c": "c.1553C>G",
          "hgvs_p": "p.Thr518Ser",
          "transcript": "ENST00000965333.1",
          "protein_id": "ENSP00000635392.1",
          "transcript_support_level": null,
          "aa_start": 518,
          "aa_end": null,
          "aa_length": 707,
          "cds_start": 1553,
          "cds_end": null,
          "cds_length": 2124,
          "cdna_start": 1576,
          "cdna_end": null,
          "cdna_length": 2322,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000965333.1"
        },
        {
          "aa_ref": "T",
          "aa_alt": "S",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 12,
          "exon_rank_end": null,
          "exon_count": 16,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "USP4",
          "gene_hgnc_id": 12627,
          "hgvs_c": "c.1496C>G",
          "hgvs_p": "p.Thr499Ser",
          "transcript": "ENST00000877489.1",
          "protein_id": "ENSP00000547548.1",
          "transcript_support_level": null,
          "aa_start": 499,
          "aa_end": null,
          "aa_length": 688,
          "cds_start": 1496,
          "cds_end": null,
          "cds_length": 2067,
          "cdna_start": 1525,
          "cdna_end": null,
          "cdna_length": 2246,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000877489.1"
        },
        {
          "aa_ref": "T",
          "aa_alt": "S",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 12,
          "exon_rank_end": null,
          "exon_count": 15,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "USP4",
          "gene_hgnc_id": 12627,
          "hgvs_c": "c.1535C>G",
          "hgvs_p": "p.Thr512Ser",
          "transcript": "ENST00000431357.1",
          "protein_id": "ENSP00000399079.1",
          "transcript_support_level": 5,
          "aa_start": 512,
          "aa_end": null,
          "aa_length": 620,
          "cds_start": 1535,
          "cds_end": null,
          "cds_length": 1863,
          "cdna_start": 1536,
          "cdna_end": null,
          "cdna_length": 2141,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000431357.1"
        },
        {
          "aa_ref": "T",
          "aa_alt": "S",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 8,
          "exon_rank_end": null,
          "exon_count": 12,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "USP4",
          "gene_hgnc_id": 12627,
          "hgvs_c": "c.755C>G",
          "hgvs_p": "p.Thr252Ser",
          "transcript": "ENST00000965326.1",
          "protein_id": "ENSP00000635385.1",
          "transcript_support_level": null,
          "aa_start": 252,
          "aa_end": null,
          "aa_length": 441,
          "cds_start": 755,
          "cds_end": null,
          "cds_length": 1326,
          "cdna_start": 769,
          "cdna_end": null,
          "cdna_length": 2076,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000965326.1"
        },
        {
          "aa_ref": null,
          "aa_alt": null,
          "canonical": false,
          "protein_coding": false,
          "strand": false,
          "consequences": [
            "non_coding_transcript_exon_variant"
          ],
          "exon_rank": 12,
          "exon_rank_end": null,
          "exon_count": 16,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "USP4",
          "gene_hgnc_id": 12627,
          "hgvs_c": "n.2835C>G",
          "hgvs_p": null,
          "transcript": "ENST00000485450.5",
          "protein_id": null,
          "transcript_support_level": 2,
          "aa_start": null,
          "aa_end": null,
          "aa_length": null,
          "cds_start": null,
          "cds_end": null,
          "cds_length": null,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": 3541,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "retained_intron",
          "feature": "ENST00000485450.5"
        },
        {
          "aa_ref": null,
          "aa_alt": null,
          "canonical": false,
          "protein_coding": false,
          "strand": true,
          "consequences": [
            "downstream_gene_variant"
          ],
          "exon_rank": null,
          "exon_rank_end": null,
          "exon_count": 5,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "USP4",
          "gene_hgnc_id": 12627,
          "hgvs_c": "n.*1C>G",
          "hgvs_p": null,
          "transcript": "ENST00000475873.2",
          "protein_id": null,
          "transcript_support_level": 3,
          "aa_start": null,
          "aa_end": null,
          "aa_length": null,
          "cds_start": null,
          "cds_end": null,
          "cds_length": null,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": 536,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "pseudogene",
          "feature": "ENST00000475873.2"
        }
      ],
      "gene_symbol": "USP4",
      "gene_hgnc_id": 12627,
      "dbsnp": null,
      "frequency_reference_population": null,
      "hom_count_reference_population": 0,
      "allele_count_reference_population": 0,
      "gnomad_exomes_af": null,
      "gnomad_genomes_af": null,
      "gnomad_exomes_ac": null,
      "gnomad_genomes_ac": null,
      "gnomad_exomes_homalt": null,
      "gnomad_genomes_homalt": null,
      "gnomad_mito_homoplasmic": null,
      "gnomad_mito_heteroplasmic": null,
      "computational_score_selected": 0.05730709433555603,
      "computational_prediction_selected": "Benign",
      "computational_source_selected": "MetaRNN",
      "splice_score_selected": 0,
      "splice_prediction_selected": "Benign",
      "splice_source_selected": "max_spliceai",
      "revel_score": 0.028,
      "revel_prediction": "Benign",
      "alphamissense_score": 0.0741,
      "alphamissense_prediction": null,
      "bayesdelnoaf_score": -0.64,
      "bayesdelnoaf_prediction": "Benign",
      "phylop100way_score": 3.418,
      "phylop100way_prediction": "Benign",
      "spliceai_max_score": 0,
      "spliceai_max_prediction": "Benign",
      "dbscsnv_ada_score": null,
      "dbscsnv_ada_prediction": null,
      "apogee2_score": null,
      "apogee2_prediction": null,
      "mitotip_score": null,
      "mitotip_prediction": null,
      "acmg_score": -2,
      "acmg_classification": "Likely_benign",
      "acmg_criteria": "PM2,BP4_Strong",
      "acmg_by_gene": [
        {
          "score": -2,
          "benign_score": 4,
          "pathogenic_score": 2,
          "criteria": [
            "PM2",
            "BP4_Strong"
          ],
          "verdict": "Likely_benign",
          "transcript": "NM_003363.4",
          "gene_symbol": "USP4",
          "hgnc_id": 12627,
          "effects": [
            "missense_variant"
          ],
          "inheritance_mode": "AR",
          "hgvs_c": "c.2321C>G",
          "hgvs_p": "p.Thr774Ser"
        }
      ],
      "clinvar_disease": "not specified",
      "clinvar_classification": "Uncertain significance",
      "clinvar_review_status": "criteria provided, single submitter",
      "clinvar_submissions_summary": "US:1",
      "phenotype_combined": "not specified",
      "pathogenicity_classification_combined": "Uncertain significance",
      "custom_annotations": null
    }
  ],
  "message": null
}
For research and educational, non-commercial use only. Not for clinical or diagnostic use. GeneBe does not provide medical advice. Data use for AI modeling is prohibited: if used, the cost is $0.001 per byte of downloaded uncompressed data.