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GeneBe API Showcase

This page demonstrates how to use the GeneBe API to query variant information. The API provides programmatic access to genomic annotations and variant data.

API presented here should be used for checking single variants. If you want to check many variants at once, please use other API endpoints that you will find in the documentation.

Documentation & Advanced Usage

Complete API documentation:docs.genebe.net/docs/api/overview/

Interactive endpoint tester:api.genebe.net/cloud/gb-api-doc/swagger-ui/

Python client for pandas:pypi.org/project/genebe/

Java CLI for VCF files:github.com/pstawinski/genebe-cli

All tools documented at:docs.genebe.net

API Request Examples for Variant: 3-49865111-A-G (hg38)

Bash / cURL Example

bash
curl "https://api.genebe.net/cloud/api-public/v1/variant?chr=3&pos=49865111&ref=A&alt=G&genome=hg38&allGenes=true"

API Response

json
{
  "variants": [
    {
      "chr": "3",
      "pos": 49865111,
      "ref": "A",
      "alt": "G",
      "effect": "intron_variant",
      "transcript": "NM_024046.5",
      "consequences": [
        {
          "aa_ref": null,
          "aa_alt": null,
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "intron_variant"
          ],
          "exon_rank": null,
          "exon_rank_end": null,
          "exon_count": 11,
          "intron_rank": 1,
          "intron_rank_end": null,
          "gene_symbol": "CAMKV",
          "gene_hgnc_id": 28788,
          "hgvs_c": "c.-14-2709T>C",
          "hgvs_p": null,
          "transcript": "NM_024046.5",
          "protein_id": "NP_076951.2",
          "transcript_support_level": null,
          "aa_start": null,
          "aa_end": null,
          "aa_length": 501,
          "cds_start": null,
          "cds_end": null,
          "cds_length": 1506,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": 2998,
          "mane_select": "ENST00000477224.6",
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "NM_024046.5"
        },
        {
          "aa_ref": null,
          "aa_alt": null,
          "canonical": true,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "intron_variant"
          ],
          "exon_rank": null,
          "exon_rank_end": null,
          "exon_count": 11,
          "intron_rank": 1,
          "intron_rank_end": null,
          "gene_symbol": "CAMKV",
          "gene_hgnc_id": 28788,
          "hgvs_c": "c.-14-2709T>C",
          "hgvs_p": null,
          "transcript": "ENST00000477224.6",
          "protein_id": "ENSP00000419195.1",
          "transcript_support_level": 1,
          "aa_start": null,
          "aa_end": null,
          "aa_length": 501,
          "cds_start": null,
          "cds_end": null,
          "cds_length": 1506,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": 2998,
          "mane_select": "NM_024046.5",
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000477224.6"
        },
        {
          "aa_ref": null,
          "aa_alt": null,
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "intron_variant"
          ],
          "exon_rank": null,
          "exon_rank_end": null,
          "exon_count": 10,
          "intron_rank": 1,
          "intron_rank_end": null,
          "gene_symbol": "CAMKV",
          "gene_hgnc_id": 28788,
          "hgvs_c": "c.-14-2709T>C",
          "hgvs_p": null,
          "transcript": "ENST00000296471.11",
          "protein_id": "ENSP00000296471.6",
          "transcript_support_level": 1,
          "aa_start": null,
          "aa_end": null,
          "aa_length": 473,
          "cds_start": null,
          "cds_end": null,
          "cds_length": 1422,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": 2913,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000296471.11"
        },
        {
          "aa_ref": null,
          "aa_alt": null,
          "canonical": false,
          "protein_coding": false,
          "strand": false,
          "consequences": [
            "intron_variant"
          ],
          "exon_rank": null,
          "exon_rank_end": null,
          "exon_count": 10,
          "intron_rank": 1,
          "intron_rank_end": null,
          "gene_symbol": "CAMKV",
          "gene_hgnc_id": 28788,
          "hgvs_c": "n.147-2709T>C",
          "hgvs_p": null,
          "transcript": "ENST00000475665.5",
          "protein_id": null,
          "transcript_support_level": 1,
          "aa_start": null,
          "aa_end": null,
          "aa_length": null,
          "cds_start": null,
          "cds_end": null,
          "cds_length": null,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": 3157,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "retained_intron",
          "feature": "ENST00000475665.5"
        },
        {
          "aa_ref": null,
          "aa_alt": null,
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "intron_variant"
          ],
          "exon_rank": null,
          "exon_rank_end": null,
          "exon_count": 11,
          "intron_rank": 1,
          "intron_rank_end": null,
          "gene_symbol": "CAMKV",
          "gene_hgnc_id": 28788,
          "hgvs_c": "c.-14-2709T>C",
          "hgvs_p": null,
          "transcript": "ENST00000911457.1",
          "protein_id": "ENSP00000581516.1",
          "transcript_support_level": null,
          "aa_start": null,
          "aa_end": null,
          "aa_length": 501,
          "cds_start": null,
          "cds_end": null,
          "cds_length": 1506,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": 3041,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000911457.1"
        },
        {
          "aa_ref": null,
          "aa_alt": null,
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "intron_variant"
          ],
          "exon_rank": null,
          "exon_rank_end": null,
          "exon_count": 11,
          "intron_rank": 1,
          "intron_rank_end": null,
          "gene_symbol": "CAMKV",
          "gene_hgnc_id": 28788,
          "hgvs_c": "c.-14-2709T>C",
          "hgvs_p": null,
          "transcript": "ENST00000911456.1",
          "protein_id": "ENSP00000581515.1",
          "transcript_support_level": null,
          "aa_start": null,
          "aa_end": null,
          "aa_length": 498,
          "cds_start": null,
          "cds_end": null,
          "cds_length": 1497,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": 3768,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000911456.1"
        },
        {
          "aa_ref": null,
          "aa_alt": null,
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "intron_variant"
          ],
          "exon_rank": null,
          "exon_rank_end": null,
          "exon_count": 11,
          "intron_rank": 1,
          "intron_rank_end": null,
          "gene_symbol": "CAMKV",
          "gene_hgnc_id": 28788,
          "hgvs_c": "c.-14-2709T>C",
          "hgvs_p": null,
          "transcript": "ENST00000865409.1",
          "protein_id": "ENSP00000535468.1",
          "transcript_support_level": null,
          "aa_start": null,
          "aa_end": null,
          "aa_length": 494,
          "cds_start": null,
          "cds_end": null,
          "cds_length": 1485,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": 2963,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000865409.1"
        },
        {
          "aa_ref": null,
          "aa_alt": null,
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "intron_variant"
          ],
          "exon_rank": null,
          "exon_rank_end": null,
          "exon_count": 12,
          "intron_rank": 1,
          "intron_rank_end": null,
          "gene_symbol": "CAMKV",
          "gene_hgnc_id": 28788,
          "hgvs_c": "c.-14-2709T>C",
          "hgvs_p": null,
          "transcript": "NM_001320147.2",
          "protein_id": "NP_001307076.1",
          "transcript_support_level": null,
          "aa_start": null,
          "aa_end": null,
          "aa_length": 470,
          "cds_start": null,
          "cds_end": null,
          "cds_length": 1413,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": 2905,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "NM_001320147.2"
        },
        {
          "aa_ref": null,
          "aa_alt": null,
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "intron_variant"
          ],
          "exon_rank": null,
          "exon_rank_end": null,
          "exon_count": 12,
          "intron_rank": 1,
          "intron_rank_end": null,
          "gene_symbol": "CAMKV",
          "gene_hgnc_id": 28788,
          "hgvs_c": "c.-14-2709T>C",
          "hgvs_p": null,
          "transcript": "ENST00000488336.5",
          "protein_id": "ENSP00000418809.1",
          "transcript_support_level": 2,
          "aa_start": null,
          "aa_end": null,
          "aa_length": 470,
          "cds_start": null,
          "cds_end": null,
          "cds_length": 1413,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": 2905,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000488336.5"
        },
        {
          "aa_ref": null,
          "aa_alt": null,
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "intron_variant"
          ],
          "exon_rank": null,
          "exon_rank_end": null,
          "exon_count": 11,
          "intron_rank": 1,
          "intron_rank_end": null,
          "gene_symbol": "CAMKV",
          "gene_hgnc_id": 28788,
          "hgvs_c": "c.-14-2709T>C",
          "hgvs_p": null,
          "transcript": "ENST00000951010.1",
          "protein_id": "ENSP00000621069.1",
          "transcript_support_level": null,
          "aa_start": null,
          "aa_end": null,
          "aa_length": 458,
          "cds_start": null,
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          "cds_length": 1377,
          "cdna_start": null,
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          "cdna_length": 2847,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000951010.1"
        },
        {
          "aa_ref": null,
          "aa_alt": null,
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "intron_variant"
          ],
          "exon_rank": null,
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          "exon_count": 11,
          "intron_rank": 1,
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          "gene_symbol": "CAMKV",
          "gene_hgnc_id": 28788,
          "hgvs_c": "c.-14-2709T>C",
          "hgvs_p": null,
          "transcript": "ENST00000463537.5",
          "protein_id": "ENSP00000417614.1",
          "transcript_support_level": 5,
          "aa_start": null,
          "aa_end": null,
          "aa_length": 434,
          "cds_start": null,
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          "cds_length": 1305,
          "cdna_start": null,
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          "cdna_length": 2818,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
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        },
        {
          "aa_ref": null,
          "aa_alt": null,
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
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          ],
          "exon_rank": null,
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          "intron_rank": 1,
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          "gene_symbol": "CAMKV",
          "gene_hgnc_id": 28788,
          "hgvs_c": "c.-14-2709T>C",
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          "transcript": "ENST00000466940.5",
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          "cds_start": null,
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          "cdna_start": null,
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          "cdna_length": 1475,
          "mane_select": null,
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          "biotype": "protein_coding",
          "feature": "ENST00000466940.5"
        },
        {
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          "consequences": [
            "intron_variant"
          ],
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          "intron_rank": 1,
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          "gene_symbol": "CAMKV",
          "gene_hgnc_id": 28788,
          "hgvs_c": "c.-201-2709T>C",
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          "transcript": "ENST00000467248.5",
          "protein_id": "ENSP00000420053.1",
          "transcript_support_level": 2,
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          "cds_start": null,
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          "cdna_start": null,
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          "feature": "ENST00000467248.5"
        },
        {
          "aa_ref": null,
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          "canonical": false,
          "protein_coding": true,
          "strand": false,
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          ],
          "exon_rank": null,
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          "exon_count": 5,
          "intron_rank": 1,
          "intron_rank_end": null,
          "gene_symbol": "CAMKV",
          "gene_hgnc_id": 28788,
          "hgvs_c": "c.-14-2709T>C",
          "hgvs_p": null,
          "transcript": "ENST00000480398.2",
          "protein_id": "ENSP00000420000.2",
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          "aa_start": null,
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          "aa_length": 122,
          "cds_start": null,
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          "mane_select": null,
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          "feature": "ENST00000480398.2"
        },
        {
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          "gene_symbol": "CAMKV",
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          "hgvs_c": "n.-14-2709T>C",
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          "transcript": "ENST00000466535.5",
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          "aa_start": null,
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          "mane_select": null,
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          "biotype": "nonsense_mediated_decay",
          "feature": "ENST00000466535.5"
        },
        {
          "aa_ref": null,
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          "canonical": false,
          "protein_coding": false,
          "strand": false,
          "consequences": [
            "intron_variant"
          ],
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          "exon_count": 3,
          "intron_rank": 1,
          "intron_rank_end": null,
          "gene_symbol": "CAMKV",
          "gene_hgnc_id": 28788,
          "hgvs_c": "n.149-2709T>C",
          "hgvs_p": null,
          "transcript": "ENST00000476105.1",
          "protein_id": null,
          "transcript_support_level": 4,
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          "cdna_length": 583,
          "mane_select": null,
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          "biotype": "retained_intron",
          "feature": "ENST00000476105.1"
        },
        {
          "aa_ref": null,
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          "consequences": [
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          ],
          "exon_rank": null,
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          "exon_count": 4,
          "intron_rank": 1,
          "intron_rank_end": null,
          "gene_symbol": "CAMKV",
          "gene_hgnc_id": 28788,
          "hgvs_c": "n.149-2709T>C",
          "hgvs_p": null,
          "transcript": "ENST00000479704.5",
          "protein_id": null,
          "transcript_support_level": 4,
          "aa_start": null,
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          "aa_length": null,
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          "cdna_start": null,
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          "cdna_length": 513,
          "mane_select": null,
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          "biotype": "retained_intron",
          "feature": "ENST00000479704.5"
        },
        {
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          "strand": false,
          "consequences": [
            "intron_variant"
          ],
          "exon_rank": null,
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          "exon_count": 12,
          "intron_rank": 1,
          "intron_rank_end": null,
          "gene_symbol": "CAMKV",
          "gene_hgnc_id": 28788,
          "hgvs_c": "n.-14-2709T>C",
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          "transcript": "ENST00000487726.5",
          "protein_id": "ENSP00000420139.1",
          "transcript_support_level": 2,
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          "cdna_start": null,
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          "cdna_length": 1589,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "nonsense_mediated_decay",
          "feature": "ENST00000487726.5"
        },
        {
          "aa_ref": null,
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          "canonical": false,
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          "strand": false,
          "consequences": [
            "intron_variant"
          ],
          "exon_rank": null,
          "exon_rank_end": null,
          "exon_count": 5,
          "intron_rank": 1,
          "intron_rank_end": null,
          "gene_symbol": "CAMKV",
          "gene_hgnc_id": 28788,
          "hgvs_c": "n.149-2709T>C",
          "hgvs_p": null,
          "transcript": "ENST00000498324.5",
          "protein_id": null,
          "transcript_support_level": 4,
          "aa_start": null,
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          "aa_length": null,
          "cds_start": null,
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          "cds_length": null,
          "cdna_start": null,
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          "cdna_length": 598,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "pseudogene",
          "feature": "ENST00000498324.5"
        }
      ],
      "gene_symbol": "CAMKV",
      "gene_hgnc_id": 28788,
      "dbsnp": "rs9821675",
      "frequency_reference_population": 0.49282202,
      "hom_count_reference_population": 19740,
      "allele_count_reference_population": 74974,
      "gnomad_exomes_af": null,
      "gnomad_genomes_af": 0.492822,
      "gnomad_exomes_ac": null,
      "gnomad_genomes_ac": 74974,
      "gnomad_exomes_homalt": null,
      "gnomad_genomes_homalt": 19740,
      "gnomad_mito_homoplasmic": null,
      "gnomad_mito_heteroplasmic": null,
      "computational_score_selected": -0.6000000238418579,
      "computational_prediction_selected": "Benign",
      "computational_source_selected": "BayesDel_noAF",
      "splice_score_selected": 0,
      "splice_prediction_selected": "Benign",
      "splice_source_selected": "max_spliceai",
      "revel_score": null,
      "revel_prediction": null,
      "alphamissense_score": null,
      "alphamissense_prediction": null,
      "bayesdelnoaf_score": -0.6,
      "bayesdelnoaf_prediction": "Benign",
      "phylop100way_score": 0.074,
      "phylop100way_prediction": "Benign",
      "spliceai_max_score": 0,
      "spliceai_max_prediction": "Benign",
      "dbscsnv_ada_score": null,
      "dbscsnv_ada_prediction": null,
      "apogee2_score": null,
      "apogee2_prediction": null,
      "mitotip_score": null,
      "mitotip_prediction": null,
      "acmg_score": -12,
      "acmg_classification": "Benign",
      "acmg_criteria": "BP4_Strong,BA1",
      "acmg_by_gene": [
        {
          "score": -12,
          "benign_score": 12,
          "pathogenic_score": 0,
          "criteria": [
            "BP4_Strong",
            "BA1"
          ],
          "verdict": "Benign",
          "transcript": "NM_024046.5",
          "gene_symbol": "CAMKV",
          "hgnc_id": 28788,
          "effects": [
            "intron_variant"
          ],
          "inheritance_mode": "AD",
          "hgvs_c": "c.-14-2709T>C",
          "hgvs_p": null
        }
      ],
      "clinvar_disease": "",
      "clinvar_classification": "",
      "clinvar_review_status": "",
      "clinvar_submissions_summary": "",
      "phenotype_combined": null,
      "pathogenicity_classification_combined": null,
      "custom_annotations": null
    }
  ],
  "message": null
}
For research and educational, non-commercial use only. Not for clinical or diagnostic use. GeneBe does not provide medical advice. Data use for AI modeling is prohibited: if used, the cost is $0.001 per byte of downloaded uncompressed data.