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GeneBe API Showcase
This page demonstrates how to use the GeneBe API to query variant information. The API provides programmatic access to genomic annotations and variant data.
API presented here should be used for checking single variants. If you want to check many variants at once, please use other API endpoints that you will find in the documentation.
Documentation & Advanced Usage
• Complete API documentation:docs.genebe.net/docs/api/overview/
• Interactive endpoint tester:api.genebe.net/cloud/gb-api-doc/swagger-ui/
• Python client for pandas:pypi.org/project/genebe/
• Java CLI for VCF files:github.com/pstawinski/genebe-cli
• All tools documented at:docs.genebe.net
API Request Examples for Variant: 3-49890524-C-T (hg38)
Bash / cURL Example
bash
curl "https://api.genebe.net/cloud/api-public/v1/variant?chr=3&pos=49890524&ref=C&alt=T&genome=hg38&allGenes=true"API Response
json
{
"variants": [
{
"chr": "3",
"pos": 49890524,
"ref": "C",
"alt": "T",
"effect": "synonymous_variant",
"transcript": "NM_002447.4",
"consequences": [
{
"aa_ref": "E",
"aa_alt": "E",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 18,
"exon_rank_end": null,
"exon_count": 20,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "MST1R",
"gene_hgnc_id": 7381,
"hgvs_c": "c.3771G>A",
"hgvs_p": "p.Glu1257Glu",
"transcript": "NM_002447.4",
"protein_id": "NP_002438.2",
"transcript_support_level": null,
"aa_start": 1257,
"aa_end": null,
"aa_length": 1400,
"cds_start": 3771,
"cds_end": null,
"cds_length": 4203,
"cdna_start": 4035,
"cdna_end": null,
"cdna_length": 4772,
"mane_select": "ENST00000296474.8",
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "E",
"aa_alt": "E",
"canonical": true,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 18,
"exon_rank_end": null,
"exon_count": 20,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "MST1R",
"gene_hgnc_id": 7381,
"hgvs_c": "c.3771G>A",
"hgvs_p": "p.Glu1257Glu",
"transcript": "ENST00000296474.8",
"protein_id": "ENSP00000296474.3",
"transcript_support_level": 1,
"aa_start": 1257,
"aa_end": null,
"aa_length": 1400,
"cds_start": 3771,
"cds_end": null,
"cds_length": 4203,
"cdna_start": 4035,
"cdna_end": null,
"cdna_length": 4772,
"mane_select": "NM_002447.4",
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "E",
"aa_alt": "E",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 16,
"exon_rank_end": null,
"exon_count": 18,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "MST1R",
"gene_hgnc_id": 7381,
"hgvs_c": "c.3453G>A",
"hgvs_p": "p.Glu1151Glu",
"transcript": "ENST00000621387.4",
"protein_id": "ENSP00000482642.1",
"transcript_support_level": 1,
"aa_start": 1151,
"aa_end": null,
"aa_length": 1294,
"cds_start": 3453,
"cds_end": null,
"cds_length": 3885,
"cdna_start": 3717,
"cdna_end": null,
"cdna_length": 4449,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "E",
"aa_alt": "E",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 17,
"exon_rank_end": null,
"exon_count": 19,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "MST1R",
"gene_hgnc_id": 7381,
"hgvs_c": "c.3624G>A",
"hgvs_p": "p.Glu1208Glu",
"transcript": "NM_001244937.3",
"protein_id": "NP_001231866.1",
"transcript_support_level": null,
"aa_start": 1208,
"aa_end": null,
"aa_length": 1351,
"cds_start": 3624,
"cds_end": null,
"cds_length": 4056,
"cdna_start": 3888,
"cdna_end": null,
"cdna_length": 4625,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "E",
"aa_alt": "E",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 17,
"exon_rank_end": null,
"exon_count": 19,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "MST1R",
"gene_hgnc_id": 7381,
"hgvs_c": "c.3624G>A",
"hgvs_p": "p.Glu1208Glu",
"transcript": "ENST00000344206.8",
"protein_id": "ENSP00000341325.4",
"transcript_support_level": 5,
"aa_start": 1208,
"aa_end": null,
"aa_length": 1351,
"cds_start": 3624,
"cds_end": null,
"cds_length": 4056,
"cdna_start": 3624,
"cdna_end": null,
"cdna_length": 4198,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "E",
"aa_alt": "E",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 17,
"exon_rank_end": null,
"exon_count": 19,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "MST1R",
"gene_hgnc_id": 7381,
"hgvs_c": "c.3564G>A",
"hgvs_p": "p.Glu1188Glu",
"transcript": "NM_001437543.1",
"protein_id": "NP_001424472.1",
"transcript_support_level": null,
"aa_start": 1188,
"aa_end": null,
"aa_length": 1331,
"cds_start": 3564,
"cds_end": null,
"cds_length": 3996,
"cdna_start": 3828,
"cdna_end": null,
"cdna_length": 4565,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "E",
"aa_alt": "E",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 17,
"exon_rank_end": null,
"exon_count": 19,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "MST1R",
"gene_hgnc_id": 7381,
"hgvs_c": "c.3564G>A",
"hgvs_p": "p.Glu1188Glu",
"transcript": "ENST00000434765.6",
"protein_id": "ENSP00000393294.2",
"transcript_support_level": 5,
"aa_start": 1188,
"aa_end": null,
"aa_length": 1331,
"cds_start": 3564,
"cds_end": null,
"cds_length": 3996,
"cdna_start": 3828,
"cdna_end": null,
"cdna_length": 4565,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "E",
"aa_alt": "E",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 17,
"exon_rank_end": null,
"exon_count": 19,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "MST1R",
"gene_hgnc_id": 7381,
"hgvs_c": "c.3516G>A",
"hgvs_p": "p.Glu1172Glu",
"transcript": "ENST00000440292.2",
"protein_id": "ENSP00000414792.2",
"transcript_support_level": 3,
"aa_start": 1172,
"aa_end": null,
"aa_length": 1315,
"cds_start": 3516,
"cds_end": null,
"cds_length": 3948,
"cdna_start": 3780,
"cdna_end": null,
"cdna_length": 4517,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "E",
"aa_alt": "E",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 16,
"exon_rank_end": null,
"exon_count": 18,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "MST1R",
"gene_hgnc_id": 7381,
"hgvs_c": "c.3453G>A",
"hgvs_p": "p.Glu1151Glu",
"transcript": "NM_001318913.2",
"protein_id": "NP_001305842.1",
"transcript_support_level": null,
"aa_start": 1151,
"aa_end": null,
"aa_length": 1294,
"cds_start": 3453,
"cds_end": null,
"cds_length": 3885,
"cdna_start": 3717,
"cdna_end": null,
"cdna_length": 4454,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "E",
"aa_alt": "E",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 18,
"exon_rank_end": null,
"exon_count": 20,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "MST1R",
"gene_hgnc_id": 7381,
"hgvs_c": "c.3774G>A",
"hgvs_p": "p.Glu1258Glu",
"transcript": "XM_005265170.5",
"protein_id": "XP_005265227.2",
"transcript_support_level": null,
"aa_start": 1258,
"aa_end": null,
"aa_length": 1401,
"cds_start": 3774,
"cds_end": null,
"cds_length": 4206,
"cdna_start": 4038,
"cdna_end": null,
"cdna_length": 4775,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "E",
"aa_alt": "E",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 18,
"exon_rank_end": null,
"exon_count": 20,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "MST1R",
"gene_hgnc_id": 7381,
"hgvs_c": "c.3654G>A",
"hgvs_p": "p.Glu1218Glu",
"transcript": "XM_011533739.3",
"protein_id": "XP_011532041.1",
"transcript_support_level": null,
"aa_start": 1218,
"aa_end": null,
"aa_length": 1361,
"cds_start": 3654,
"cds_end": null,
"cds_length": 4086,
"cdna_start": 3918,
"cdna_end": null,
"cdna_length": 4655,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "E",
"aa_alt": "E",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 18,
"exon_rank_end": null,
"exon_count": 20,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "MST1R",
"gene_hgnc_id": 7381,
"hgvs_c": "c.3651G>A",
"hgvs_p": "p.Glu1217Glu",
"transcript": "XM_047448162.1",
"protein_id": "XP_047304118.1",
"transcript_support_level": null,
"aa_start": 1217,
"aa_end": null,
"aa_length": 1360,
"cds_start": 3651,
"cds_end": null,
"cds_length": 4083,
"cdna_start": 3915,
"cdna_end": null,
"cdna_length": 4652,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "E",
"aa_alt": "E",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 17,
"exon_rank_end": null,
"exon_count": 19,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "MST1R",
"gene_hgnc_id": 7381,
"hgvs_c": "c.3627G>A",
"hgvs_p": "p.Glu1209Glu",
"transcript": "XM_011533740.3",
"protein_id": "XP_011532042.1",
"transcript_support_level": null,
"aa_start": 1209,
"aa_end": null,
"aa_length": 1352,
"cds_start": 3627,
"cds_end": null,
"cds_length": 4059,
"cdna_start": 3891,
"cdna_end": null,
"cdna_length": 4628,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "E",
"aa_alt": "E",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 17,
"exon_rank_end": null,
"exon_count": 19,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "MST1R",
"gene_hgnc_id": 7381,
"hgvs_c": "c.3567G>A",
"hgvs_p": "p.Glu1189Glu",
"transcript": "XM_011533741.3",
"protein_id": "XP_011532043.1",
"transcript_support_level": null,
"aa_start": 1189,
"aa_end": null,
"aa_length": 1332,
"cds_start": 3567,
"cds_end": null,
"cds_length": 3999,
"cdna_start": 3831,
"cdna_end": null,
"cdna_length": 4568,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "E",
"aa_alt": "E",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 18,
"exon_rank_end": null,
"exon_count": 19,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "MST1R",
"gene_hgnc_id": 7381,
"hgvs_c": "c.3774G>A",
"hgvs_p": "p.Glu1258Glu",
"transcript": "XM_011533742.3",
"protein_id": "XP_011532044.1",
"transcript_support_level": null,
"aa_start": 1258,
"aa_end": null,
"aa_length": 1324,
"cds_start": 3774,
"cds_end": null,
"cds_length": 3975,
"cdna_start": 4038,
"cdna_end": null,
"cdna_length": 4638,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "E",
"aa_alt": "E",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 18,
"exon_rank_end": null,
"exon_count": 19,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "MST1R",
"gene_hgnc_id": 7381,
"hgvs_c": "c.3771G>A",
"hgvs_p": "p.Glu1257Glu",
"transcript": "XM_047448164.1",
"protein_id": "XP_047304120.1",
"transcript_support_level": null,
"aa_start": 1257,
"aa_end": null,
"aa_length": 1323,
"cds_start": 3771,
"cds_end": null,
"cds_length": 3972,
"cdna_start": 4035,
"cdna_end": null,
"cdna_length": 4635,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "E",
"aa_alt": "E",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 16,
"exon_rank_end": null,
"exon_count": 18,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "MST1R",
"gene_hgnc_id": 7381,
"hgvs_c": "c.3456G>A",
"hgvs_p": "p.Glu1152Glu",
"transcript": "XM_011533744.3",
"protein_id": "XP_011532046.1",
"transcript_support_level": null,
"aa_start": 1152,
"aa_end": null,
"aa_length": 1295,
"cds_start": 3456,
"cds_end": null,
"cds_length": 3888,
"cdna_start": 3720,
"cdna_end": null,
"cdna_length": 4457,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "E",
"aa_alt": "E",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 18,
"exon_rank_end": null,
"exon_count": 19,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "MST1R",
"gene_hgnc_id": 7381,
"hgvs_c": "c.3651G>A",
"hgvs_p": "p.Glu1217Glu",
"transcript": "XM_047448166.1",
"protein_id": "XP_047304122.1",
"transcript_support_level": null,
"aa_start": 1217,
"aa_end": null,
"aa_length": 1283,
"cds_start": 3651,
"cds_end": null,
"cds_length": 3852,
"cdna_start": 3915,
"cdna_end": null,
"cdna_length": 4515,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "E",
"aa_alt": "E",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 16,
"exon_rank_end": null,
"exon_count": 18,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "MST1R",
"gene_hgnc_id": 7381,
"hgvs_c": "c.3420G>A",
"hgvs_p": "p.Glu1140Glu",
"transcript": "XM_047448167.1",
"protein_id": "XP_047304123.1",
"transcript_support_level": null,
"aa_start": 1140,
"aa_end": null,
"aa_length": 1283,
"cds_start": 3420,
"cds_end": null,
"cds_length": 3852,
"cdna_start": 3684,
"cdna_end": null,
"cdna_length": 4421,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "E",
"aa_alt": "E",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 16,
"exon_rank_end": null,
"exon_count": 18,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "MST1R",
"gene_hgnc_id": 7381,
"hgvs_c": "c.3417G>A",
"hgvs_p": "p.Glu1139Glu",
"transcript": "XM_047448168.1",
"protein_id": "XP_047304124.1",
"transcript_support_level": null,
"aa_start": 1139,
"aa_end": null,
"aa_length": 1282,
"cds_start": 3417,
"cds_end": null,
"cds_length": 3849,
"cdna_start": 3681,
"cdna_end": null,
"cdna_length": 4418,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "E",
"aa_alt": "E",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 17,
"exon_rank_end": null,
"exon_count": 18,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "MST1R",
"gene_hgnc_id": 7381,
"hgvs_c": "c.3627G>A",
"hgvs_p": "p.Glu1209Glu",
"transcript": "XM_047448169.1",
"protein_id": "XP_047304125.1",
"transcript_support_level": null,
"aa_start": 1209,
"aa_end": null,
"aa_length": 1275,
"cds_start": 3627,
"cds_end": null,
"cds_length": 3828,
"cdna_start": 3891,
"cdna_end": null,
"cdna_length": 4491,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "E",
"aa_alt": "E",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 17,
"exon_rank_end": null,
"exon_count": 18,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "MST1R",
"gene_hgnc_id": 7381,
"hgvs_c": "c.3624G>A",
"hgvs_p": "p.Glu1208Glu",
"transcript": "XM_047448170.1",
"protein_id": "XP_047304126.1",
"transcript_support_level": null,
"aa_start": 1208,
"aa_end": null,
"aa_length": 1274,
"cds_start": 3624,
"cds_end": null,
"cds_length": 3825,
"cdna_start": 3888,
"cdna_end": null,
"cdna_length": 4488,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "E",
"aa_alt": "E",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 17,
"exon_rank_end": null,
"exon_count": 18,
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}