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GeneBe API Showcase

This page demonstrates how to use the GeneBe API to query variant information. The API provides programmatic access to genomic annotations and variant data.

API presented here should be used for checking single variants. If you want to check many variants at once, please use other API endpoints that you will find in the documentation.

Documentation & Advanced Usage

Complete API documentation:docs.genebe.net/docs/api/overview/

Interactive endpoint tester:api.genebe.net/cloud/gb-api-doc/swagger-ui/

Python client for pandas:pypi.org/project/genebe/

Java CLI for VCF files:github.com/pstawinski/genebe-cli

All tools documented at:docs.genebe.net

API Request Examples for Variant: 3-50288900-C-G (hg38)

Bash / cURL Example

bash
curl "https://api.genebe.net/cloud/api-public/v1/variant?chr=3&pos=50288900&ref=C&alt=G&genome=hg38&allGenes=true"

API Response

json
{
  "message": null,
  "variants": [
    {
      "acmg_by_gene": [
        {
          "benign_score": 2,
          "criteria": [
            "PM2",
            "BP4_Moderate"
          ],
          "effects": [
            "missense_variant"
          ],
          "gene_symbol": "IFRD2",
          "hgnc_id": 5457,
          "hgvs_c": "c.923G>C",
          "hgvs_p": "p.Ser308Thr",
          "inheritance_mode": "AR",
          "pathogenic_score": 2,
          "score": 0,
          "transcript": "NM_006764.5",
          "verdict": "Uncertain_significance"
        }
      ],
      "acmg_classification": "Uncertain_significance",
      "acmg_criteria": "PM2,BP4_Moderate",
      "acmg_score": 0,
      "allele_count_reference_population": 0,
      "alphamissense_prediction": null,
      "alphamissense_score": 0.0736,
      "alt": "G",
      "apogee2_prediction": null,
      "apogee2_score": null,
      "bayesdelnoaf_prediction": "Benign",
      "bayesdelnoaf_score": -0.57,
      "chr": "3",
      "clinvar_classification": "Uncertain significance",
      "clinvar_disease": "not specified",
      "clinvar_review_status": "criteria provided, single submitter",
      "clinvar_submissions_summary": "US:1",
      "computational_prediction_selected": "Benign",
      "computational_score_selected": 0.07224062085151672,
      "computational_source_selected": "MetaRNN",
      "consequences": [
        {
          "aa_alt": "T",
          "aa_end": null,
          "aa_length": 442,
          "aa_ref": "S",
          "aa_start": 308,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 1943,
          "cdna_start": 1078,
          "cds_end": null,
          "cds_length": 1329,
          "cds_start": 923,
          "consequences": [
            "missense_variant"
          ],
          "exon_count": 12,
          "exon_rank": 9,
          "exon_rank_end": null,
          "feature": "NM_006764.5",
          "gene_hgnc_id": 5457,
          "gene_symbol": "IFRD2",
          "hgvs_c": "c.923G>C",
          "hgvs_p": "p.Ser308Thr",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": "ENST00000417626.8",
          "protein_coding": true,
          "protein_id": "NP_006755.5",
          "strand": false,
          "transcript": "NM_006764.5",
          "transcript_support_level": null
        },
        {
          "aa_alt": "T",
          "aa_end": null,
          "aa_length": 442,
          "aa_ref": "S",
          "aa_start": 308,
          "biotype": "protein_coding",
          "canonical": true,
          "cdna_end": null,
          "cdna_length": 1943,
          "cdna_start": 1078,
          "cds_end": null,
          "cds_length": 1329,
          "cds_start": 923,
          "consequences": [
            "missense_variant"
          ],
          "exon_count": 12,
          "exon_rank": 9,
          "exon_rank_end": null,
          "feature": "ENST00000417626.8",
          "gene_hgnc_id": 5457,
          "gene_symbol": "IFRD2",
          "hgvs_c": "c.923G>C",
          "hgvs_p": "p.Ser308Thr",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": "NM_006764.5",
          "protein_coding": true,
          "protein_id": "ENSP00000402849.4",
          "strand": false,
          "transcript": "ENST00000417626.8",
          "transcript_support_level": 1
        },
        {
          "aa_alt": "T",
          "aa_end": null,
          "aa_length": 449,
          "aa_ref": "S",
          "aa_start": 315,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 1959,
          "cdna_start": 1097,
          "cds_end": null,
          "cds_length": 1350,
          "cds_start": 944,
          "consequences": [
            "missense_variant"
          ],
          "exon_count": 12,
          "exon_rank": 9,
          "exon_rank_end": null,
          "feature": "ENST00000921977.1",
          "gene_hgnc_id": 5457,
          "gene_symbol": "IFRD2",
          "hgvs_c": "c.944G>C",
          "hgvs_p": "p.Ser315Thr",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "ENSP00000592036.1",
          "strand": false,
          "transcript": "ENST00000921977.1",
          "transcript_support_level": null
        },
        {
          "aa_alt": "T",
          "aa_end": null,
          "aa_length": 446,
          "aa_ref": "S",
          "aa_start": 312,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 1942,
          "cdna_start": 1088,
          "cds_end": null,
          "cds_length": 1341,
          "cds_start": 935,
          "consequences": [
            "missense_variant"
          ],
          "exon_count": 12,
          "exon_rank": 9,
          "exon_rank_end": null,
          "feature": "ENST00000879012.1",
          "gene_hgnc_id": 5457,
          "gene_symbol": "IFRD2",
          "hgvs_c": "c.935G>C",
          "hgvs_p": "p.Ser312Thr",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "ENSP00000549071.1",
          "strand": false,
          "transcript": "ENST00000879012.1",
          "transcript_support_level": null
        },
        {
          "aa_alt": "T",
          "aa_end": null,
          "aa_length": 442,
          "aa_ref": "S",
          "aa_start": 308,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 2275,
          "cdna_start": 1421,
          "cds_end": null,
          "cds_length": 1329,
          "cds_start": 923,
          "consequences": [
            "missense_variant"
          ],
          "exon_count": 15,
          "exon_rank": 12,
          "exon_rank_end": null,
          "feature": "ENST00000436390.5",
          "gene_hgnc_id": 5457,
          "gene_symbol": "IFRD2",
          "hgvs_c": "c.923G>C",
          "hgvs_p": "p.Ser308Thr",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "ENSP00000392316.1",
          "strand": false,
          "transcript": "ENST00000436390.5",
          "transcript_support_level": 2
        },
        {
          "aa_alt": "T",
          "aa_end": null,
          "aa_length": 441,
          "aa_ref": "S",
          "aa_start": 307,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 1931,
          "cdna_start": 1068,
          "cds_end": null,
          "cds_length": 1326,
          "cds_start": 920,
          "consequences": [
            "missense_variant"
          ],
          "exon_count": 12,
          "exon_rank": 9,
          "exon_rank_end": null,
          "feature": "ENST00000879013.1",
          "gene_hgnc_id": 5457,
          "gene_symbol": "IFRD2",
          "hgvs_c": "c.920G>C",
          "hgvs_p": "p.Ser307Thr",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "ENSP00000549072.1",
          "strand": false,
          "transcript": "ENST00000879013.1",
          "transcript_support_level": null
        },
        {
          "aa_alt": "T",
          "aa_end": null,
          "aa_length": 433,
          "aa_ref": "S",
          "aa_start": 299,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 1914,
          "cdna_start": 1049,
          "cds_end": null,
          "cds_length": 1302,
          "cds_start": 896,
          "consequences": [
            "missense_variant"
          ],
          "exon_count": 12,
          "exon_rank": 9,
          "exon_rank_end": null,
          "feature": "ENST00000879009.1",
          "gene_hgnc_id": 5457,
          "gene_symbol": "IFRD2",
          "hgvs_c": "c.896G>C",
          "hgvs_p": "p.Ser299Thr",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "ENSP00000549068.1",
          "strand": false,
          "transcript": "ENST00000879009.1",
          "transcript_support_level": null
        },
        {
          "aa_alt": "T",
          "aa_end": null,
          "aa_length": 429,
          "aa_ref": "S",
          "aa_start": 295,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 1898,
          "cdna_start": 1037,
          "cds_end": null,
          "cds_length": 1290,
          "cds_start": 884,
          "consequences": [
            "missense_variant"
          ],
          "exon_count": 12,
          "exon_rank": 9,
          "exon_rank_end": null,
          "feature": "ENST00000879011.1",
          "gene_hgnc_id": 5457,
          "gene_symbol": "IFRD2",
          "hgvs_c": "c.884G>C",
          "hgvs_p": "p.Ser295Thr",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "ENSP00000549070.1",
          "strand": false,
          "transcript": "ENST00000879011.1",
          "transcript_support_level": null
        },
        {
          "aa_alt": "T",
          "aa_end": null,
          "aa_length": 425,
          "aa_ref": "S",
          "aa_start": 291,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 1879,
          "cdna_start": 1025,
          "cds_end": null,
          "cds_length": 1278,
          "cds_start": 872,
          "consequences": [
            "missense_variant"
          ],
          "exon_count": 11,
          "exon_rank": 8,
          "exon_rank_end": null,
          "feature": "ENST00000948688.1",
          "gene_hgnc_id": 5457,
          "gene_symbol": "IFRD2",
          "hgvs_c": "c.872G>C",
          "hgvs_p": "p.Ser291Thr",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "ENSP00000618747.1",
          "strand": false,
          "transcript": "ENST00000948688.1",
          "transcript_support_level": null
        },
        {
          "aa_alt": "T",
          "aa_end": null,
          "aa_length": 410,
          "aa_ref": "S",
          "aa_start": 308,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 1845,
          "cdna_start": 1076,
          "cds_end": null,
          "cds_length": 1233,
          "cds_start": 923,
          "consequences": [
            "missense_variant"
          ],
          "exon_count": 11,
          "exon_rank": 9,
          "exon_rank_end": null,
          "feature": "ENST00000948686.1",
          "gene_hgnc_id": 5457,
          "gene_symbol": "IFRD2",
          "hgvs_c": "c.923G>C",
          "hgvs_p": "p.Ser308Thr",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "ENSP00000618745.1",
          "strand": false,
          "transcript": "ENST00000948686.1",
          "transcript_support_level": null
        },
        {
          "aa_alt": "T",
          "aa_end": null,
          "aa_length": 401,
          "aa_ref": "S",
          "aa_start": 267,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 1818,
          "cdna_start": 953,
          "cds_end": null,
          "cds_length": 1206,
          "cds_start": 800,
          "consequences": [
            "missense_variant"
          ],
          "exon_count": 12,
          "exon_rank": 9,
          "exon_rank_end": null,
          "feature": "ENST00000879010.1",
          "gene_hgnc_id": 5457,
          "gene_symbol": "IFRD2",
          "hgvs_c": "c.800G>C",
          "hgvs_p": "p.Ser267Thr",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "ENSP00000549069.1",
          "strand": false,
          "transcript": "ENST00000879010.1",
          "transcript_support_level": null
        },
        {
          "aa_alt": "T",
          "aa_end": null,
          "aa_length": 380,
          "aa_ref": "S",
          "aa_start": 246,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 1744,
          "cdna_start": 890,
          "cds_end": null,
          "cds_length": 1143,
          "cds_start": 737,
          "consequences": [
            "missense_variant"
          ],
          "exon_count": 11,
          "exon_rank": 8,
          "exon_rank_end": null,
          "feature": "ENST00000879014.1",
          "gene_hgnc_id": 5457,
          "gene_symbol": "IFRD2",
          "hgvs_c": "c.737G>C",
          "hgvs_p": "p.Ser246Thr",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "ENSP00000549073.1",
          "strand": false,
          "transcript": "ENST00000879014.1",
          "transcript_support_level": null
        },
        {
          "aa_alt": "T",
          "aa_end": null,
          "aa_length": 372,
          "aa_ref": "S",
          "aa_start": 238,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 1718,
          "cdna_start": 866,
          "cds_end": null,
          "cds_length": 1119,
          "cds_start": 713,
          "consequences": [
            "missense_variant"
          ],
          "exon_count": 10,
          "exon_rank": 7,
          "exon_rank_end": null,
          "feature": "ENST00000948689.1",
          "gene_hgnc_id": 5457,
          "gene_symbol": "IFRD2",
          "hgvs_c": "c.713G>C",
          "hgvs_p": "p.Ser238Thr",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "ENSP00000618748.1",
          "strand": false,
          "transcript": "ENST00000948689.1",
          "transcript_support_level": null
        },
        {
          "aa_alt": "T",
          "aa_end": null,
          "aa_length": 346,
          "aa_ref": "S",
          "aa_start": 212,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 1653,
          "cdna_start": 788,
          "cds_end": null,
          "cds_length": 1041,
          "cds_start": 635,
          "consequences": [
            "missense_variant"
          ],
          "exon_count": 10,
          "exon_rank": 7,
          "exon_rank_end": null,
          "feature": "ENST00000879008.1",
          "gene_hgnc_id": 5457,
          "gene_symbol": "IFRD2",
          "hgvs_c": "c.635G>C",
          "hgvs_p": "p.Ser212Thr",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "ENSP00000549067.1",
          "strand": false,
          "transcript": "ENST00000879008.1",
          "transcript_support_level": null
        },
        {
          "aa_alt": "T",
          "aa_end": null,
          "aa_length": 337,
          "aa_ref": "S",
          "aa_start": 203,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 1615,
          "cdna_start": 761,
          "cds_end": null,
          "cds_length": 1014,
          "cds_start": 608,
          "consequences": [
            "missense_variant"
          ],
          "exon_count": 10,
          "exon_rank": 7,
          "exon_rank_end": null,
          "feature": "ENST00000948690.1",
          "gene_hgnc_id": 5457,
          "gene_symbol": "IFRD2",
          "hgvs_c": "c.608G>C",
          "hgvs_p": "p.Ser203Thr",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "ENSP00000618749.1",
          "strand": false,
          "transcript": "ENST00000948690.1",
          "transcript_support_level": null
        },
        {
          "aa_alt": "T",
          "aa_end": null,
          "aa_length": 270,
          "aa_ref": "S",
          "aa_start": 136,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 1419,
          "cdna_start": 557,
          "cds_end": null,
          "cds_length": 813,
          "cds_start": 407,
          "consequences": [
            "missense_variant"
          ],
          "exon_count": 8,
          "exon_rank": 5,
          "exon_rank_end": null,
          "feature": "ENST00000948687.1",
          "gene_hgnc_id": 5457,
          "gene_symbol": "IFRD2",
          "hgvs_c": "c.407G>C",
          "hgvs_p": "p.Ser136Thr",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "ENSP00000618746.1",
          "strand": false,
          "transcript": "ENST00000948687.1",
          "transcript_support_level": null
        },
        {
          "aa_alt": null,
          "aa_end": null,
          "aa_length": null,
          "aa_ref": null,
          "aa_start": null,
          "biotype": "nonsense_mediated_decay",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 1137,
          "cdna_start": null,
          "cds_end": null,
          "cds_length": null,
          "cds_start": null,
          "consequences": [
            "non_coding_transcript_exon_variant"
          ],
          "exon_count": 7,
          "exon_rank": 7,
          "exon_rank_end": null,
          "feature": "ENST00000414734.5",
          "gene_hgnc_id": 5457,
          "gene_symbol": "IFRD2",
          "hgvs_c": "n.*696G>C",
          "hgvs_p": null,
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": false,
          "protein_id": "ENSP00000413726.1",
          "strand": false,
          "transcript": "ENST00000414734.5",
          "transcript_support_level": 2
        },
        {
          "aa_alt": null,
          "aa_end": null,
          "aa_length": null,
          "aa_ref": null,
          "aa_start": null,
          "biotype": "nonsense_mediated_decay",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 917,
          "cdna_start": null,
          "cds_end": null,
          "cds_length": null,
          "cds_start": null,
          "consequences": [
            "non_coding_transcript_exon_variant"
          ],
          "exon_count": 8,
          "exon_rank": 6,
          "exon_rank_end": null,
          "feature": "ENST00000438296.1",
          "gene_hgnc_id": 5457,
          "gene_symbol": "IFRD2",
          "hgvs_c": "n.*100G>C",
          "hgvs_p": null,
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": false,
          "protein_id": "ENSP00000415448.1",
          "strand": false,
          "transcript": "ENST00000438296.1",
          "transcript_support_level": 5
        },
        {
          "aa_alt": null,
          "aa_end": null,
          "aa_length": null,
          "aa_ref": null,
          "aa_start": null,
          "biotype": "retained_intron",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 902,
          "cdna_start": null,
          "cds_end": null,
          "cds_length": null,
          "cds_start": null,
          "consequences": [
            "non_coding_transcript_exon_variant"
          ],
          "exon_count": 5,
          "exon_rank": 3,
          "exon_rank_end": null,
          "feature": "ENST00000464258.5",
          "gene_hgnc_id": 5457,
          "gene_symbol": "IFRD2",
          "hgvs_c": "n.299G>C",
          "hgvs_p": null,
          "intron_rank": null,
          "intron_rank_end": null,
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}
For research and educational, non-commercial use only. Not for clinical or diagnostic use. GeneBe does not provide medical advice. Data use for AI modeling is prohibited: if used, the cost is $0.001 per byte of downloaded uncompressed data.