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GeneBe API Showcase
This page demonstrates how to use the GeneBe API to query variant information. The API provides programmatic access to genomic annotations and variant data.
API presented here should be used for checking single variants. If you want to check many variants at once, please use other API endpoints that you will find in the documentation.
Documentation & Advanced Usage
• Complete API documentation:docs.genebe.net/docs/api/overview/
• Interactive endpoint tester:api.genebe.net/cloud/gb-api-doc/swagger-ui/
• Python client for pandas:pypi.org/project/genebe/
• Java CLI for VCF files:github.com/pstawinski/genebe-cli
• All tools documented at:docs.genebe.net
API Request Examples for Variant: 3-55529316-T-C (hg38)
Bash / cURL Example
bash
curl "https://api.genebe.net/cloud/api-public/v1/variant?chr=3&pos=55529316&ref=T&alt=C&genome=hg38&allGenes=true"API Response
json
{
"variants": [
{
"chr": "3",
"pos": 55529316,
"ref": "T",
"alt": "C",
"effect": "intron_variant",
"transcript": "NM_015576.3",
"consequences": [
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 18,
"intron_rank": 17,
"intron_rank_end": null,
"gene_symbol": "ERC2",
"gene_hgnc_id": 31922,
"hgvs_c": "c.*40-18040A>G",
"hgvs_p": null,
"transcript": "NM_015576.3",
"protein_id": "NP_056391.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 957,
"cds_start": null,
"cds_end": null,
"cds_length": 2874,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 6239,
"mane_select": "ENST00000288221.11",
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_015576.3"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": true,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 18,
"intron_rank": 17,
"intron_rank_end": null,
"gene_symbol": "ERC2",
"gene_hgnc_id": 31922,
"hgvs_c": "c.*40-18040A>G",
"hgvs_p": null,
"transcript": "ENST00000288221.11",
"protein_id": "ENSP00000288221.6",
"transcript_support_level": 1,
"aa_start": null,
"aa_end": null,
"aa_length": 957,
"cds_start": null,
"cds_end": null,
"cds_length": 2874,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 6239,
"mane_select": "NM_015576.3",
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000288221.11"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": false,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 19,
"intron_rank": 18,
"intron_rank_end": null,
"gene_symbol": "ERC2",
"gene_hgnc_id": 31922,
"hgvs_c": "n.*227-18040A>G",
"hgvs_p": null,
"transcript": "ENST00000460849.5",
"protein_id": "ENSP00000417445.1",
"transcript_support_level": 1,
"aa_start": null,
"aa_end": null,
"aa_length": null,
"cds_start": null,
"cds_end": null,
"cds_length": null,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 3831,
"mane_select": null,
"mane_plus": null,
"biotype": "nonsense_mediated_decay",
"feature": "ENST00000460849.5"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": false,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 3,
"intron_rank": 2,
"intron_rank_end": null,
"gene_symbol": "ERC2",
"gene_hgnc_id": 31922,
"hgvs_c": "n.552-18040A>G",
"hgvs_p": null,
"transcript": "ENST00000484530.5",
"protein_id": null,
"transcript_support_level": 1,
"aa_start": null,
"aa_end": null,
"aa_length": null,
"cds_start": null,
"cds_end": null,
"cds_length": null,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 2594,
"mane_select": null,
"mane_plus": null,
"biotype": "pseudogene",
"feature": "ENST00000484530.5"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": false,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 3,
"intron_rank": 2,
"intron_rank_end": null,
"gene_symbol": "ERC2",
"gene_hgnc_id": 31922,
"hgvs_c": "n.523-18040A>G",
"hgvs_p": null,
"transcript": "ENST00000486496.5",
"protein_id": null,
"transcript_support_level": 1,
"aa_start": null,
"aa_end": null,
"aa_length": null,
"cds_start": null,
"cds_end": null,
"cds_length": null,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 3488,
"mane_select": null,
"mane_plus": null,
"biotype": "pseudogene",
"feature": "ENST00000486496.5"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 18,
"intron_rank": 17,
"intron_rank_end": null,
"gene_symbol": "ERC2",
"gene_hgnc_id": 31922,
"hgvs_c": "c.*40-18040A>G",
"hgvs_p": null,
"transcript": "ENST00000940588.1",
"protein_id": "ENSP00000610647.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 967,
"cds_start": null,
"cds_end": null,
"cds_length": 2904,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 6130,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000940588.1"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 18,
"intron_rank": 17,
"intron_rank_end": null,
"gene_symbol": "ERC2",
"gene_hgnc_id": 31922,
"hgvs_c": "c.*40-18040A>G",
"hgvs_p": null,
"transcript": "ENST00000492584.3",
"protein_id": "ENSP00000417280.3",
"transcript_support_level": 5,
"aa_start": null,
"aa_end": null,
"aa_length": 965,
"cds_start": null,
"cds_end": null,
"cds_length": 2898,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 6210,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000492584.3"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 18,
"intron_rank": 17,
"intron_rank_end": null,
"gene_symbol": "ERC2",
"gene_hgnc_id": 31922,
"hgvs_c": "c.*40-18040A>G",
"hgvs_p": null,
"transcript": "ENST00000941628.1",
"protein_id": "ENSP00000611687.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 965,
"cds_start": null,
"cds_end": null,
"cds_length": 2898,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 6151,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000941628.1"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 21,
"intron_rank": 20,
"intron_rank_end": null,
"gene_symbol": "ERC2",
"gene_hgnc_id": 31922,
"hgvs_c": "c.*160-18040A>G",
"hgvs_p": null,
"transcript": "XM_047447941.1",
"protein_id": "XP_047303897.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 1001,
"cds_start": null,
"cds_end": null,
"cds_length": 3006,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 6372,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "XM_047447941.1"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 19,
"intron_rank": 18,
"intron_rank_end": null,
"gene_symbol": "ERC2",
"gene_hgnc_id": 31922,
"hgvs_c": "c.*131-18040A>G",
"hgvs_p": null,
"transcript": "XM_017006141.2",
"protein_id": "XP_016861630.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 986,
"cds_start": null,
"cds_end": null,
"cds_length": 2961,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 6417,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "XM_017006141.2"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 18,
"intron_rank": 17,
"intron_rank_end": null,
"gene_symbol": "ERC2",
"gene_hgnc_id": 31922,
"hgvs_c": "c.*131-18040A>G",
"hgvs_p": null,
"transcript": "XM_047447942.1",
"protein_id": "XP_047303898.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 984,
"cds_start": null,
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"cds_length": 2955,
"cdna_start": null,
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"cdna_length": 6411,
"mane_select": null,
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"biotype": "protein_coding",
"feature": "XM_047447942.1"
},
{
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"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
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"exon_count": 18,
"intron_rank": 17,
"intron_rank_end": null,
"gene_symbol": "ERC2",
"gene_hgnc_id": 31922,
"hgvs_c": "c.*131-18040A>G",
"hgvs_p": null,
"transcript": "XM_047447943.1",
"protein_id": "XP_047303899.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 982,
"cds_start": null,
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"cdna_start": null,
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"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "XM_047447943.1"
},
{
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"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 19,
"intron_rank": 18,
"intron_rank_end": null,
"gene_symbol": "ERC2",
"gene_hgnc_id": 31922,
"hgvs_c": "c.*131-18040A>G",
"hgvs_p": null,
"transcript": "XM_017006142.2",
"protein_id": "XP_016861631.1",
"transcript_support_level": null,
"aa_start": null,
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"cds_start": null,
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"cdna_start": null,
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"mane_select": null,
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"biotype": "protein_coding",
"feature": "XM_017006142.2"
},
{
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"protein_coding": true,
"strand": false,
"consequences": [
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],
"exon_rank": null,
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"exon_count": 18,
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"intron_rank_end": null,
"gene_symbol": "ERC2",
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"hgvs_c": "c.*131-18040A>G",
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"transcript": "XM_047447944.1",
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"feature": "XM_047447944.1"
},
{
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"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
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"exon_count": 18,
"intron_rank": 17,
"intron_rank_end": null,
"gene_symbol": "ERC2",
"gene_hgnc_id": 31922,
"hgvs_c": "c.*160-18040A>G",
"hgvs_p": null,
"transcript": "XM_047447945.1",
"protein_id": "XP_047303901.1",
"transcript_support_level": null,
"aa_start": null,
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"cds_start": null,
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"cdna_start": null,
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"mane_select": null,
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"biotype": "protein_coding",
"feature": "XM_047447945.1"
},
{
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"protein_coding": true,
"strand": false,
"consequences": [
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],
"exon_rank": null,
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"exon_count": 18,
"intron_rank": 17,
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"gene_symbol": "ERC2",
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"hgvs_c": "c.*160-18040A>G",
"hgvs_p": null,
"transcript": "XM_047447946.1",
"protein_id": "XP_047303902.1",
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"mane_select": null,
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"biotype": "protein_coding",
"feature": "XM_047447946.1"
},
{
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"protein_coding": true,
"strand": false,
"consequences": [
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],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 18,
"intron_rank": 17,
"intron_rank_end": null,
"gene_symbol": "ERC2",
"gene_hgnc_id": 31922,
"hgvs_c": "c.*131-18040A>G",
"hgvs_p": null,
"transcript": "XM_047447947.1",
"protein_id": "XP_047303903.1",
"transcript_support_level": null,
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"mane_select": null,
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"biotype": "protein_coding",
"feature": "XM_047447947.1"
},
{
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"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
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],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 18,
"intron_rank": 17,
"intron_rank_end": null,
"gene_symbol": "ERC2",
"gene_hgnc_id": 31922,
"hgvs_c": "c.*131-18040A>G",
"hgvs_p": null,
"transcript": "XM_017006146.2",
"protein_id": "XP_016861635.1",
"transcript_support_level": null,
"aa_start": null,
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"aa_length": 974,
"cds_start": null,
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"mane_select": null,
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"biotype": "protein_coding",
"feature": "XM_017006146.2"
},
{
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"protein_coding": true,
"strand": false,
"consequences": [
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],
"exon_rank": null,
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"intron_rank": 16,
"intron_rank_end": null,
"gene_symbol": "ERC2",
"gene_hgnc_id": 31922,
"hgvs_c": "c.*131-18040A>G",
"hgvs_p": null,
"transcript": "XM_017006148.2",
"protein_id": "XP_016861637.1",
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},
{
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"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
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"intron_rank": 16,
"intron_rank_end": null,
"gene_symbol": "ERC2",
"gene_hgnc_id": 31922,
"hgvs_c": "c.*160-18040A>G",
"hgvs_p": null,
"transcript": "XM_047447948.1",
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},
{
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"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
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"intron_rank": 17,
"intron_rank_end": null,
"gene_symbol": "ERC2",
"gene_hgnc_id": 31922,
"hgvs_c": "c.*131-18040A>G",
"hgvs_p": null,
"transcript": "XM_017006151.2",
"protein_id": "XP_016861640.1",
"transcript_support_level": null,
"aa_start": null,
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"cds_start": null,
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"cdna_start": null,
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"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "XM_017006151.2"
},
{
"aa_ref": null,
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"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 18,
"intron_rank": 17,
"intron_rank_end": null,
"gene_symbol": "ERC2",
"gene_hgnc_id": 31922,
"hgvs_c": "c.*40-18040A>G",
"hgvs_p": null,
"transcript": "XM_047447949.1",
"protein_id": "XP_047303905.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
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"cds_start": null,
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"cdna_start": null,
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"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "XM_047447949.1"
},
{
"aa_ref": null,
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"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
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}
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}