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GeneBe API Showcase
This page demonstrates how to use the GeneBe API to query variant information. The API provides programmatic access to genomic annotations and variant data.
API presented here should be used for checking single variants. If you want to check many variants at once, please use other API endpoints that you will find in the documentation.
Documentation & Advanced Usage
• Complete API documentation:docs.genebe.net/docs/api/overview/
• Interactive endpoint tester:api.genebe.net/cloud/gb-api-doc/swagger-ui/
• Python client for pandas:pypi.org/project/genebe/
• Java CLI for VCF files:github.com/pstawinski/genebe-cli
• All tools documented at:docs.genebe.net
API Request Examples for Variant: 3-56737223-A-C (hg38)
Bash / cURL Example
bash
curl "https://api.genebe.net/cloud/api-public/v1/variant?chr=3&pos=56737223&ref=A&alt=C&genome=hg38&allGenes=true"API Response
json
{
"variants": [
{
"chr": "3",
"pos": 56737223,
"ref": "A",
"alt": "C",
"effect": "missense_variant",
"transcript": "ENST00000296315.8",
"consequences": [
{
"aa_ref": "L",
"aa_alt": "V",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 8,
"exon_rank_end": null,
"exon_count": 10,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ARHGEF3",
"gene_hgnc_id": 683,
"hgvs_c": "c.1003T>G",
"hgvs_p": "p.Leu335Val",
"transcript": "NM_019555.3",
"protein_id": "NP_062455.1",
"transcript_support_level": null,
"aa_start": 335,
"aa_end": null,
"aa_length": 526,
"cds_start": 1003,
"cds_end": null,
"cds_length": 1581,
"cdna_start": 1154,
"cdna_end": null,
"cdna_length": 3582,
"mane_select": "ENST00000296315.8",
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "L",
"aa_alt": "V",
"canonical": true,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 8,
"exon_rank_end": null,
"exon_count": 10,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ARHGEF3",
"gene_hgnc_id": 683,
"hgvs_c": "c.1003T>G",
"hgvs_p": "p.Leu335Val",
"transcript": "ENST00000296315.8",
"protein_id": "ENSP00000296315.3",
"transcript_support_level": 1,
"aa_start": 335,
"aa_end": null,
"aa_length": 526,
"cds_start": 1003,
"cds_end": null,
"cds_length": 1581,
"cdna_start": 1154,
"cdna_end": null,
"cdna_length": 3582,
"mane_select": "NM_019555.3",
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "L",
"aa_alt": "V",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 11,
"exon_rank_end": null,
"exon_count": 13,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ARHGEF3",
"gene_hgnc_id": 683,
"hgvs_c": "c.1099T>G",
"hgvs_p": "p.Leu367Val",
"transcript": "ENST00000338458.8",
"protein_id": "ENSP00000341071.4",
"transcript_support_level": 1,
"aa_start": 367,
"aa_end": null,
"aa_length": 558,
"cds_start": 1099,
"cds_end": null,
"cds_length": 1677,
"cdna_start": 1209,
"cdna_end": null,
"cdna_length": 3639,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "L",
"aa_alt": "V",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 8,
"exon_rank_end": null,
"exon_count": 10,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ARHGEF3",
"gene_hgnc_id": 683,
"hgvs_c": "c.1021T>G",
"hgvs_p": "p.Leu341Val",
"transcript": "ENST00000413728.6",
"protein_id": "ENSP00000410922.2",
"transcript_support_level": 1,
"aa_start": 341,
"aa_end": null,
"aa_length": 532,
"cds_start": 1021,
"cds_end": null,
"cds_length": 1599,
"cdna_start": 1565,
"cdna_end": null,
"cdna_length": 3992,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "L",
"aa_alt": "V",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 8,
"exon_rank_end": null,
"exon_count": 9,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ARHGEF3",
"gene_hgnc_id": 683,
"hgvs_c": "c.1003T>G",
"hgvs_p": "p.Leu335Val",
"transcript": "ENST00000495373.5",
"protein_id": "ENSP00000417986.1",
"transcript_support_level": 1,
"aa_start": 335,
"aa_end": null,
"aa_length": 416,
"cds_start": 1003,
"cds_end": null,
"cds_length": 1251,
"cdna_start": 1154,
"cdna_end": null,
"cdna_length": 2024,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": false,
"strand": false,
"consequences": [
"non_coding_transcript_exon_variant"
],
"exon_rank": 7,
"exon_rank_end": null,
"exon_count": 9,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ARHGEF3",
"gene_hgnc_id": 683,
"hgvs_c": "n.*368T>G",
"hgvs_p": null,
"transcript": "ENST00000465659.5",
"protein_id": "ENSP00000417810.1",
"transcript_support_level": 1,
"aa_start": null,
"aa_end": null,
"aa_length": null,
"cds_start": -4,
"cds_end": null,
"cds_length": null,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 2693,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": false,
"strand": false,
"consequences": [
"3_prime_UTR_variant"
],
"exon_rank": 7,
"exon_rank_end": null,
"exon_count": 9,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ARHGEF3",
"gene_hgnc_id": 683,
"hgvs_c": "n.*368T>G",
"hgvs_p": null,
"transcript": "ENST00000465659.5",
"protein_id": "ENSP00000417810.1",
"transcript_support_level": 1,
"aa_start": null,
"aa_end": null,
"aa_length": null,
"cds_start": -4,
"cds_end": null,
"cds_length": null,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 2693,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "L",
"aa_alt": "V",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 11,
"exon_rank_end": null,
"exon_count": 13,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ARHGEF3",
"gene_hgnc_id": 683,
"hgvs_c": "c.1099T>G",
"hgvs_p": "p.Leu367Val",
"transcript": "NM_001128615.2",
"protein_id": "NP_001122087.1",
"transcript_support_level": null,
"aa_start": 367,
"aa_end": null,
"aa_length": 558,
"cds_start": 1099,
"cds_end": null,
"cds_length": 1677,
"cdna_start": 1169,
"cdna_end": null,
"cdna_length": 3597,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "L",
"aa_alt": "V",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 11,
"exon_rank_end": null,
"exon_count": 13,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ARHGEF3",
"gene_hgnc_id": 683,
"hgvs_c": "c.1099T>G",
"hgvs_p": "p.Leu367Val",
"transcript": "NM_001377407.1",
"protein_id": "NP_001364336.1",
"transcript_support_level": null,
"aa_start": 367,
"aa_end": null,
"aa_length": 558,
"cds_start": 1099,
"cds_end": null,
"cds_length": 1677,
"cdna_start": 1364,
"cdna_end": null,
"cdna_length": 3792,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "L",
"aa_alt": "V",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 13,
"exon_rank_end": null,
"exon_count": 15,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ARHGEF3",
"gene_hgnc_id": 683,
"hgvs_c": "c.1039T>G",
"hgvs_p": "p.Leu347Val",
"transcript": "NM_001377408.1",
"protein_id": "NP_001364337.1",
"transcript_support_level": null,
"aa_start": 347,
"aa_end": null,
"aa_length": 538,
"cds_start": 1039,
"cds_end": null,
"cds_length": 1617,
"cdna_start": 1471,
"cdna_end": null,
"cdna_length": 3899,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "L",
"aa_alt": "V",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 12,
"exon_rank_end": null,
"exon_count": 14,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ARHGEF3",
"gene_hgnc_id": 683,
"hgvs_c": "c.1039T>G",
"hgvs_p": "p.Leu347Val",
"transcript": "NM_001377409.1",
"protein_id": "NP_001364338.1",
"transcript_support_level": null,
"aa_start": 347,
"aa_end": null,
"aa_length": 538,
"cds_start": 1039,
"cds_end": null,
"cds_length": 1617,
"cdna_start": 1324,
"cdna_end": null,
"cdna_length": 3752,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "L",
"aa_alt": "V",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 11,
"exon_rank_end": null,
"exon_count": 13,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ARHGEF3",
"gene_hgnc_id": 683,
"hgvs_c": "c.1039T>G",
"hgvs_p": "p.Leu347Val",
"transcript": "NM_001377410.1",
"protein_id": "NP_001364339.1",
"transcript_support_level": null,
"aa_start": 347,
"aa_end": null,
"aa_length": 538,
"cds_start": 1039,
"cds_end": null,
"cds_length": 1617,
"cdna_start": 1235,
"cdna_end": null,
"cdna_length": 3663,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "L",
"aa_alt": "V",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 8,
"exon_rank_end": null,
"exon_count": 10,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ARHGEF3",
"gene_hgnc_id": 683,
"hgvs_c": "c.1021T>G",
"hgvs_p": "p.Leu341Val",
"transcript": "NM_001128616.2",
"protein_id": "NP_001122088.1",
"transcript_support_level": null,
"aa_start": 341,
"aa_end": null,
"aa_length": 532,
"cds_start": 1021,
"cds_end": null,
"cds_length": 1599,
"cdna_start": 1625,
"cdna_end": null,
"cdna_length": 4053,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "L",
"aa_alt": "V",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 9,
"exon_rank_end": null,
"exon_count": 11,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ARHGEF3",
"gene_hgnc_id": 683,
"hgvs_c": "c.1021T>G",
"hgvs_p": "p.Leu341Val",
"transcript": "NM_001289698.2",
"protein_id": "NP_001276627.1",
"transcript_support_level": null,
"aa_start": 341,
"aa_end": null,
"aa_length": 532,
"cds_start": 1021,
"cds_end": null,
"cds_length": 1599,
"cdna_start": 1098,
"cdna_end": null,
"cdna_length": 3526,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "L",
"aa_alt": "V",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 9,
"exon_rank_end": null,
"exon_count": 11,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ARHGEF3",
"gene_hgnc_id": 683,
"hgvs_c": "c.1021T>G",
"hgvs_p": "p.Leu341Val",
"transcript": "ENST00000496106.5",
"protein_id": "ENSP00000420420.1",
"transcript_support_level": 2,
"aa_start": 341,
"aa_end": null,
"aa_length": 532,
"cds_start": 1021,
"cds_end": null,
"cds_length": 1599,
"cdna_start": 1133,
"cdna_end": null,
"cdna_length": 1994,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "L",
"aa_alt": "V",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 10,
"exon_rank_end": null,
"exon_count": 12,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ARHGEF3",
"gene_hgnc_id": 683,
"hgvs_c": "c.1006T>G",
"hgvs_p": "p.Leu336Val",
"transcript": "NM_001377411.1",
"protein_id": "NP_001364340.1",
"transcript_support_level": null,
"aa_start": 336,
"aa_end": null,
"aa_length": 527,
"cds_start": 1006,
"cds_end": null,
"cds_length": 1584,
"cdna_start": 1080,
"cdna_end": null,
"cdna_length": 3508,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "L",
"aa_alt": "V",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 10,
"exon_rank_end": null,
"exon_count": 12,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ARHGEF3",
"gene_hgnc_id": 683,
"hgvs_c": "c.1006T>G",
"hgvs_p": "p.Leu336Val",
"transcript": "NM_001377412.1",
"protein_id": "NP_001364341.1",
"transcript_support_level": null,
"aa_start": 336,
"aa_end": null,
"aa_length": 527,
"cds_start": 1006,
"cds_end": null,
"cds_length": 1584,
"cdna_start": 1275,
"cdna_end": null,
"cdna_length": 3703,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "L",
"aa_alt": "V",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 8,
"exon_rank_end": null,
"exon_count": 10,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ARHGEF3",
"gene_hgnc_id": 683,
"hgvs_c": "c.916T>G",
"hgvs_p": "p.Leu306Val",
"transcript": "ENST00000497267.5",
"protein_id": "ENSP00000418826.1",
"transcript_support_level": 2,
"aa_start": 306,
"aa_end": null,
"aa_length": 497,
"cds_start": 916,
"cds_end": null,
"cds_length": 1494,
"cdna_start": 1370,
"cdna_end": null,
"cdna_length": 2197,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "L",
"aa_alt": "V",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 8,
"exon_rank_end": null,
"exon_count": 10,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ARHGEF3",
"gene_hgnc_id": 683,
"hgvs_c": "c.1021T>G",
"hgvs_p": "p.Leu341Val",
"transcript": "NM_001377413.1",
"protein_id": "NP_001364342.1",
"transcript_support_level": null,
"aa_start": 341,
"aa_end": null,
"aa_length": 457,
"cds_start": 1021,
"cds_end": null,
"cds_length": 1374,
"cdna_start": 1625,
"cdna_end": null,
"cdna_length": 4004,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "L",
"aa_alt": "V",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 8,
"exon_rank_end": null,
"exon_count": 10,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ARHGEF3",
"gene_hgnc_id": 683,
"hgvs_c": "c.1003T>G",
"hgvs_p": "p.Leu335Val",
"transcript": "NM_001377414.1",
"protein_id": "NP_001364343.1",
"transcript_support_level": null,
"aa_start": 335,
"aa_end": null,
"aa_length": 451,
"cds_start": 1003,
"cds_end": null,
"cds_length": 1356,
"cdna_start": 1154,
"cdna_end": null,
"cdna_length": 3533,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "L",
"aa_alt": "V",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 8,
"exon_rank_end": null,
"exon_count": 9,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ARHGEF3",
"gene_hgnc_id": 683,
"hgvs_c": "c.1003T>G",
"hgvs_p": "p.Leu335Val",
"transcript": "NM_001377415.1",
"protein_id": "NP_001364344.1",
"transcript_support_level": null,
"aa_start": 335,
"aa_end": null,
"aa_length": 416,
"cds_start": 1003,
"cds_end": null,
"cds_length": 1251,
"cdna_start": 1154,
"cdna_end": null,
"cdna_length": 2024,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "L",
"aa_alt": "V",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 11,
"exon_rank_end": null,
"exon_count": 13,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ARHGEF3",
"gene_hgnc_id": 683,
"hgvs_c": "c.1099T>G",
"hgvs_p": "p.Leu367Val",
"transcript": "XM_047448222.1",
"protein_id": "XP_047304178.1",
"transcript_support_level": null,
"aa_start": 367,
"aa_end": null,
"aa_length": 558,
"cds_start": 1099,
"cds_end": null,
"cds_length": 1677,
"cdna_start": 7645,
"cdna_end": null,
"cdna_length": 10073,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "L",
"aa_alt": "V",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 12,
"exon_rank_end": null,
"exon_count": 14,
"intron_rank": null,
"intron_rank_end": null,
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}