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GeneBe API Showcase
This page demonstrates how to use the GeneBe API to query variant information. The API provides programmatic access to genomic annotations and variant data.
API presented here should be used for checking single variants. If you want to check many variants at once, please use other API endpoints that you will find in the documentation.
Documentation & Advanced Usage
• Complete API documentation:docs.genebe.net/docs/api/overview/
• Interactive endpoint tester:api.genebe.net/cloud/gb-api-doc/swagger-ui/
• Python client for pandas:pypi.org/project/genebe/
• Java CLI for VCF files:github.com/pstawinski/genebe-cli
• All tools documented at:docs.genebe.net
API Request Examples for Variant: 3-56737255-T-C (hg38)
Bash / cURL Example
bash
curl "https://api.genebe.net/cloud/api-public/v1/variant?chr=3&pos=56737255&ref=T&alt=C&genome=hg38&allGenes=true"API Response
json
{
"variants": [
{
"chr": "3",
"pos": 56737255,
"ref": "T",
"alt": "C",
"effect": "missense_variant",
"transcript": "NM_001128615.2",
"consequences": [
{
"aa_ref": "Q",
"aa_alt": "R",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 8,
"exon_rank_end": null,
"exon_count": 10,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ARHGEF3",
"gene_hgnc_id": 683,
"hgvs_c": "c.971A>G",
"hgvs_p": "p.Gln324Arg",
"transcript": "NM_019555.3",
"protein_id": "NP_062455.1",
"transcript_support_level": null,
"aa_start": 324,
"aa_end": null,
"aa_length": 526,
"cds_start": 971,
"cds_end": null,
"cds_length": 1581,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": "ENST00000296315.8",
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_019555.3"
},
{
"aa_ref": "Q",
"aa_alt": "R",
"canonical": true,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 8,
"exon_rank_end": null,
"exon_count": 10,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ARHGEF3",
"gene_hgnc_id": 683,
"hgvs_c": "c.971A>G",
"hgvs_p": "p.Gln324Arg",
"transcript": "ENST00000296315.8",
"protein_id": "ENSP00000296315.3",
"transcript_support_level": 1,
"aa_start": 324,
"aa_end": null,
"aa_length": 526,
"cds_start": 971,
"cds_end": null,
"cds_length": 1581,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": "NM_019555.3",
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000296315.8"
},
{
"aa_ref": "Q",
"aa_alt": "R",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 11,
"exon_rank_end": null,
"exon_count": 13,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ARHGEF3",
"gene_hgnc_id": 683,
"hgvs_c": "c.1067A>G",
"hgvs_p": "p.Gln356Arg",
"transcript": "ENST00000338458.8",
"protein_id": "ENSP00000341071.4",
"transcript_support_level": 1,
"aa_start": 356,
"aa_end": null,
"aa_length": 558,
"cds_start": 1067,
"cds_end": null,
"cds_length": 1677,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000338458.8"
},
{
"aa_ref": "Q",
"aa_alt": "R",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 8,
"exon_rank_end": null,
"exon_count": 10,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ARHGEF3",
"gene_hgnc_id": 683,
"hgvs_c": "c.989A>G",
"hgvs_p": "p.Gln330Arg",
"transcript": "ENST00000413728.6",
"protein_id": "ENSP00000410922.2",
"transcript_support_level": 1,
"aa_start": 330,
"aa_end": null,
"aa_length": 532,
"cds_start": 989,
"cds_end": null,
"cds_length": 1599,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000413728.6"
},
{
"aa_ref": "Q",
"aa_alt": "R",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 8,
"exon_rank_end": null,
"exon_count": 9,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ARHGEF3",
"gene_hgnc_id": 683,
"hgvs_c": "c.971A>G",
"hgvs_p": "p.Gln324Arg",
"transcript": "ENST00000495373.5",
"protein_id": "ENSP00000417986.1",
"transcript_support_level": 1,
"aa_start": 324,
"aa_end": null,
"aa_length": 416,
"cds_start": 971,
"cds_end": null,
"cds_length": 1251,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000495373.5"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": false,
"strand": false,
"consequences": [
"non_coding_transcript_exon_variant"
],
"exon_rank": 7,
"exon_rank_end": null,
"exon_count": 9,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ARHGEF3",
"gene_hgnc_id": 683,
"hgvs_c": "n.*336A>G",
"hgvs_p": null,
"transcript": "ENST00000465659.5",
"protein_id": "ENSP00000417810.1",
"transcript_support_level": 1,
"aa_start": null,
"aa_end": null,
"aa_length": null,
"cds_start": null,
"cds_end": null,
"cds_length": null,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "nonsense_mediated_decay",
"feature": "ENST00000465659.5"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": false,
"strand": false,
"consequences": [
"3_prime_UTR_variant"
],
"exon_rank": 7,
"exon_rank_end": null,
"exon_count": 9,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ARHGEF3",
"gene_hgnc_id": 683,
"hgvs_c": "n.*336A>G",
"hgvs_p": null,
"transcript": "ENST00000465659.5",
"protein_id": "ENSP00000417810.1",
"transcript_support_level": 1,
"aa_start": null,
"aa_end": null,
"aa_length": null,
"cds_start": null,
"cds_end": null,
"cds_length": null,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "nonsense_mediated_decay",
"feature": "ENST00000465659.5"
},
{
"aa_ref": "Q",
"aa_alt": "R",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 11,
"exon_rank_end": null,
"exon_count": 13,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ARHGEF3",
"gene_hgnc_id": 683,
"hgvs_c": "c.1067A>G",
"hgvs_p": "p.Gln356Arg",
"transcript": "NM_001128615.2",
"protein_id": "NP_001122087.1",
"transcript_support_level": null,
"aa_start": 356,
"aa_end": null,
"aa_length": 558,
"cds_start": 1067,
"cds_end": null,
"cds_length": 1677,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001128615.2"
},
{
"aa_ref": "Q",
"aa_alt": "R",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 11,
"exon_rank_end": null,
"exon_count": 13,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ARHGEF3",
"gene_hgnc_id": 683,
"hgvs_c": "c.1067A>G",
"hgvs_p": "p.Gln356Arg",
"transcript": "NM_001377407.1",
"protein_id": "NP_001364336.1",
"transcript_support_level": null,
"aa_start": 356,
"aa_end": null,
"aa_length": 558,
"cds_start": 1067,
"cds_end": null,
"cds_length": 1677,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001377407.1"
},
{
"aa_ref": "Q",
"aa_alt": "R",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 13,
"exon_rank_end": null,
"exon_count": 15,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ARHGEF3",
"gene_hgnc_id": 683,
"hgvs_c": "c.1007A>G",
"hgvs_p": "p.Gln336Arg",
"transcript": "NM_001377408.1",
"protein_id": "NP_001364337.1",
"transcript_support_level": null,
"aa_start": 336,
"aa_end": null,
"aa_length": 538,
"cds_start": 1007,
"cds_end": null,
"cds_length": 1617,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001377408.1"
},
{
"aa_ref": "Q",
"aa_alt": "R",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 12,
"exon_rank_end": null,
"exon_count": 14,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ARHGEF3",
"gene_hgnc_id": 683,
"hgvs_c": "c.1007A>G",
"hgvs_p": "p.Gln336Arg",
"transcript": "NM_001377409.1",
"protein_id": "NP_001364338.1",
"transcript_support_level": null,
"aa_start": 336,
"aa_end": null,
"aa_length": 538,
"cds_start": 1007,
"cds_end": null,
"cds_length": 1617,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001377409.1"
},
{
"aa_ref": "Q",
"aa_alt": "R",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 11,
"exon_rank_end": null,
"exon_count": 13,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ARHGEF3",
"gene_hgnc_id": 683,
"hgvs_c": "c.1007A>G",
"hgvs_p": "p.Gln336Arg",
"transcript": "NM_001377410.1",
"protein_id": "NP_001364339.1",
"transcript_support_level": null,
"aa_start": 336,
"aa_end": null,
"aa_length": 538,
"cds_start": 1007,
"cds_end": null,
"cds_length": 1617,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001377410.1"
},
{
"aa_ref": "Q",
"aa_alt": "R",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 9,
"exon_rank_end": null,
"exon_count": 11,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ARHGEF3",
"gene_hgnc_id": 683,
"hgvs_c": "c.1004A>G",
"hgvs_p": "p.Gln335Arg",
"transcript": "ENST00000863032.1",
"protein_id": "ENSP00000533091.1",
"transcript_support_level": null,
"aa_start": 335,
"aa_end": null,
"aa_length": 537,
"cds_start": 1004,
"cds_end": null,
"cds_length": 1614,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000863032.1"
},
{
"aa_ref": "Q",
"aa_alt": "R",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 8,
"exon_rank_end": null,
"exon_count": 10,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ARHGEF3",
"gene_hgnc_id": 683,
"hgvs_c": "c.989A>G",
"hgvs_p": "p.Gln330Arg",
"transcript": "NM_001128616.2",
"protein_id": "NP_001122088.1",
"transcript_support_level": null,
"aa_start": 330,
"aa_end": null,
"aa_length": 532,
"cds_start": 989,
"cds_end": null,
"cds_length": 1599,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001128616.2"
},
{
"aa_ref": "Q",
"aa_alt": "R",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 9,
"exon_rank_end": null,
"exon_count": 11,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ARHGEF3",
"gene_hgnc_id": 683,
"hgvs_c": "c.989A>G",
"hgvs_p": "p.Gln330Arg",
"transcript": "NM_001289698.2",
"protein_id": "NP_001276627.1",
"transcript_support_level": null,
"aa_start": 330,
"aa_end": null,
"aa_length": 532,
"cds_start": 989,
"cds_end": null,
"cds_length": 1599,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001289698.2"
},
{
"aa_ref": "Q",
"aa_alt": "R",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 9,
"exon_rank_end": null,
"exon_count": 11,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ARHGEF3",
"gene_hgnc_id": 683,
"hgvs_c": "c.989A>G",
"hgvs_p": "p.Gln330Arg",
"transcript": "ENST00000496106.5",
"protein_id": "ENSP00000420420.1",
"transcript_support_level": 2,
"aa_start": 330,
"aa_end": null,
"aa_length": 532,
"cds_start": 989,
"cds_end": null,
"cds_length": 1599,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000496106.5"
},
{
"aa_ref": "Q",
"aa_alt": "R",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 10,
"exon_rank_end": null,
"exon_count": 12,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ARHGEF3",
"gene_hgnc_id": 683,
"hgvs_c": "c.974A>G",
"hgvs_p": "p.Gln325Arg",
"transcript": "NM_001377411.1",
"protein_id": "NP_001364340.1",
"transcript_support_level": null,
"aa_start": 325,
"aa_end": null,
"aa_length": 527,
"cds_start": 974,
"cds_end": null,
"cds_length": 1584,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001377411.1"
},
{
"aa_ref": "Q",
"aa_alt": "R",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 10,
"exon_rank_end": null,
"exon_count": 12,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ARHGEF3",
"gene_hgnc_id": 683,
"hgvs_c": "c.974A>G",
"hgvs_p": "p.Gln325Arg",
"transcript": "NM_001377412.1",
"protein_id": "NP_001364341.1",
"transcript_support_level": null,
"aa_start": 325,
"aa_end": null,
"aa_length": 527,
"cds_start": 974,
"cds_end": null,
"cds_length": 1584,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001377412.1"
},
{
"aa_ref": "Q",
"aa_alt": "R",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 8,
"exon_rank_end": null,
"exon_count": 10,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ARHGEF3",
"gene_hgnc_id": 683,
"hgvs_c": "c.884A>G",
"hgvs_p": "p.Gln295Arg",
"transcript": "ENST00000497267.5",
"protein_id": "ENSP00000418826.1",
"transcript_support_level": 2,
"aa_start": 295,
"aa_end": null,
"aa_length": 497,
"cds_start": 884,
"cds_end": null,
"cds_length": 1494,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000497267.5"
},
{
"aa_ref": "Q",
"aa_alt": "R",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 7,
"exon_rank_end": null,
"exon_count": 9,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ARHGEF3",
"gene_hgnc_id": 683,
"hgvs_c": "c.863A>G",
"hgvs_p": "p.Gln288Arg",
"transcript": "ENST00000863034.1",
"protein_id": "ENSP00000533093.1",
"transcript_support_level": null,
"aa_start": 288,
"aa_end": null,
"aa_length": 490,
"cds_start": 863,
"cds_end": null,
"cds_length": 1473,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000863034.1"
},
{
"aa_ref": "Q",
"aa_alt": "R",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 6,
"exon_rank_end": null,
"exon_count": 8,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ARHGEF3",
"gene_hgnc_id": 683,
"hgvs_c": "c.797A>G",
"hgvs_p": "p.Gln266Arg",
"transcript": "ENST00000863033.1",
"protein_id": "ENSP00000533092.1",
"transcript_support_level": null,
"aa_start": 266,
"aa_end": null,
"aa_length": 468,
"cds_start": 797,
"cds_end": null,
"cds_length": 1407,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000863033.1"
},
{
"aa_ref": "Q",
"aa_alt": "R",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 8,
"exon_rank_end": null,
"exon_count": 10,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ARHGEF3",
"gene_hgnc_id": 683,
"hgvs_c": "c.989A>G",
"hgvs_p": "p.Gln330Arg",
"transcript": "NM_001377413.1",
"protein_id": "NP_001364342.1",
"transcript_support_level": null,
"aa_start": 330,
"aa_end": null,
"aa_length": 457,
"cds_start": 989,
"cds_end": null,
"cds_length": 1374,
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}