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GeneBe API Showcase
This page demonstrates how to use the GeneBe API to query variant information. The API provides programmatic access to genomic annotations and variant data.
API presented here should be used for checking single variants. If you want to check many variants at once, please use other API endpoints that you will find in the documentation.
Documentation & Advanced Usage
• Complete API documentation:docs.genebe.net/docs/api/overview/
• Interactive endpoint tester:api.genebe.net/cloud/gb-api-doc/swagger-ui/
• Python client for pandas:pypi.org/project/genebe/
• Java CLI for VCF files:github.com/pstawinski/genebe-cli
• All tools documented at:docs.genebe.net
API Request Examples for Variant: 3-58526510-A-T (hg38)
Bash / cURL Example
bash
curl "https://api.genebe.net/cloud/api-public/v1/variant?chr=3&pos=58526510&ref=A&alt=T&genome=hg38&allGenes=true"API Response
json
{
"variants": [
{
"chr": "3",
"pos": 58526510,
"ref": "A",
"alt": "T",
"effect": "stop_gained",
"transcript": "NM_003500.4",
"consequences": [
{
"aa_ref": "C",
"aa_alt": "*",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"stop_gained"
],
"exon_rank": 10,
"exon_rank_end": null,
"exon_count": 15,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ACOX2",
"gene_hgnc_id": 120,
"hgvs_c": "c.1302T>A",
"hgvs_p": "p.Cys434*",
"transcript": "NM_003500.4",
"protein_id": "NP_003491.1",
"transcript_support_level": null,
"aa_start": 434,
"aa_end": null,
"aa_length": 681,
"cds_start": 1302,
"cds_end": null,
"cds_length": 2046,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": "ENST00000302819.10",
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_003500.4"
},
{
"aa_ref": "C",
"aa_alt": "*",
"canonical": true,
"protein_coding": true,
"strand": false,
"consequences": [
"stop_gained"
],
"exon_rank": 10,
"exon_rank_end": null,
"exon_count": 15,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ACOX2",
"gene_hgnc_id": 120,
"hgvs_c": "c.1302T>A",
"hgvs_p": "p.Cys434*",
"transcript": "ENST00000302819.10",
"protein_id": "ENSP00000307697.5",
"transcript_support_level": 1,
"aa_start": 434,
"aa_end": null,
"aa_length": 681,
"cds_start": 1302,
"cds_end": null,
"cds_length": 2046,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": "NM_003500.4",
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000302819.10"
},
{
"aa_ref": "C",
"aa_alt": "*",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"stop_gained"
],
"exon_rank": 10,
"exon_rank_end": null,
"exon_count": 15,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ACOX2",
"gene_hgnc_id": 120,
"hgvs_c": "c.1374T>A",
"hgvs_p": "p.Cys458*",
"transcript": "ENST00000900718.1",
"protein_id": "ENSP00000570777.1",
"transcript_support_level": null,
"aa_start": 458,
"aa_end": null,
"aa_length": 705,
"cds_start": 1374,
"cds_end": null,
"cds_length": 2118,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000900718.1"
},
{
"aa_ref": "C",
"aa_alt": "*",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"stop_gained"
],
"exon_rank": 10,
"exon_rank_end": null,
"exon_count": 15,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ACOX2",
"gene_hgnc_id": 120,
"hgvs_c": "c.1326T>A",
"hgvs_p": "p.Cys442*",
"transcript": "ENST00000900721.1",
"protein_id": "ENSP00000570780.1",
"transcript_support_level": null,
"aa_start": 442,
"aa_end": null,
"aa_length": 689,
"cds_start": 1326,
"cds_end": null,
"cds_length": 2070,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000900721.1"
},
{
"aa_ref": "C",
"aa_alt": "*",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"stop_gained"
],
"exon_rank": 10,
"exon_rank_end": null,
"exon_count": 15,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ACOX2",
"gene_hgnc_id": 120,
"hgvs_c": "c.1302T>A",
"hgvs_p": "p.Cys434*",
"transcript": "ENST00000900725.1",
"protein_id": "ENSP00000570784.1",
"transcript_support_level": null,
"aa_start": 434,
"aa_end": null,
"aa_length": 682,
"cds_start": 1302,
"cds_end": null,
"cds_length": 2049,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000900725.1"
},
{
"aa_ref": "C",
"aa_alt": "*",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"stop_gained"
],
"exon_rank": 11,
"exon_rank_end": null,
"exon_count": 16,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ACOX2",
"gene_hgnc_id": 120,
"hgvs_c": "c.1302T>A",
"hgvs_p": "p.Cys434*",
"transcript": "ENST00000900712.1",
"protein_id": "ENSP00000570771.1",
"transcript_support_level": null,
"aa_start": 434,
"aa_end": null,
"aa_length": 681,
"cds_start": 1302,
"cds_end": null,
"cds_length": 2046,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000900712.1"
},
{
"aa_ref": "C",
"aa_alt": "*",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"stop_gained"
],
"exon_rank": 11,
"exon_rank_end": null,
"exon_count": 16,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ACOX2",
"gene_hgnc_id": 120,
"hgvs_c": "c.1302T>A",
"hgvs_p": "p.Cys434*",
"transcript": "ENST00000900713.1",
"protein_id": "ENSP00000570772.1",
"transcript_support_level": null,
"aa_start": 434,
"aa_end": null,
"aa_length": 681,
"cds_start": 1302,
"cds_end": null,
"cds_length": 2046,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000900713.1"
},
{
"aa_ref": "C",
"aa_alt": "*",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"stop_gained"
],
"exon_rank": 10,
"exon_rank_end": null,
"exon_count": 15,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ACOX2",
"gene_hgnc_id": 120,
"hgvs_c": "c.1302T>A",
"hgvs_p": "p.Cys434*",
"transcript": "ENST00000900714.1",
"protein_id": "ENSP00000570773.1",
"transcript_support_level": null,
"aa_start": 434,
"aa_end": null,
"aa_length": 681,
"cds_start": 1302,
"cds_end": null,
"cds_length": 2046,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000900714.1"
},
{
"aa_ref": "C",
"aa_alt": "*",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"stop_gained"
],
"exon_rank": 11,
"exon_rank_end": null,
"exon_count": 16,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ACOX2",
"gene_hgnc_id": 120,
"hgvs_c": "c.1302T>A",
"hgvs_p": "p.Cys434*",
"transcript": "ENST00000900715.1",
"protein_id": "ENSP00000570774.1",
"transcript_support_level": null,
"aa_start": 434,
"aa_end": null,
"aa_length": 681,
"cds_start": 1302,
"cds_end": null,
"cds_length": 2046,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000900715.1"
},
{
"aa_ref": "C",
"aa_alt": "*",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"stop_gained"
],
"exon_rank": 10,
"exon_rank_end": null,
"exon_count": 15,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ACOX2",
"gene_hgnc_id": 120,
"hgvs_c": "c.1302T>A",
"hgvs_p": "p.Cys434*",
"transcript": "ENST00000900717.1",
"protein_id": "ENSP00000570776.1",
"transcript_support_level": null,
"aa_start": 434,
"aa_end": null,
"aa_length": 681,
"cds_start": 1302,
"cds_end": null,
"cds_length": 2046,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000900717.1"
},
{
"aa_ref": "C",
"aa_alt": "*",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"stop_gained"
],
"exon_rank": 11,
"exon_rank_end": null,
"exon_count": 16,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ACOX2",
"gene_hgnc_id": 120,
"hgvs_c": "c.1302T>A",
"hgvs_p": "p.Cys434*",
"transcript": "ENST00000900720.1",
"protein_id": "ENSP00000570779.1",
"transcript_support_level": null,
"aa_start": 434,
"aa_end": null,
"aa_length": 681,
"cds_start": 1302,
"cds_end": null,
"cds_length": 2046,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000900720.1"
},
{
"aa_ref": "C",
"aa_alt": "*",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"stop_gained"
],
"exon_rank": 10,
"exon_rank_end": null,
"exon_count": 15,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ACOX2",
"gene_hgnc_id": 120,
"hgvs_c": "c.1302T>A",
"hgvs_p": "p.Cys434*",
"transcript": "ENST00000900727.1",
"protein_id": "ENSP00000570786.1",
"transcript_support_level": null,
"aa_start": 434,
"aa_end": null,
"aa_length": 681,
"cds_start": 1302,
"cds_end": null,
"cds_length": 2046,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000900727.1"
},
{
"aa_ref": "C",
"aa_alt": "*",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"stop_gained"
],
"exon_rank": 9,
"exon_rank_end": null,
"exon_count": 14,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ACOX2",
"gene_hgnc_id": 120,
"hgvs_c": "c.1302T>A",
"hgvs_p": "p.Cys434*",
"transcript": "ENST00000900732.1",
"protein_id": "ENSP00000570791.1",
"transcript_support_level": null,
"aa_start": 434,
"aa_end": null,
"aa_length": 681,
"cds_start": 1302,
"cds_end": null,
"cds_length": 2046,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000900732.1"
},
{
"aa_ref": "C",
"aa_alt": "*",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"stop_gained"
],
"exon_rank": 10,
"exon_rank_end": null,
"exon_count": 15,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ACOX2",
"gene_hgnc_id": 120,
"hgvs_c": "c.1269T>A",
"hgvs_p": "p.Cys423*",
"transcript": "ENST00000900728.1",
"protein_id": "ENSP00000570787.1",
"transcript_support_level": null,
"aa_start": 423,
"aa_end": null,
"aa_length": 670,
"cds_start": 1269,
"cds_end": null,
"cds_length": 2013,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000900728.1"
},
{
"aa_ref": "C",
"aa_alt": "*",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"stop_gained"
],
"exon_rank": 10,
"exon_rank_end": null,
"exon_count": 15,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ACOX2",
"gene_hgnc_id": 120,
"hgvs_c": "c.1260T>A",
"hgvs_p": "p.Cys420*",
"transcript": "ENST00000459701.6",
"protein_id": "ENSP00000418562.2",
"transcript_support_level": 5,
"aa_start": 420,
"aa_end": null,
"aa_length": 667,
"cds_start": 1260,
"cds_end": null,
"cds_length": 2004,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000459701.6"
},
{
"aa_ref": "C",
"aa_alt": "*",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"stop_gained"
],
"exon_rank": 11,
"exon_rank_end": null,
"exon_count": 16,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ACOX2",
"gene_hgnc_id": 120,
"hgvs_c": "c.1260T>A",
"hgvs_p": "p.Cys420*",
"transcript": "ENST00000900722.1",
"protein_id": "ENSP00000570781.1",
"transcript_support_level": null,
"aa_start": 420,
"aa_end": null,
"aa_length": 667,
"cds_start": 1260,
"cds_end": null,
"cds_length": 2004,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000900722.1"
},
{
"aa_ref": "C",
"aa_alt": "*",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"stop_gained"
],
"exon_rank": 11,
"exon_rank_end": null,
"exon_count": 16,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ACOX2",
"gene_hgnc_id": 120,
"hgvs_c": "c.1260T>A",
"hgvs_p": "p.Cys420*",
"transcript": "ENST00000900724.1",
"protein_id": "ENSP00000570783.1",
"transcript_support_level": null,
"aa_start": 420,
"aa_end": null,
"aa_length": 667,
"cds_start": 1260,
"cds_end": null,
"cds_length": 2004,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000900724.1"
},
{
"aa_ref": "C",
"aa_alt": "*",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"stop_gained"
],
"exon_rank": 11,
"exon_rank_end": null,
"exon_count": 16,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ACOX2",
"gene_hgnc_id": 120,
"hgvs_c": "c.1260T>A",
"hgvs_p": "p.Cys420*",
"transcript": "ENST00000900729.1",
"protein_id": "ENSP00000570788.1",
"transcript_support_level": null,
"aa_start": 420,
"aa_end": null,
"aa_length": 667,
"cds_start": 1260,
"cds_end": null,
"cds_length": 2004,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000900729.1"
},
{
"aa_ref": "C",
"aa_alt": "*",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"stop_gained"
],
"exon_rank": 10,
"exon_rank_end": null,
"exon_count": 15,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ACOX2",
"gene_hgnc_id": 120,
"hgvs_c": "c.1260T>A",
"hgvs_p": "p.Cys420*",
"transcript": "ENST00000900730.1",
"protein_id": "ENSP00000570789.1",
"transcript_support_level": null,
"aa_start": 420,
"aa_end": null,
"aa_length": 667,
"cds_start": 1260,
"cds_end": null,
"cds_length": 2004,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000900730.1"
},
{
"aa_ref": "C",
"aa_alt": "*",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"stop_gained"
],
"exon_rank": 10,
"exon_rank_end": null,
"exon_count": 15,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ACOX2",
"gene_hgnc_id": 120,
"hgvs_c": "c.1260T>A",
"hgvs_p": "p.Cys420*",
"transcript": "ENST00000900731.1",
"protein_id": "ENSP00000570790.1",
"transcript_support_level": null,
"aa_start": 420,
"aa_end": null,
"aa_length": 667,
"cds_start": 1260,
"cds_end": null,
"cds_length": 2004,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000900731.1"
},
{
"aa_ref": "C",
"aa_alt": "*",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"stop_gained"
],
"exon_rank": 10,
"exon_rank_end": null,
"exon_count": 15,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ACOX2",
"gene_hgnc_id": 120,
"hgvs_c": "c.1302T>A",
"hgvs_p": "p.Cys434*",
"transcript": "ENST00000900726.1",
"protein_id": "ENSP00000570785.1",
"transcript_support_level": null,
"aa_start": 434,
"aa_end": null,
"aa_length": 646,
"cds_start": 1302,
"cds_end": null,
"cds_length": 1941,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000900726.1"
},
{
"aa_ref": "C",
"aa_alt": "*",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"stop_gained"
],
"exon_rank": 10,
"exon_rank_end": null,
"exon_count": 15,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ACOX2",
"gene_hgnc_id": 120,
"hgvs_c": "c.1089T>A",
"hgvs_p": "p.Cys363*",
"transcript": "ENST00000943385.1",
"protein_id": "ENSP00000613444.1",
"transcript_support_level": null,
"aa_start": 363,
"aa_end": null,
"aa_length": 610,
"cds_start": 1089,
"cds_end": null,
"cds_length": 1833,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000943385.1"
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{
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"verdict": "Uncertain_significance",
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],
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"clinvar_classification": "",
"clinvar_review_status": "",
"clinvar_submissions_summary": "",
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"custom_annotations": null
}
],
"message": null
}