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GeneBe API Showcase
This page demonstrates how to use the GeneBe API to query variant information. The API provides programmatic access to genomic annotations and variant data.
API presented here should be used for checking single variants. If you want to check many variants at once, please use other API endpoints that you will find in the documentation.
Documentation & Advanced Usage
• Complete API documentation:docs.genebe.net/docs/api/overview/
• Interactive endpoint tester:api.genebe.net/cloud/gb-api-doc/swagger-ui/
• Python client for pandas:pypi.org/project/genebe/
• Java CLI for VCF files:github.com/pstawinski/genebe-cli
• All tools documented at:docs.genebe.net
API Request Examples for Variant: 3-62399451-G-T (hg38)
Bash / cURL Example
bash
curl "https://api.genebe.net/cloud/api-public/v1/variant?chr=3&pos=62399451&ref=G&alt=T&genome=hg38&allGenes=true"API Response
json
{
"variants": [
{
"chr": "3",
"pos": 62399451,
"ref": "G",
"alt": "T",
"effect": "synonymous_variant",
"transcript": "NM_001438347.1",
"consequences": [
{
"aa_ref": "G",
"aa_alt": "G",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 30,
"exon_rank_end": null,
"exon_count": 30,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CADPS",
"gene_hgnc_id": 1426,
"hgvs_c": "c.4017C>A",
"hgvs_p": "p.Gly1339Gly",
"transcript": "NM_003716.4",
"protein_id": "NP_003707.2",
"transcript_support_level": null,
"aa_start": 1339,
"aa_end": null,
"aa_length": 1353,
"cds_start": 4017,
"cds_end": null,
"cds_length": 4062,
"cdna_start": 4404,
"cdna_end": null,
"cdna_length": 5507,
"mane_select": "ENST00000383710.9",
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_003716.4"
},
{
"aa_ref": "G",
"aa_alt": "G",
"canonical": true,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 30,
"exon_rank_end": null,
"exon_count": 30,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CADPS",
"gene_hgnc_id": 1426,
"hgvs_c": "c.4017C>A",
"hgvs_p": "p.Gly1339Gly",
"transcript": "ENST00000383710.9",
"protein_id": "ENSP00000373215.4",
"transcript_support_level": 1,
"aa_start": 1339,
"aa_end": null,
"aa_length": 1353,
"cds_start": 4017,
"cds_end": null,
"cds_length": 4062,
"cdna_start": 4404,
"cdna_end": null,
"cdna_length": 5507,
"mane_select": "NM_003716.4",
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000383710.9"
},
{
"aa_ref": "G",
"aa_alt": "G",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 28,
"exon_rank_end": null,
"exon_count": 28,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CADPS",
"gene_hgnc_id": 1426,
"hgvs_c": "c.3990C>A",
"hgvs_p": "p.Gly1330Gly",
"transcript": "ENST00000612439.4",
"protein_id": "ENSP00000484365.1",
"transcript_support_level": 1,
"aa_start": 1330,
"aa_end": null,
"aa_length": 1344,
"cds_start": 3990,
"cds_end": null,
"cds_length": 4035,
"cdna_start": 4350,
"cdna_end": null,
"cdna_length": 5455,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000612439.4"
},
{
"aa_ref": "G",
"aa_alt": "G",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 28,
"exon_rank_end": null,
"exon_count": 28,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CADPS",
"gene_hgnc_id": 1426,
"hgvs_c": "c.3900C>A",
"hgvs_p": "p.Gly1300Gly",
"transcript": "ENST00000283269.13",
"protein_id": "ENSP00000283269.9",
"transcript_support_level": 1,
"aa_start": 1300,
"aa_end": null,
"aa_length": 1314,
"cds_start": 3900,
"cds_end": null,
"cds_length": 3945,
"cdna_start": 4112,
"cdna_end": null,
"cdna_length": 4591,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000283269.13"
},
{
"aa_ref": "G",
"aa_alt": "G",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 27,
"exon_rank_end": null,
"exon_count": 27,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CADPS",
"gene_hgnc_id": 1426,
"hgvs_c": "c.3780C>A",
"hgvs_p": "p.Gly1260Gly",
"transcript": "ENST00000357948.7",
"protein_id": "ENSP00000350632.3",
"transcript_support_level": 1,
"aa_start": 1260,
"aa_end": null,
"aa_length": 1274,
"cds_start": 3780,
"cds_end": null,
"cds_length": 3825,
"cdna_start": 4089,
"cdna_end": null,
"cdna_length": 5190,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000357948.7"
},
{
"aa_ref": "G",
"aa_alt": "G",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 10,
"exon_rank_end": null,
"exon_count": 10,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CADPS",
"gene_hgnc_id": 1426,
"hgvs_c": "c.990C>A",
"hgvs_p": "p.Gly330Gly",
"transcript": "ENST00000473635.5",
"protein_id": "ENSP00000418889.1",
"transcript_support_level": 1,
"aa_start": 330,
"aa_end": null,
"aa_length": 344,
"cds_start": 990,
"cds_end": null,
"cds_length": 1035,
"cdna_start": 992,
"cdna_end": null,
"cdna_length": 2095,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000473635.5"
},
{
"aa_ref": "G",
"aa_alt": "G",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 31,
"exon_rank_end": null,
"exon_count": 31,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CADPS",
"gene_hgnc_id": 1426,
"hgvs_c": "c.4077C>A",
"hgvs_p": "p.Gly1359Gly",
"transcript": "NM_001438347.1",
"protein_id": "NP_001425276.1",
"transcript_support_level": null,
"aa_start": 1359,
"aa_end": null,
"aa_length": 1373,
"cds_start": 4077,
"cds_end": null,
"cds_length": 4122,
"cdna_start": 4464,
"cdna_end": null,
"cdna_length": 5567,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001438347.1"
},
{
"aa_ref": "G",
"aa_alt": "G",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 30,
"exon_rank_end": null,
"exon_count": 30,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CADPS",
"gene_hgnc_id": 1426,
"hgvs_c": "c.4065C>A",
"hgvs_p": "p.Gly1355Gly",
"transcript": "NM_001438348.1",
"protein_id": "NP_001425277.1",
"transcript_support_level": null,
"aa_start": 1355,
"aa_end": null,
"aa_length": 1369,
"cds_start": 4065,
"cds_end": null,
"cds_length": 4110,
"cdna_start": 4452,
"cdna_end": null,
"cdna_length": 5555,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001438348.1"
},
{
"aa_ref": "G",
"aa_alt": "G",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 31,
"exon_rank_end": null,
"exon_count": 31,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CADPS",
"gene_hgnc_id": 1426,
"hgvs_c": "c.4029C>A",
"hgvs_p": "p.Gly1343Gly",
"transcript": "NM_001438349.1",
"protein_id": "NP_001425278.1",
"transcript_support_level": null,
"aa_start": 1343,
"aa_end": null,
"aa_length": 1357,
"cds_start": 4029,
"cds_end": null,
"cds_length": 4074,
"cdna_start": 4416,
"cdna_end": null,
"cdna_length": 5519,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001438349.1"
},
{
"aa_ref": "G",
"aa_alt": "G",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 29,
"exon_rank_end": null,
"exon_count": 29,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CADPS",
"gene_hgnc_id": 1426,
"hgvs_c": "c.3996C>A",
"hgvs_p": "p.Gly1332Gly",
"transcript": "ENST00000951695.1",
"protein_id": "ENSP00000621754.1",
"transcript_support_level": null,
"aa_start": 1332,
"aa_end": null,
"aa_length": 1346,
"cds_start": 3996,
"cds_end": null,
"cds_length": 4041,
"cdna_start": 4337,
"cdna_end": null,
"cdna_length": 5433,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000951695.1"
},
{
"aa_ref": "G",
"aa_alt": "G",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 28,
"exon_rank_end": null,
"exon_count": 28,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CADPS",
"gene_hgnc_id": 1426,
"hgvs_c": "c.3990C>A",
"hgvs_p": "p.Gly1330Gly",
"transcript": "NM_001437891.1",
"protein_id": "NP_001424820.1",
"transcript_support_level": null,
"aa_start": 1330,
"aa_end": null,
"aa_length": 1344,
"cds_start": 3990,
"cds_end": null,
"cds_length": 4035,
"cdna_start": 4377,
"cdna_end": null,
"cdna_length": 5480,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001437891.1"
},
{
"aa_ref": "G",
"aa_alt": "G",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 29,
"exon_rank_end": null,
"exon_count": 29,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CADPS",
"gene_hgnc_id": 1426,
"hgvs_c": "c.3918C>A",
"hgvs_p": "p.Gly1306Gly",
"transcript": "NM_001438350.1",
"protein_id": "NP_001425279.1",
"transcript_support_level": null,
"aa_start": 1306,
"aa_end": null,
"aa_length": 1320,
"cds_start": 3918,
"cds_end": null,
"cds_length": 3963,
"cdna_start": 4305,
"cdna_end": null,
"cdna_length": 5408,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001438350.1"
},
{
"aa_ref": "G",
"aa_alt": "G",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 29,
"exon_rank_end": null,
"exon_count": 29,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CADPS",
"gene_hgnc_id": 1426,
"hgvs_c": "c.3918C>A",
"hgvs_p": "p.Gly1306Gly",
"transcript": "ENST00000951692.1",
"protein_id": "ENSP00000621751.1",
"transcript_support_level": null,
"aa_start": 1306,
"aa_end": null,
"aa_length": 1320,
"cds_start": 3918,
"cds_end": null,
"cds_length": 3963,
"cdna_start": 4452,
"cdna_end": null,
"cdna_length": 5554,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000951692.1"
},
{
"aa_ref": "G",
"aa_alt": "G",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 29,
"exon_rank_end": null,
"exon_count": 29,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CADPS",
"gene_hgnc_id": 1426,
"hgvs_c": "c.3915C>A",
"hgvs_p": "p.Gly1305Gly",
"transcript": "ENST00000951696.1",
"protein_id": "ENSP00000621755.1",
"transcript_support_level": null,
"aa_start": 1305,
"aa_end": null,
"aa_length": 1319,
"cds_start": 3915,
"cds_end": null,
"cds_length": 3960,
"cdna_start": 4247,
"cdna_end": null,
"cdna_length": 5351,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000951696.1"
},
{
"aa_ref": "G",
"aa_alt": "G",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 28,
"exon_rank_end": null,
"exon_count": 28,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CADPS",
"gene_hgnc_id": 1426,
"hgvs_c": "c.3900C>A",
"hgvs_p": "p.Gly1300Gly",
"transcript": "NM_183394.3",
"protein_id": "NP_899631.1",
"transcript_support_level": null,
"aa_start": 1300,
"aa_end": null,
"aa_length": 1314,
"cds_start": 3900,
"cds_end": null,
"cds_length": 3945,
"cdna_start": 4287,
"cdna_end": null,
"cdna_length": 5390,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_183394.3"
},
{
"aa_ref": "G",
"aa_alt": "G",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 28,
"exon_rank_end": null,
"exon_count": 28,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CADPS",
"gene_hgnc_id": 1426,
"hgvs_c": "c.3849C>A",
"hgvs_p": "p.Gly1283Gly",
"transcript": "NM_001438351.1",
"protein_id": "NP_001425280.1",
"transcript_support_level": null,
"aa_start": 1283,
"aa_end": null,
"aa_length": 1297,
"cds_start": 3849,
"cds_end": null,
"cds_length": 3894,
"cdna_start": 4236,
"cdna_end": null,
"cdna_length": 5339,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001438351.1"
},
{
"aa_ref": "G",
"aa_alt": "G",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 28,
"exon_rank_end": null,
"exon_count": 28,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CADPS",
"gene_hgnc_id": 1426,
"hgvs_c": "c.3849C>A",
"hgvs_p": "p.Gly1283Gly",
"transcript": "ENST00000951693.1",
"protein_id": "ENSP00000621752.1",
"transcript_support_level": null,
"aa_start": 1283,
"aa_end": null,
"aa_length": 1297,
"cds_start": 3849,
"cds_end": null,
"cds_length": 3894,
"cdna_start": 4215,
"cdna_end": null,
"cdna_length": 5312,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000951693.1"
},
{
"aa_ref": "G",
"aa_alt": "G",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 28,
"exon_rank_end": null,
"exon_count": 28,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CADPS",
"gene_hgnc_id": 1426,
"hgvs_c": "c.3846C>A",
"hgvs_p": "p.Gly1282Gly",
"transcript": "ENST00000951694.1",
"protein_id": "ENSP00000621753.1",
"transcript_support_level": null,
"aa_start": 1282,
"aa_end": null,
"aa_length": 1296,
"cds_start": 3846,
"cds_end": null,
"cds_length": 3891,
"cdna_start": 4206,
"cdna_end": null,
"cdna_length": 5307,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000951694.1"
},
{
"aa_ref": "G",
"aa_alt": "G",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 27,
"exon_rank_end": null,
"exon_count": 27,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CADPS",
"gene_hgnc_id": 1426,
"hgvs_c": "c.3831C>A",
"hgvs_p": "p.Gly1277Gly",
"transcript": "NM_001438352.1",
"protein_id": "NP_001425281.1",
"transcript_support_level": null,
"aa_start": 1277,
"aa_end": null,
"aa_length": 1291,
"cds_start": 3831,
"cds_end": null,
"cds_length": 3876,
"cdna_start": 4218,
"cdna_end": null,
"cdna_length": 5321,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001438352.1"
},
{
"aa_ref": "G",
"aa_alt": "G",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 27,
"exon_rank_end": null,
"exon_count": 27,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CADPS",
"gene_hgnc_id": 1426,
"hgvs_c": "c.3831C>A",
"hgvs_p": "p.Gly1277Gly",
"transcript": "ENST00000935174.1",
"protein_id": "ENSP00000605233.1",
"transcript_support_level": null,
"aa_start": 1277,
"aa_end": null,
"aa_length": 1291,
"cds_start": 3831,
"cds_end": null,
"cds_length": 3876,
"cdna_start": 4173,
"cdna_end": null,
"cdna_length": 5278,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000935174.1"
},
{
"aa_ref": "G",
"aa_alt": "G",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 27,
"exon_rank_end": null,
"exon_count": 27,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CADPS",
"gene_hgnc_id": 1426,
"hgvs_c": "c.3780C>A",
"hgvs_p": "p.Gly1260Gly",
"transcript": "NM_183393.3",
"protein_id": "NP_899630.1",
"transcript_support_level": null,
"aa_start": 1260,
"aa_end": null,
"aa_length": 1274,
"cds_start": 3780,
"cds_end": null,
"cds_length": 3825,
"cdna_start": 4167,
"cdna_end": null,
"cdna_length": 5270,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_183393.3"
},
{
"aa_ref": "G",
"aa_alt": "G",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 34,
"exon_rank_end": null,
"exon_count": 34,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CADPS",
"gene_hgnc_id": 1426,
"hgvs_c": "c.4263C>A",
"hgvs_p": "p.Gly1421Gly",
"transcript": "XM_047449093.1",
"protein_id": "XP_047305049.1",
"transcript_support_level": null,
"aa_start": 1421,
"aa_end": null,
"aa_length": 1435,
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}
],
"message": null
}