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GeneBe API Showcase
This page demonstrates how to use the GeneBe API to query variant information. The API provides programmatic access to genomic annotations and variant data.
API presented here should be used for checking single variants. If you want to check many variants at once, please use other API endpoints that you will find in the documentation.
Documentation & Advanced Usage
• Complete API documentation:docs.genebe.net/docs/api/overview/
• Interactive endpoint tester:api.genebe.net/cloud/gb-api-doc/swagger-ui/
• Python client for pandas:pypi.org/project/genebe/
• Java CLI for VCF files:github.com/pstawinski/genebe-cli
• All tools documented at:docs.genebe.net
API Request Examples for Variant: 3-9911022-A-C (hg38)
Bash / cURL Example
bash
curl "https://api.genebe.net/cloud/api-public/v1/variant?chr=3&pos=9911022&ref=A&alt=C&genome=hg38&allGenes=true"API Response
json
{
"variants": [
{
"chr": "3",
"pos": 9911022,
"ref": "A",
"alt": "C",
"effect": "synonymous_variant",
"transcript": "ENST00000383814.8",
"consequences": [
{
"aa_ref": "T",
"aa_alt": "T",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 9,
"exon_rank_end": null,
"exon_count": 16,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "IL17RE",
"gene_hgnc_id": 18439,
"hgvs_c": "c.960A>C",
"hgvs_p": "p.Thr320Thr",
"transcript": "NM_153480.2",
"protein_id": "NP_705613.1",
"transcript_support_level": null,
"aa_start": 320,
"aa_end": null,
"aa_length": 667,
"cds_start": 960,
"cds_end": null,
"cds_length": 2004,
"cdna_start": 1045,
"cdna_end": null,
"cdna_length": 2679,
"mane_select": "ENST00000383814.8",
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "T",
"aa_alt": "T",
"canonical": true,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 9,
"exon_rank_end": null,
"exon_count": 16,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "IL17RE",
"gene_hgnc_id": 18439,
"hgvs_c": "c.960A>C",
"hgvs_p": "p.Thr320Thr",
"transcript": "ENST00000383814.8",
"protein_id": "ENSP00000373325.3",
"transcript_support_level": 1,
"aa_start": 320,
"aa_end": null,
"aa_length": 667,
"cds_start": 960,
"cds_end": null,
"cds_length": 2004,
"cdna_start": 1045,
"cdna_end": null,
"cdna_length": 2679,
"mane_select": "NM_153480.2",
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "T",
"aa_alt": "T",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 10,
"exon_rank_end": null,
"exon_count": 17,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "IL17RE",
"gene_hgnc_id": 18439,
"hgvs_c": "c.1059A>C",
"hgvs_p": "p.Thr353Thr",
"transcript": "ENST00000421412.5",
"protein_id": "ENSP00000404916.1",
"transcript_support_level": 1,
"aa_start": 353,
"aa_end": null,
"aa_length": 700,
"cds_start": 1059,
"cds_end": null,
"cds_length": 2103,
"cdna_start": 1077,
"cdna_end": null,
"cdna_length": 2158,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "T",
"aa_alt": "T",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 10,
"exon_rank_end": null,
"exon_count": 17,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "IL17RE",
"gene_hgnc_id": 18439,
"hgvs_c": "c.1080A>C",
"hgvs_p": "p.Thr360Thr",
"transcript": "NM_153483.2",
"protein_id": "NP_705616.2",
"transcript_support_level": null,
"aa_start": 360,
"aa_end": null,
"aa_length": 707,
"cds_start": 1080,
"cds_end": null,
"cds_length": 2124,
"cdna_start": 1084,
"cdna_end": null,
"cdna_length": 2723,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "T",
"aa_alt": "T",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 7,
"exon_rank_end": null,
"exon_count": 14,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "IL17RE",
"gene_hgnc_id": 18439,
"hgvs_c": "c.612A>C",
"hgvs_p": "p.Thr204Thr",
"transcript": "NM_153481.2",
"protein_id": "NP_705614.1",
"transcript_support_level": null,
"aa_start": 204,
"aa_end": null,
"aa_length": 551,
"cds_start": 612,
"cds_end": null,
"cds_length": 1656,
"cdna_start": 909,
"cdna_end": null,
"cdna_length": 2543,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "T",
"aa_alt": "T",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 9,
"exon_rank_end": null,
"exon_count": 16,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "IL17RE",
"gene_hgnc_id": 18439,
"hgvs_c": "c.960A>C",
"hgvs_p": "p.Thr320Thr",
"transcript": "NM_001193380.2",
"protein_id": "NP_001180309.1",
"transcript_support_level": null,
"aa_start": 320,
"aa_end": null,
"aa_length": 533,
"cds_start": 960,
"cds_end": null,
"cds_length": 1602,
"cdna_start": 1045,
"cdna_end": null,
"cdna_length": 2752,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "T",
"aa_alt": "T",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 9,
"exon_rank_end": null,
"exon_count": 16,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "IL17RE",
"gene_hgnc_id": 18439,
"hgvs_c": "c.960A>C",
"hgvs_p": "p.Thr320Thr",
"transcript": "ENST00000454190.6",
"protein_id": "ENSP00000388086.2",
"transcript_support_level": 2,
"aa_start": 320,
"aa_end": null,
"aa_length": 533,
"cds_start": 960,
"cds_end": null,
"cds_length": 1602,
"cdna_start": 1045,
"cdna_end": null,
"cdna_length": 2757,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "T",
"aa_alt": "T",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 10,
"exon_rank_end": null,
"exon_count": 17,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "IL17RE",
"gene_hgnc_id": 18439,
"hgvs_c": "c.960A>C",
"hgvs_p": "p.Thr320Thr",
"transcript": "XM_047447458.1",
"protein_id": "XP_047303414.1",
"transcript_support_level": null,
"aa_start": 320,
"aa_end": null,
"aa_length": 667,
"cds_start": 960,
"cds_end": null,
"cds_length": 2004,
"cdna_start": 1093,
"cdna_end": null,
"cdna_length": 2732,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "T",
"aa_alt": "T",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 9,
"exon_rank_end": null,
"exon_count": 16,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "IL17RE",
"gene_hgnc_id": 18439,
"hgvs_c": "c.960A>C",
"hgvs_p": "p.Thr320Thr",
"transcript": "XM_047447459.1",
"protein_id": "XP_047303415.1",
"transcript_support_level": null,
"aa_start": 320,
"aa_end": null,
"aa_length": 667,
"cds_start": 960,
"cds_end": null,
"cds_length": 2004,
"cdna_start": 964,
"cdna_end": null,
"cdna_length": 2603,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "T",
"aa_alt": "T",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 9,
"exon_rank_end": null,
"exon_count": 16,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "IL17RE",
"gene_hgnc_id": 18439,
"hgvs_c": "c.840A>C",
"hgvs_p": "p.Thr280Thr",
"transcript": "XM_011533361.4",
"protein_id": "XP_011531663.2",
"transcript_support_level": null,
"aa_start": 280,
"aa_end": null,
"aa_length": 627,
"cds_start": 840,
"cds_end": null,
"cds_length": 1884,
"cdna_start": 974,
"cdna_end": null,
"cdna_length": 2613,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "T",
"aa_alt": "T",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 8,
"exon_rank_end": null,
"exon_count": 15,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "IL17RE",
"gene_hgnc_id": 18439,
"hgvs_c": "c.612A>C",
"hgvs_p": "p.Thr204Thr",
"transcript": "XM_006712976.2",
"protein_id": "XP_006713039.1",
"transcript_support_level": null,
"aa_start": 204,
"aa_end": null,
"aa_length": 551,
"cds_start": 612,
"cds_end": null,
"cds_length": 1656,
"cdna_start": 1029,
"cdna_end": null,
"cdna_length": 2668,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "T",
"aa_alt": "T",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 10,
"exon_rank_end": null,
"exon_count": 17,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "IL17RE",
"gene_hgnc_id": 18439,
"hgvs_c": "c.960A>C",
"hgvs_p": "p.Thr320Thr",
"transcript": "XM_047447460.1",
"protein_id": "XP_047303416.1",
"transcript_support_level": null,
"aa_start": 320,
"aa_end": null,
"aa_length": 533,
"cds_start": 960,
"cds_end": null,
"cds_length": 1602,
"cdna_start": 1084,
"cdna_end": null,
"cdna_length": 2796,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "T",
"aa_alt": "T",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 10,
"exon_rank_end": null,
"exon_count": 16,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "IL17RE",
"gene_hgnc_id": 18439,
"hgvs_c": "c.960A>C",
"hgvs_p": "p.Thr320Thr",
"transcript": "XM_024453350.2",
"protein_id": "XP_024309118.1",
"transcript_support_level": null,
"aa_start": 320,
"aa_end": null,
"aa_length": 506,
"cds_start": 960,
"cds_end": null,
"cds_length": 1521,
"cdna_start": 1082,
"cdna_end": null,
"cdna_length": 3335,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "T",
"aa_alt": "T",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 10,
"exon_rank_end": null,
"exon_count": 16,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "IL17RE",
"gene_hgnc_id": 18439,
"hgvs_c": "c.960A>C",
"hgvs_p": "p.Thr320Thr",
"transcript": "XM_011533362.3",
"protein_id": "XP_011531664.1",
"transcript_support_level": null,
"aa_start": 320,
"aa_end": null,
"aa_length": 457,
"cds_start": 960,
"cds_end": null,
"cds_length": 1374,
"cdna_start": 1083,
"cdna_end": null,
"cdna_length": 2567,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "T",
"aa_alt": "T",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 10,
"exon_rank_end": null,
"exon_count": 15,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "IL17RE",
"gene_hgnc_id": 18439,
"hgvs_c": "c.960A>C",
"hgvs_p": "p.Thr320Thr",
"transcript": "XM_047447462.1",
"protein_id": "XP_047303418.1",
"transcript_support_level": null,
"aa_start": 320,
"aa_end": null,
"aa_length": 430,
"cds_start": 960,
"cds_end": null,
"cds_length": 1293,
"cdna_start": 1081,
"cdna_end": null,
"cdna_length": 1513,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "T",
"aa_alt": "T",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 10,
"exon_rank_end": null,
"exon_count": 14,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "IL17RE",
"gene_hgnc_id": 18439,
"hgvs_c": "c.960A>C",
"hgvs_p": "p.Thr320Thr",
"transcript": "XM_011533363.3",
"protein_id": "XP_011531665.1",
"transcript_support_level": null,
"aa_start": 320,
"aa_end": null,
"aa_length": 410,
"cds_start": 960,
"cds_end": null,
"cds_length": 1233,
"cdna_start": 1023,
"cdna_end": null,
"cdna_length": 1388,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "T",
"aa_alt": "T",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 10,
"exon_rank_end": null,
"exon_count": 14,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "IL17RE",
"gene_hgnc_id": 18439,
"hgvs_c": "c.960A>C",
"hgvs_p": "p.Thr320Thr",
"transcript": "XM_011533364.3",
"protein_id": "XP_011531666.1",
"transcript_support_level": null,
"aa_start": 320,
"aa_end": null,
"aa_length": 381,
"cds_start": 960,
"cds_end": null,
"cds_length": 1146,
"cdna_start": 1027,
"cdna_end": null,
"cdna_length": 1300,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": false,
"strand": true,
"consequences": [
"non_coding_transcript_exon_variant"
],
"exon_rank": 8,
"exon_rank_end": null,
"exon_count": 15,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "IL17RE",
"gene_hgnc_id": 18439,
"hgvs_c": "n.*383A>C",
"hgvs_p": null,
"transcript": "ENST00000383815.7",
"protein_id": "ENSP00000373326.3",
"transcript_support_level": 2,
"aa_start": null,
"aa_end": null,
"aa_length": null,
"cds_start": -4,
"cds_end": null,
"cds_length": null,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 2808,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": false,
"strand": true,
"consequences": [
"non_coding_transcript_exon_variant"
],
"exon_rank": 7,
"exon_rank_end": null,
"exon_count": 14,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "IL17RE",
"gene_hgnc_id": 18439,
"hgvs_c": "n.*383A>C",
"hgvs_p": null,
"transcript": "ENST00000434065.5",
"protein_id": "ENSP00000415701.1",
"transcript_support_level": 2,
"aa_start": null,
"aa_end": null,
"aa_length": null,
"cds_start": -4,
"cds_end": null,
"cds_length": null,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 2541,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": false,
"strand": true,
"consequences": [
"non_coding_transcript_exon_variant"
],
"exon_rank": 5,
"exon_rank_end": null,
"exon_count": 8,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "IL17RE",
"gene_hgnc_id": 18439,
"hgvs_c": "n.*86A>C",
"hgvs_p": null,
"transcript": "ENST00000444427.5",
"protein_id": "ENSP00000406076.1",
"transcript_support_level": 2,
"aa_start": null,
"aa_end": null,
"aa_length": null,
"cds_start": -4,
"cds_end": null,
"cds_length": null,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 952,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": false,
"strand": true,
"consequences": [
"non_coding_transcript_exon_variant"
],
"exon_rank": 1,
"exon_rank_end": null,
"exon_count": 3,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "IL17RE",
"gene_hgnc_id": 18439,
"hgvs_c": "n.158A>C",
"hgvs_p": null,
"transcript": "ENST00000483258.1",
"protein_id": null,
"transcript_support_level": 3,
"aa_start": null,
"aa_end": null,
"aa_length": null,
"cds_start": -4,
"cds_end": null,
"cds_length": null,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 375,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": false,
"strand": true,
"consequences": [
"non_coding_transcript_exon_variant"
],
"exon_rank": 8,
"exon_rank_end": null,
"exon_count": 15,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "IL17RE",
"gene_hgnc_id": 18439,
"hgvs_c": "n.1029A>C",
"hgvs_p": null,
"transcript": "NR_104198.2",
"protein_id": null,
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": null,
"cds_start": -4,
"cds_end": null,
"cds_length": null,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 2809,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": false,
"strand": true,
"consequences": [
"non_coding_transcript_exon_variant"
],
"exon_rank": 10,
"exon_rank_end": null,
"exon_count": 15,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "IL17RE",
"gene_hgnc_id": 18439,
"hgvs_c": "n.1027A>C",
"hgvs_p": null,
"transcript": "XR_940382.4",
"protein_id": null,
"transcript_support_level": null,
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],
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"splice_prediction_selected": "Benign",
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{
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"BP4_Strong",
"BP7"
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"verdict": "Likely_benign",
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"effects": [
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],
"clinvar_disease": "",
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"clinvar_review_status": "",
"clinvar_submissions_summary": "",
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"custom_annotations": null
}
],
"message": null
}