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GeneBe API Showcase
This page demonstrates how to use the GeneBe API to query variant information. The API provides programmatic access to genomic annotations and variant data.
API presented here should be used for checking single variants. If you want to check many variants at once, please use other API endpoints that you will find in the documentation.
Documentation & Advanced Usage
• Complete API documentation:docs.genebe.net/docs/api/overview/
• Interactive endpoint tester:api.genebe.net/cloud/gb-api-doc/swagger-ui/
• Python client for pandas:pypi.org/project/genebe/
• Java CLI for VCF files:github.com/pstawinski/genebe-cli
• All tools documented at:docs.genebe.net
API Request Examples for Variant: 3-9933198-A-T (hg38)
Bash / cURL Example
bash
curl "https://api.genebe.net/cloud/api-public/v1/variant?chr=3&pos=9933198&ref=A&alt=T&genome=hg38&allGenes=true"API Response
json
{
"variants": [
{
"chr": "3",
"pos": 9933198,
"ref": "A",
"alt": "T",
"effect": "missense_variant",
"transcript": "NM_153461.4",
"consequences": [
{
"aa_ref": "S",
"aa_alt": "C",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 19,
"exon_rank_end": null,
"exon_count": 19,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "IL17RC",
"gene_hgnc_id": 18358,
"hgvs_c": "c.1768A>T",
"hgvs_p": "p.Ser590Cys",
"transcript": "NM_153460.4",
"protein_id": "NP_703190.2",
"transcript_support_level": null,
"aa_start": 590,
"aa_end": null,
"aa_length": 720,
"cds_start": 1768,
"cds_end": null,
"cds_length": 2163,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": "ENST00000403601.8",
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_153460.4"
},
{
"aa_ref": "S",
"aa_alt": "C",
"canonical": true,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 19,
"exon_rank_end": null,
"exon_count": 19,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "IL17RC",
"gene_hgnc_id": 18358,
"hgvs_c": "c.1768A>T",
"hgvs_p": "p.Ser590Cys",
"transcript": "ENST00000403601.8",
"protein_id": "ENSP00000384969.3",
"transcript_support_level": 1,
"aa_start": 590,
"aa_end": null,
"aa_length": 720,
"cds_start": 1768,
"cds_end": null,
"cds_length": 2163,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": "NM_153460.4",
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000403601.8"
},
{
"aa_ref": "S",
"aa_alt": "C",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 18,
"exon_rank_end": null,
"exon_count": 18,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "IL17RC",
"gene_hgnc_id": 18358,
"hgvs_c": "c.1729A>T",
"hgvs_p": "p.Ser577Cys",
"transcript": "ENST00000413608.2",
"protein_id": "ENSP00000396064.1",
"transcript_support_level": 1,
"aa_start": 577,
"aa_end": null,
"aa_length": 707,
"cds_start": 1729,
"cds_end": null,
"cds_length": 2124,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000413608.2"
},
{
"aa_ref": "S",
"aa_alt": "C",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 18,
"exon_rank_end": null,
"exon_count": 18,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "IL17RC",
"gene_hgnc_id": 18358,
"hgvs_c": "c.1723A>T",
"hgvs_p": "p.Ser575Cys",
"transcript": "ENST00000383812.9",
"protein_id": "ENSP00000373323.4",
"transcript_support_level": 1,
"aa_start": 575,
"aa_end": null,
"aa_length": 705,
"cds_start": 1723,
"cds_end": null,
"cds_length": 2118,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000383812.9"
},
{
"aa_ref": "S",
"aa_alt": "C",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 17,
"exon_rank_end": null,
"exon_count": 17,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "IL17RC",
"gene_hgnc_id": 18358,
"hgvs_c": "c.1678A>T",
"hgvs_p": "p.Ser560Cys",
"transcript": "ENST00000416074.6",
"protein_id": "ENSP00000395315.3",
"transcript_support_level": 1,
"aa_start": 560,
"aa_end": null,
"aa_length": 690,
"cds_start": 1678,
"cds_end": null,
"cds_length": 2073,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000416074.6"
},
{
"aa_ref": "S",
"aa_alt": "C",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 17,
"exon_rank_end": null,
"exon_count": 17,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "IL17RC",
"gene_hgnc_id": 18358,
"hgvs_c": "c.1672A>T",
"hgvs_p": "p.Ser558Cys",
"transcript": "ENST00000455057.5",
"protein_id": "ENSP00000407894.1",
"transcript_support_level": 1,
"aa_start": 558,
"aa_end": null,
"aa_length": 688,
"cds_start": 1672,
"cds_end": null,
"cds_length": 2067,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000455057.5"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"3_prime_UTR_variant"
],
"exon_rank": 17,
"exon_rank_end": null,
"exon_count": 17,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "IL17RC",
"gene_hgnc_id": 18358,
"hgvs_c": "c.*200A>T",
"hgvs_p": null,
"transcript": "ENST00000483582.5",
"protein_id": "ENSP00000512844.1",
"transcript_support_level": 1,
"aa_start": null,
"aa_end": null,
"aa_length": 538,
"cds_start": null,
"cds_end": null,
"cds_length": 1617,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000483582.5"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": false,
"strand": true,
"consequences": [
"non_coding_transcript_exon_variant"
],
"exon_rank": 17,
"exon_rank_end": null,
"exon_count": 17,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "IL17RC",
"gene_hgnc_id": 18358,
"hgvs_c": "n.*1461A>T",
"hgvs_p": null,
"transcript": "ENST00000451271.5",
"protein_id": "ENSP00000412777.1",
"transcript_support_level": 1,
"aa_start": null,
"aa_end": null,
"aa_length": null,
"cds_start": null,
"cds_end": null,
"cds_length": null,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "nonsense_mediated_decay",
"feature": "ENST00000451271.5"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": false,
"strand": true,
"consequences": [
"non_coding_transcript_exon_variant"
],
"exon_rank": 15,
"exon_rank_end": null,
"exon_count": 15,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "IL17RC",
"gene_hgnc_id": 18358,
"hgvs_c": "n.2301A>T",
"hgvs_p": null,
"transcript": "ENST00000469686.6",
"protein_id": null,
"transcript_support_level": 1,
"aa_start": null,
"aa_end": null,
"aa_length": null,
"cds_start": null,
"cds_end": null,
"cds_length": null,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "retained_intron",
"feature": "ENST00000469686.6"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": false,
"strand": true,
"consequences": [
"3_prime_UTR_variant"
],
"exon_rank": 17,
"exon_rank_end": null,
"exon_count": 17,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "IL17RC",
"gene_hgnc_id": 18358,
"hgvs_c": "n.*1461A>T",
"hgvs_p": null,
"transcript": "ENST00000451271.5",
"protein_id": "ENSP00000412777.1",
"transcript_support_level": 1,
"aa_start": null,
"aa_end": null,
"aa_length": null,
"cds_start": null,
"cds_end": null,
"cds_length": null,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "nonsense_mediated_decay",
"feature": "ENST00000451271.5"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": true,
"protein_coding": false,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 24,
"intron_rank": 16,
"intron_rank_end": null,
"gene_symbol": "ENSG00000288550",
"gene_hgnc_id": null,
"hgvs_c": "n.1399+495A>T",
"hgvs_p": null,
"transcript": "ENST00000683484.1",
"protein_id": "ENSP00000507040.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": null,
"cds_start": null,
"cds_end": null,
"cds_length": null,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "nonsense_mediated_decay",
"feature": "ENST00000683484.1"
},
{
"aa_ref": "S",
"aa_alt": "C",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 19,
"exon_rank_end": null,
"exon_count": 19,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "IL17RC",
"gene_hgnc_id": 18358,
"hgvs_c": "c.1981A>T",
"hgvs_p": "p.Ser661Cys",
"transcript": "NM_153461.4",
"protein_id": "NP_703191.2",
"transcript_support_level": null,
"aa_start": 661,
"aa_end": null,
"aa_length": 791,
"cds_start": 1981,
"cds_end": null,
"cds_length": 2376,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_153461.4"
},
{
"aa_ref": "S",
"aa_alt": "C",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 19,
"exon_rank_end": null,
"exon_count": 19,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "IL17RC",
"gene_hgnc_id": 18358,
"hgvs_c": "c.1981A>T",
"hgvs_p": "p.Ser661Cys",
"transcript": "ENST00000295981.7",
"protein_id": "ENSP00000295981.3",
"transcript_support_level": 2,
"aa_start": 661,
"aa_end": null,
"aa_length": 791,
"cds_start": 1981,
"cds_end": null,
"cds_length": 2376,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000295981.7"
},
{
"aa_ref": "S",
"aa_alt": "C",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 18,
"exon_rank_end": null,
"exon_count": 18,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "IL17RC",
"gene_hgnc_id": 18358,
"hgvs_c": "c.1936A>T",
"hgvs_p": "p.Ser646Cys",
"transcript": "ENST00000869960.1",
"protein_id": "ENSP00000540019.1",
"transcript_support_level": null,
"aa_start": 646,
"aa_end": null,
"aa_length": 776,
"cds_start": 1936,
"cds_end": null,
"cds_length": 2331,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000869960.1"
},
{
"aa_ref": "S",
"aa_alt": "C",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 20,
"exon_rank_end": null,
"exon_count": 20,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "IL17RC",
"gene_hgnc_id": 18358,
"hgvs_c": "c.1900A>T",
"hgvs_p": "p.Ser634Cys",
"transcript": "ENST00000869962.1",
"protein_id": "ENSP00000540021.1",
"transcript_support_level": null,
"aa_start": 634,
"aa_end": null,
"aa_length": 764,
"cds_start": 1900,
"cds_end": null,
"cds_length": 2295,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000869962.1"
},
{
"aa_ref": "S",
"aa_alt": "C",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 20,
"exon_rank_end": null,
"exon_count": 20,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "IL17RC",
"gene_hgnc_id": 18358,
"hgvs_c": "c.1861A>T",
"hgvs_p": "p.Ser621Cys",
"transcript": "ENST00000869980.1",
"protein_id": "ENSP00000540039.1",
"transcript_support_level": null,
"aa_start": 621,
"aa_end": null,
"aa_length": 751,
"cds_start": 1861,
"cds_end": null,
"cds_length": 2256,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000869980.1"
},
{
"aa_ref": "S",
"aa_alt": "C",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 19,
"exon_rank_end": null,
"exon_count": 19,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "IL17RC",
"gene_hgnc_id": 18358,
"hgvs_c": "c.1861A>T",
"hgvs_p": "p.Ser621Cys",
"transcript": "ENST00000870007.1",
"protein_id": "ENSP00000540066.1",
"transcript_support_level": null,
"aa_start": 621,
"aa_end": null,
"aa_length": 751,
"cds_start": 1861,
"cds_end": null,
"cds_length": 2256,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000870007.1"
},
{
"aa_ref": "S",
"aa_alt": "C",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 17,
"exon_rank_end": null,
"exon_count": 17,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "IL17RC",
"gene_hgnc_id": 18358,
"hgvs_c": "c.1858A>T",
"hgvs_p": "p.Ser620Cys",
"transcript": "ENST00000869959.1",
"protein_id": "ENSP00000540018.1",
"transcript_support_level": null,
"aa_start": 620,
"aa_end": null,
"aa_length": 750,
"cds_start": 1858,
"cds_end": null,
"cds_length": 2253,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000869959.1"
},
{
"aa_ref": "S",
"aa_alt": "C",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 19,
"exon_rank_end": null,
"exon_count": 19,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "IL17RC",
"gene_hgnc_id": 18358,
"hgvs_c": "c.1840A>T",
"hgvs_p": "p.Ser614Cys",
"transcript": "ENST00000870010.1",
"protein_id": "ENSP00000540069.1",
"transcript_support_level": null,
"aa_start": 614,
"aa_end": null,
"aa_length": 744,
"cds_start": 1840,
"cds_end": null,
"cds_length": 2235,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000870010.1"
},
{
"aa_ref": "S",
"aa_alt": "C",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 19,
"exon_rank_end": null,
"exon_count": 19,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "IL17RC",
"gene_hgnc_id": 18358,
"hgvs_c": "c.1792A>T",
"hgvs_p": "p.Ser598Cys",
"transcript": "ENST00000869992.1",
"protein_id": "ENSP00000540051.1",
"transcript_support_level": null,
"aa_start": 598,
"aa_end": null,
"aa_length": 728,
"cds_start": 1792,
"cds_end": null,
"cds_length": 2187,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000869992.1"
},
{
"aa_ref": "S",
"aa_alt": "C",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 16,
"exon_rank_end": null,
"exon_count": 16,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "IL17RC",
"gene_hgnc_id": 18358,
"hgvs_c": "c.1786A>T",
"hgvs_p": "p.Ser596Cys",
"transcript": "ENST00000869955.1",
"protein_id": "ENSP00000540014.1",
"transcript_support_level": null,
"aa_start": 596,
"aa_end": null,
"aa_length": 726,
"cds_start": 1786,
"cds_end": null,
"cds_length": 2181,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000869955.1"
},
{
"aa_ref": "S",
"aa_alt": "C",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 19,
"exon_rank_end": null,
"exon_count": 19,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "IL17RC",
"gene_hgnc_id": 18358,
"hgvs_c": "c.1771A>T",
"hgvs_p": "p.Ser591Cys",
"transcript": "ENST00000869952.1",
"protein_id": "ENSP00000540011.1",
"transcript_support_level": null,
"aa_start": 591,
"aa_end": null,
"aa_length": 721,
"cds_start": 1771,
"cds_end": null,
"cds_length": 2166,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
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}