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GeneBe API Showcase
This page demonstrates how to use the GeneBe API to query variant information. The API provides programmatic access to genomic annotations and variant data.
API presented here should be used for checking single variants. If you want to check many variants at once, please use other API endpoints that you will find in the documentation.
Documentation & Advanced Usage
• Complete API documentation:docs.genebe.net/docs/api/overview/
• Interactive endpoint tester:api.genebe.net/cloud/gb-api-doc/swagger-ui/
• Python client for pandas:pypi.org/project/genebe/
• Java CLI for VCF files:github.com/pstawinski/genebe-cli
• All tools documented at:docs.genebe.net
API Request Examples for Variant: 4-103056781-T-G (hg38)
Bash / cURL Example
bash
curl "https://api.genebe.net/cloud/api-public/v1/variant?chr=4&pos=103056781&ref=T&alt=G&genome=hg38&allGenes=true"API Response
json
{
"variants": [
{
"chr": "4",
"pos": 103056781,
"ref": "T",
"alt": "G",
"effect": "intron_variant",
"transcript": "NM_178833.7",
"consequences": [
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 12,
"intron_rank": 4,
"intron_rank_end": null,
"gene_symbol": "SLC9B2",
"gene_hgnc_id": 25143,
"hgvs_c": "c.442+1020A>C",
"hgvs_p": null,
"transcript": "NM_178833.7",
"protein_id": "NP_849155.2",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 537,
"cds_start": null,
"cds_end": null,
"cds_length": 1614,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": "ENST00000394785.9",
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_178833.7"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": true,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 12,
"intron_rank": 4,
"intron_rank_end": null,
"gene_symbol": "SLC9B2",
"gene_hgnc_id": 25143,
"hgvs_c": "c.442+1020A>C",
"hgvs_p": null,
"transcript": "ENST00000394785.9",
"protein_id": "ENSP00000378265.3",
"transcript_support_level": 2,
"aa_start": null,
"aa_end": null,
"aa_length": 537,
"cds_start": null,
"cds_end": null,
"cds_length": 1614,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": "NM_178833.7",
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000394785.9"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 13,
"intron_rank": 4,
"intron_rank_end": null,
"gene_symbol": "SLC9B2",
"gene_hgnc_id": 25143,
"hgvs_c": "c.442+1020A>C",
"hgvs_p": null,
"transcript": "ENST00000362026.7",
"protein_id": "ENSP00000354574.3",
"transcript_support_level": 1,
"aa_start": null,
"aa_end": null,
"aa_length": 537,
"cds_start": null,
"cds_end": null,
"cds_length": 1614,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000362026.7"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 8,
"intron_rank": 1,
"intron_rank_end": null,
"gene_symbol": "SLC9B2",
"gene_hgnc_id": 25143,
"hgvs_c": "c.142+1020A>C",
"hgvs_p": null,
"transcript": "ENST00000506288.5",
"protein_id": "ENSP00000421943.1",
"transcript_support_level": 1,
"aa_start": null,
"aa_end": null,
"aa_length": 354,
"cds_start": null,
"cds_end": null,
"cds_length": 1065,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000506288.5"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 12,
"intron_rank": 4,
"intron_rank_end": null,
"gene_symbol": "SLC9B2",
"gene_hgnc_id": 25143,
"hgvs_c": "c.442+1020A>C",
"hgvs_p": null,
"transcript": "ENST00000890707.1",
"protein_id": "ENSP00000560766.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 561,
"cds_start": null,
"cds_end": null,
"cds_length": 1686,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000890707.1"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 13,
"intron_rank": 4,
"intron_rank_end": null,
"gene_symbol": "SLC9B2",
"gene_hgnc_id": 25143,
"hgvs_c": "c.442+1020A>C",
"hgvs_p": null,
"transcript": "ENST00000971270.1",
"protein_id": "ENSP00000641329.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 561,
"cds_start": null,
"cds_end": null,
"cds_length": 1686,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000971270.1"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 13,
"intron_rank": 4,
"intron_rank_end": null,
"gene_symbol": "SLC9B2",
"gene_hgnc_id": 25143,
"hgvs_c": "c.442+1020A>C",
"hgvs_p": null,
"transcript": "ENST00000890702.1",
"protein_id": "ENSP00000560761.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 552,
"cds_start": null,
"cds_end": null,
"cds_length": 1659,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000890702.1"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 13,
"intron_rank": 4,
"intron_rank_end": null,
"gene_symbol": "SLC9B2",
"gene_hgnc_id": 25143,
"hgvs_c": "c.442+1020A>C",
"hgvs_p": null,
"transcript": "NM_001370201.1",
"protein_id": "NP_001357130.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 537,
"cds_start": null,
"cds_end": null,
"cds_length": 1614,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001370201.1"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 13,
"intron_rank": 4,
"intron_rank_end": null,
"gene_symbol": "SLC9B2",
"gene_hgnc_id": 25143,
"hgvs_c": "c.442+1020A>C",
"hgvs_p": null,
"transcript": "NM_001370202.1",
"protein_id": "NP_001357131.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 537,
"cds_start": null,
"cds_end": null,
"cds_length": 1614,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001370202.1"
},
{
"aa_ref": null,
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"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 14,
"intron_rank": 5,
"intron_rank_end": null,
"gene_symbol": "SLC9B2",
"gene_hgnc_id": 25143,
"hgvs_c": "c.442+1020A>C",
"hgvs_p": null,
"transcript": "ENST00000890695.1",
"protein_id": "ENSP00000560754.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 537,
"cds_start": null,
"cds_end": null,
"cds_length": 1614,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000890695.1"
},
{
"aa_ref": null,
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"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 13,
"intron_rank": 4,
"intron_rank_end": null,
"gene_symbol": "SLC9B2",
"gene_hgnc_id": 25143,
"hgvs_c": "c.442+1020A>C",
"hgvs_p": null,
"transcript": "ENST00000890694.1",
"protein_id": "ENSP00000560753.1",
"transcript_support_level": null,
"aa_start": null,
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"aa_length": 530,
"cds_start": null,
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"cdna_start": null,
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"mane_select": null,
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"biotype": "protein_coding",
"feature": "ENST00000890694.1"
},
{
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"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
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"exon_count": 12,
"intron_rank": 4,
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"gene_symbol": "SLC9B2",
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"hgvs_c": "c.442+1020A>C",
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"transcript": "ENST00000890700.1",
"protein_id": "ENSP00000560759.1",
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"cds_start": null,
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"cdna_start": null,
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"mane_select": null,
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"biotype": "protein_coding",
"feature": "ENST00000890700.1"
},
{
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"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 13,
"intron_rank": 4,
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"gene_symbol": "SLC9B2",
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"hgvs_c": "c.442+1020A>C",
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"transcript": "ENST00000971268.1",
"protein_id": "ENSP00000641327.1",
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"cds_start": null,
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"cdna_start": null,
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"mane_select": null,
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"biotype": "protein_coding",
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},
{
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"strand": false,
"consequences": [
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],
"exon_rank": null,
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"gene_symbol": "SLC9B2",
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"hgvs_c": "c.272-6399A>C",
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"feature": "ENST00000890701.1"
},
{
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"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
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"exon_count": 11,
"intron_rank": 4,
"intron_rank_end": null,
"gene_symbol": "SLC9B2",
"gene_hgnc_id": 25143,
"hgvs_c": "c.442+1020A>C",
"hgvs_p": null,
"transcript": "ENST00000890704.1",
"protein_id": "ENSP00000560763.1",
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"biotype": "protein_coding",
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},
{
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],
"exon_rank": null,
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"gene_symbol": "SLC9B2",
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"hgvs_c": "c.442+1020A>C",
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"biotype": "protein_coding",
"feature": "ENST00000971269.1"
},
{
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"protein_coding": true,
"strand": false,
"consequences": [
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],
"exon_rank": null,
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"exon_count": 11,
"intron_rank": 3,
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"gene_symbol": "SLC9B2",
"gene_hgnc_id": 25143,
"hgvs_c": "c.272-6399A>C",
"hgvs_p": null,
"transcript": "NM_001300754.2",
"protein_id": "NP_001287683.1",
"transcript_support_level": null,
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"biotype": "protein_coding",
"feature": "NM_001300754.2"
},
{
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"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 11,
"intron_rank": 3,
"intron_rank_end": null,
"gene_symbol": "SLC9B2",
"gene_hgnc_id": 25143,
"hgvs_c": "c.272-6399A>C",
"hgvs_p": null,
"transcript": "NM_001370203.1",
"protein_id": "NP_001357132.1",
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"aa_start": null,
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"feature": "NM_001370203.1"
},
{
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"strand": false,
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],
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"intron_rank": 3,
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"gene_symbol": "SLC9B2",
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},
{
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"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
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"intron_rank": 3,
"intron_rank_end": null,
"gene_symbol": "SLC9B2",
"gene_hgnc_id": 25143,
"hgvs_c": "c.272-6399A>C",
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"transcript": "ENST00000503230.5",
"protein_id": "ENSP00000422477.1",
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},
{
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"strand": false,
"consequences": [
"intron_variant"
],
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"intron_rank": 3,
"intron_rank_end": null,
"gene_symbol": "SLC9B2",
"gene_hgnc_id": 25143,
"hgvs_c": "c.272-6399A>C",
"hgvs_p": null,
"transcript": "ENST00000890692.1",
"protein_id": "ENSP00000560751.1",
"transcript_support_level": null,
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"cds_start": null,
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"cdna_start": null,
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"mane_select": null,
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"biotype": "protein_coding",
"feature": "ENST00000890692.1"
},
{
"aa_ref": null,
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"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 11,
"intron_rank": 3,
"intron_rank_end": null,
"gene_symbol": "SLC9B2",
"gene_hgnc_id": 25143,
"hgvs_c": "c.272-6399A>C",
"hgvs_p": null,
"transcript": "ENST00000890696.1",
"protein_id": "ENSP00000560755.1",
"transcript_support_level": null,
"aa_start": null,
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"cds_start": null,
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"cdna_start": null,
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"cdna_length": null,
"mane_select": null,
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"biotype": "protein_coding",
"feature": "ENST00000890696.1"
},
{
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"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
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