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GeneBe API Showcase
This page demonstrates how to use the GeneBe API to query variant information. The API provides programmatic access to genomic annotations and variant data.
API presented here should be used for checking single variants. If you want to check many variants at once, please use other API endpoints that you will find in the documentation.
Documentation & Advanced Usage
• Complete API documentation:docs.genebe.net/docs/api/overview/
• Interactive endpoint tester:api.genebe.net/cloud/gb-api-doc/swagger-ui/
• Python client for pandas:pypi.org/project/genebe/
• Java CLI for VCF files:github.com/pstawinski/genebe-cli
• All tools documented at:docs.genebe.net
API Request Examples for Variant: 4-103109041-G-A (hg38)
Bash / cURL Example
bash
curl "https://api.genebe.net/cloud/api-public/v1/variant?chr=4&pos=103109041&ref=G&alt=A&genome=hg38&allGenes=true"API Response
json
{
"variants": [
{
"chr": "4",
"pos": 103109041,
"ref": "G",
"alt": "A",
"effect": "synonymous_variant",
"transcript": "NM_001813.3",
"consequences": [
{
"aa_ref": "T",
"aa_alt": "T",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 48,
"exon_rank_end": null,
"exon_count": 49,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CENPE",
"gene_hgnc_id": 1856,
"hgvs_c": "c.7773C>T",
"hgvs_p": "p.Thr2591Thr",
"transcript": "NM_001813.3",
"protein_id": "NP_001804.2",
"transcript_support_level": null,
"aa_start": 2591,
"aa_end": null,
"aa_length": 2701,
"cds_start": 7773,
"cds_end": null,
"cds_length": 8106,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": "ENST00000265148.9",
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001813.3"
},
{
"aa_ref": "T",
"aa_alt": "T",
"canonical": true,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 48,
"exon_rank_end": null,
"exon_count": 49,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CENPE",
"gene_hgnc_id": 1856,
"hgvs_c": "c.7773C>T",
"hgvs_p": "p.Thr2591Thr",
"transcript": "ENST00000265148.9",
"protein_id": "ENSP00000265148.3",
"transcript_support_level": 2,
"aa_start": 2591,
"aa_end": null,
"aa_length": 2701,
"cds_start": 7773,
"cds_end": null,
"cds_length": 8106,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": "NM_001813.3",
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000265148.9"
},
{
"aa_ref": "T",
"aa_alt": "T",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 46,
"exon_rank_end": null,
"exon_count": 47,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CENPE",
"gene_hgnc_id": 1856,
"hgvs_c": "c.7410C>T",
"hgvs_p": "p.Thr2470Thr",
"transcript": "ENST00000380026.8",
"protein_id": "ENSP00000369365.3",
"transcript_support_level": 1,
"aa_start": 2470,
"aa_end": null,
"aa_length": 2580,
"cds_start": 7410,
"cds_end": null,
"cds_length": 7743,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000380026.8"
},
{
"aa_ref": "T",
"aa_alt": "T",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 48,
"exon_rank_end": null,
"exon_count": 49,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CENPE",
"gene_hgnc_id": 1856,
"hgvs_c": "c.7776C>T",
"hgvs_p": "p.Thr2592Thr",
"transcript": "ENST00000933323.1",
"protein_id": "ENSP00000603382.1",
"transcript_support_level": null,
"aa_start": 2592,
"aa_end": null,
"aa_length": 2702,
"cds_start": 7776,
"cds_end": null,
"cds_length": 8109,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000933323.1"
},
{
"aa_ref": "T",
"aa_alt": "T",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 47,
"exon_rank_end": null,
"exon_count": 48,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CENPE",
"gene_hgnc_id": 1856,
"hgvs_c": "c.7698C>T",
"hgvs_p": "p.Thr2566Thr",
"transcript": "ENST00000933319.1",
"protein_id": "ENSP00000603378.1",
"transcript_support_level": null,
"aa_start": 2566,
"aa_end": null,
"aa_length": 2676,
"cds_start": 7698,
"cds_end": null,
"cds_length": 8031,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000933319.1"
},
{
"aa_ref": "T",
"aa_alt": "T",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 47,
"exon_rank_end": null,
"exon_count": 48,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CENPE",
"gene_hgnc_id": 1856,
"hgvs_c": "c.7485C>T",
"hgvs_p": "p.Thr2495Thr",
"transcript": "ENST00000933321.1",
"protein_id": "ENSP00000603380.1",
"transcript_support_level": null,
"aa_start": 2495,
"aa_end": null,
"aa_length": 2605,
"cds_start": 7485,
"cds_end": null,
"cds_length": 7818,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000933321.1"
},
{
"aa_ref": "T",
"aa_alt": "T",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 47,
"exon_rank_end": null,
"exon_count": 48,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CENPE",
"gene_hgnc_id": 1856,
"hgvs_c": "c.7482C>T",
"hgvs_p": "p.Thr2494Thr",
"transcript": "ENST00000933320.1",
"protein_id": "ENSP00000603379.1",
"transcript_support_level": null,
"aa_start": 2494,
"aa_end": null,
"aa_length": 2604,
"cds_start": 7482,
"cds_end": null,
"cds_length": 7815,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000933320.1"
},
{
"aa_ref": "T",
"aa_alt": "T",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 46,
"exon_rank_end": null,
"exon_count": 47,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CENPE",
"gene_hgnc_id": 1856,
"hgvs_c": "c.7410C>T",
"hgvs_p": "p.Thr2470Thr",
"transcript": "NM_001286734.2",
"protein_id": "NP_001273663.1",
"transcript_support_level": null,
"aa_start": 2470,
"aa_end": null,
"aa_length": 2580,
"cds_start": 7410,
"cds_end": null,
"cds_length": 7743,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001286734.2"
},
{
"aa_ref": "T",
"aa_alt": "T",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 46,
"exon_rank_end": null,
"exon_count": 47,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CENPE",
"gene_hgnc_id": 1856,
"hgvs_c": "c.7407C>T",
"hgvs_p": "p.Thr2469Thr",
"transcript": "ENST00000933322.1",
"protein_id": "ENSP00000603381.1",
"transcript_support_level": null,
"aa_start": 2469,
"aa_end": null,
"aa_length": 2579,
"cds_start": 7407,
"cds_end": null,
"cds_length": 7740,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000933322.1"
},
{
"aa_ref": "T",
"aa_alt": "T",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 45,
"exon_rank_end": null,
"exon_count": 46,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CENPE",
"gene_hgnc_id": 1856,
"hgvs_c": "c.7248C>T",
"hgvs_p": "p.Thr2416Thr",
"transcript": "ENST00000933324.1",
"protein_id": "ENSP00000603383.1",
"transcript_support_level": null,
"aa_start": 2416,
"aa_end": null,
"aa_length": 2526,
"cds_start": 7248,
"cds_end": null,
"cds_length": 7581,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000933324.1"
},
{
"aa_ref": "T",
"aa_alt": "T",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 44,
"exon_rank_end": null,
"exon_count": 45,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CENPE",
"gene_hgnc_id": 1856,
"hgvs_c": "c.7083C>T",
"hgvs_p": "p.Thr2361Thr",
"transcript": "ENST00000960876.1",
"protein_id": "ENSP00000630935.1",
"transcript_support_level": null,
"aa_start": 2361,
"aa_end": null,
"aa_length": 2471,
"cds_start": 7083,
"cds_end": null,
"cds_length": 7416,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000960876.1"
},
{
"aa_ref": "T",
"aa_alt": "T",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 47,
"exon_rank_end": null,
"exon_count": 48,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CENPE",
"gene_hgnc_id": 1856,
"hgvs_c": "c.7698C>T",
"hgvs_p": "p.Thr2566Thr",
"transcript": "XM_011531544.3",
"protein_id": "XP_011529846.1",
"transcript_support_level": null,
"aa_start": 2566,
"aa_end": null,
"aa_length": 2676,
"cds_start": 7698,
"cds_end": null,
"cds_length": 8031,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "XM_011531544.3"
},
{
"aa_ref": "T",
"aa_alt": "T",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 47,
"exon_rank_end": null,
"exon_count": 48,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CENPE",
"gene_hgnc_id": 1856,
"hgvs_c": "c.7614C>T",
"hgvs_p": "p.Thr2538Thr",
"transcript": "XM_011531545.3",
"protein_id": "XP_011529847.1",
"transcript_support_level": null,
"aa_start": 2538,
"aa_end": null,
"aa_length": 2648,
"cds_start": 7614,
"cds_end": null,
"cds_length": 7947,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "XM_011531545.3"
},
{
"aa_ref": "T",
"aa_alt": "T",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 47,
"exon_rank_end": null,
"exon_count": 48,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CENPE",
"gene_hgnc_id": 1856,
"hgvs_c": "c.7569C>T",
"hgvs_p": "p.Thr2523Thr",
"transcript": "XM_011531546.4",
"protein_id": "XP_011529848.1",
"transcript_support_level": null,
"aa_start": 2523,
"aa_end": null,
"aa_length": 2633,
"cds_start": 7569,
"cds_end": null,
"cds_length": 7902,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "XM_011531546.4"
},
{
"aa_ref": "T",
"aa_alt": "T",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 46,
"exon_rank_end": null,
"exon_count": 47,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CENPE",
"gene_hgnc_id": 1856,
"hgvs_c": "c.7539C>T",
"hgvs_p": "p.Thr2513Thr",
"transcript": "XM_047449533.1",
"protein_id": "XP_047305489.1",
"transcript_support_level": null,
"aa_start": 2513,
"aa_end": null,
"aa_length": 2623,
"cds_start": 7539,
"cds_end": null,
"cds_length": 7872,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "XM_047449533.1"
},
{
"aa_ref": "T",
"aa_alt": "T",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 46,
"exon_rank_end": null,
"exon_count": 47,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CENPE",
"gene_hgnc_id": 1856,
"hgvs_c": "c.7494C>T",
"hgvs_p": "p.Thr2498Thr",
"transcript": "XM_047449534.1",
"protein_id": "XP_047305490.1",
"transcript_support_level": null,
"aa_start": 2498,
"aa_end": null,
"aa_length": 2608,
"cds_start": 7494,
"cds_end": null,
"cds_length": 7827,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "XM_047449534.1"
},
{
"aa_ref": "T",
"aa_alt": "T",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 47,
"exon_rank_end": null,
"exon_count": 48,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CENPE",
"gene_hgnc_id": 1856,
"hgvs_c": "c.7485C>T",
"hgvs_p": "p.Thr2495Thr",
"transcript": "XM_011531547.3",
"protein_id": "XP_011529849.1",
"transcript_support_level": null,
"aa_start": 2495,
"aa_end": null,
"aa_length": 2605,
"cds_start": 7485,
"cds_end": null,
"cds_length": 7818,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "XM_011531547.3"
},
{
"aa_ref": "T",
"aa_alt": "T",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 47,
"exon_rank_end": null,
"exon_count": 48,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CENPE",
"gene_hgnc_id": 1856,
"hgvs_c": "c.7482C>T",
"hgvs_p": "p.Thr2494Thr",
"transcript": "XM_011531548.3",
"protein_id": "XP_011529850.1",
"transcript_support_level": null,
"aa_start": 2494,
"aa_end": null,
"aa_length": 2604,
"cds_start": 7482,
"cds_end": null,
"cds_length": 7815,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "XM_011531548.3"
},
{
"aa_ref": "T",
"aa_alt": "T",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 46,
"exon_rank_end": null,
"exon_count": 47,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CENPE",
"gene_hgnc_id": 1856,
"hgvs_c": "c.7410C>T",
"hgvs_p": "p.Thr2470Thr",
"transcript": "XM_047449535.1",
"protein_id": "XP_047305491.1",
"transcript_support_level": null,
"aa_start": 2470,
"aa_end": null,
"aa_length": 2580,
"cds_start": 7410,
"cds_end": null,
"cds_length": 7743,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "XM_047449535.1"
},
{
"aa_ref": "T",
"aa_alt": "T",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 46,
"exon_rank_end": null,
"exon_count": 47,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CENPE",
"gene_hgnc_id": 1856,
"hgvs_c": "c.7407C>T",
"hgvs_p": "p.Thr2469Thr",
"transcript": "XM_047449536.1",
"protein_id": "XP_047305492.1",
"transcript_support_level": null,
"aa_start": 2469,
"aa_end": null,
"aa_length": 2579,
"cds_start": 7407,
"cds_end": null,
"cds_length": 7740,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "XM_047449536.1"
},
{
"aa_ref": "T",
"aa_alt": "T",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 46,
"exon_rank_end": null,
"exon_count": 47,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CENPE",
"gene_hgnc_id": 1856,
"hgvs_c": "c.7329C>T",
"hgvs_p": "p.Thr2443Thr",
"transcript": "XM_011531549.3",
"protein_id": "XP_011529851.1",
"transcript_support_level": null,
"aa_start": 2443,
"aa_end": null,
"aa_length": 2553,
"cds_start": 7329,
"cds_end": null,
"cds_length": 7662,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "XM_011531549.3"
},
{
"aa_ref": "T",
"aa_alt": "T",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 46,
"exon_rank_end": null,
"exon_count": 47,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CENPE",
"gene_hgnc_id": 1856,
"hgvs_c": "c.7326C>T",
"hgvs_p": "p.Thr2442Thr",
"transcript": "XM_047449538.1",
"protein_id": "XP_047305494.1",
"transcript_support_level": null,
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}
],
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}