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GeneBe API Showcase
This page demonstrates how to use the GeneBe API to query variant information. The API provides programmatic access to genomic annotations and variant data.
API presented here should be used for checking single variants. If you want to check many variants at once, please use other API endpoints that you will find in the documentation.
Documentation & Advanced Usage
• Complete API documentation:docs.genebe.net/docs/api/overview/
• Interactive endpoint tester:api.genebe.net/cloud/gb-api-doc/swagger-ui/
• Python client for pandas:pypi.org/project/genebe/
• Java CLI for VCF files:github.com/pstawinski/genebe-cli
• All tools documented at:docs.genebe.net
API Request Examples for Variant: 4-105895680-G-C (hg38)
Bash / cURL Example
bash
curl "https://api.genebe.net/cloud/api-public/v1/variant?chr=4&pos=105895680&ref=G&alt=C&genome=hg38&allGenes=true"API Response
json
{
"variants": [
{
"chr": "4",
"pos": 105895680,
"ref": "G",
"alt": "C",
"effect": "missense_variant",
"transcript": "NM_001184691.2",
"consequences": [
{
"aa_ref": "V",
"aa_alt": "L",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 1,
"exon_rank_end": null,
"exon_count": 12,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "NPNT",
"gene_hgnc_id": 27405,
"hgvs_c": "c.28G>C",
"hgvs_p": "p.Val10Leu",
"transcript": "NM_001033047.3",
"protein_id": "NP_001028219.1",
"transcript_support_level": null,
"aa_start": 10,
"aa_end": null,
"aa_length": 565,
"cds_start": 28,
"cds_end": null,
"cds_length": 1698,
"cdna_start": 210,
"cdna_end": null,
"cdna_length": 4561,
"mane_select": "ENST00000379987.7",
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001033047.3"
},
{
"aa_ref": "V",
"aa_alt": "L",
"canonical": true,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 1,
"exon_rank_end": null,
"exon_count": 12,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "NPNT",
"gene_hgnc_id": 27405,
"hgvs_c": "c.28G>C",
"hgvs_p": "p.Val10Leu",
"transcript": "ENST00000379987.7",
"protein_id": "ENSP00000369323.2",
"transcript_support_level": 1,
"aa_start": 10,
"aa_end": null,
"aa_length": 565,
"cds_start": 28,
"cds_end": null,
"cds_length": 1698,
"cdna_start": 210,
"cdna_end": null,
"cdna_length": 4561,
"mane_select": "NM_001033047.3",
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000379987.7"
},
{
"aa_ref": "V",
"aa_alt": "L",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 1,
"exon_rank_end": null,
"exon_count": 11,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "NPNT",
"gene_hgnc_id": 27405,
"hgvs_c": "c.28G>C",
"hgvs_p": "p.Val10Leu",
"transcript": "ENST00000305572.12",
"protein_id": "ENSP00000302557.8",
"transcript_support_level": 1,
"aa_start": 10,
"aa_end": null,
"aa_length": 509,
"cds_start": 28,
"cds_end": null,
"cds_length": 1530,
"cdna_start": 230,
"cdna_end": null,
"cdna_length": 3003,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000305572.12"
},
{
"aa_ref": "V",
"aa_alt": "L",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 1,
"exon_rank_end": null,
"exon_count": 14,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "NPNT",
"gene_hgnc_id": 27405,
"hgvs_c": "c.28G>C",
"hgvs_p": "p.Val10Leu",
"transcript": "ENST00000876321.1",
"protein_id": "ENSP00000546380.1",
"transcript_support_level": null,
"aa_start": 10,
"aa_end": null,
"aa_length": 617,
"cds_start": 28,
"cds_end": null,
"cds_length": 1854,
"cdna_start": 208,
"cdna_end": null,
"cdna_length": 4713,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000876321.1"
},
{
"aa_ref": "V",
"aa_alt": "L",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 1,
"exon_rank_end": null,
"exon_count": 14,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "NPNT",
"gene_hgnc_id": 27405,
"hgvs_c": "c.28G>C",
"hgvs_p": "p.Val10Leu",
"transcript": "ENST00000503451.5",
"protein_id": "ENSP00000426146.1",
"transcript_support_level": 5,
"aa_start": 10,
"aa_end": null,
"aa_length": 608,
"cds_start": 28,
"cds_end": null,
"cds_length": 1829,
"cdna_start": 28,
"cdna_end": null,
"cdna_length": 1829,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000503451.5"
},
{
"aa_ref": "V",
"aa_alt": "L",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 1,
"exon_rank_end": null,
"exon_count": 13,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "NPNT",
"gene_hgnc_id": 27405,
"hgvs_c": "c.28G>C",
"hgvs_p": "p.Val10Leu",
"transcript": "NM_001184691.2",
"protein_id": "NP_001171620.1",
"transcript_support_level": null,
"aa_start": 10,
"aa_end": null,
"aa_length": 595,
"cds_start": 28,
"cds_end": null,
"cds_length": 1788,
"cdna_start": 210,
"cdna_end": null,
"cdna_length": 4651,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001184691.2"
},
{
"aa_ref": "V",
"aa_alt": "L",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 1,
"exon_rank_end": null,
"exon_count": 13,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "NPNT",
"gene_hgnc_id": 27405,
"hgvs_c": "c.28G>C",
"hgvs_p": "p.Val10Leu",
"transcript": "ENST00000427316.6",
"protein_id": "ENSP00000389252.2",
"transcript_support_level": 2,
"aa_start": 10,
"aa_end": null,
"aa_length": 595,
"cds_start": 28,
"cds_end": null,
"cds_length": 1788,
"cdna_start": 240,
"cdna_end": null,
"cdna_length": 2481,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000427316.6"
},
{
"aa_ref": "V",
"aa_alt": "L",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 1,
"exon_rank_end": null,
"exon_count": 13,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "NPNT",
"gene_hgnc_id": 27405,
"hgvs_c": "c.28G>C",
"hgvs_p": "p.Val10Leu",
"transcript": "ENST00000963218.1",
"protein_id": "ENSP00000633277.1",
"transcript_support_level": null,
"aa_start": 10,
"aa_end": null,
"aa_length": 583,
"cds_start": 28,
"cds_end": null,
"cds_length": 1752,
"cdna_start": 173,
"cdna_end": null,
"cdna_length": 4571,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000963218.1"
},
{
"aa_ref": "V",
"aa_alt": "L",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 1,
"exon_rank_end": null,
"exon_count": 13,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "NPNT",
"gene_hgnc_id": 27405,
"hgvs_c": "c.28G>C",
"hgvs_p": "p.Val10Leu",
"transcript": "NM_001184690.2",
"protein_id": "NP_001171619.1",
"transcript_support_level": null,
"aa_start": 10,
"aa_end": null,
"aa_length": 582,
"cds_start": 28,
"cds_end": null,
"cds_length": 1749,
"cdna_start": 210,
"cdna_end": null,
"cdna_length": 4612,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001184690.2"
},
{
"aa_ref": "V",
"aa_alt": "L",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 1,
"exon_rank_end": null,
"exon_count": 13,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "NPNT",
"gene_hgnc_id": 27405,
"hgvs_c": "c.28G>C",
"hgvs_p": "p.Val10Leu",
"transcript": "ENST00000453617.6",
"protein_id": "ENSP00000402884.2",
"transcript_support_level": 2,
"aa_start": 10,
"aa_end": null,
"aa_length": 582,
"cds_start": 28,
"cds_end": null,
"cds_length": 1749,
"cdna_start": 241,
"cdna_end": null,
"cdna_length": 2419,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000453617.6"
},
{
"aa_ref": "V",
"aa_alt": "L",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 1,
"exon_rank_end": null,
"exon_count": 12,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "NPNT",
"gene_hgnc_id": 27405,
"hgvs_c": "c.28G>C",
"hgvs_p": "p.Val10Leu",
"transcript": "NM_001184693.2",
"protein_id": "NP_001171622.1",
"transcript_support_level": null,
"aa_start": 10,
"aa_end": null,
"aa_length": 566,
"cds_start": 28,
"cds_end": null,
"cds_length": 1701,
"cdna_start": 210,
"cdna_end": null,
"cdna_length": 4564,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001184693.2"
},
{
"aa_ref": "V",
"aa_alt": "L",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 1,
"exon_rank_end": null,
"exon_count": 12,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "NPNT",
"gene_hgnc_id": 27405,
"hgvs_c": "c.28G>C",
"hgvs_p": "p.Val10Leu",
"transcript": "ENST00000506666.5",
"protein_id": "ENSP00000422474.1",
"transcript_support_level": 2,
"aa_start": 10,
"aa_end": null,
"aa_length": 566,
"cds_start": 28,
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"cds_length": 1701,
"cdna_start": 188,
"cdna_end": null,
"cdna_length": 2187,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000506666.5"
},
{
"aa_ref": "V",
"aa_alt": "L",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 1,
"exon_rank_end": null,
"exon_count": 12,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "NPNT",
"gene_hgnc_id": 27405,
"hgvs_c": "c.28G>C",
"hgvs_p": "p.Val10Leu",
"transcript": "ENST00000876319.1",
"protein_id": "ENSP00000546378.1",
"transcript_support_level": null,
"aa_start": 10,
"aa_end": null,
"aa_length": 553,
"cds_start": 28,
"cds_end": null,
"cds_length": 1662,
"cdna_start": 240,
"cdna_end": null,
"cdna_length": 4555,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000876319.1"
},
{
"aa_ref": "V",
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"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 1,
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"intron_rank": null,
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"gene_symbol": "NPNT",
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"hgvs_c": "c.28G>C",
"hgvs_p": "p.Val10Leu",
"transcript": "NM_001184692.2",
"protein_id": "NP_001171621.1",
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"aa_start": 10,
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"cds_start": 28,
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"cdna_start": 210,
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"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001184692.2"
},
{
"aa_ref": "V",
"aa_alt": "L",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 1,
"exon_rank_end": null,
"exon_count": 11,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "NPNT",
"gene_hgnc_id": 27405,
"hgvs_c": "c.28G>C",
"hgvs_p": "p.Val10Leu",
"transcript": "ENST00000514622.5",
"protein_id": "ENSP00000422044.1",
"transcript_support_level": 2,
"aa_start": 10,
"aa_end": null,
"aa_length": 536,
"cds_start": 28,
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"cdna_start": 240,
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"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000514622.5"
},
{
"aa_ref": "V",
"aa_alt": "L",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 1,
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"exon_count": 11,
"intron_rank": null,
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"gene_symbol": "NPNT",
"gene_hgnc_id": 27405,
"hgvs_c": "c.28G>C",
"hgvs_p": "p.Val10Leu",
"transcript": "ENST00000876320.1",
"protein_id": "ENSP00000546379.1",
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"aa_start": 10,
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"cds_start": 28,
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"cdna_start": 239,
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"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000876320.1"
},
{
"aa_ref": "V",
"aa_alt": "L",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 1,
"exon_rank_end": null,
"exon_count": 10,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "NPNT",
"gene_hgnc_id": 27405,
"hgvs_c": "c.28G>C",
"hgvs_p": "p.Val10Leu",
"transcript": "ENST00000876322.1",
"protein_id": "ENSP00000546381.1",
"transcript_support_level": null,
"aa_start": 10,
"aa_end": null,
"aa_length": 505,
"cds_start": 28,
"cds_end": null,
"cds_length": 1518,
"cdna_start": 146,
"cdna_end": null,
"cdna_length": 3050,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000876322.1"
},
{
"aa_ref": "V",
"aa_alt": "L",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 1,
"exon_rank_end": null,
"exon_count": 6,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "NPNT",
"gene_hgnc_id": 27405,
"hgvs_c": "c.28G>C",
"hgvs_p": "p.Val10Leu",
"transcript": "ENST00000876323.1",
"protein_id": "ENSP00000546382.1",
"transcript_support_level": null,
"aa_start": 10,
"aa_end": null,
"aa_length": 236,
"cds_start": 28,
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"cdna_start": 239,
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"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000876323.1"
},
{
"aa_ref": "V",
"aa_alt": "L",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 1,
"exon_rank_end": null,
"exon_count": 14,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "NPNT",
"gene_hgnc_id": 27405,
"hgvs_c": "c.28G>C",
"hgvs_p": "p.Val10Leu",
"transcript": "XM_011531820.3",
"protein_id": "XP_011530122.1",
"transcript_support_level": null,
"aa_start": 10,
"aa_end": null,
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"cds_start": 28,
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"cdna_start": 210,
"cdna_end": null,
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"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "XM_011531820.3"
},
{
"aa_ref": "V",
"aa_alt": "L",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 1,
"exon_rank_end": null,
"exon_count": 14,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "NPNT",
"gene_hgnc_id": 27405,
"hgvs_c": "c.28G>C",
"hgvs_p": "p.Val10Leu",
"transcript": "XM_005262888.5",
"protein_id": "XP_005262945.1",
"transcript_support_level": null,
"aa_start": 10,
"aa_end": null,
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"cds_start": 28,
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"cdna_start": 210,
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"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "XM_005262888.5"
},
{
"aa_ref": "V",
"aa_alt": "L",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 1,
"exon_rank_end": null,
"exon_count": 13,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "NPNT",
"gene_hgnc_id": 27405,
"hgvs_c": "c.28G>C",
"hgvs_p": "p.Val10Leu",
"transcript": "XM_011531822.3",
"protein_id": "XP_011530124.1",
"transcript_support_level": null,
"aa_start": 10,
"aa_end": null,
"aa_length": 596,
"cds_start": 28,
"cds_end": null,
"cds_length": 1791,
"cdna_start": 210,
"cdna_end": null,
"cdna_length": 4654,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "XM_011531822.3"
},
{
"aa_ref": "V",
"aa_alt": "L",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 1,
"exon_rank_end": null,
"exon_count": 13,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "NPNT",
"gene_hgnc_id": 27405,
"hgvs_c": "c.28G>C",
"hgvs_p": "p.Val10Leu",
"transcript": "XM_011531823.3",
"protein_id": "XP_011530125.1",
"transcript_support_level": null,
"aa_start": 10,
"aa_end": null,
"aa_length": 584,
"cds_start": 28,
"cds_end": null,
"cds_length": 1755,
"cdna_start": 210,
"cdna_end": null,
"cdna_length": 4618,
"mane_select": null,
"mane_plus": null,
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