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GeneBe API Showcase
This page demonstrates how to use the GeneBe API to query variant information. The API provides programmatic access to genomic annotations and variant data.
API presented here should be used for checking single variants. If you want to check many variants at once, please use other API endpoints that you will find in the documentation.
Documentation & Advanced Usage
• Complete API documentation:docs.genebe.net/docs/api/overview/
• Interactive endpoint tester:api.genebe.net/cloud/gb-api-doc/swagger-ui/
• Python client for pandas:pypi.org/project/genebe/
• Java CLI for VCF files:github.com/pstawinski/genebe-cli
• All tools documented at:docs.genebe.net
API Request Examples for Variant: 4-121686023-T-G (hg38)
Bash / cURL Example
bash
curl "https://api.genebe.net/cloud/api-public/v1/variant?chr=4&pos=121686023&ref=T&alt=G&genome=hg38&allGenes=true"API Response
json
{
"variants": [
{
"chr": "4",
"pos": 121686023,
"ref": "T",
"alt": "G",
"effect": "intron_variant",
"transcript": "NM_001154.4",
"consequences": [
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 13,
"intron_rank": 3,
"intron_rank_end": null,
"gene_symbol": "ANXA5",
"gene_hgnc_id": 543,
"hgvs_c": "c.94+265A>C",
"hgvs_p": null,
"transcript": "NM_001154.4",
"protein_id": "NP_001145.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 320,
"cds_start": null,
"cds_end": null,
"cds_length": 963,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": "ENST00000296511.10",
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001154.4"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": true,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 13,
"intron_rank": 3,
"intron_rank_end": null,
"gene_symbol": "ANXA5",
"gene_hgnc_id": 543,
"hgvs_c": "c.94+265A>C",
"hgvs_p": null,
"transcript": "ENST00000296511.10",
"protein_id": "ENSP00000296511.5",
"transcript_support_level": 1,
"aa_start": null,
"aa_end": null,
"aa_length": 320,
"cds_start": null,
"cds_end": null,
"cds_length": 963,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": "NM_001154.4",
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000296511.10"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 14,
"intron_rank": 3,
"intron_rank_end": null,
"gene_symbol": "ANXA5",
"gene_hgnc_id": 543,
"hgvs_c": "c.95-127A>C",
"hgvs_p": null,
"transcript": "ENST00000969932.1",
"protein_id": "ENSP00000639991.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 355,
"cds_start": null,
"cds_end": null,
"cds_length": 1068,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000969932.1"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 13,
"intron_rank": 3,
"intron_rank_end": null,
"gene_symbol": "ANXA5",
"gene_hgnc_id": 543,
"hgvs_c": "c.94+265A>C",
"hgvs_p": null,
"transcript": "ENST00000969927.1",
"protein_id": "ENSP00000639986.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 336,
"cds_start": null,
"cds_end": null,
"cds_length": 1011,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000969927.1"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 14,
"intron_rank": 3,
"intron_rank_end": null,
"gene_symbol": "ANXA5",
"gene_hgnc_id": 543,
"hgvs_c": "c.94+265A>C",
"hgvs_p": null,
"transcript": "ENST00000923804.1",
"protein_id": "ENSP00000593863.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 329,
"cds_start": null,
"cds_end": null,
"cds_length": 990,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000923804.1"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 13,
"intron_rank": 3,
"intron_rank_end": null,
"gene_symbol": "ANXA5",
"gene_hgnc_id": 543,
"hgvs_c": "c.94+265A>C",
"hgvs_p": null,
"transcript": "ENST00000854796.1",
"protein_id": "ENSP00000524855.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 321,
"cds_start": null,
"cds_end": null,
"cds_length": 966,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000854796.1"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 13,
"intron_rank": 3,
"intron_rank_end": null,
"gene_symbol": "ANXA5",
"gene_hgnc_id": 543,
"hgvs_c": "c.94+265A>C",
"hgvs_p": null,
"transcript": "ENST00000854797.1",
"protein_id": "ENSP00000524856.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 320,
"cds_start": null,
"cds_end": null,
"cds_length": 963,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000854797.1"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 13,
"intron_rank": 3,
"intron_rank_end": null,
"gene_symbol": "ANXA5",
"gene_hgnc_id": 543,
"hgvs_c": "c.94+265A>C",
"hgvs_p": null,
"transcript": "ENST00000923799.1",
"protein_id": "ENSP00000593858.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 320,
"cds_start": null,
"cds_end": null,
"cds_length": 963,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000923799.1"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 13,
"intron_rank": 3,
"intron_rank_end": null,
"gene_symbol": "ANXA5",
"gene_hgnc_id": 543,
"hgvs_c": "c.94+265A>C",
"hgvs_p": null,
"transcript": "ENST00000923806.1",
"protein_id": "ENSP00000593865.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 320,
"cds_start": null,
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"cdna_start": null,
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"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000923806.1"
},
{
"aa_ref": null,
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"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
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"exon_count": 13,
"intron_rank": 3,
"intron_rank_end": null,
"gene_symbol": "ANXA5",
"gene_hgnc_id": 543,
"hgvs_c": "c.94+265A>C",
"hgvs_p": null,
"transcript": "ENST00000969935.1",
"protein_id": "ENSP00000639994.1",
"transcript_support_level": null,
"aa_start": null,
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"aa_length": 320,
"cds_start": null,
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"cdna_start": null,
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"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000969935.1"
},
{
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"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
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"exon_count": 13,
"intron_rank": 3,
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"gene_symbol": "ANXA5",
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"hgvs_c": "c.94+265A>C",
"hgvs_p": null,
"transcript": "ENST00000854798.1",
"protein_id": "ENSP00000524857.1",
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"cds_start": null,
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"cdna_start": null,
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},
{
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],
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"gene_symbol": "ANXA5",
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"transcript": "ENST00000923807.1",
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"feature": "ENST00000923807.1"
},
{
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"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
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"gene_symbol": "ANXA5",
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"hgvs_c": "c.94+265A>C",
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"transcript": "ENST00000854799.1",
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},
{
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"strand": false,
"consequences": [
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],
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"gene_symbol": "ANXA5",
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},
{
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"strand": false,
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],
"exon_rank": null,
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"intron_rank": 3,
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"gene_symbol": "ANXA5",
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"hgvs_c": "c.94+265A>C",
"hgvs_p": null,
"transcript": "ENST00000969931.1",
"protein_id": "ENSP00000639990.1",
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},
{
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],
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"gene_symbol": "ANXA5",
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"hgvs_c": "c.94+265A>C",
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"transcript": "ENST00000969928.1",
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},
{
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"strand": false,
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],
"exon_rank": null,
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"intron_rank": 3,
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"gene_symbol": "ANXA5",
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"hgvs_c": "c.94+265A>C",
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"transcript": "ENST00000854795.1",
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},
{
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"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
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],
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"exon_count": 12,
"intron_rank": 3,
"intron_rank_end": null,
"gene_symbol": "ANXA5",
"gene_hgnc_id": 543,
"hgvs_c": "c.94+265A>C",
"hgvs_p": null,
"transcript": "ENST00000969933.1",
"protein_id": "ENSP00000639992.1",
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"feature": "ENST00000969933.1"
},
{
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"strand": false,
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],
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"intron_rank": 3,
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},
{
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"strand": false,
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],
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"gene_symbol": "ANXA5",
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},
{
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"consequences": [
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],
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"biotype": "protein_coding",
"feature": "ENST00000923805.1"
},
{
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"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
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"exon_count": 12,
"intron_rank": 3,
"intron_rank_end": null,
"gene_symbol": "ANXA5",
"gene_hgnc_id": 543,
"hgvs_c": "c.94+265A>C",
"hgvs_p": null,
"transcript": "ENST00000969936.1",
"protein_id": "ENSP00000639995.1",
"transcript_support_level": null,
"aa_start": null,
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"aa_length": 276,
"cds_start": null,
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"cdna_start": null,
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"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000969936.1"
},
{
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"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
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"exon_count": 11,
"intron_rank": 3,
"intron_rank_end": null,
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