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GeneBe API Showcase

This page demonstrates how to use the GeneBe API to query variant information. The API provides programmatic access to genomic annotations and variant data.

API presented here should be used for checking single variants. If you want to check many variants at once, please use other API endpoints that you will find in the documentation.

Documentation & Advanced Usage

Complete API documentation:docs.genebe.net/docs/api/overview/

Interactive endpoint tester:api.genebe.net/cloud/gb-api-doc/swagger-ui/

Python client for pandas:pypi.org/project/genebe/

Java CLI for VCF files:github.com/pstawinski/genebe-cli

All tools documented at:docs.genebe.net

API Request Examples for Variant: 4-139292563-T-C (hg38)

Bash / cURL Example

bash
curl "https://api.genebe.net/cloud/api-public/v1/variant?chr=4&pos=139292563&ref=T&alt=C&genome=hg38&allGenes=true"

API Response

json
{
  "variants": [
    {
      "chr": "4",
      "pos": 139292563,
      "ref": "T",
      "alt": "C",
      "effect": "missense_variant",
      "transcript": "NM_002494.3",
      "consequences": [
        {
          "aa_ref": "N",
          "aa_alt": "S",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 5,
          "exon_rank_end": null,
          "exon_count": 6,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "NDUFC1",
          "gene_hgnc_id": 7705,
          "hgvs_c": "c.218A>G",
          "hgvs_p": "p.Asn73Ser",
          "transcript": "NM_001184989.2",
          "protein_id": "NP_001171918.1",
          "transcript_support_level": null,
          "aa_start": 73,
          "aa_end": null,
          "aa_length": 76,
          "cds_start": 218,
          "cds_end": null,
          "cds_length": 231,
          "cdna_start": 501,
          "cdna_end": null,
          "cdna_length": 696,
          "mane_select": "ENST00000394223.2",
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "NM_001184989.2"
        },
        {
          "aa_ref": "N",
          "aa_alt": "S",
          "canonical": true,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 5,
          "exon_rank_end": null,
          "exon_count": 6,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "NDUFC1",
          "gene_hgnc_id": 7705,
          "hgvs_c": "c.218A>G",
          "hgvs_p": "p.Asn73Ser",
          "transcript": "ENST00000394223.2",
          "protein_id": "ENSP00000377770.1",
          "transcript_support_level": 3,
          "aa_start": 73,
          "aa_end": null,
          "aa_length": 76,
          "cds_start": 218,
          "cds_end": null,
          "cds_length": 231,
          "cdna_start": 501,
          "cdna_end": null,
          "cdna_length": 696,
          "mane_select": "NM_001184989.2",
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000394223.2"
        },
        {
          "aa_ref": "N",
          "aa_alt": "S",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 4,
          "exon_rank_end": null,
          "exon_count": 5,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "NDUFC1",
          "gene_hgnc_id": 7705,
          "hgvs_c": "c.218A>G",
          "hgvs_p": "p.Asn73Ser",
          "transcript": "ENST00000505036.5",
          "protein_id": "ENSP00000421195.1",
          "transcript_support_level": 1,
          "aa_start": 73,
          "aa_end": null,
          "aa_length": 76,
          "cds_start": 218,
          "cds_end": null,
          "cds_length": 231,
          "cdna_start": 621,
          "cdna_end": null,
          "cdna_length": 809,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000505036.5"
        },
        {
          "aa_ref": "N",
          "aa_alt": "S",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 5,
          "exon_rank_end": null,
          "exon_count": 6,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "NDUFC1",
          "gene_hgnc_id": 7705,
          "hgvs_c": "c.218A>G",
          "hgvs_p": "p.Asn73Ser",
          "transcript": "NM_001184986.1",
          "protein_id": "NP_001171915.1",
          "transcript_support_level": null,
          "aa_start": 73,
          "aa_end": null,
          "aa_length": 76,
          "cds_start": 218,
          "cds_end": null,
          "cds_length": 231,
          "cdna_start": 1048,
          "cdna_end": null,
          "cdna_length": 1257,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "NM_001184986.1"
        },
        {
          "aa_ref": "N",
          "aa_alt": "S",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 4,
          "exon_rank_end": null,
          "exon_count": 5,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "NDUFC1",
          "gene_hgnc_id": 7705,
          "hgvs_c": "c.218A>G",
          "hgvs_p": "p.Asn73Ser",
          "transcript": "NM_001184987.1",
          "protein_id": "NP_001171916.1",
          "transcript_support_level": null,
          "aa_start": 73,
          "aa_end": null,
          "aa_length": 76,
          "cds_start": 218,
          "cds_end": null,
          "cds_length": 231,
          "cdna_start": 516,
          "cdna_end": null,
          "cdna_length": 725,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "NM_001184987.1"
        },
        {
          "aa_ref": "N",
          "aa_alt": "S",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 5,
          "exon_rank_end": null,
          "exon_count": 6,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "NDUFC1",
          "gene_hgnc_id": 7705,
          "hgvs_c": "c.218A>G",
          "hgvs_p": "p.Asn73Ser",
          "transcript": "NM_001184988.1",
          "protein_id": "NP_001171917.1",
          "transcript_support_level": null,
          "aa_start": 73,
          "aa_end": null,
          "aa_length": 76,
          "cds_start": 218,
          "cds_end": null,
          "cds_length": 231,
          "cdna_start": 552,
          "cdna_end": null,
          "cdna_length": 761,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "NM_001184988.1"
        },
        {
          "aa_ref": "N",
          "aa_alt": "S",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 4,
          "exon_rank_end": null,
          "exon_count": 5,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "NDUFC1",
          "gene_hgnc_id": 7705,
          "hgvs_c": "c.218A>G",
          "hgvs_p": "p.Asn73Ser",
          "transcript": "NM_001184990.1",
          "protein_id": "NP_001171919.1",
          "transcript_support_level": null,
          "aa_start": 73,
          "aa_end": null,
          "aa_length": 76,
          "cds_start": 218,
          "cds_end": null,
          "cds_length": 231,
          "cdna_start": 512,
          "cdna_end": null,
          "cdna_length": 721,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "NM_001184990.1"
        },
        {
          "aa_ref": "N",
          "aa_alt": "S",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 4,
          "exon_rank_end": null,
          "exon_count": 5,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "NDUFC1",
          "gene_hgnc_id": 7705,
          "hgvs_c": "c.218A>G",
          "hgvs_p": "p.Asn73Ser",
          "transcript": "NM_001184991.1",
          "protein_id": "NP_001171920.1",
          "transcript_support_level": null,
          "aa_start": 73,
          "aa_end": null,
          "aa_length": 76,
          "cds_start": 218,
          "cds_end": null,
          "cds_length": 231,
          "cdna_start": 989,
          "cdna_end": null,
          "cdna_length": 1198,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "NM_001184991.1"
        },
        {
          "aa_ref": "N",
          "aa_alt": "S",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 4,
          "exon_rank_end": null,
          "exon_count": 5,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "NDUFC1",
          "gene_hgnc_id": 7705,
          "hgvs_c": "c.218A>G",
          "hgvs_p": "p.Asn73Ser",
          "transcript": "NM_002494.3",
          "protein_id": "NP_002485.1",
          "transcript_support_level": null,
          "aa_start": 73,
          "aa_end": null,
          "aa_length": 76,
          "cds_start": 218,
          "cds_end": null,
          "cds_length": 231,
          "cdna_start": 651,
          "cdna_end": null,
          "cdna_length": 860,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "NM_002494.3"
        },
        {
          "aa_ref": "N",
          "aa_alt": "S",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 5,
          "exon_rank_end": null,
          "exon_count": 6,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "NDUFC1",
          "gene_hgnc_id": 7705,
          "hgvs_c": "c.218A>G",
          "hgvs_p": "p.Asn73Ser",
          "transcript": "ENST00000394228.5",
          "protein_id": "ENSP00000377775.1",
          "transcript_support_level": 2,
          "aa_start": 73,
          "aa_end": null,
          "aa_length": 76,
          "cds_start": 218,
          "cds_end": null,
          "cds_length": 231,
          "cdna_start": 552,
          "cdna_end": null,
          "cdna_length": 761,
          "mane_select": null,
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          "biotype": "protein_coding",
          "feature": "ENST00000394228.5"
        },
        {
          "aa_ref": "N",
          "aa_alt": "S",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 4,
          "exon_rank_end": null,
          "exon_count": 5,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "NDUFC1",
          "gene_hgnc_id": 7705,
          "hgvs_c": "c.218A>G",
          "hgvs_p": "p.Asn73Ser",
          "transcript": "ENST00000539002.5",
          "protein_id": "ENSP00000440133.1",
          "transcript_support_level": 2,
          "aa_start": 73,
          "aa_end": null,
          "aa_length": 76,
          "cds_start": 218,
          "cds_end": null,
          "cds_length": 231,
          "cdna_start": 989,
          "cdna_end": null,
          "cdna_length": 1198,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000539002.5"
        },
        {
          "aa_ref": "N",
          "aa_alt": "S",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
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          ],
          "exon_rank": 4,
          "exon_rank_end": null,
          "exon_count": 5,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "NDUFC1",
          "gene_hgnc_id": 7705,
          "hgvs_c": "c.218A>G",
          "hgvs_p": "p.Asn73Ser",
          "transcript": "ENST00000539387.5",
          "protein_id": "ENSP00000439882.1",
          "transcript_support_level": 2,
          "aa_start": 73,
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          "aa_length": 76,
          "cds_start": 218,
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          "cds_length": 231,
          "cdna_start": 516,
          "cdna_end": null,
          "cdna_length": 725,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000539387.5"
        },
        {
          "aa_ref": "N",
          "aa_alt": "S",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 5,
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          "exon_count": 6,
          "intron_rank": null,
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          "gene_symbol": "NDUFC1",
          "gene_hgnc_id": 7705,
          "hgvs_c": "c.218A>G",
          "hgvs_p": "p.Asn73Ser",
          "transcript": "ENST00000544855.5",
          "protein_id": "ENSP00000441126.1",
          "transcript_support_level": 3,
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          "cds_start": 218,
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          "cds_length": 231,
          "cdna_start": 1048,
          "cdna_end": null,
          "cdna_length": 1257,
          "mane_select": null,
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          "biotype": "protein_coding",
          "feature": "ENST00000544855.5"
        },
        {
          "aa_ref": "N",
          "aa_alt": "S",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 4,
          "exon_rank_end": null,
          "exon_count": 5,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "NDUFC1",
          "gene_hgnc_id": 7705,
          "hgvs_c": "c.218A>G",
          "hgvs_p": "p.Asn73Ser",
          "transcript": "ENST00000854294.1",
          "protein_id": "ENSP00000524353.1",
          "transcript_support_level": null,
          "aa_start": 73,
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          "cds_start": 218,
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          "cdna_start": 494,
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          "biotype": "protein_coding",
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        },
        {
          "aa_ref": "N",
          "aa_alt": "S",
          "canonical": false,
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          "consequences": [
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          ],
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          "intron_rank": null,
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          "gene_symbol": "NDUFC1",
          "gene_hgnc_id": 7705,
          "hgvs_c": "c.218A>G",
          "hgvs_p": "p.Asn73Ser",
          "transcript": "ENST00000854296.1",
          "protein_id": "ENSP00000524355.1",
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          "cds_start": 218,
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          "cdna_start": 654,
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          "cdna_length": 804,
          "mane_select": null,
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          "biotype": "protein_coding",
          "feature": "ENST00000854296.1"
        },
        {
          "aa_ref": "N",
          "aa_alt": "S",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
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          ],
          "exon_rank": 6,
          "exon_rank_end": null,
          "exon_count": 7,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "NDUFC1",
          "gene_hgnc_id": 7705,
          "hgvs_c": "c.218A>G",
          "hgvs_p": "p.Asn73Ser",
          "transcript": "ENST00000854297.1",
          "protein_id": "ENSP00000524356.1",
          "transcript_support_level": null,
          "aa_start": 73,
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          "cds_start": 218,
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          "cdna_start": 571,
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          "biotype": "protein_coding",
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        },
        {
          "aa_ref": "N",
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          "canonical": false,
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          "strand": false,
          "consequences": [
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          ],
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          "exon_count": 5,
          "intron_rank": null,
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          "gene_symbol": "NDUFC1",
          "gene_hgnc_id": 7705,
          "hgvs_c": "c.218A>G",
          "hgvs_p": "p.Asn73Ser",
          "transcript": "ENST00000854298.1",
          "protein_id": "ENSP00000524357.1",
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          "biotype": "protein_coding",
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        },
        {
          "aa_ref": "N",
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          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "NDUFC1",
          "gene_hgnc_id": 7705,
          "hgvs_c": "c.218A>G",
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          "transcript": "ENST00000854299.1",
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          "mane_select": null,
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          "biotype": "protein_coding",
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        },
        {
          "aa_ref": "N",
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          "consequences": [
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          ],
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          "gene_symbol": "NDUFC1",
          "gene_hgnc_id": 7705,
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          "hgvs_p": "p.Asn73Ser",
          "transcript": "ENST00000854300.1",
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          "cdna_end": null,
          "cdna_length": 1308,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000854300.1"
        },
        {
          "aa_ref": "N",
          "aa_alt": "S",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 6,
          "exon_rank_end": null,
          "exon_count": 7,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "NDUFC1",
          "gene_hgnc_id": 7705,
          "hgvs_c": "c.218A>G",
          "hgvs_p": "p.Asn73Ser",
          "transcript": "ENST00000854301.1",
          "protein_id": "ENSP00000524360.1",
          "transcript_support_level": null,
          "aa_start": 73,
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          "aa_length": 76,
          "cds_start": 218,
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          "cdna_start": 848,
          "cdna_end": null,
          "cdna_length": 1040,
          "mane_select": null,
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      "clinvar_classification": "Uncertain significance",
      "clinvar_review_status": "criteria provided, single submitter",
      "clinvar_submissions_summary": "US:1",
      "phenotype_combined": "not specified",
      "pathogenicity_classification_combined": "Uncertain significance",
      "custom_annotations": null
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  "message": null
}
For research and educational, non-commercial use only. Not for clinical or diagnostic use. GeneBe does not provide medical advice. Data use for AI modeling is prohibited: if used, the cost is $0.001 per byte of downloaded uncompressed data.