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GeneBe API Showcase
This page demonstrates how to use the GeneBe API to query variant information. The API provides programmatic access to genomic annotations and variant data.
API presented here should be used for checking single variants. If you want to check many variants at once, please use other API endpoints that you will find in the documentation.
Documentation & Advanced Usage
• Complete API documentation:docs.genebe.net/docs/api/overview/
• Interactive endpoint tester:api.genebe.net/cloud/gb-api-doc/swagger-ui/
• Python client for pandas:pypi.org/project/genebe/
• Java CLI for VCF files:github.com/pstawinski/genebe-cli
• All tools documented at:docs.genebe.net
API Request Examples for Variant: 4-152411746-T-A (hg38)
Bash / cURL Example
bash
curl "https://api.genebe.net/cloud/api-public/v1/variant?chr=4&pos=152411746&ref=T&alt=A&genome=hg38&allGenes=true"API Response
json
{
"variants": [
{
"chr": "4",
"pos": 152411746,
"ref": "T",
"alt": "A",
"effect": "stop_gained",
"transcript": "ENST00000281708.10",
"consequences": [
{
"aa_ref": "R",
"aa_alt": "*",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"stop_gained"
],
"exon_rank": 4,
"exon_rank_end": null,
"exon_count": 14,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "FBXW7",
"gene_hgnc_id": 16712,
"hgvs_c": "c.58A>T",
"hgvs_p": "p.Arg20*",
"transcript": "NM_001349798.2",
"protein_id": "NP_001336727.1",
"transcript_support_level": null,
"aa_start": 20,
"aa_end": null,
"aa_length": 707,
"cds_start": 58,
"cds_end": null,
"cds_length": 2124,
"cdna_start": 1236,
"cdna_end": null,
"cdna_length": 5639,
"mane_select": "ENST00000281708.10",
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "R",
"aa_alt": "*",
"canonical": true,
"protein_coding": true,
"strand": false,
"consequences": [
"stop_gained"
],
"exon_rank": 4,
"exon_rank_end": null,
"exon_count": 14,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "FBXW7",
"gene_hgnc_id": 16712,
"hgvs_c": "c.58A>T",
"hgvs_p": "p.Arg20*",
"transcript": "ENST00000281708.10",
"protein_id": "ENSP00000281708.3",
"transcript_support_level": 1,
"aa_start": 20,
"aa_end": null,
"aa_length": 707,
"cds_start": 58,
"cds_end": null,
"cds_length": 2124,
"cdna_start": 1236,
"cdna_end": null,
"cdna_length": 5639,
"mane_select": "NM_001349798.2",
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "R",
"aa_alt": "*",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"stop_gained"
],
"exon_rank": 2,
"exon_rank_end": null,
"exon_count": 12,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "FBXW7",
"gene_hgnc_id": 16712,
"hgvs_c": "c.58A>T",
"hgvs_p": "p.Arg20*",
"transcript": "ENST00000603548.6",
"protein_id": "ENSP00000474725.1",
"transcript_support_level": 1,
"aa_start": 20,
"aa_end": null,
"aa_length": 707,
"cds_start": 58,
"cds_end": null,
"cds_length": 2124,
"cdna_start": 1250,
"cdna_end": null,
"cdna_length": 5653,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "R",
"aa_alt": "*",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"stop_gained"
],
"exon_rank": 1,
"exon_rank_end": null,
"exon_count": 11,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "FBXW7",
"gene_hgnc_id": 16712,
"hgvs_c": "c.58A>T",
"hgvs_p": "p.Arg20*",
"transcript": "ENST00000603841.1",
"protein_id": "ENSP00000474971.1",
"transcript_support_level": 1,
"aa_start": 20,
"aa_end": null,
"aa_length": 707,
"cds_start": 58,
"cds_end": null,
"cds_length": 2124,
"cdna_start": 133,
"cdna_end": null,
"cdna_length": 2261,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "R",
"aa_alt": "*",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"stop_gained"
],
"exon_rank": 4,
"exon_rank_end": null,
"exon_count": 4,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "FBXW7",
"gene_hgnc_id": 16712,
"hgvs_c": "c.58A>T",
"hgvs_p": "p.Arg20*",
"transcript": "ENST00000604872.6",
"protein_id": "ENSP00000474751.1",
"transcript_support_level": 1,
"aa_start": 20,
"aa_end": null,
"aa_length": 176,
"cds_start": 58,
"cds_end": null,
"cds_length": 531,
"cdna_start": 335,
"cdna_end": null,
"cdna_length": 921,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "R",
"aa_alt": "*",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"stop_gained"
],
"exon_rank": 2,
"exon_rank_end": null,
"exon_count": 12,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "FBXW7",
"gene_hgnc_id": 16712,
"hgvs_c": "c.58A>T",
"hgvs_p": "p.Arg20*",
"transcript": "NM_033632.3",
"protein_id": "NP_361014.1",
"transcript_support_level": null,
"aa_start": 20,
"aa_end": null,
"aa_length": 707,
"cds_start": 58,
"cds_end": null,
"cds_length": 2124,
"cdna_start": 220,
"cdna_end": null,
"cdna_length": 3909,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "R",
"aa_alt": "*",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"stop_gained"
],
"exon_rank": 4,
"exon_rank_end": null,
"exon_count": 14,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "FBXW7",
"gene_hgnc_id": 16712,
"hgvs_c": "c.58A>T",
"hgvs_p": "p.Arg20*",
"transcript": "ENST00000703553.1",
"protein_id": "ENSP00000515369.1",
"transcript_support_level": null,
"aa_start": 20,
"aa_end": null,
"aa_length": 689,
"cds_start": 58,
"cds_end": null,
"cds_length": 2070,
"cdna_start": 743,
"cdna_end": null,
"cdna_length": 2755,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "R",
"aa_alt": "*",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"stop_gained"
],
"exon_rank": 4,
"exon_rank_end": null,
"exon_count": 4,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "FBXW7",
"gene_hgnc_id": 16712,
"hgvs_c": "c.58A>T",
"hgvs_p": "p.Arg20*",
"transcript": "NM_001257069.1",
"protein_id": "NP_001243998.1",
"transcript_support_level": null,
"aa_start": 20,
"aa_end": null,
"aa_length": 176,
"cds_start": 58,
"cds_end": null,
"cds_length": 531,
"cdna_start": 385,
"cdna_end": null,
"cdna_length": 971,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "R",
"aa_alt": "*",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"stop_gained"
],
"exon_rank": 2,
"exon_rank_end": null,
"exon_count": 2,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "FBXW7",
"gene_hgnc_id": 16712,
"hgvs_c": "c.58A>T",
"hgvs_p": "p.Arg20*",
"transcript": "ENST00000605042.1",
"protein_id": "ENSP00000474538.1",
"transcript_support_level": 3,
"aa_start": 20,
"aa_end": null,
"aa_length": 157,
"cds_start": 58,
"cds_end": null,
"cds_length": 475,
"cdna_start": 254,
"cdna_end": null,
"cdna_length": 671,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "R",
"aa_alt": "*",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"stop_gained"
],
"exon_rank": 2,
"exon_rank_end": null,
"exon_count": 2,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "FBXW7",
"gene_hgnc_id": 16712,
"hgvs_c": "c.58A>T",
"hgvs_p": "p.Arg20*",
"transcript": "ENST00000642901.1",
"protein_id": "ENSP00000495905.1",
"transcript_support_level": null,
"aa_start": 20,
"aa_end": null,
"aa_length": 69,
"cds_start": 58,
"cds_end": null,
"cds_length": 211,
"cdna_start": 242,
"cdna_end": null,
"cdna_length": 395,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "R",
"aa_alt": "*",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"stop_gained"
],
"exon_rank": 3,
"exon_rank_end": null,
"exon_count": 3,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "FBXW7",
"gene_hgnc_id": 16712,
"hgvs_c": "c.58A>T",
"hgvs_p": "p.Arg20*",
"transcript": "ENST00000643834.1",
"protein_id": "ENSP00000495702.1",
"transcript_support_level": null,
"aa_start": 20,
"aa_end": null,
"aa_length": 69,
"cds_start": 58,
"cds_end": null,
"cds_length": 211,
"cdna_start": 292,
"cdna_end": null,
"cdna_length": 445,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "R",
"aa_alt": "*",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"stop_gained"
],
"exon_rank": 5,
"exon_rank_end": null,
"exon_count": 5,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "FBXW7",
"gene_hgnc_id": 16712,
"hgvs_c": "c.58A>T",
"hgvs_p": "p.Arg20*",
"transcript": "ENST00000647166.1",
"protein_id": "ENSP00000495753.1",
"transcript_support_level": null,
"aa_start": 20,
"aa_end": null,
"aa_length": 69,
"cds_start": 58,
"cds_end": null,
"cds_length": 211,
"cdna_start": 502,
"cdna_end": null,
"cdna_length": 655,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "R",
"aa_alt": "*",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"stop_gained"
],
"exon_rank": 3,
"exon_rank_end": null,
"exon_count": 13,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "FBXW7",
"gene_hgnc_id": 16712,
"hgvs_c": "c.58A>T",
"hgvs_p": "p.Arg20*",
"transcript": "XM_011532084.3",
"protein_id": "XP_011530386.1",
"transcript_support_level": null,
"aa_start": 20,
"aa_end": null,
"aa_length": 707,
"cds_start": 58,
"cds_end": null,
"cds_length": 2124,
"cdna_start": 1186,
"cdna_end": null,
"cdna_length": 5589,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "R",
"aa_alt": "*",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"stop_gained"
],
"exon_rank": 2,
"exon_rank_end": null,
"exon_count": 12,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "FBXW7",
"gene_hgnc_id": 16712,
"hgvs_c": "c.58A>T",
"hgvs_p": "p.Arg20*",
"transcript": "XM_011532085.3",
"protein_id": "XP_011530387.1",
"transcript_support_level": null,
"aa_start": 20,
"aa_end": null,
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"cds_start": 58,
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"cdna_start": 1093,
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"mane_select": null,
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"biotype": null,
"feature": null
},
{
"aa_ref": "R",
"aa_alt": "*",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"stop_gained"
],
"exon_rank": 5,
"exon_rank_end": null,
"exon_count": 15,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "FBXW7",
"gene_hgnc_id": 16712,
"hgvs_c": "c.58A>T",
"hgvs_p": "p.Arg20*",
"transcript": "XM_024454123.2",
"protein_id": "XP_024309891.1",
"transcript_support_level": null,
"aa_start": 20,
"aa_end": null,
"aa_length": 707,
"cds_start": 58,
"cds_end": null,
"cds_length": 2124,
"cdna_start": 1284,
"cdna_end": null,
"cdna_length": 5687,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "R",
"aa_alt": "*",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"stop_gained"
],
"exon_rank": 7,
"exon_rank_end": null,
"exon_count": 17,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "FBXW7",
"gene_hgnc_id": 16712,
"hgvs_c": "c.58A>T",
"hgvs_p": "p.Arg20*",
"transcript": "XM_047415897.1",
"protein_id": "XP_047271853.1",
"transcript_support_level": null,
"aa_start": 20,
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"cds_start": 58,
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"cdna_start": 42610,
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},
{
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"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"stop_gained"
],
"exon_rank": 4,
"exon_rank_end": null,
"exon_count": 14,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "FBXW7",
"gene_hgnc_id": 16712,
"hgvs_c": "c.58A>T",
"hgvs_p": "p.Arg20*",
"transcript": "XM_047415898.1",
"protein_id": "XP_047271854.1",
"transcript_support_level": null,
"aa_start": 20,
"aa_end": null,
"aa_length": 707,
"cds_start": 58,
"cds_end": null,
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"cdna_start": 574,
"cdna_end": null,
"cdna_length": 4977,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "R",
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"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"stop_gained"
],
"exon_rank": 3,
"exon_rank_end": null,
"exon_count": 13,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "FBXW7",
"gene_hgnc_id": 16712,
"hgvs_c": "c.58A>T",
"hgvs_p": "p.Arg20*",
"transcript": "XM_047415899.1",
"protein_id": "XP_047271855.1",
"transcript_support_level": null,
"aa_start": 20,
"aa_end": null,
"aa_length": 707,
"cds_start": 58,
"cds_end": null,
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"cdna_start": 8085,
"cdna_end": null,
"cdna_length": 12488,
"mane_select": null,
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"biotype": null,
"feature": null
},
{
"aa_ref": "R",
"aa_alt": "*",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"stop_gained"
],
"exon_rank": 3,
"exon_rank_end": null,
"exon_count": 13,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "FBXW7",
"gene_hgnc_id": 16712,
"hgvs_c": "c.58A>T",
"hgvs_p": "p.Arg20*",
"transcript": "XM_047415900.1",
"protein_id": "XP_047271856.1",
"transcript_support_level": null,
"aa_start": 20,
"aa_end": null,
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"cds_start": 58,
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"feature": null
},
{
"aa_ref": "R",
"aa_alt": "*",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"stop_gained"
],
"exon_rank": 4,
"exon_rank_end": null,
"exon_count": 14,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "FBXW7",
"gene_hgnc_id": 16712,
"hgvs_c": "c.58A>T",
"hgvs_p": "p.Arg20*",
"transcript": "XM_047415901.1",
"protein_id": "XP_047271857.1",
"transcript_support_level": null,
"aa_start": 20,
"aa_end": null,
"aa_length": 707,
"cds_start": 58,
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"cdna_start": 7584,
"cdna_end": null,
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"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": false,
"strand": false,
"consequences": [
"non_coding_transcript_exon_variant"
],
"exon_rank": 3,
"exon_rank_end": null,
"exon_count": 14,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "FBXW7",
"gene_hgnc_id": 16712,
"hgvs_c": "n.58A>T",
"hgvs_p": null,
"transcript": "ENST00000703554.1",
"protein_id": "ENSP00000515370.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": null,
"cds_start": -4,
"cds_end": null,
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"cdna_start": null,
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"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"5_prime_UTR_variant"
],
"exon_rank": 4,
"exon_rank_end": null,
"exon_count": 15,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "FBXW7",
"gene_hgnc_id": 16712,
"hgvs_c": "c.-205A>T",
"hgvs_p": null,
"transcript": "XM_011532086.3",
"protein_id": "XP_011530388.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 679,
"cds_start": -4,
"cds_end": null,
"cds_length": 2040,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 5817,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"5_prime_UTR_variant"
],
"exon_rank": 3,
"exon_rank_end": null,
"exon_count": 14,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "FBXW7",
"gene_hgnc_id": 16712,
"hgvs_c": "c.-205A>T",
"hgvs_p": null,
"transcript": "XM_011532087.3",
"protein_id": "XP_011530389.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
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}
],
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}