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GeneBe API Showcase
This page demonstrates how to use the GeneBe API to query variant information. The API provides programmatic access to genomic annotations and variant data.
API presented here should be used for checking single variants. If you want to check many variants at once, please use other API endpoints that you will find in the documentation.
Documentation & Advanced Usage
• Complete API documentation:docs.genebe.net/docs/api/overview/
• Interactive endpoint tester:api.genebe.net/cloud/gb-api-doc/swagger-ui/
• Python client for pandas:pypi.org/project/genebe/
• Java CLI for VCF files:github.com/pstawinski/genebe-cli
• All tools documented at:docs.genebe.net
API Request Examples for Variant: 4-153703546-G-T (hg38)
Bash / cURL Example
bash
curl "https://api.genebe.net/cloud/api-public/v1/variant?chr=4&pos=153703546&ref=G&alt=T&genome=hg38&allGenes=true"API Response
json
{
"variants": [
{
"chr": "4",
"pos": 153703546,
"ref": "G",
"alt": "T",
"effect": "synonymous_variant",
"transcript": "ENST00000642700.2",
"consequences": [
{
"aa_ref": "L",
"aa_alt": "L",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 3,
"exon_rank_end": null,
"exon_count": 3,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "TLR2",
"gene_hgnc_id": 11848,
"hgvs_c": "c.639G>T",
"hgvs_p": "p.Leu213Leu",
"transcript": "NM_001318789.2",
"protein_id": "NP_001305718.1",
"transcript_support_level": null,
"aa_start": 213,
"aa_end": null,
"aa_length": 784,
"cds_start": 639,
"cds_end": null,
"cds_length": 2355,
"cdna_start": 882,
"cdna_end": null,
"cdna_length": 3596,
"mane_select": "ENST00000642700.2",
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "L",
"aa_alt": "L",
"canonical": true,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 3,
"exon_rank_end": null,
"exon_count": 3,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "TLR2",
"gene_hgnc_id": 11848,
"hgvs_c": "c.639G>T",
"hgvs_p": "p.Leu213Leu",
"transcript": "ENST00000642700.2",
"protein_id": "ENSP00000494425.1",
"transcript_support_level": null,
"aa_start": 213,
"aa_end": null,
"aa_length": 784,
"cds_start": 639,
"cds_end": null,
"cds_length": 2355,
"cdna_start": 882,
"cdna_end": null,
"cdna_length": 3596,
"mane_select": "NM_001318789.2",
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "L",
"aa_alt": "L",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 4,
"exon_rank_end": null,
"exon_count": 4,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "TLR2",
"gene_hgnc_id": 11848,
"hgvs_c": "c.639G>T",
"hgvs_p": "p.Leu213Leu",
"transcript": "NM_001318787.2",
"protein_id": "NP_001305716.1",
"transcript_support_level": null,
"aa_start": 213,
"aa_end": null,
"aa_length": 784,
"cds_start": 639,
"cds_end": null,
"cds_length": 2355,
"cdna_start": 1092,
"cdna_end": null,
"cdna_length": 3806,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "L",
"aa_alt": "L",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 3,
"exon_rank_end": null,
"exon_count": 3,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "TLR2",
"gene_hgnc_id": 11848,
"hgvs_c": "c.639G>T",
"hgvs_p": "p.Leu213Leu",
"transcript": "NM_001318790.2",
"protein_id": "NP_001305719.1",
"transcript_support_level": null,
"aa_start": 213,
"aa_end": null,
"aa_length": 784,
"cds_start": 639,
"cds_end": null,
"cds_length": 2355,
"cdna_start": 859,
"cdna_end": null,
"cdna_length": 3573,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "L",
"aa_alt": "L",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 3,
"exon_rank_end": null,
"exon_count": 3,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "TLR2",
"gene_hgnc_id": 11848,
"hgvs_c": "c.639G>T",
"hgvs_p": "p.Leu213Leu",
"transcript": "NM_001318791.2",
"protein_id": "NP_001305720.1",
"transcript_support_level": null,
"aa_start": 213,
"aa_end": null,
"aa_length": 784,
"cds_start": 639,
"cds_end": null,
"cds_length": 2355,
"cdna_start": 848,
"cdna_end": null,
"cdna_length": 3562,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "L",
"aa_alt": "L",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 3,
"exon_rank_end": null,
"exon_count": 3,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "TLR2",
"gene_hgnc_id": 11848,
"hgvs_c": "c.639G>T",
"hgvs_p": "p.Leu213Leu",
"transcript": "NM_001318793.2",
"protein_id": "NP_001305722.1",
"transcript_support_level": null,
"aa_start": 213,
"aa_end": null,
"aa_length": 784,
"cds_start": 639,
"cds_end": null,
"cds_length": 2355,
"cdna_start": 844,
"cdna_end": null,
"cdna_length": 3558,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "L",
"aa_alt": "L",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 3,
"exon_rank_end": null,
"exon_count": 3,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "TLR2",
"gene_hgnc_id": 11848,
"hgvs_c": "c.639G>T",
"hgvs_p": "p.Leu213Leu",
"transcript": "NM_001318795.2",
"protein_id": "NP_001305724.1",
"transcript_support_level": null,
"aa_start": 213,
"aa_end": null,
"aa_length": 784,
"cds_start": 639,
"cds_end": null,
"cds_length": 2355,
"cdna_start": 823,
"cdna_end": null,
"cdna_length": 3537,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "L",
"aa_alt": "L",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 3,
"exon_rank_end": null,
"exon_count": 3,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "TLR2",
"gene_hgnc_id": 11848,
"hgvs_c": "c.639G>T",
"hgvs_p": "p.Leu213Leu",
"transcript": "NM_001318796.2",
"protein_id": "NP_001305725.1",
"transcript_support_level": null,
"aa_start": 213,
"aa_end": null,
"aa_length": 784,
"cds_start": 639,
"cds_end": null,
"cds_length": 2355,
"cdna_start": 808,
"cdna_end": null,
"cdna_length": 3522,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "L",
"aa_alt": "L",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 3,
"exon_rank_end": null,
"exon_count": 3,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "TLR2",
"gene_hgnc_id": 11848,
"hgvs_c": "c.639G>T",
"hgvs_p": "p.Leu213Leu",
"transcript": "NM_003264.5",
"protein_id": "NP_003255.2",
"transcript_support_level": null,
"aa_start": 213,
"aa_end": null,
"aa_length": 784,
"cds_start": 639,
"cds_end": null,
"cds_length": 2355,
"cdna_start": 867,
"cdna_end": null,
"cdna_length": 3581,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "L",
"aa_alt": "L",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 3,
"exon_rank_end": null,
"exon_count": 3,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "TLR2",
"gene_hgnc_id": 11848,
"hgvs_c": "c.639G>T",
"hgvs_p": "p.Leu213Leu",
"transcript": "ENST00000260010.7",
"protein_id": "ENSP00000260010.6",
"transcript_support_level": 6,
"aa_start": 213,
"aa_end": null,
"aa_length": 784,
"cds_start": 639,
"cds_end": null,
"cds_length": 2355,
"cdna_start": 2310,
"cdna_end": null,
"cdna_length": 4463,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "L",
"aa_alt": "L",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 3,
"exon_rank_end": null,
"exon_count": 3,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "TLR2",
"gene_hgnc_id": 11848,
"hgvs_c": "c.639G>T",
"hgvs_p": "p.Leu213Leu",
"transcript": "ENST00000642580.1",
"protein_id": "ENSP00000495339.1",
"transcript_support_level": null,
"aa_start": 213,
"aa_end": null,
"aa_length": 784,
"cds_start": 639,
"cds_end": null,
"cds_length": 2355,
"cdna_start": 823,
"cdna_end": null,
"cdna_length": 2979,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "L",
"aa_alt": "L",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 4,
"exon_rank_end": null,
"exon_count": 4,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "TLR2",
"gene_hgnc_id": 11848,
"hgvs_c": "c.639G>T",
"hgvs_p": "p.Leu213Leu",
"transcript": "ENST00000643501.2",
"protein_id": "ENSP00000496208.2",
"transcript_support_level": null,
"aa_start": 213,
"aa_end": null,
"aa_length": 784,
"cds_start": 639,
"cds_end": null,
"cds_length": 2355,
"cdna_start": 1092,
"cdna_end": null,
"cdna_length": 3806,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "L",
"aa_alt": "L",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 4,
"exon_rank_end": null,
"exon_count": 4,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "TLR2",
"gene_hgnc_id": 11848,
"hgvs_c": "c.639G>T",
"hgvs_p": "p.Leu213Leu",
"transcript": "ENST00000646219.2",
"protein_id": "ENSP00000496676.2",
"transcript_support_level": null,
"aa_start": 213,
"aa_end": null,
"aa_length": 784,
"cds_start": 639,
"cds_end": null,
"cds_length": 2355,
"cdna_start": 1185,
"cdna_end": null,
"cdna_length": 3899,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "L",
"aa_alt": "L",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 3,
"exon_rank_end": null,
"exon_count": 3,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "TLR2",
"gene_hgnc_id": 11848,
"hgvs_c": "c.639G>T",
"hgvs_p": "p.Leu213Leu",
"transcript": "ENST00000646900.2",
"protein_id": "ENSP00000493968.2",
"transcript_support_level": null,
"aa_start": 213,
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"cds_start": 639,
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"cdna_start": 1077,
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"cdna_length": 3227,
"mane_select": null,
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"biotype": null,
"feature": null
},
{
"aa_ref": "L",
"aa_alt": "L",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 3,
"exon_rank_end": null,
"exon_count": 3,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "TLR2",
"gene_hgnc_id": 11848,
"hgvs_c": "c.639G>T",
"hgvs_p": "p.Leu213Leu",
"transcript": "ENST00000714431.1",
"protein_id": "ENSP00000519700.1",
"transcript_support_level": null,
"aa_start": 213,
"aa_end": null,
"aa_length": 784,
"cds_start": 639,
"cds_end": null,
"cds_length": 2355,
"cdna_start": 1074,
"cdna_end": null,
"cdna_length": 3225,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "L",
"aa_alt": "L",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 4,
"exon_rank_end": null,
"exon_count": 4,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "TLR2",
"gene_hgnc_id": 11848,
"hgvs_c": "c.639G>T",
"hgvs_p": "p.Leu213Leu",
"transcript": "ENST00000714432.1",
"protein_id": "ENSP00000519701.1",
"transcript_support_level": null,
"aa_start": 213,
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"cdna_start": 1212,
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"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "L",
"aa_alt": "L",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 3,
"exon_rank_end": null,
"exon_count": 3,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "TLR2",
"gene_hgnc_id": 11848,
"hgvs_c": "c.639G>T",
"hgvs_p": "p.Leu213Leu",
"transcript": "ENST00000714433.1",
"protein_id": "ENSP00000519702.1",
"transcript_support_level": null,
"aa_start": 213,
"aa_end": null,
"aa_length": 784,
"cds_start": 639,
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"cds_length": 2355,
"cdna_start": 1060,
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"cdna_length": 3213,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "L",
"aa_alt": "L",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 3,
"exon_rank_end": null,
"exon_count": 3,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "TLR2",
"gene_hgnc_id": 11848,
"hgvs_c": "c.639G>T",
"hgvs_p": "p.Leu213Leu",
"transcript": "ENST00000714434.1",
"protein_id": "ENSP00000519703.1",
"transcript_support_level": null,
"aa_start": 213,
"aa_end": null,
"aa_length": 784,
"cds_start": 639,
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"cdna_start": 875,
"cdna_end": null,
"cdna_length": 3031,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "L",
"aa_alt": "L",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 4,
"exon_rank_end": null,
"exon_count": 4,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "TLR2",
"gene_hgnc_id": 11848,
"hgvs_c": "c.639G>T",
"hgvs_p": "p.Leu213Leu",
"transcript": "ENST00000714435.1",
"protein_id": "ENSP00000519704.1",
"transcript_support_level": null,
"aa_start": 213,
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"feature": null
},
{
"aa_ref": "L",
"aa_alt": "L",
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"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 3,
"exon_rank_end": null,
"exon_count": 3,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "TLR2",
"gene_hgnc_id": 11848,
"hgvs_c": "c.639G>T",
"hgvs_p": "p.Leu213Leu",
"transcript": "XM_011532215.3",
"protein_id": "XP_011530517.1",
"transcript_support_level": null,
"aa_start": 213,
"aa_end": null,
"aa_length": 784,
"cds_start": 639,
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"feature": null
},
{
"aa_ref": "L",
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"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 2,
"exon_rank_end": null,
"exon_count": 2,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "TLR2",
"gene_hgnc_id": 11848,
"hgvs_c": "c.639G>T",
"hgvs_p": "p.Leu213Leu",
"transcript": "XM_011532216.3",
"protein_id": "XP_011530518.1",
"transcript_support_level": null,
"aa_start": 213,
"aa_end": null,
"aa_length": 784,
"cds_start": 639,
"cds_end": null,
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"cdna_start": 736,
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"cdna_length": 3450,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "L",
"aa_alt": "L",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 4,
"exon_rank_end": null,
"exon_count": 4,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "TLR2",
"gene_hgnc_id": 11848,
"hgvs_c": "c.639G>T",
"hgvs_p": "p.Leu213Leu",
"transcript": "XM_017008573.2",
"protein_id": "XP_016864062.1",
"transcript_support_level": null,
"aa_start": 213,
"aa_end": null,
"aa_length": 784,
"cds_start": 639,
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"cds_length": 2355,
"cdna_start": 1166,
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"cdna_length": 3880,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "L",
"aa_alt": "L",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 4,
"exon_rank_end": null,
"exon_count": 4,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "TLR2",
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}
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}