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GeneBe API Showcase
This page demonstrates how to use the GeneBe API to query variant information. The API provides programmatic access to genomic annotations and variant data.
API presented here should be used for checking single variants. If you want to check many variants at once, please use other API endpoints that you will find in the documentation.
Documentation & Advanced Usage
• Complete API documentation:docs.genebe.net/docs/api/overview/
• Interactive endpoint tester:api.genebe.net/cloud/gb-api-doc/swagger-ui/
• Python client for pandas:pypi.org/project/genebe/
• Java CLI for VCF files:github.com/pstawinski/genebe-cli
• All tools documented at:docs.genebe.net
API Request Examples for Variant: 4-15625853-C-A (hg38)
Bash / cURL Example
bash
curl "https://api.genebe.net/cloud/api-public/v1/variant?chr=4&pos=15625853&ref=C&alt=A&genome=hg38&allGenes=true"API Response
json
{
"variants": [
{
"chr": "4",
"pos": 15625853,
"ref": "C",
"alt": "A",
"effect": "missense_variant",
"transcript": "NM_012161.4",
"consequences": [
{
"aa_ref": "G",
"aa_alt": "C",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 9,
"exon_rank_end": null,
"exon_count": 11,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "FBXL5",
"gene_hgnc_id": 13602,
"hgvs_c": "c.1249G>T",
"hgvs_p": "p.Gly417Cys",
"transcript": "NM_012161.4",
"protein_id": "NP_036293.1",
"transcript_support_level": null,
"aa_start": 417,
"aa_end": null,
"aa_length": 691,
"cds_start": 1249,
"cds_end": null,
"cds_length": 2076,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": "ENST00000341285.8",
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_012161.4"
},
{
"aa_ref": "G",
"aa_alt": "C",
"canonical": true,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 9,
"exon_rank_end": null,
"exon_count": 11,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "FBXL5",
"gene_hgnc_id": 13602,
"hgvs_c": "c.1249G>T",
"hgvs_p": "p.Gly417Cys",
"transcript": "ENST00000341285.8",
"protein_id": "ENSP00000344866.3",
"transcript_support_level": 1,
"aa_start": 417,
"aa_end": null,
"aa_length": 691,
"cds_start": 1249,
"cds_end": null,
"cds_length": 2076,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": "NM_012161.4",
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000341285.8"
},
{
"aa_ref": "G",
"aa_alt": "C",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 9,
"exon_rank_end": null,
"exon_count": 11,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "FBXL5",
"gene_hgnc_id": 13602,
"hgvs_c": "c.1198G>T",
"hgvs_p": "p.Gly400Cys",
"transcript": "ENST00000412094.6",
"protein_id": "ENSP00000408679.2",
"transcript_support_level": 1,
"aa_start": 400,
"aa_end": null,
"aa_length": 674,
"cds_start": 1198,
"cds_end": null,
"cds_length": 2025,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000412094.6"
},
{
"aa_ref": "G",
"aa_alt": "C",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 7,
"exon_rank_end": null,
"exon_count": 9,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "FBXL5",
"gene_hgnc_id": 13602,
"hgvs_c": "c.1009G>T",
"hgvs_p": "p.Gly337Cys",
"transcript": "ENST00000513163.5",
"protein_id": "ENSP00000425472.1",
"transcript_support_level": 1,
"aa_start": 337,
"aa_end": null,
"aa_length": 611,
"cds_start": 1009,
"cds_end": null,
"cds_length": 1836,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000513163.5"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": false,
"strand": false,
"consequences": [
"non_coding_transcript_exon_variant"
],
"exon_rank": 9,
"exon_rank_end": null,
"exon_count": 10,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "FBXL5",
"gene_hgnc_id": 13602,
"hgvs_c": "n.1303G>T",
"hgvs_p": null,
"transcript": "ENST00000507700.5",
"protein_id": null,
"transcript_support_level": 1,
"aa_start": null,
"aa_end": null,
"aa_length": null,
"cds_start": null,
"cds_end": null,
"cds_length": null,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "retained_intron",
"feature": "ENST00000507700.5"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": false,
"strand": false,
"consequences": [
"non_coding_transcript_exon_variant"
],
"exon_rank": 10,
"exon_rank_end": null,
"exon_count": 12,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "FBXL5",
"gene_hgnc_id": 13602,
"hgvs_c": "n.*1020G>T",
"hgvs_p": null,
"transcript": "ENST00000511441.5",
"protein_id": "ENSP00000425027.1",
"transcript_support_level": 1,
"aa_start": null,
"aa_end": null,
"aa_length": null,
"cds_start": null,
"cds_end": null,
"cds_length": null,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "nonsense_mediated_decay",
"feature": "ENST00000511441.5"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": false,
"strand": false,
"consequences": [
"3_prime_UTR_variant"
],
"exon_rank": 10,
"exon_rank_end": null,
"exon_count": 12,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "FBXL5",
"gene_hgnc_id": 13602,
"hgvs_c": "n.*1020G>T",
"hgvs_p": null,
"transcript": "ENST00000511441.5",
"protein_id": "ENSP00000425027.1",
"transcript_support_level": 1,
"aa_start": null,
"aa_end": null,
"aa_length": null,
"cds_start": null,
"cds_end": null,
"cds_length": null,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "nonsense_mediated_decay",
"feature": "ENST00000511441.5"
},
{
"aa_ref": "G",
"aa_alt": "C",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 9,
"exon_rank_end": null,
"exon_count": 11,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "FBXL5",
"gene_hgnc_id": 13602,
"hgvs_c": "c.1249G>T",
"hgvs_p": "p.Gly417Cys",
"transcript": "ENST00000945529.1",
"protein_id": "ENSP00000615588.1",
"transcript_support_level": null,
"aa_start": 417,
"aa_end": null,
"aa_length": 703,
"cds_start": 1249,
"cds_end": null,
"cds_length": 2112,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000945529.1"
},
{
"aa_ref": "G",
"aa_alt": "C",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 9,
"exon_rank_end": null,
"exon_count": 11,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "FBXL5",
"gene_hgnc_id": 13602,
"hgvs_c": "c.1252G>T",
"hgvs_p": "p.Gly418Cys",
"transcript": "ENST00000945524.1",
"protein_id": "ENSP00000615583.1",
"transcript_support_level": null,
"aa_start": 418,
"aa_end": null,
"aa_length": 692,
"cds_start": 1252,
"cds_end": null,
"cds_length": 2079,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000945524.1"
},
{
"aa_ref": "G",
"aa_alt": "C",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 9,
"exon_rank_end": null,
"exon_count": 11,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "FBXL5",
"gene_hgnc_id": 13602,
"hgvs_c": "c.1249G>T",
"hgvs_p": "p.Gly417Cys",
"transcript": "ENST00000945525.1",
"protein_id": "ENSP00000615584.1",
"transcript_support_level": null,
"aa_start": 417,
"aa_end": null,
"aa_length": 691,
"cds_start": 1249,
"cds_end": null,
"cds_length": 2076,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000945525.1"
},
{
"aa_ref": "G",
"aa_alt": "C",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 9,
"exon_rank_end": null,
"exon_count": 11,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "FBXL5",
"gene_hgnc_id": 13602,
"hgvs_c": "c.1246G>T",
"hgvs_p": "p.Gly416Cys",
"transcript": "NM_001193534.2",
"protein_id": "NP_001180463.1",
"transcript_support_level": null,
"aa_start": 416,
"aa_end": null,
"aa_length": 690,
"cds_start": 1246,
"cds_end": null,
"cds_length": 2073,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001193534.2"
},
{
"aa_ref": "G",
"aa_alt": "C",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 9,
"exon_rank_end": null,
"exon_count": 11,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "FBXL5",
"gene_hgnc_id": 13602,
"hgvs_c": "c.1246G>T",
"hgvs_p": "p.Gly416Cys",
"transcript": "ENST00000884015.1",
"protein_id": "ENSP00000554074.1",
"transcript_support_level": null,
"aa_start": 416,
"aa_end": null,
"aa_length": 690,
"cds_start": 1246,
"cds_end": null,
"cds_length": 2073,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000884015.1"
},
{
"aa_ref": "G",
"aa_alt": "C",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 9,
"exon_rank_end": null,
"exon_count": 11,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "FBXL5",
"gene_hgnc_id": 13602,
"hgvs_c": "c.1246G>T",
"hgvs_p": "p.Gly416Cys",
"transcript": "ENST00000884018.1",
"protein_id": "ENSP00000554077.1",
"transcript_support_level": null,
"aa_start": 416,
"aa_end": null,
"aa_length": 690,
"cds_start": 1246,
"cds_end": null,
"cds_length": 2073,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000884018.1"
},
{
"aa_ref": "G",
"aa_alt": "C",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 9,
"exon_rank_end": null,
"exon_count": 11,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "FBXL5",
"gene_hgnc_id": 13602,
"hgvs_c": "c.1240G>T",
"hgvs_p": "p.Gly414Cys",
"transcript": "ENST00000884017.1",
"protein_id": "ENSP00000554076.1",
"transcript_support_level": null,
"aa_start": 414,
"aa_end": null,
"aa_length": 688,
"cds_start": 1240,
"cds_end": null,
"cds_length": 2067,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000884017.1"
},
{
"aa_ref": "G",
"aa_alt": "C",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 9,
"exon_rank_end": null,
"exon_count": 11,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "FBXL5",
"gene_hgnc_id": 13602,
"hgvs_c": "c.1201G>T",
"hgvs_p": "p.Gly401Cys",
"transcript": "ENST00000945528.1",
"protein_id": "ENSP00000615587.1",
"transcript_support_level": null,
"aa_start": 401,
"aa_end": null,
"aa_length": 675,
"cds_start": 1201,
"cds_end": null,
"cds_length": 2028,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000945528.1"
},
{
"aa_ref": "G",
"aa_alt": "C",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 9,
"exon_rank_end": null,
"exon_count": 11,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "FBXL5",
"gene_hgnc_id": 13602,
"hgvs_c": "c.1198G>T",
"hgvs_p": "p.Gly400Cys",
"transcript": "NM_001193535.2",
"protein_id": "NP_001180464.1",
"transcript_support_level": null,
"aa_start": 400,
"aa_end": null,
"aa_length": 674,
"cds_start": 1198,
"cds_end": null,
"cds_length": 2025,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001193535.2"
},
{
"aa_ref": "G",
"aa_alt": "C",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 9,
"exon_rank_end": null,
"exon_count": 11,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "FBXL5",
"gene_hgnc_id": 13602,
"hgvs_c": "c.1195G>T",
"hgvs_p": "p.Gly399Cys",
"transcript": "ENST00000884014.1",
"protein_id": "ENSP00000554073.1",
"transcript_support_level": null,
"aa_start": 399,
"aa_end": null,
"aa_length": 673,
"cds_start": 1195,
"cds_end": null,
"cds_length": 2022,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000884014.1"
},
{
"aa_ref": "G",
"aa_alt": "C",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 9,
"exon_rank_end": null,
"exon_count": 11,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "FBXL5",
"gene_hgnc_id": 13602,
"hgvs_c": "c.1195G>T",
"hgvs_p": "p.Gly399Cys",
"transcript": "ENST00000884016.1",
"protein_id": "ENSP00000554075.1",
"transcript_support_level": null,
"aa_start": 399,
"aa_end": null,
"aa_length": 673,
"cds_start": 1195,
"cds_end": null,
"cds_length": 2022,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000884016.1"
},
{
"aa_ref": "G",
"aa_alt": "C",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 9,
"exon_rank_end": null,
"exon_count": 11,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "FBXL5",
"gene_hgnc_id": 13602,
"hgvs_c": "c.1192G>T",
"hgvs_p": "p.Gly398Cys",
"transcript": "ENST00000928640.1",
"protein_id": "ENSP00000598699.1",
"transcript_support_level": null,
"aa_start": 398,
"aa_end": null,
"aa_length": 672,
"cds_start": 1192,
"cds_end": null,
"cds_length": 2019,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000928640.1"
},
{
"aa_ref": "G",
"aa_alt": "C",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 8,
"exon_rank_end": null,
"exon_count": 10,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "FBXL5",
"gene_hgnc_id": 13602,
"hgvs_c": "c.1156G>T",
"hgvs_p": "p.Gly386Cys",
"transcript": "ENST00000945526.1",
"protein_id": "ENSP00000615585.1",
"transcript_support_level": null,
"aa_start": 386,
"aa_end": null,
"aa_length": 660,
"cds_start": 1156,
"cds_end": null,
"cds_length": 1983,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000945526.1"
},
{
"aa_ref": "G",
"aa_alt": "C",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 8,
"exon_rank_end": null,
"exon_count": 10,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "FBXL5",
"gene_hgnc_id": 13602,
"hgvs_c": "c.1150G>T",
"hgvs_p": "p.Gly384Cys",
"transcript": "ENST00000945530.1",
"protein_id": "ENSP00000615589.1",
"transcript_support_level": null,
"aa_start": 384,
"aa_end": null,
"aa_length": 658,
"cds_start": 1150,
"cds_end": null,
"cds_length": 1977,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000945530.1"
},
{
"aa_ref": "G",
"aa_alt": "C",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 8,
"exon_rank_end": null,
"exon_count": 10,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "FBXL5",
"gene_hgnc_id": 13602,
"hgvs_c": "c.1033G>T",
"hgvs_p": "p.Gly345Cys",
"transcript": "ENST00000884013.1",
"protein_id": "ENSP00000554072.1",
"transcript_support_level": null,
"aa_start": 345,
"aa_end": null,
"aa_length": 619,
"cds_start": 1033,
"cds_end": null,
"cds_length": 1860,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
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"phenotype_combined": "not specified",
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}
],
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}