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GeneBe API Showcase
This page demonstrates how to use the GeneBe API to query variant information. The API provides programmatic access to genomic annotations and variant data.
API presented here should be used for checking single variants. If you want to check many variants at once, please use other API endpoints that you will find in the documentation.
Documentation & Advanced Usage
• Complete API documentation:docs.genebe.net/docs/api/overview/
• Interactive endpoint tester:api.genebe.net/cloud/gb-api-doc/swagger-ui/
• Python client for pandas:pypi.org/project/genebe/
• Java CLI for VCF files:github.com/pstawinski/genebe-cli
• All tools documented at:docs.genebe.net
API Request Examples for Variant: 4-17990709-A-G (hg38)
Bash / cURL Example
bash
curl "https://api.genebe.net/cloud/api-public/v1/variant?chr=4&pos=17990709&ref=A&alt=G&genome=hg38&allGenes=true"API Response
json
{
"variants": [
{
"chr": "4",
"pos": 17990709,
"ref": "A",
"alt": "G",
"effect": "intron_variant",
"transcript": "ENST00000635767.2",
"consequences": [
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 8,
"intron_rank": 1,
"intron_rank_end": null,
"gene_symbol": "LCORL",
"gene_hgnc_id": 30776,
"hgvs_c": "c.155-17824T>C",
"hgvs_p": null,
"transcript": "NM_001394446.1",
"protein_id": "NP_001381375.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 1871,
"cds_start": -4,
"cds_end": null,
"cds_length": 5616,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 10321,
"mane_select": "ENST00000635767.2",
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": true,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 8,
"intron_rank": 1,
"intron_rank_end": null,
"gene_symbol": "LCORL",
"gene_hgnc_id": 30776,
"hgvs_c": "c.155-17824T>C",
"hgvs_p": null,
"transcript": "ENST00000635767.2",
"protein_id": "ENSP00000490600.1",
"transcript_support_level": 5,
"aa_start": null,
"aa_end": null,
"aa_length": 1871,
"cds_start": -4,
"cds_end": null,
"cds_length": 5616,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 10321,
"mane_select": "NM_001394446.1",
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 7,
"intron_rank": 1,
"intron_rank_end": null,
"gene_symbol": "LCORL",
"gene_hgnc_id": 30776,
"hgvs_c": "c.155-17824T>C",
"hgvs_p": null,
"transcript": "ENST00000326877.8",
"protein_id": "ENSP00000317566.3",
"transcript_support_level": 1,
"aa_start": null,
"aa_end": null,
"aa_length": 318,
"cds_start": -4,
"cds_end": null,
"cds_length": 957,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 5604,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 7,
"intron_rank": 1,
"intron_rank_end": null,
"gene_symbol": "LCORL",
"gene_hgnc_id": 30776,
"hgvs_c": "c.155-17824T>C",
"hgvs_p": null,
"transcript": "NM_001166139.2",
"protein_id": "NP_001159611.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 602,
"cds_start": -4,
"cds_end": null,
"cds_length": 1809,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 5058,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 7,
"intron_rank": 1,
"intron_rank_end": null,
"gene_symbol": "LCORL",
"gene_hgnc_id": 30776,
"hgvs_c": "c.155-17824T>C",
"hgvs_p": null,
"transcript": "ENST00000382226.5",
"protein_id": "ENSP00000371661.5",
"transcript_support_level": 5,
"aa_start": null,
"aa_end": null,
"aa_length": 602,
"cds_start": -4,
"cds_end": null,
"cds_length": 1809,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 5009,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 7,
"intron_rank": 1,
"intron_rank_end": null,
"gene_symbol": "LCORL",
"gene_hgnc_id": 30776,
"hgvs_c": "c.-98-17824T>C",
"hgvs_p": null,
"transcript": "ENST00000382224.5",
"protein_id": "ENSP00000371659.1",
"transcript_support_level": 5,
"aa_start": null,
"aa_end": null,
"aa_length": 518,
"cds_start": -4,
"cds_end": null,
"cds_length": 1557,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 4984,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 8,
"intron_rank": 1,
"intron_rank_end": null,
"gene_symbol": "LCORL",
"gene_hgnc_id": 30776,
"hgvs_c": "c.-373-17824T>C",
"hgvs_p": null,
"transcript": "NM_001365658.1",
"protein_id": "NP_001352587.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 442,
"cds_start": -4,
"cds_end": null,
"cds_length": 1329,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 5101,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 8,
"intron_rank": 1,
"intron_rank_end": null,
"gene_symbol": "LCORL",
"gene_hgnc_id": 30776,
"hgvs_c": "c.-373-17824T>C",
"hgvs_p": null,
"transcript": "NM_001365659.1",
"protein_id": "NP_001352588.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 442,
"cds_start": -4,
"cds_end": null,
"cds_length": 1329,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 5105,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 9,
"intron_rank": 1,
"intron_rank_end": null,
"gene_symbol": "LCORL",
"gene_hgnc_id": 30776,
"hgvs_c": "c.152-17824T>C",
"hgvs_p": null,
"transcript": "ENST00000675605.1",
"protein_id": "ENSP00000501939.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 432,
"cds_start": -4,
"cds_end": null,
"cds_length": 1299,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 2106,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
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"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 8,
"intron_rank": 1,
"intron_rank_end": null,
"gene_symbol": "LCORL",
"gene_hgnc_id": 30776,
"hgvs_c": "c.155-17824T>C",
"hgvs_p": null,
"transcript": "NM_001365660.1",
"protein_id": "NP_001352589.1",
"transcript_support_level": null,
"aa_start": null,
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"aa_length": 327,
"cds_start": -4,
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"cdna_start": null,
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"mane_select": null,
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"biotype": null,
"feature": null
},
{
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"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
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"exon_count": 8,
"intron_rank": 1,
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"gene_symbol": "LCORL",
"gene_hgnc_id": 30776,
"hgvs_c": "c.155-17824T>C",
"hgvs_p": null,
"transcript": "ENST00000675143.1",
"protein_id": "ENSP00000502692.1",
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"cds_start": -4,
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},
{
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"strand": false,
"consequences": [
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],
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"gene_symbol": "LCORL",
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"transcript": "NM_153686.8",
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},
{
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"strand": false,
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],
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"intron_rank": 1,
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"gene_symbol": "LCORL",
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"hgvs_c": "c.155-17824T>C",
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"transcript": "NM_001365661.1",
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},
{
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],
"exon_rank": null,
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"gene_symbol": "LCORL",
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"hgvs_c": "c.155-17824T>C",
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},
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],
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"transcript": "ENST00000675927.1",
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},
{
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],
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"gene_symbol": "LCORL",
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"hgvs_c": "c.155-17824T>C",
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],
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"gene_symbol": "LCORL",
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"hgvs_c": "c.155-17824T>C",
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"transcript": "NM_001365663.1",
"protein_id": "NP_001352592.1",
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},
{
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"consequences": [
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],
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"intron_rank": 1,
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"gene_symbol": "LCORL",
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"hgvs_c": "c.155-17824T>C",
"hgvs_p": null,
"transcript": "NM_001365665.1",
"protein_id": "NP_001352594.1",
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},
{
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],
"exon_rank": null,
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"gene_symbol": "LCORL",
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"transcript": "ENST00000510451.5",
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},
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],
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},
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],
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},
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"consequences": [
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],
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"gene_symbol": "LCORL",
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"hgvs_c": "n.151-17824T>C",
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"transcript": "ENST00000675131.1",
"protein_id": "ENSP00000501990.1",
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},
{
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"strand": false,
"consequences": [
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],
"exon_rank": null,
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"exon_count": 8,
"intron_rank": 1,
"intron_rank_end": null,
"gene_symbol": "LCORL",
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"hgvs_c": "n.155-17824T>C",
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"transcript": "ENST00000676061.1",
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}