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GeneBe API Showcase
This page demonstrates how to use the GeneBe API to query variant information. The API provides programmatic access to genomic annotations and variant data.
API presented here should be used for checking single variants. If you want to check many variants at once, please use other API endpoints that you will find in the documentation.
Documentation & Advanced Usage
• Complete API documentation:docs.genebe.net/docs/api/overview/
• Interactive endpoint tester:api.genebe.net/cloud/gb-api-doc/swagger-ui/
• Python client for pandas:pypi.org/project/genebe/
• Java CLI for VCF files:github.com/pstawinski/genebe-cli
• All tools documented at:docs.genebe.net
API Request Examples for Variant: 4-182651237-C-T (hg38)
Bash / cURL Example
bash
curl "https://api.genebe.net/cloud/api-public/v1/variant?chr=4&pos=182651237&ref=C&alt=T&genome=hg38&allGenes=true"API Response
json
{
"variants": [
{
"chr": "4",
"pos": 182651237,
"ref": "C",
"alt": "T",
"effect": "intron_variant",
"transcript": "NM_001415969.1",
"consequences": [
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 28,
"intron_rank": 5,
"intron_rank_end": null,
"gene_symbol": "TENM3",
"gene_hgnc_id": 29944,
"hgvs_c": "c.989-2534C>T",
"hgvs_p": null,
"transcript": "NM_001080477.4",
"protein_id": "NP_001073946.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 2699,
"cds_start": null,
"cds_end": null,
"cds_length": 8100,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": "ENST00000511685.6",
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001080477.4"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": true,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 28,
"intron_rank": 5,
"intron_rank_end": null,
"gene_symbol": "TENM3",
"gene_hgnc_id": 29944,
"hgvs_c": "c.989-2534C>T",
"hgvs_p": null,
"transcript": "ENST00000511685.6",
"protein_id": "ENSP00000424226.1",
"transcript_support_level": 5,
"aa_start": null,
"aa_end": null,
"aa_length": 2699,
"cds_start": null,
"cds_end": null,
"cds_length": 8100,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": "NM_001080477.4",
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000511685.6"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 31,
"intron_rank": 5,
"intron_rank_end": null,
"gene_symbol": "TENM3",
"gene_hgnc_id": 29944,
"hgvs_c": "c.989-2534C>T",
"hgvs_p": null,
"transcript": "ENST00000851056.1",
"protein_id": "ENSP00000521125.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 2722,
"cds_start": null,
"cds_end": null,
"cds_length": 8169,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000851056.1"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 31,
"intron_rank": 5,
"intron_rank_end": null,
"gene_symbol": "TENM3",
"gene_hgnc_id": 29944,
"hgvs_c": "c.989-2534C>T",
"hgvs_p": null,
"transcript": "ENST00000851057.1",
"protein_id": "ENSP00000521126.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 2721,
"cds_start": null,
"cds_end": null,
"cds_length": 8166,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000851057.1"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 29,
"intron_rank": 4,
"intron_rank_end": null,
"gene_symbol": "TENM3",
"gene_hgnc_id": 29944,
"hgvs_c": "c.989-2534C>T",
"hgvs_p": null,
"transcript": "ENST00000851055.1",
"protein_id": "ENSP00000521124.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 2715,
"cds_start": null,
"cds_end": null,
"cds_length": 8148,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000851055.1"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 29,
"intron_rank": 5,
"intron_rank_end": null,
"gene_symbol": "TENM3",
"gene_hgnc_id": 29944,
"hgvs_c": "c.989-2534C>T",
"hgvs_p": null,
"transcript": "NM_001415969.1",
"protein_id": "NP_001402898.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 2706,
"cds_start": null,
"cds_end": null,
"cds_length": 8121,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001415969.1"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 29,
"intron_rank": 5,
"intron_rank_end": null,
"gene_symbol": "TENM3",
"gene_hgnc_id": 29944,
"hgvs_c": "c.989-2534C>T",
"hgvs_p": null,
"transcript": "NM_001415970.1",
"protein_id": "NP_001402899.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 2706,
"cds_start": null,
"cds_end": null,
"cds_length": 8121,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001415970.1"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 29,
"intron_rank": 5,
"intron_rank_end": null,
"gene_symbol": "TENM3",
"gene_hgnc_id": 29944,
"hgvs_c": "c.989-2534C>T",
"hgvs_p": null,
"transcript": "ENST00000851042.1",
"protein_id": "ENSP00000521111.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 2706,
"cds_start": null,
"cds_end": null,
"cds_length": 8121,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000851042.1"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 29,
"intron_rank": 5,
"intron_rank_end": null,
"gene_symbol": "TENM3",
"gene_hgnc_id": 29944,
"hgvs_c": "c.989-2534C>T",
"hgvs_p": null,
"transcript": "ENST00000851043.1",
"protein_id": "ENSP00000521112.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 2706,
"cds_start": null,
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"cds_length": 8121,
"cdna_start": null,
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"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000851043.1"
},
{
"aa_ref": null,
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"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 29,
"intron_rank": 5,
"intron_rank_end": null,
"gene_symbol": "TENM3",
"gene_hgnc_id": 29944,
"hgvs_c": "c.989-2534C>T",
"hgvs_p": null,
"transcript": "NM_001415968.1",
"protein_id": "NP_001402897.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 2705,
"cds_start": null,
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"cds_length": 8118,
"cdna_start": null,
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"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001415968.1"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
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"exon_count": 29,
"intron_rank": 5,
"intron_rank_end": null,
"gene_symbol": "TENM3",
"gene_hgnc_id": 29944,
"hgvs_c": "c.989-2534C>T",
"hgvs_p": null,
"transcript": "ENST00000512480.6",
"protein_id": "ENSP00000421320.2",
"transcript_support_level": 3,
"aa_start": null,
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"aa_length": 2705,
"cds_start": null,
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"cdna_start": null,
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},
{
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"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
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"gene_symbol": "TENM3",
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"hgvs_c": "c.989-2534C>T",
"hgvs_p": null,
"transcript": "NM_001415971.1",
"protein_id": "NP_001402900.1",
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"biotype": "protein_coding",
"feature": "NM_001415971.1"
},
{
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"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
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"intron_rank": 5,
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"gene_symbol": "TENM3",
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"hgvs_c": "c.989-2534C>T",
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"transcript": "NM_001415973.1",
"protein_id": "NP_001402902.1",
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"biotype": "protein_coding",
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},
{
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"strand": true,
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],
"exon_rank": null,
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"gene_symbol": "TENM3",
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},
{
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"protein_coding": true,
"strand": true,
"consequences": [
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],
"exon_rank": null,
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"exon_count": 28,
"intron_rank": 5,
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"gene_symbol": "TENM3",
"gene_hgnc_id": 29944,
"hgvs_c": "c.989-2534C>T",
"hgvs_p": null,
"transcript": "ENST00000851046.1",
"protein_id": "ENSP00000521115.1",
"transcript_support_level": null,
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},
{
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],
"exon_rank": null,
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"gene_symbol": "TENM3",
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"hgvs_c": "c.989-2534C>T",
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},
{
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"protein_coding": true,
"strand": true,
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],
"exon_rank": null,
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"exon_count": 28,
"intron_rank": 5,
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"gene_symbol": "TENM3",
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"hgvs_c": "c.989-2534C>T",
"hgvs_p": null,
"transcript": "NM_001415975.1",
"protein_id": "NP_001402904.1",
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},
{
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"strand": true,
"consequences": [
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],
"exon_rank": null,
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"exon_count": 28,
"intron_rank": 5,
"intron_rank_end": null,
"gene_symbol": "TENM3",
"gene_hgnc_id": 29944,
"hgvs_c": "c.989-2534C>T",
"hgvs_p": null,
"transcript": "ENST00000851051.1",
"protein_id": "ENSP00000521120.1",
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},
{
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"strand": true,
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],
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"intron_rank": 5,
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"gene_symbol": "TENM3",
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},
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"strand": true,
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],
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"intron_rank": 4,
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"gene_symbol": "TENM3",
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"hgvs_c": "c.710-2534C>T",
"hgvs_p": null,
"transcript": "NM_001415967.1",
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},
{
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"strand": true,
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"intron_variant"
],
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"intron_rank": 4,
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"gene_symbol": "TENM3",
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"hgvs_c": "c.710-2534C>T",
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"transcript": "ENST00000851041.1",
"protein_id": "ENSP00000521110.1",
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"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000851041.1"
},
{
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"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 27,
"intron_rank": 4,
"intron_rank_end": null,
"gene_symbol": "TENM3",
"gene_hgnc_id": 29944,
"hgvs_c": "c.710-2534C>T",
"hgvs_p": null,
"transcript": "NM_001415976.1",
"protein_id": "NP_001402905.1",
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"feature": "NM_001415976.1"
},
{
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"protein_coding": true,
"strand": true,
"consequences": [
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}
],
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}