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GeneBe API Showcase
This page demonstrates how to use the GeneBe API to query variant information. The API provides programmatic access to genomic annotations and variant data.
API presented here should be used for checking single variants. If you want to check many variants at once, please use other API endpoints that you will find in the documentation.
Documentation & Advanced Usage
• Complete API documentation:docs.genebe.net/docs/api/overview/
• Interactive endpoint tester:api.genebe.net/cloud/gb-api-doc/swagger-ui/
• Python client for pandas:pypi.org/project/genebe/
• Java CLI for VCF files:github.com/pstawinski/genebe-cli
• All tools documented at:docs.genebe.net
API Request Examples for Variant: 4-182799697-C-G (hg38)
Bash / cURL Example
bash
curl "https://api.genebe.net/cloud/api-public/v1/variant?chr=4&pos=182799697&ref=C&alt=G&genome=hg38&allGenes=true"API Response
json
{
"variants": [
{
"chr": "4",
"pos": 182799697,
"ref": "C",
"alt": "G",
"effect": "synonymous_variant",
"transcript": "ENST00000511685.6",
"consequences": [
{
"aa_ref": "G",
"aa_alt": "G",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 28,
"exon_rank_end": null,
"exon_count": 28,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "TENM3",
"gene_hgnc_id": 29944,
"hgvs_c": "c.7446C>G",
"hgvs_p": "p.Gly2482Gly",
"transcript": "NM_001080477.4",
"protein_id": "NP_001073946.1",
"transcript_support_level": null,
"aa_start": 2482,
"aa_end": null,
"aa_length": 2699,
"cds_start": 7446,
"cds_end": null,
"cds_length": 8100,
"cdna_start": 7596,
"cdna_end": null,
"cdna_length": 10923,
"mane_select": "ENST00000511685.6",
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "G",
"aa_alt": "G",
"canonical": true,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 28,
"exon_rank_end": null,
"exon_count": 28,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "TENM3",
"gene_hgnc_id": 29944,
"hgvs_c": "c.7446C>G",
"hgvs_p": "p.Gly2482Gly",
"transcript": "ENST00000511685.6",
"protein_id": "ENSP00000424226.1",
"transcript_support_level": 5,
"aa_start": 2482,
"aa_end": null,
"aa_length": 2699,
"cds_start": 7446,
"cds_end": null,
"cds_length": 8100,
"cdna_start": 7596,
"cdna_end": null,
"cdna_length": 10923,
"mane_select": "NM_001080477.4",
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "G",
"aa_alt": "G",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 29,
"exon_rank_end": null,
"exon_count": 29,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "TENM3",
"gene_hgnc_id": 29944,
"hgvs_c": "c.7467C>G",
"hgvs_p": "p.Gly2489Gly",
"transcript": "NM_001415969.1",
"protein_id": "NP_001402898.1",
"transcript_support_level": null,
"aa_start": 2489,
"aa_end": null,
"aa_length": 2706,
"cds_start": 7467,
"cds_end": null,
"cds_length": 8121,
"cdna_start": 7741,
"cdna_end": null,
"cdna_length": 11068,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "G",
"aa_alt": "G",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 29,
"exon_rank_end": null,
"exon_count": 29,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "TENM3",
"gene_hgnc_id": 29944,
"hgvs_c": "c.7467C>G",
"hgvs_p": "p.Gly2489Gly",
"transcript": "NM_001415970.1",
"protein_id": "NP_001402899.1",
"transcript_support_level": null,
"aa_start": 2489,
"aa_end": null,
"aa_length": 2706,
"cds_start": 7467,
"cds_end": null,
"cds_length": 8121,
"cdna_start": 7638,
"cdna_end": null,
"cdna_length": 10965,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "G",
"aa_alt": "G",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 29,
"exon_rank_end": null,
"exon_count": 29,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "TENM3",
"gene_hgnc_id": 29944,
"hgvs_c": "c.7464C>G",
"hgvs_p": "p.Gly2488Gly",
"transcript": "NM_001415968.1",
"protein_id": "NP_001402897.1",
"transcript_support_level": null,
"aa_start": 2488,
"aa_end": null,
"aa_length": 2705,
"cds_start": 7464,
"cds_end": null,
"cds_length": 8118,
"cdna_start": 7635,
"cdna_end": null,
"cdna_length": 10962,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "G",
"aa_alt": "G",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 28,
"exon_rank_end": null,
"exon_count": 28,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "TENM3",
"gene_hgnc_id": 29944,
"hgvs_c": "c.7446C>G",
"hgvs_p": "p.Gly2482Gly",
"transcript": "NM_001415971.1",
"protein_id": "NP_001402900.1",
"transcript_support_level": null,
"aa_start": 2482,
"aa_end": null,
"aa_length": 2699,
"cds_start": 7446,
"cds_end": null,
"cds_length": 8100,
"cdna_start": 7720,
"cdna_end": null,
"cdna_length": 11047,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "G",
"aa_alt": "G",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 28,
"exon_rank_end": null,
"exon_count": 28,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "TENM3",
"gene_hgnc_id": 29944,
"hgvs_c": "c.7446C>G",
"hgvs_p": "p.Gly2482Gly",
"transcript": "NM_001415973.1",
"protein_id": "NP_001402902.1",
"transcript_support_level": null,
"aa_start": 2482,
"aa_end": null,
"aa_length": 2699,
"cds_start": 7446,
"cds_end": null,
"cds_length": 8100,
"cdna_start": 7617,
"cdna_end": null,
"cdna_length": 10944,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "G",
"aa_alt": "G",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 28,
"exon_rank_end": null,
"exon_count": 28,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "TENM3",
"gene_hgnc_id": 29944,
"hgvs_c": "c.7443C>G",
"hgvs_p": "p.Gly2481Gly",
"transcript": "NM_001415974.1",
"protein_id": "NP_001402903.1",
"transcript_support_level": null,
"aa_start": 2481,
"aa_end": null,
"aa_length": 2698,
"cds_start": 7443,
"cds_end": null,
"cds_length": 8097,
"cdna_start": 7717,
"cdna_end": null,
"cdna_length": 11044,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "G",
"aa_alt": "G",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 28,
"exon_rank_end": null,
"exon_count": 28,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "TENM3",
"gene_hgnc_id": 29944,
"hgvs_c": "c.7443C>G",
"hgvs_p": "p.Gly2481Gly",
"transcript": "NM_001415975.1",
"protein_id": "NP_001402904.1",
"transcript_support_level": null,
"aa_start": 2481,
"aa_end": null,
"aa_length": 2698,
"cds_start": 7443,
"cds_end": null,
"cds_length": 8097,
"cdna_start": 7614,
"cdna_end": null,
"cdna_length": 10941,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "G",
"aa_alt": "G",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 28,
"exon_rank_end": null,
"exon_count": 28,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "TENM3",
"gene_hgnc_id": 29944,
"hgvs_c": "c.7188C>G",
"hgvs_p": "p.Gly2396Gly",
"transcript": "NM_001415967.1",
"protein_id": "NP_001402896.1",
"transcript_support_level": null,
"aa_start": 2396,
"aa_end": null,
"aa_length": 2613,
"cds_start": 7188,
"cds_end": null,
"cds_length": 7842,
"cdna_start": 7359,
"cdna_end": null,
"cdna_length": 10686,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "G",
"aa_alt": "G",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 27,
"exon_rank_end": null,
"exon_count": 27,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "TENM3",
"gene_hgnc_id": 29944,
"hgvs_c": "c.7167C>G",
"hgvs_p": "p.Gly2389Gly",
"transcript": "NM_001415976.1",
"protein_id": "NP_001402905.1",
"transcript_support_level": null,
"aa_start": 2389,
"aa_end": null,
"aa_length": 2606,
"cds_start": 7167,
"cds_end": null,
"cds_length": 7821,
"cdna_start": 7441,
"cdna_end": null,
"cdna_length": 10768,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "G",
"aa_alt": "G",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 27,
"exon_rank_end": null,
"exon_count": 27,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "TENM3",
"gene_hgnc_id": 29944,
"hgvs_c": "c.7167C>G",
"hgvs_p": "p.Gly2389Gly",
"transcript": "NM_001415977.1",
"protein_id": "NP_001402906.1",
"transcript_support_level": null,
"aa_start": 2389,
"aa_end": null,
"aa_length": 2606,
"cds_start": 7167,
"cds_end": null,
"cds_length": 7821,
"cdna_start": 7338,
"cdna_end": null,
"cdna_length": 10665,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "G",
"aa_alt": "G",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 27,
"exon_rank_end": null,
"exon_count": 27,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "TENM3",
"gene_hgnc_id": 29944,
"hgvs_c": "c.7164C>G",
"hgvs_p": "p.Gly2388Gly",
"transcript": "NM_001415966.1",
"protein_id": "NP_001402895.1",
"transcript_support_level": null,
"aa_start": 2388,
"aa_end": null,
"aa_length": 2605,
"cds_start": 7164,
"cds_end": null,
"cds_length": 7818,
"cdna_start": 7335,
"cdna_end": null,
"cdna_length": 10662,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "G",
"aa_alt": "G",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 28,
"exon_rank_end": null,
"exon_count": 28,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "TENM3",
"gene_hgnc_id": 29944,
"hgvs_c": "c.6678C>G",
"hgvs_p": "p.Gly2226Gly",
"transcript": "NM_001415960.1",
"protein_id": "NP_001402889.1",
"transcript_support_level": null,
"aa_start": 2226,
"aa_end": null,
"aa_length": 2443,
"cds_start": 6678,
"cds_end": null,
"cds_length": 7332,
"cdna_start": 7051,
"cdna_end": null,
"cdna_length": 10378,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "G",
"aa_alt": "G",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 27,
"exon_rank_end": null,
"exon_count": 27,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "TENM3",
"gene_hgnc_id": 29944,
"hgvs_c": "c.6651C>G",
"hgvs_p": "p.Gly2217Gly",
"transcript": "NM_001415961.1",
"protein_id": "NP_001402890.1",
"transcript_support_level": null,
"aa_start": 2217,
"aa_end": null,
"aa_length": 2434,
"cds_start": 6651,
"cds_end": null,
"cds_length": 7305,
"cdna_start": 7024,
"cdna_end": null,
"cdna_length": 10351,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "G",
"aa_alt": "G",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 27,
"exon_rank_end": null,
"exon_count": 27,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "TENM3",
"gene_hgnc_id": 29944,
"hgvs_c": "c.6648C>G",
"hgvs_p": "p.Gly2216Gly",
"transcript": "NM_001415962.1",
"protein_id": "NP_001402891.1",
"transcript_support_level": null,
"aa_start": 2216,
"aa_end": null,
"aa_length": 2433,
"cds_start": 6648,
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"cds_length": 7302,
"cdna_start": 7021,
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"cdna_length": 10348,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "G",
"aa_alt": "G",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 26,
"exon_rank_end": null,
"exon_count": 26,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "TENM3",
"gene_hgnc_id": 29944,
"hgvs_c": "c.6630C>G",
"hgvs_p": "p.Gly2210Gly",
"transcript": "NM_001415963.1",
"protein_id": "NP_001402892.1",
"transcript_support_level": null,
"aa_start": 2210,
"aa_end": null,
"aa_length": 2427,
"cds_start": 6630,
"cds_end": null,
"cds_length": 7284,
"cdna_start": 7003,
"cdna_end": null,
"cdna_length": 10330,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "G",
"aa_alt": "G",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 26,
"exon_rank_end": null,
"exon_count": 26,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "TENM3",
"gene_hgnc_id": 29944,
"hgvs_c": "c.6627C>G",
"hgvs_p": "p.Gly2209Gly",
"transcript": "NM_001415964.1",
"protein_id": "NP_001402893.1",
"transcript_support_level": null,
"aa_start": 2209,
"aa_end": null,
"aa_length": 2426,
"cds_start": 6627,
"cds_end": null,
"cds_length": 7281,
"cdna_start": 7000,
"cdna_end": null,
"cdna_length": 10327,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "G",
"aa_alt": "G",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 33,
"exon_rank_end": null,
"exon_count": 33,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "TENM3",
"gene_hgnc_id": 29944,
"hgvs_c": "c.7494C>G",
"hgvs_p": "p.Gly2498Gly",
"transcript": "XM_017008385.2",
"protein_id": "XP_016863874.1",
"transcript_support_level": null,
"aa_start": 2498,
"aa_end": null,
"aa_length": 2715,
"cds_start": 7494,
"cds_end": null,
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"cdna_start": 8053,
"cdna_end": null,
"cdna_length": 11380,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "G",
"aa_alt": "G",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 30,
"exon_rank_end": null,
"exon_count": 30,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "TENM3",
"gene_hgnc_id": 29944,
"hgvs_c": "c.7494C>G",
"hgvs_p": "p.Gly2498Gly",
"transcript": "XM_017008386.2",
"protein_id": "XP_016863875.1",
"transcript_support_level": null,
"aa_start": 2498,
"aa_end": null,
"aa_length": 2715,
"cds_start": 7494,
"cds_end": null,
"cds_length": 8148,
"cdna_start": 7768,
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"cdna_length": 11095,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "G",
"aa_alt": "G",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 30,
"exon_rank_end": null,
"exon_count": 30,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "TENM3",
"gene_hgnc_id": 29944,
"hgvs_c": "c.7494C>G",
"hgvs_p": "p.Gly2498Gly",
"transcript": "XM_017008387.3",
"protein_id": "XP_016863876.1",
"transcript_support_level": null,
"aa_start": 2498,
"aa_end": null,
"aa_length": 2715,
"cds_start": 7494,
"cds_end": null,
"cds_length": 8148,
"cdna_start": 7665,
"cdna_end": null,
"cdna_length": 10992,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "G",
"aa_alt": "G",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 30,
"exon_rank_end": null,
"exon_count": 30,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "TENM3",
"gene_hgnc_id": 29944,
"hgvs_c": "c.7494C>G",
"hgvs_p": "p.Gly2498Gly",
"transcript": "XM_017008388.2",
"protein_id": "XP_016863877.1",
"transcript_support_level": null,
"aa_start": 2498,
"aa_end": null,
"aa_length": 2715,
"cds_start": 7494,
"cds_end": null,
"cds_length": 8148,
"cdna_start": 7726,
"cdna_end": null,
"cdna_length": 11053,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "G",
"aa_alt": "G",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 33,
"exon_rank_end": null,
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}