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GeneBe API Showcase
This page demonstrates how to use the GeneBe API to query variant information. The API provides programmatic access to genomic annotations and variant data.
API presented here should be used for checking single variants. If you want to check many variants at once, please use other API endpoints that you will find in the documentation.
Documentation & Advanced Usage
• Complete API documentation:docs.genebe.net/docs/api/overview/
• Interactive endpoint tester:api.genebe.net/cloud/gb-api-doc/swagger-ui/
• Python client for pandas:pypi.org/project/genebe/
• Java CLI for VCF files:github.com/pstawinski/genebe-cli
• All tools documented at:docs.genebe.net
API Request Examples for Variant: 4-182799697-C-T (hg38)
Bash / cURL Example
bash
curl "https://api.genebe.net/cloud/api-public/v1/variant?chr=4&pos=182799697&ref=C&alt=T&genome=hg38&allGenes=true"API Response
json
{
"variants": [
{
"chr": "4",
"pos": 182799697,
"ref": "C",
"alt": "T",
"effect": "synonymous_variant",
"transcript": "NM_001415969.1",
"consequences": [
{
"aa_ref": "G",
"aa_alt": "G",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 28,
"exon_rank_end": null,
"exon_count": 28,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "TENM3",
"gene_hgnc_id": 29944,
"hgvs_c": "c.7446C>T",
"hgvs_p": "p.Gly2482Gly",
"transcript": "NM_001080477.4",
"protein_id": "NP_001073946.1",
"transcript_support_level": null,
"aa_start": 2482,
"aa_end": null,
"aa_length": 2699,
"cds_start": 7446,
"cds_end": null,
"cds_length": 8100,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": "ENST00000511685.6",
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001080477.4"
},
{
"aa_ref": "G",
"aa_alt": "G",
"canonical": true,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 28,
"exon_rank_end": null,
"exon_count": 28,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "TENM3",
"gene_hgnc_id": 29944,
"hgvs_c": "c.7446C>T",
"hgvs_p": "p.Gly2482Gly",
"transcript": "ENST00000511685.6",
"protein_id": "ENSP00000424226.1",
"transcript_support_level": 5,
"aa_start": 2482,
"aa_end": null,
"aa_length": 2699,
"cds_start": 7446,
"cds_end": null,
"cds_length": 8100,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": "NM_001080477.4",
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000511685.6"
},
{
"aa_ref": "G",
"aa_alt": "G",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 31,
"exon_rank_end": null,
"exon_count": 31,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "TENM3",
"gene_hgnc_id": 29944,
"hgvs_c": "c.7515C>T",
"hgvs_p": "p.Gly2505Gly",
"transcript": "ENST00000851056.1",
"protein_id": "ENSP00000521125.1",
"transcript_support_level": null,
"aa_start": 2505,
"aa_end": null,
"aa_length": 2722,
"cds_start": 7515,
"cds_end": null,
"cds_length": 8169,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000851056.1"
},
{
"aa_ref": "G",
"aa_alt": "G",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 31,
"exon_rank_end": null,
"exon_count": 31,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "TENM3",
"gene_hgnc_id": 29944,
"hgvs_c": "c.7512C>T",
"hgvs_p": "p.Gly2504Gly",
"transcript": "ENST00000851057.1",
"protein_id": "ENSP00000521126.1",
"transcript_support_level": null,
"aa_start": 2504,
"aa_end": null,
"aa_length": 2721,
"cds_start": 7512,
"cds_end": null,
"cds_length": 8166,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000851057.1"
},
{
"aa_ref": "G",
"aa_alt": "G",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 29,
"exon_rank_end": null,
"exon_count": 29,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "TENM3",
"gene_hgnc_id": 29944,
"hgvs_c": "c.7494C>T",
"hgvs_p": "p.Gly2498Gly",
"transcript": "ENST00000851055.1",
"protein_id": "ENSP00000521124.1",
"transcript_support_level": null,
"aa_start": 2498,
"aa_end": null,
"aa_length": 2715,
"cds_start": 7494,
"cds_end": null,
"cds_length": 8148,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000851055.1"
},
{
"aa_ref": "G",
"aa_alt": "G",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 29,
"exon_rank_end": null,
"exon_count": 29,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "TENM3",
"gene_hgnc_id": 29944,
"hgvs_c": "c.7467C>T",
"hgvs_p": "p.Gly2489Gly",
"transcript": "NM_001415969.1",
"protein_id": "NP_001402898.1",
"transcript_support_level": null,
"aa_start": 2489,
"aa_end": null,
"aa_length": 2706,
"cds_start": 7467,
"cds_end": null,
"cds_length": 8121,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001415969.1"
},
{
"aa_ref": "G",
"aa_alt": "G",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 29,
"exon_rank_end": null,
"exon_count": 29,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "TENM3",
"gene_hgnc_id": 29944,
"hgvs_c": "c.7467C>T",
"hgvs_p": "p.Gly2489Gly",
"transcript": "NM_001415970.1",
"protein_id": "NP_001402899.1",
"transcript_support_level": null,
"aa_start": 2489,
"aa_end": null,
"aa_length": 2706,
"cds_start": 7467,
"cds_end": null,
"cds_length": 8121,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001415970.1"
},
{
"aa_ref": "G",
"aa_alt": "G",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 29,
"exon_rank_end": null,
"exon_count": 29,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "TENM3",
"gene_hgnc_id": 29944,
"hgvs_c": "c.7467C>T",
"hgvs_p": "p.Gly2489Gly",
"transcript": "ENST00000851042.1",
"protein_id": "ENSP00000521111.1",
"transcript_support_level": null,
"aa_start": 2489,
"aa_end": null,
"aa_length": 2706,
"cds_start": 7467,
"cds_end": null,
"cds_length": 8121,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000851042.1"
},
{
"aa_ref": "G",
"aa_alt": "G",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 29,
"exon_rank_end": null,
"exon_count": 29,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "TENM3",
"gene_hgnc_id": 29944,
"hgvs_c": "c.7467C>T",
"hgvs_p": "p.Gly2489Gly",
"transcript": "ENST00000851043.1",
"protein_id": "ENSP00000521112.1",
"transcript_support_level": null,
"aa_start": 2489,
"aa_end": null,
"aa_length": 2706,
"cds_start": 7467,
"cds_end": null,
"cds_length": 8121,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000851043.1"
},
{
"aa_ref": "G",
"aa_alt": "G",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 29,
"exon_rank_end": null,
"exon_count": 29,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "TENM3",
"gene_hgnc_id": 29944,
"hgvs_c": "c.7464C>T",
"hgvs_p": "p.Gly2488Gly",
"transcript": "NM_001415968.1",
"protein_id": "NP_001402897.1",
"transcript_support_level": null,
"aa_start": 2488,
"aa_end": null,
"aa_length": 2705,
"cds_start": 7464,
"cds_end": null,
"cds_length": 8118,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001415968.1"
},
{
"aa_ref": "G",
"aa_alt": "G",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 29,
"exon_rank_end": null,
"exon_count": 29,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "TENM3",
"gene_hgnc_id": 29944,
"hgvs_c": "c.7464C>T",
"hgvs_p": "p.Gly2488Gly",
"transcript": "ENST00000512480.6",
"protein_id": "ENSP00000421320.2",
"transcript_support_level": 3,
"aa_start": 2488,
"aa_end": null,
"aa_length": 2705,
"cds_start": 7464,
"cds_end": null,
"cds_length": 8118,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000512480.6"
},
{
"aa_ref": "G",
"aa_alt": "G",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 28,
"exon_rank_end": null,
"exon_count": 28,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "TENM3",
"gene_hgnc_id": 29944,
"hgvs_c": "c.7446C>T",
"hgvs_p": "p.Gly2482Gly",
"transcript": "NM_001415971.1",
"protein_id": "NP_001402900.1",
"transcript_support_level": null,
"aa_start": 2482,
"aa_end": null,
"aa_length": 2699,
"cds_start": 7446,
"cds_end": null,
"cds_length": 8100,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001415971.1"
},
{
"aa_ref": "G",
"aa_alt": "G",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 28,
"exon_rank_end": null,
"exon_count": 28,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "TENM3",
"gene_hgnc_id": 29944,
"hgvs_c": "c.7446C>T",
"hgvs_p": "p.Gly2482Gly",
"transcript": "NM_001415973.1",
"protein_id": "NP_001402902.1",
"transcript_support_level": null,
"aa_start": 2482,
"aa_end": null,
"aa_length": 2699,
"cds_start": 7446,
"cds_end": null,
"cds_length": 8100,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001415973.1"
},
{
"aa_ref": "G",
"aa_alt": "G",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 28,
"exon_rank_end": null,
"exon_count": 28,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "TENM3",
"gene_hgnc_id": 29944,
"hgvs_c": "c.7446C>T",
"hgvs_p": "p.Gly2482Gly",
"transcript": "ENST00000851045.1",
"protein_id": "ENSP00000521114.1",
"transcript_support_level": null,
"aa_start": 2482,
"aa_end": null,
"aa_length": 2699,
"cds_start": 7446,
"cds_end": null,
"cds_length": 8100,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000851045.1"
},
{
"aa_ref": "G",
"aa_alt": "G",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 28,
"exon_rank_end": null,
"exon_count": 28,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "TENM3",
"gene_hgnc_id": 29944,
"hgvs_c": "c.7446C>T",
"hgvs_p": "p.Gly2482Gly",
"transcript": "ENST00000851046.1",
"protein_id": "ENSP00000521115.1",
"transcript_support_level": null,
"aa_start": 2482,
"aa_end": null,
"aa_length": 2699,
"cds_start": 7446,
"cds_end": null,
"cds_length": 8100,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000851046.1"
},
{
"aa_ref": "G",
"aa_alt": "G",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 28,
"exon_rank_end": null,
"exon_count": 28,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "TENM3",
"gene_hgnc_id": 29944,
"hgvs_c": "c.7443C>T",
"hgvs_p": "p.Gly2481Gly",
"transcript": "NM_001415974.1",
"protein_id": "NP_001402903.1",
"transcript_support_level": null,
"aa_start": 2481,
"aa_end": null,
"aa_length": 2698,
"cds_start": 7443,
"cds_end": null,
"cds_length": 8097,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001415974.1"
},
{
"aa_ref": "G",
"aa_alt": "G",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 28,
"exon_rank_end": null,
"exon_count": 28,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "TENM3",
"gene_hgnc_id": 29944,
"hgvs_c": "c.7443C>T",
"hgvs_p": "p.Gly2481Gly",
"transcript": "NM_001415975.1",
"protein_id": "NP_001402904.1",
"transcript_support_level": null,
"aa_start": 2481,
"aa_end": null,
"aa_length": 2698,
"cds_start": 7443,
"cds_end": null,
"cds_length": 8097,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001415975.1"
},
{
"aa_ref": "G",
"aa_alt": "G",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 28,
"exon_rank_end": null,
"exon_count": 28,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "TENM3",
"gene_hgnc_id": 29944,
"hgvs_c": "c.7443C>T",
"hgvs_p": "p.Gly2481Gly",
"transcript": "ENST00000851051.1",
"protein_id": "ENSP00000521120.1",
"transcript_support_level": null,
"aa_start": 2481,
"aa_end": null,
"aa_length": 2698,
"cds_start": 7443,
"cds_end": null,
"cds_length": 8097,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000851051.1"
},
{
"aa_ref": "G",
"aa_alt": "G",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 28,
"exon_rank_end": null,
"exon_count": 28,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "TENM3",
"gene_hgnc_id": 29944,
"hgvs_c": "c.7443C>T",
"hgvs_p": "p.Gly2481Gly",
"transcript": "ENST00000851052.1",
"protein_id": "ENSP00000521121.1",
"transcript_support_level": null,
"aa_start": 2481,
"aa_end": null,
"aa_length": 2698,
"cds_start": 7443,
"cds_end": null,
"cds_length": 8097,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000851052.1"
},
{
"aa_ref": "G",
"aa_alt": "G",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 28,
"exon_rank_end": null,
"exon_count": 28,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "TENM3",
"gene_hgnc_id": 29944,
"hgvs_c": "c.7188C>T",
"hgvs_p": "p.Gly2396Gly",
"transcript": "NM_001415967.1",
"protein_id": "NP_001402896.1",
"transcript_support_level": null,
"aa_start": 2396,
"aa_end": null,
"aa_length": 2613,
"cds_start": 7188,
"cds_end": null,
"cds_length": 7842,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001415967.1"
},
{
"aa_ref": "G",
"aa_alt": "G",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 28,
"exon_rank_end": null,
"exon_count": 28,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "TENM3",
"gene_hgnc_id": 29944,
"hgvs_c": "c.7188C>T",
"hgvs_p": "p.Gly2396Gly",
"transcript": "ENST00000851041.1",
"protein_id": "ENSP00000521110.1",
"transcript_support_level": null,
"aa_start": 2396,
"aa_end": null,
"aa_length": 2613,
"cds_start": 7188,
"cds_end": null,
"cds_length": 7842,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000851041.1"
},
{
"aa_ref": "G",
"aa_alt": "G",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 27,
"exon_rank_end": null,
"exon_count": 27,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "TENM3",
"gene_hgnc_id": 29944,
"hgvs_c": "c.7167C>T",
"hgvs_p": "p.Gly2389Gly",
"transcript": "NM_001415976.1",
"protein_id": "NP_001402905.1",
"transcript_support_level": null,
"aa_start": 2389,
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{
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{
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{
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{
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],
"gene_symbol": "TENM3",
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"dbsnp": "rs11223",
"frequency_reference_population": 0.11828144,
"hom_count_reference_population": 13281,
"allele_count_reference_population": 183261,
"gnomad_exomes_af": 0.112793,
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"gnomad_exomes_ac": 157589,
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"gnomad_mito_homoplasmic": null,
"gnomad_mito_heteroplasmic": null,
"computational_score_selected": -0.30000001192092896,
"computational_prediction_selected": "Benign",
"computational_source_selected": "BayesDel_noAF",
"splice_score_selected": 0,
"splice_prediction_selected": "Benign",
"splice_source_selected": "max_spliceai",
"revel_score": null,
"revel_prediction": null,
"alphamissense_score": null,
"alphamissense_prediction": null,
"bayesdelnoaf_score": -0.3,
"bayesdelnoaf_prediction": "Benign",
"phylop100way_score": 0.125,
"phylop100way_prediction": "Benign",
"spliceai_max_score": 0,
"spliceai_max_prediction": "Benign",
"dbscsnv_ada_score": null,
"dbscsnv_ada_prediction": null,
"apogee2_score": null,
"apogee2_prediction": null,
"mitotip_score": null,
"mitotip_prediction": null,
"acmg_score": -19,
"acmg_classification": "Benign",
"acmg_criteria": "BP4_Moderate,BP6_Very_Strong,BP7,BA1",
"acmg_by_gene": [
{
"score": -19,
"benign_score": 19,
"pathogenic_score": 0,
"criteria": [
"BP4_Moderate",
"BP6_Very_Strong",
"BP7",
"BA1"
],
"verdict": "Benign",
"transcript": "NM_001415969.1",
"gene_symbol": "TENM3",
"hgnc_id": 29944,
"effects": [
"synonymous_variant"
],
"inheritance_mode": "AR,AD",
"hgvs_c": "c.7467C>T",
"hgvs_p": "p.Gly2489Gly"
}
],
"clinvar_disease": "not provided,not specified",
"clinvar_classification": "Benign",
"clinvar_review_status": "criteria provided, multiple submitters, no conflicts",
"clinvar_submissions_summary": "B:4",
"phenotype_combined": "not specified|not provided",
"pathogenicity_classification_combined": "Benign",
"custom_annotations": null
}
],
"message": null
}